Detailed information for compound 574671

Basic information

Technical information
  • TDR Targets ID: 574671
  • Name: [1-[[4-methyl-7-(morpholine-4-carbonylamino)- 2-oxo-chromen-3-yl]methyl]-2-morpholino-ethyl ] (E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate hydrochloride
  • MW: 688.164 | Formula: C34H42ClN3O10
  • H donors: 1 H acceptors: 3 LogP: 3.33 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(C=CC(=O)OC(Cc2c(=O)oc3c(c2C)ccc(c3)NC(=O)N2CCOCC2)CN2CCOCC2)cc(c1OC)OC.Cl
  • InChi: 1S/C34H41N3O10.ClH/c1-22-26-7-6-24(35-34(40)37-11-15-45-16-12-37)19-28(26)47-33(39)27(22)20-25(21-36-9-13-44-14-10-36)46-31(38)8-5-23-17-29(41-2)32(43-4)30(18-23)42-3;/h5-8,17-19,25H,9-16,20-21H2,1-4H3,(H,35,40);1H/b8-5+;
  • InChiKey: VYASFWMYUYWMLJ-HAAWTFQLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(3,4,5-trimethoxyphenyl)-2-propenoic acid [1-[[4-methyl-7-[[morpholino(oxo)methyl]amino]-2-oxo-1-benzopyran-3-yl]methyl]-2-morpholinoethyl] ester hydrochloride
  • [1-[4-methyl-7-(morpholin-4-ylcarbonylamino)-2-oxo-chromen-3-yl]-3-morpholin-4-yl-propan-2-yl] (E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate hydrochloride
  • (E)-3-(3,4,5-trimethoxyphenyl)acrylic acid [1-[[2-keto-4-methyl-7-(morpholine-4-carbonylamino)chromen-3-yl]methyl]-2-morpholino-ethyl] ester hydrochloride
  • [1-[4-methyl-7-(morpholine-4-carbonylamino)-2-oxochromen-3-yl]-3-morpholin-4-ylpropan-2-yl] (E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate hydrochloride
  • TVX 2656
  • (E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid [1-[[4-methyl-7-[(morpholino-oxomethyl)amino]-2-oxo-3-chromenyl]methyl]-2-morpholinoethyl] ester hydrochloride
  • 62885-98-7
  • 2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)-, 1-((4-methyl-7-((4-morpholinylcarbonyl)amino)-2-oxo-2H-1-benzopyran-3-yl)methyl)-2-(4-morpholinyl)ethyl ester, monohydrochloride
  • Cinecromen hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum enoyl-acyl carrier reductase 0.0183 0.5248 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.112 0.1976
Onchocerca volvulus 0.0036 0.066 0.3448
Onchocerca volvulus 0.0036 0.066 0.3448
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0194 0.037
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.0231 0.0073
Loa Loa (eye worm) hypothetical protein 0.0086 0.2222 0.5909
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0194 0.0516
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.1778 0.9204
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0183 0.5248 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0231 0.0073
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0183 0.5248 1
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0183 0.5248 0.5176
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0231 0.0073
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.066 0.1755
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0194 0.0178
Onchocerca volvulus 0.0056 0.1275 0.6657
Giardia lamblia Casein kinase II beta chain 0.0076 0.1915 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0194 0.1014
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0022 0.0231 0.0213
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.1778 0.924
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Toxoplasma gondii kringle domain-containing protein 0.0056 0.1275 0.1143
Trichomonas vaginalis hypothetical protein 0.0183 0.5248 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0056 0.1275 0.3389
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0183 0.5248 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Plasmodium vivax casein kinase II beta chain, putative 0.0076 0.1915 0.3508
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.1778 0.3388
Onchocerca volvulus 0.002 0.0149 0.0776
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.112 0.1976
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0194 0.0257
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0076 0.1915 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0183 0.5248 1
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.002 0.0149 0.0395
Loa Loa (eye worm) hypothetical protein 0.0021 0.0194 0.0516
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0036 0.066 0.0519
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0022 0.0231 0.0213
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0114 0.0303
Echinococcus granulosus casein kinase ii subunit beta 0.0076 0.1915 1
Loa Loa (eye worm) Csnk2b protein 0.0076 0.1915 0.5091
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.0231 0.0073
Leishmania major hypothetical protein, conserved 0.0056 0.1275 0.6445
Toxoplasma gondii microneme protein MIC4 0.0036 0.066 0.0519
Plasmodium falciparum casein kinase II beta chain 0.0076 0.1915 0.3508
Loa Loa (eye worm) hypothetical protein 0.0056 0.1275 0.3389
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0194 0.0257
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0194 0.0178
Onchocerca volvulus 0.0021 0.0194 0.1014
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0194 0.0445
Loa Loa (eye worm) hypothetical protein 0.0036 0.066 0.1755
Brugia malayi PAN domain containing protein 0.0036 0.066 0.1755
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0194 0.0873
Toxoplasma gondii ck2 beta subunit 0.0076 0.1915 0.1793
Onchocerca volvulus 0.0021 0.0194 0.1014
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0231 0.0073
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0231 0.0073
Plasmodium falciparum casein kinase II beta chain 0.0076 0.1915 0.3508
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0194 0.0178
Leishmania major phospholipase c-like protein 0.002 0.0149 0.0193
Onchocerca volvulus 0.0021 0.0194 0.1014
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0194 0.037
Loa Loa (eye worm) hypothetical protein 0.0054 0.1211 0.322
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.1778 0.3134
Brugia malayi PAN domain containing protein 0.0036 0.066 0.1755
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.1778 0.924
Loa Loa (eye worm) oxidoreductase 0.0021 0.0194 0.0516
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.1778 0.3388
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.1778 0.9204
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0183 0.5248 0.5
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.002 0.0149 0.0776
Brugia malayi PAN domain containing protein 0.0036 0.066 0.1755
Toxoplasma gondii PAN domain-containing protein 0.0036 0.066 0.0519
Toxoplasma gondii subtilisin SUB12 0.0036 0.066 0.0519
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0194 0.0257
Schistosoma mansoni phospholipase C beta 0.0019 0.0114 0.0512
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0231 0.0073
Toxoplasma gondii PAN domain-containing protein 0.0336 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0231 0.0073
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.1778 0.3388
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.066 0.1755
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0194 0.0178
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Schistosoma mansoni casein kinase II beta subunit 0.0076 0.1915 0.8615
Brugia malayi AMP-binding enzyme family protein 0.0072 0.1778 0.4727
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0194 0.037
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.1778 0.3388
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0194 0.037
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0194 0.0445
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0231 0.0073
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0231 0.0073
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0076 0.1915 1
Plasmodium vivax casein kinase II beta chain, putative 0.0076 0.1915 0.3508
Mycobacterium ulcerans hypothetical protein 0.0072 0.1778 0.3388
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0076 0.1915 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0194 0.0516
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0194 0.0156
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.1778 0.924
Loa Loa (eye worm) hypothetical protein 0.0054 0.1211 0.322
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0194 0.037
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.066 0.1755
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0194 0.037
Echinococcus granulosus tissue type plasminogen activator 0.0056 0.1275 0.6657
Loa Loa (eye worm) hypothetical protein 0.0036 0.066 0.1755
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0194 0.0156
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.1915 1
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.066 0.1755
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.112 0.1976
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0231 0.0073
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.066 0.1755
Onchocerca volvulus 0.002 0.0149 0.0776
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.002 0.0149 0.0395
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0194 0.037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.1778 0.3256
Onchocerca volvulus 0.0072 0.1778 0.9285
Toxoplasma gondii microneme protein MIC17B 0.0036 0.066 0.0519
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0194 0.0516
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0194 0.037
Onchocerca volvulus 0.0036 0.066 0.3448
Loa Loa (eye worm) hypothetical protein 0.0086 0.2222 0.5909
Brugia malayi Csnk2b protein 0.0076 0.1915 0.5091
Onchocerca volvulus 0.0036 0.066 0.3448
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.1915 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0194 0.0445
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0194 0.0178
Loa Loa (eye worm) hypothetical protein 0.0036 0.066 0.1755
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0194 0.0046
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.1778 0.3134
Toxoplasma gondii microneme protein, putative 0.0036 0.066 0.0519
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.1778 0.3256
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0194 0.0178
Toxoplasma gondii PAN domain-containing protein 0.0036 0.066 0.0519
Toxoplasma gondii microneme protein MIC17A 0.0036 0.066 0.0519
Loa Loa (eye worm) hypothetical protein 0.0072 0.1778 0.4727
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0194 0.0516
Toxoplasma gondii PAN domain-containing protein 0.0036 0.066 0.0519
Brugia malayi PAN domain containing protein 0.0036 0.066 0.1755
Brugia malayi AMP-binding enzyme family protein 0.0072 0.1778 0.4727
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0194 0.0178
Loa Loa (eye worm) hypothetical protein 0.0054 0.1211 0.322
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0231 0.0073
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0194 0.1014
Toxoplasma gondii hypothetical protein 0.0036 0.066 0.0519
Loa Loa (eye worm) hypothetical protein 0.0054 0.1211 0.322
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0231 0.0073
Onchocerca volvulus 0.0036 0.066 0.3448
Schistosoma mansoni hypothetical protein 0.0056 0.1275 0.5735
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0194 0.0046
Loa Loa (eye worm) hypothetical protein 0.0072 0.1778 0.4727
Brugia malayi PAN domain containing protein 0.0036 0.066 0.1755
Onchocerca volvulus 0.0036 0.066 0.3448
Brugia malayi PAN domain containing protein 0.0036 0.066 0.1755
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0194 0.0257
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0194 0.037
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.1275 0.6375
Loa Loa (eye worm) Plcb4 protein 0.0019 0.0114 0.0303
Onchocerca volvulus 0.0036 0.066 0.3448
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0395
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0194 0.0178
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0194 0.0178
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0076 0.1915 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.1778 0.3388
Loa Loa (eye worm) hypothetical protein 0.0072 0.1778 0.4727
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0183 0.5248 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.112 0.1976
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0194 0.0178
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0194 0.037
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0395
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.1211 0.2137
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.1915 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0194 0.037
Toxoplasma gondii hypothetical protein 0.0036 0.066 0.0519
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0194 0.037
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0076 0.1915 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0194 0.037
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0194 0.037
Brugia malayi PAN domain containing protein 0.0036 0.066 0.1755
Schistosoma mansoni eyes absent homolog 0.0086 0.2222 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0194 0.0516
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.002 0.0149 0.0776
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0076 0.1915 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1211 0.322
Brugia malayi casein kinase II, putaitve 0.0022 0.0231 0.0613
Echinococcus multilocularis tissue type plasminogen activator 0.0056 0.1275 0.6657
Loa Loa (eye worm) hypothetical protein 0.0036 0.066 0.1755
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Toxoplasma gondii PAN/Apple domain-containing protein 0.0036 0.066 0.0519
Loa Loa (eye worm) hypothetical protein 0.0036 0.066 0.1755
Brugia malayi PAN domain containing protein 0.0036 0.066 0.1755
Loa Loa (eye worm) casein kinase II 0.0022 0.0231 0.0613
Echinococcus multilocularis casein kinase ii subunit beta 0.0076 0.1915 1
Onchocerca volvulus 0.0036 0.066 0.3448
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0231 0.0073
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0056 0.1275 0.2261
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0194 0.0178
Brugia malayi Protein kinase domain containing protein 0.0056 0.1275 0.3389
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.1778 0.3388
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0194 0.0046
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0194 0.0516
Loa Loa (eye worm) hypothetical protein 0.0036 0.066 0.1755
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0231 0.0073
Brugia malayi PAN domain containing protein 0.0036 0.066 0.1755
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0019 0.0114 0.0303
Onchocerca volvulus 0.0036 0.066 0.3448
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0136 0.3761 1
Toxoplasma gondii microneme protein MIC17C 0.0036 0.066 0.0519
Brugia malayi AMP-binding enzyme family protein 0.0072 0.1778 0.4727
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.1778 0.3388
Toxoplasma gondii PAN domain-containing protein 0.0036 0.066 0.0519
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0194 0.0257
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0194 0.0257
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0194 0.037
Onchocerca volvulus 0.0021 0.0194 0.1014
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0194 0.0516
Onchocerca volvulus 0.0036 0.066 0.3448
Brugia malayi PAN domain containing protein 0.0036 0.066 0.1755
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0194 0.037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0114 0.0303
Brugia malayi Variant SH3 domain containing protein 0.0136 0.3761 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.1211 0.2154
Plasmodium falciparum cysteine repeat modular protein 1 0.0056 0.1275 0.2261
Brugia malayi Kringle domain containing protein 0.0056 0.1275 0.3389
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0194 0.0516
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0194 0.037
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.1778 0.9204
Loa Loa (eye worm) hypothetical protein 0.0021 0.0194 0.0516
Loa Loa (eye worm) hypothetical protein 0.0036 0.066 0.1755
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1915 0.3405
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.1211 0.2137
Onchocerca volvulus 0.0036 0.066 0.3448
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0076 0.1915 0.1793
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.1211 0.2308
Brugia malayi hypothetical protein 0.0086 0.2222 0.5909

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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