Detailed information for compound 569999

Basic information

Technical information
  • TDR Targets ID: 569999
  • Name: hexane-1,3,6-triamine
  • MW: 131.219 | Formula: C6H17N3
  • H donors: 3 H acceptors: 0 LogP: -1.46 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCC(CCN)N
  • InChi: 1S/C6H17N3/c7-4-1-2-6(9)3-5-8/h6H,1-5,7-9H2
  • InChiKey: AXEYWFGSQDLHDX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [4-amino-1-(2-aminoethyl)butyl]amine
  • 1,3,6-triaminohexane
  • 55911-96-1
  • 1,3,6-Hexanetriamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0598 0.1455
Schistosoma mansoni bromodomain containing protein 0.0069 0.3313 0.3249
Schistosoma mansoni hypothetical protein 0.0179 1 1
Schistosoma mansoni hypothetical protein 0.0082 0.4108 0.4052
Schistosoma mansoni lamin 0.0028 0.0808 0.072
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0398 0.0969
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0398 0.0969
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0398 0.0969
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0398 0.019
Schistosoma mansoni zinc finger protein 0.0021 0.0381 0.029
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0398 0.019
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0398 0.0969
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0398 0.0307
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.1631 0.145
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0398 0.0307
Onchocerca volvulus 0.0028 0.0808 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0211 0.0513
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0398 0.0969
Brugia malayi nuclear hormone receptor 0.0022 0.0398 0.0969
Echinococcus multilocularis zinc finger protein 0.0021 0.0381 0.0173
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0598 1
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0398 0.0307
Loa Loa (eye worm) hypothetical protein 0.0022 0.0398 0.0969
Loa Loa (eye worm) hypothetical protein 0.0047 0.1929 0.4695
Schistosoma mansoni coup transcription factor 0.0022 0.0398 0.0307
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0398 0.019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0598 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0398 0.0969
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.3496 0.3355
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0082 0.4108 0.398
Loa Loa (eye worm) hypothetical protein 0.0019 0.0211 0.0513
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0082 0.4108 0.398
Loa Loa (eye worm) hypothetical protein 0.0028 0.0776 0.1889
Loa Loa (eye worm) hypothetical protein 0.0022 0.0398 0.0969
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0598 0.148
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0398 0.019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0398 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0398 0.0969
Loa Loa (eye worm) hypothetical protein 0.0025 0.0598 0.1455
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0398 0.0307
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0398 0.0969
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.3496 0.3355
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0398 0.019
Echinococcus granulosus transcription factor Dp 1 0.0042 0.1631 0.145
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0398 0.0307
Schistosoma mansoni lamin 0.0028 0.0808 0.072
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0398 0.0969
Loa Loa (eye worm) hypothetical protein 0.0022 0.0398 0.0969
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0398 0.0307
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.058 0.0376
Loa Loa (eye worm) hypothetical protein 0.0022 0.0398 0.0969
Loa Loa (eye worm) hypothetical protein 0.0025 0.0598 0.1455
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0398 0.019
Onchocerca volvulus 0.0028 0.0808 1
Schistosoma mansoni hypothetical protein 0.0023 0.0452 0.0361
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0598 0.148
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0398 0.0969
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0598 0.1455
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.058 0.0376
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0082 0.4108 0.398
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0598 0.1455
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0398 0.0969
Brugia malayi PHD-finger family protein 0.0027 0.0739 0.1799
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0398 0.019
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.3072 0.2923
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0598 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0211 0.0513
Echinococcus granulosus lamin dm0 0.0028 0.0808 0.0609
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0398 0.019
Echinococcus granulosus zinc finger protein 0.0021 0.0381 0.0173
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0398 0.0307
Brugia malayi Bromodomain containing protein 0.0042 0.1637 0.3985
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0398 0.019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0398 0.0969
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0398 0.0307
Schistosoma mansoni hypothetical protein 0.0082 0.4108 0.4052
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0598 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.18 0.4383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0398 0.0969
Brugia malayi nuclear receptor NHR-88 0.0022 0.0398 0.0969
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0211 0.139
Echinococcus multilocularis lamin dm0 0.0028 0.0808 0.0609
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0398 0.0307
Schistosoma mansoni intermediate filament proteins 0.0028 0.0808 0.072
Loa Loa (eye worm) hypothetical protein 0.0078 0.3812 0.928
Echinococcus multilocularis lamin 0.0028 0.0808 0.0609
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0398 0.019
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0598 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.3496 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.1478 0.1294
Loa Loa (eye worm) hypothetical protein 0.0082 0.4108 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0598 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0398 0.019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.3072 0.2923
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0211 0.5
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0398 0.0307
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.3496 0.8511
Onchocerca volvulus 0.0025 0.0598 0.487
Brugia malayi ecdysteroid receptor 0.0022 0.0398 0.0969
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0211 0.5
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0082 0.4108 1
Echinococcus granulosus lamin 0.0028 0.0808 0.0609
Loa Loa (eye worm) hypothetical protein 0.0025 0.0598 0.1455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0398 0.0969
Loa Loa (eye worm) hypothetical protein 0.0019 0.0211 0.0513
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0598 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0398 0.0969
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0598 1
Schistosoma mansoni hypothetical protein 0.0179 1 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.3496 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0212 0.0119
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.3496 1
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0082 0.4108 0.398
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.3496 0.8511
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0398 0.0969
Loa Loa (eye worm) hypothetical protein 0.0028 0.0808 0.1967
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0398 0.019
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0598 1
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0398 0.019
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0808 0.1967
Schistosoma mansoni hypothetical protein 0.0082 0.4108 0.4052
Echinococcus multilocularis musashi 0.0028 0.0808 0.0609
Echinococcus granulosus intermediate filament protein 0.0028 0.0808 0.0609
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0398 0.0969
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0398 0.019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0398 0.0969
Loa Loa (eye worm) hypothetical protein 0.0019 0.0212 0.0516
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0398 0.0969
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.3496 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0398 0.0307
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0398 0.019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0398 0.0969
Loa Loa (eye worm) hypothetical protein 0.0022 0.0398 0.0969
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.3496 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0598 0.148
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0398 0.0969
Brugia malayi steroid hormone receptor 0.0022 0.0398 0.0969
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0082 0.4108 0.4052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0212 0.0119
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.058 0.0491
Mycobacterium ulcerans hypothetical protein 0.0025 0.0598 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0211 0.0513
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0211 0.5
Schistosoma mansoni apoptosis regulator bax 0.0082 0.4108 0.4052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0398 0.0969
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0398 0.0969
Echinococcus multilocularis geminin 0.0179 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0808 0.1967
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0398 0.0969
Brugia malayi Bromodomain containing protein 0.0082 0.4099 0.9978
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0253 0.0616
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.1478 0.1294
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.3496 0.3434
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0398 0.0969
Brugia malayi intermediate filament protein 0.0028 0.0808 0.1967
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0398 0.0307
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0398 0.019
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0598 1
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0452 0.11
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0212 0.0119
Loa Loa (eye worm) apoptosis regulator protein 0.0082 0.4108 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0398 0.0969
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0398 0.019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0398 0.0969
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0598 1
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0808 0.1967
Loa Loa (eye worm) hypothetical protein 0.0042 0.1642 0.3997
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0212 0.0119

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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