Detailed information for compound 574069

Basic information

Technical information
  • TDR Targets ID: 574069
  • Name: 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2, 3-dihydro-1H-carbazol-4-one hydrochloride
  • MW: 329.824 | Formula: C18H20ClN3O
  • H donors: 0 H acceptors: 2 LogP: 3.09 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C(CCc2c1c1ccccc1n2C)Cn1ccnc1C.Cl
  • InChi: 1S/C18H19N3O.ClH/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H
  • InChiKey: MKBLHFILKIKSQM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-methyl-3-[(2-methyl-1-imidazolyl)methyl]-2,3-dihydro-1H-carbazol-4-one hydrochloride
  • Ondansetron
  • 110204-46-1
  • 110707-92-1
  • 99614-01-4
  • Zudan
  • 1H-Carbazol-4-one, 2,3-dihydro-9-methyl-3-((2-methylimidazol-1-yl)methyl)-, hydrochloride, dihydrate
  • 9-Methyl-3-((2-methylimidazol-1-yl)methyl)-2,3-dihydro-1H-carbazol-4-one hydrochloride 2H2O
  • FE6373975
  • NSC665799
  • 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-, monohydrochloride
  • 9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-4H-carbazol-4-one monohydrochloride
  • GR 38032F
  • SN 307

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 5 (sodium/choline cotransporter), member 7 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus high affinity choline transporter 1 Get druggable targets OG5_131601 All targets in OG5_131601
Schistosoma japonicum IPR001734,Na+/solute symporter,domain-containing Get druggable targets OG5_131601 All targets in OG5_131601
Schistosoma mansoni high-affinity choline transporter Get druggable targets OG5_131601 All targets in OG5_131601
Schistosoma japonicum High affinity choline transporter 1, putative Get druggable targets OG5_131601 All targets in OG5_131601
Brugia malayi GH02984p Get druggable targets OG5_131601 All targets in OG5_131601
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131601 All targets in OG5_131601
Echinococcus multilocularis high affinity choline transporter 1 Get druggable targets OG5_131601 All targets in OG5_131601
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0306 0.0254
Onchocerca volvulus 0.0035 0.0689 0.3951
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8384 1
Trichomonas vaginalis esterase, putative 0.0035 0.0689 0.0821
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0046 0.0965 0.0952
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1302 0.1252
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8384 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0439 0.0385
Schistosoma mansoni sodium/solute symporter 0.0046 0.0965 0.0952
Brugia malayi beta-lactamase family protein 0.0035 0.0689 0.0638
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.8384 1
Echinococcus multilocularis high affinity choline transporter 1 0.042 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0439 0.0399
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.2096 0.2051
Schistosoma mansoni high-affinity choline transporter 0.042 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0689 0.0675
Echinococcus granulosus high affinity choline transporter 1 0.042 1 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0178 0.4159 1
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.1446 0.14
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.4016 1
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0172 0.4012 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0689 0.0675
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.2096 0.2084
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0689 0.0675
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0178 0.4159 0.4127
Echinococcus multilocularis tar DNA binding protein 0.0066 0.1446 0.1433
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0027 0.0508 0.0598
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1302 0.1255
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0285 0.027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.2096 0.2053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8384 1
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0172 0.4012 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0172 0.4012 0.9622
Echinococcus granulosus tar DNA binding protein 0.0066 0.1446 0.1433
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0057 0.0042
Echinococcus multilocularis geminin 0.0205 0.4796 0.4788
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0689 0.0816
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0689 0.1083
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0439 0.0415
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0178 0.4159 0.415
Brugia malayi hypothetical protein 0.0016 0.0229 0.0176
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8384 1
Echinococcus multilocularis carbonic anhydrase 0.0084 0.1872 0.1859
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0172 0.4012 0.9622
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0766 0.1291
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0689 0.0816
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1446 0.1433
Echinococcus granulosus geminin 0.0205 0.4796 0.4788
Schistosoma mansoni inositol transporter 0.0046 0.0965 0.0952
Onchocerca volvulus 0.0035 0.0689 0.3951
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.085 0.1014
Schistosoma mansoni hypothetical protein 0.0019 0.0306 0.0292
Schistosoma mansoni cpg binding protein 0.0028 0.0528 0.0514
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0306 0.0292
Brugia malayi Erv1 / Alr family protein 0.0027 0.0508 0.0456
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1446 0.1433
Trypanosoma cruzi quiescin sulfhydryl oxidase, putative 0.0027 0.0508 0.0575
Loa Loa (eye worm) hypothetical protein 0.0027 0.0508 0.0454
Schistosoma mansoni ap endonuclease 0.0018 0.0285 0.027
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.3261 0.3251
Schistosoma mansoni hypothetical protein 0.0019 0.0306 0.0292
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0689 0.0816
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0689 0.0821
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0178 0.4159 1
Echinococcus granulosus sulfhydryl oxidase 1 0.0027 0.0508 0.0494
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0084 0.1872 0.1828
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.2096 0.2084
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0439 0.0399
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2096 0.2084
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.085 0.1516
Schistosoma mansoni carbonic anhydrase-related 0.0084 0.1872 0.1859
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0689 0.1042
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0689 0.0821
Echinococcus multilocularis cpg binding protein 0.003 0.0567 0.0553
Toxoplasma gondii ABC1 family protein 0.0035 0.0689 0.1083
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0841 0.0791
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0112 0.0097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8384 1
Toxoplasma gondii Erv1 / Alr family protein 0.0172 0.4012 1
Schistosoma mansoni hypothetical protein 0.0019 0.0306 0.0292
Schistosoma mansoni hypothetical protein 0.0084 0.1872 0.1859
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0178 0.4159 0.415
Mycobacterium ulcerans hypothetical protein 0.0035 0.0689 0.1082
Schistosoma mansoni hypothetical protein 0.0205 0.4796 0.4788
Echinococcus multilocularis GPCR, family 2 0.0019 0.0306 0.0292
Leishmania major hypothetical protein, conserved 0.0172 0.4012 0.9622
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.2096 0.2084
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0689 0.0821
Loa Loa (eye worm) hypothetical protein 0.042 1 1
Schistosoma mansoni carbonic anhydrase-related 0.0084 0.1872 0.1859
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0178 0.4159 0.4126
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0172 0.4012 0.4003
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.4016 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0689 0.0821
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0306 0.0251
Schistosoma mansoni hypothetical protein 0.0205 0.4796 0.4788
Loa Loa (eye worm) hypothetical protein 0.0035 0.0689 0.0636
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0285 0.0232
Schistosoma mansoni carbonic anhydrase 0.0084 0.1872 0.1859
Brugia malayi TAR-binding protein 0.0066 0.1446 0.14
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0084 0.1872 0.1828
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0528 0.0474
Trypanosoma brucei quiescin sulfhydryl oxidase 0.0027 0.0508 0.0575
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.4016 0.7542
Echinococcus multilocularis carbonic anhydrase II 0.0178 0.4159 0.415
Mycobacterium tuberculosis Conserved protein 0.0035 0.0689 0.0816
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0046 0.0965 0.1826
Plasmodium falciparum carbonic anhydrase 0.0084 0.1872 0.4257
Loa Loa (eye worm) hypothetical protein 0.0046 0.0965 0.0914
Schistosoma mansoni hypothetical protein 0.0019 0.0306 0.0292
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0285 0.034
Brugia malayi Augmenter of liver regeneration 0.0172 0.4012 0.398
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1293 0.128
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.085 0.1516
Loa Loa (eye worm) hypothetical protein 0.0027 0.0508 0.0454
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0285 0.023
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0766 0.0594
Schistosoma mansoni ap endonuclease 0.0018 0.0285 0.027
Loa Loa (eye worm) hypothetical protein 0.0084 0.1872 0.1825
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0084 0.1872 0.1825
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0306 0.0292
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0112 0.0097
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.085 0.0836
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0689 0.0816
Trypanosoma cruzi quiescin sulfhydryl oxidase, putative 0.0027 0.0508 0.0575
Echinococcus granulosus solute carrier family 5 0.0046 0.0965 0.0952
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0689 0.0821
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0178 0.4159 0.4127
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0439 0.0415
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0046 0.0965 0.0952
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.3261 0.3251
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8384 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0689 0.1042
Leishmania major hypothetical protein, conserved 0.0035 0.0689 0.1042
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0084 0.1872 0.1828
Loa Loa (eye worm) hypothetical protein 0.0035 0.0689 0.0636
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.2096 0.2084
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0306 0.0292
Echinococcus multilocularis carbonic anhydrase 0.0084 0.1872 0.1859
Onchocerca volvulus 0.0028 0.0528 0.0441
Onchocerca volvulus 0.0046 0.0965 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0689 0.1082
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0084 0.1872 0.1828
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0689 0.1082
Loa Loa (eye worm) hypothetical protein 0.0041 0.0841 0.0789
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0689 0.0816
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0689 0.1042
Toxoplasma gondii Erv1 / Alr family protein 0.0172 0.4012 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1446 0.1433
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1222 0.2515
Echinococcus granulosus carbonic anhydrase 0.0084 0.1872 0.1859
Mycobacterium tuberculosis Conserved protein 0.0035 0.0689 0.0816
Loa Loa (eye worm) RNA binding protein 0.0066 0.1446 0.1397
Loa Loa (eye worm) hypothetical protein 0.0035 0.0689 0.0636
Mycobacterium ulcerans beta-lactamase 0.0035 0.0689 0.1082
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0084 0.1872 0.1828
Echinococcus multilocularis sulfhydryl oxidase 1 0.0027 0.0508 0.0494
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0172 0.4012 0.4003
Schistosoma mansoni carbonic anhydrase-related 0.0084 0.1872 0.1859
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.3165 0.3155
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0172 0.4012 0.9622
Toxoplasma gondii Erv1 / Alr family protein 0.0027 0.0508 0.0598
Leishmania major hypothetical protein, conserved 0.0025 0.0439 0.0399
Schistosoma mansoni hypothetical protein 0.0011 0.0112 0.0097
Loa Loa (eye worm) hypothetical protein 0.0035 0.0689 0.0636
Echinococcus granulosus carbonic anhydrase II 0.0178 0.4159 0.415
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0306 0.0254
Echinococcus granulosus GPCR family 2 0.0019 0.0306 0.0292
Toxoplasma gondii hypothetical protein 0.0084 0.1872 0.4257
Mycobacterium ulcerans lipase LipD 0.0035 0.0689 0.1082
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0046 0.0965 0.0952
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0285 0.027
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.3261 0.3225
Echinococcus granulosus cpg binding protein 0.003 0.0567 0.0553
Loa Loa (eye worm) hypothetical protein 0.0035 0.0689 0.0636
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0306 0.0292
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.5232 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1302 0.1252
Loa Loa (eye worm) Erv1/Alr family protein 0.0027 0.0508 0.0454
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0285 0.5
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0439 0.0415
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1302 0.1255
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8384 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0689 0.0816
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0172 0.4012 0.9622
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1446 0.1433
Schistosoma mansoni quiescin q6-related sulfhydryl oxidase 0.0027 0.0508 0.0494
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0285 0.034
Schistosoma mansoni hypothetical protein 0.0041 0.0841 0.0827
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.8384 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0689 0.0816
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0046 0.0965 0.0952
Echinococcus granulosus carbonic anhydrase 0.0084 0.1872 0.1859
Loa Loa (eye worm) acetyltransferase 0.0141 0.3261 0.3223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0306 0.0251
Echinococcus multilocularis carbonic anhydrase 0.0084 0.1872 0.1859
Echinococcus granulosus carbonic anhydrase 0.0084 0.1872 0.1859
Brugia malayi beta-lactamase family protein 0.0035 0.0689 0.0638
Trypanosoma brucei carbonic anhydrase-like protein 0.0178 0.4159 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0689 0.0816
Loa Loa (eye worm) beta-lactamase 0.0035 0.0689 0.0636
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.085 0.1516
Loa Loa (eye worm) hepatopoietin HPO2 0.0172 0.4012 0.3978
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0689 0.0636
Echinococcus granulosus sodium:glucose cotransporter 0.0046 0.0965 0.0952
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0766 0.0594
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.8384 1
Echinococcus granulosus sodium:glucose cotransporter 2 0.0046 0.0965 0.0952
Loa Loa (eye worm) hypothetical protein 0.0035 0.0689 0.0636
Echinococcus granulosus sodium:myo inositol cotransporter 0.0046 0.0965 0.0952
Echinococcus multilocularis solute carrier family 5 0.0046 0.0965 0.0952
Brugia malayi CXXC zinc finger family protein 0.0028 0.0528 0.0477
Loa Loa (eye worm) quiescin Q6 0.0027 0.0508 0.0454
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0439 0.0415
Onchocerca volvulus 0.0035 0.0689 0.3951
Schistosoma mansoni cpg binding protein 0.003 0.0567 0.0553
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0689 0.0638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2096 0.2084
Loa Loa (eye worm) hypothetical protein 0.0084 0.1872 0.1825
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0057 0.0042
Schistosoma mansoni cpg binding protein 0.003 0.0567 0.0553
Brugia malayi Sodium:solute symporter family protein 0.0046 0.0965 0.0916
Brugia malayi beta-lactamase 0.0035 0.0689 0.0638
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0439 0.0399
Brugia malayi quiescin Q6 0.0027 0.0508 0.0456
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2096 0.2084
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0689 0.0675
Loa Loa (eye worm) hypothetical protein 0.0084 0.1872 0.1825
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0508 0.0598
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1446 0.1433
Brugia malayi RNA binding protein 0.0066 0.1446 0.14
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.8384 1
Loa Loa (eye worm) TAR-binding protein 0.0066 0.1446 0.1397
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.8384 1
Loa Loa (eye worm) carbonic anhydrase 3 0.0178 0.4159 0.4126
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.085 0.1014
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.1446 0.1397
Leishmania major carbonic anhydrase-like protein 0.0178 0.4159 1
Schistosoma mansoni inositol transporter 0.0046 0.0965 0.0952
Brugia malayi hypothetical protein 0.0025 0.0439 0.0388

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 1.353455823 uM PUBCHEM_BIOASSAY: Dose responses of compounds that inhibit the Choline Transporter (CHT) - 10 point CRC. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 1.674110771 uM PUBCHEM_BIOASSAY: Dose responses of compounds that inhibit the Choline Transporter (CHT) - 5 point CRC. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488975, AID488997, AID493221, AID493222] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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