Detailed information for compound 574717

Basic information

Technical information
  • TDR Targets ID: 574717
  • Name: bis-p-tolyliodonium iodide
  • MW: 436.07 | Formula: C14H14I2
  • H donors: 0 H acceptors: 0 LogP: 5.94 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)[I+]c1ccc(cc1)C.[I-]
  • InChi: 1S/C14H14I.HI/c1-11-3-7-13(8-4-11)15-14-9-5-12(2)6-10-14;/h3-10H,1-2H3;1H/q+1;/p-1
  • InChiKey: SHERLYYRDQWENB-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • bis(4-methylphenyl)iodanium iodide
  • bis(4-methylphenyl)iodonium iodide
  • 6293-70-5
  • NSC8987

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0037 0.0441
Echinococcus granulosus transmembrane protease serine 3 0.0015 0.0037 0.0357
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0116 0.0485
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0088 0.0541
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0132 0.0075
Onchocerca volvulus 0.0015 0.0037 0.0357
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0132 0.0075
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0037 0.0441
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0536 0.2356
Onchocerca volvulus 0.0072 0.077 0.9275
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0013 0.0007 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0116 0.0713
Onchocerca volvulus 0.0036 0.031 0.3683
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0116 0.0485
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0037 0.0441
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0116 0.0485
Echinococcus granulosus casein kinase ii subunit beta 0.0076 0.083 1
Schistosoma mansoni casein kinase II beta subunit 0.0076 0.083 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0116 0.1323
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.015
Giardia lamblia Casein kinase II beta chain 0.0076 0.083 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0116 0.0485
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0031 0.0058
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.077 0.3399
Brugia malayi Kringle domain containing protein 0.0056 0.0565 0.3472
Echinococcus multilocularis laminin 0.0014 0.0031 0.0024
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.1871
Schistosoma mansoni egf-like domain protein 0.0014 0.0031 0.0379
Onchocerca volvulus 0.0036 0.031 0.3683
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0076 0.083 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0536 0.3265
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0116 0.0713
Brugia malayi PAN domain containing protein 0.0036 0.031 0.1907
Plasmodium vivax phospholipase C-like, putative 0.0019 0.0088 0.036
Onchocerca volvulus 0.0036 0.031 0.3683
Toxoplasma gondii kringle domain-containing protein 0.0056 0.0565 0.1336
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0076 0.083 1
Plasmodium vivax casein kinase II beta chain, putative 0.0076 0.083 0.3665
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0116 0.1323
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0116 0.1323
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0536 0.2356
Loa Loa (eye worm) hypothetical protein 0.0021 0.0116 0.0672
Plasmodium falciparum enoyl-acyl carrier reductase 0.0186 0.2252 1
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0116 0.0485
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0116 0.0485
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.1871
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0116 0.0485
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.077 0.9275
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.077 0.3399
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0037 0.0441
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0031 0.0058
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0536 0.2356
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0116 0.0485
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0186 0.2252 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.077 0.3399
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.002 0.0103 0.0631
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.1871
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.002 0.0103 0.1161
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0116 0.1323
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.1871
Onchocerca volvulus 0.0015 0.0037 0.0357
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0116 0.0485
Echinococcus granulosus laminin 0.0014 0.0031 0.0295
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0078 0.0317
Brugia malayi Csnk2b protein 0.0076 0.083 0.5101
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0132 0.0075
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0116 0.0485
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0037 0.0441
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0132 0.0075
Onchocerca volvulus 0.0036 0.031 0.3683
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0116 0.0485
Loa Loa (eye worm) Csnk2b protein 0.0076 0.083 0.5079
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0116 0.1323
Loa Loa (eye worm) trypsin family protein 0.0015 0.0037 0.0181
Schistosoma mansoni hypothetical protein 0.0015 0.0037 0.0441
Loa Loa (eye worm) hypothetical protein 0.0072 0.077 0.4711
Brugia malayi PAN domain containing protein 0.0036 0.031 0.1907
Brugia malayi AMP-binding enzyme family protein 0.0072 0.077 0.4734
Onchocerca volvulus 0.002 0.0103 0.1161
Onchocerca volvulus 0.0036 0.031 0.3683
Brugia malayi Trypsin family protein 0.0015 0.0037 0.0225
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.077 0.9275
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0132 0.0075
Brugia malayi PAN domain containing protein 0.0036 0.031 0.1907
Onchocerca volvulus 0.0036 0.031 0.3683
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.083 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0116 0.0485
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.077 0.3399
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Brugia malayi Trypsin family protein 0.0015 0.0037 0.0225
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0116 0.1323
Toxoplasma gondii PAN domain-containing protein 0.0335 0.4183 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0037 0.0441
Onchocerca volvulus 0.002 0.0103 0.1161
Toxoplasma gondii PAN/Apple domain-containing protein 0.0036 0.031 0.0726
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0037 0.0441
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0076 0.083 1
Schistosoma mansoni dihydropteridine reductase 0.0013 0.0007 0.0087
Toxoplasma gondii microneme protein MIC17A 0.0036 0.031 0.0726
Echinococcus multilocularis Mastin 0.0015 0.0037 0.0029
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0037 0.0441
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0037 0.0441
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0116 0.0485
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0116 0.0261
Toxoplasma gondii microneme protein MIC17B 0.0036 0.031 0.0726
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.031 0.1871
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0116 0.0485
Echinococcus multilocularis transmembrane protease serine 3 0.0015 0.0037 0.0029
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0116 0.1323
Brugia malayi Protein kinase domain containing protein 0.0056 0.0565 0.3472
Onchocerca volvulus 0.0021 0.0116 0.1323
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Echinococcus granulosus tissue type plasminogen activator 0.0056 0.0565 0.6779
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0116 0.0485
Brugia malayi PAN domain containing protein 0.0036 0.031 0.1907
Plasmodium falciparum casein kinase II beta chain 0.0076 0.083 0.3665
Brugia malayi Trypsin family protein 0.0015 0.0037 0.0225
Brugia malayi AMP-binding enzyme family protein 0.0072 0.077 0.4734
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0181
Onchocerca volvulus 0.0021 0.0116 0.1323
Leishmania major hypothetical protein, conserved 0.0056 0.0565 0.6779
Onchocerca volvulus 0.0036 0.031 0.3683
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0132 0.0075
Trichomonas vaginalis hypothetical protein 0.0186 0.2252 1
Toxoplasma gondii PAN domain-containing protein 0.0036 0.031 0.0726
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0116 0.0672
Plasmodium falciparum cysteine repeat modular protein 1 0.0056 0.0565 0.2485
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0132 0.0075
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0019 0.0088 0.0983
Onchocerca volvulus 0.0036 0.031 0.3683
Brugia malayi Trypsin-like protease protein 5 0.0015 0.0037 0.0225
Toxoplasma gondii microneme protein MIC4 0.0036 0.031 0.0726
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0076 0.083 1
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0076 0.083 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0181
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0186 0.2252 1
Onchocerca volvulus 0.0015 0.0037 0.0357
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0015 0.0037 0.0225
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0186 0.2252 1
Brugia malayi PAN domain containing protein 0.0036 0.031 0.1907
Loa Loa (eye worm) hypothetical protein 0.0072 0.077 0.4711
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0019 0.0088 0.0983
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.077 0.3399
Echinococcus granulosus enteropeptidase 0.0015 0.0037 0.0357
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.015
Toxoplasma gondii ck2 beta subunit 0.0076 0.083 0.1971
Mycobacterium ulcerans hypothetical protein 0.0015 0.0037 0.0131
Loa Loa (eye worm) casein kinase II 0.0022 0.0132 0.0771
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0116 0.1323
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.002 0.0103 0.1161
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0132 0.0075
Toxoplasma gondii PAN domain-containing protein 0.0036 0.031 0.0726
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0116 0.1323
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.002 0.0103 0.059
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0116 0.0485
Echinococcus multilocularis Tolloid protein 1 0.0014 0.0031 0.0024
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0037 0.0441
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0007 0.0044
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0181
Brugia malayi Variant SH3 domain containing protein 0.0138 0.1627 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.077 0.3399
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0181
Loa Loa (eye worm) hypothetical protein 0.002 0.0103 0.059
Toxoplasma gondii PAN domain-containing protein 0.0036 0.031 0.0726
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0498 0.2188
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0007 0.0044
Toxoplasma gondii PAN domain-containing protein 0.0335 0.4183 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0181
Brugia malayi Trypsin family protein 0.0015 0.0037 0.0225
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0022 0.0132 0.1518
Onchocerca volvulus 0.0036 0.031 0.3683
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0036 0.031 0.0726
Brugia malayi AMP-binding enzyme family protein 0.0072 0.077 0.4734
Onchocerca volvulus 0.0015 0.0037 0.0357
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0116 0.0485
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0037 0.0441
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0498 0.2188
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0186 0.2252 0.5377
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.0132 0.0075
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0181
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0116 0.0485
Onchocerca volvulus 0.0056 0.0565 0.6779
Loa Loa (eye worm) oxidoreductase 0.0021 0.0116 0.0672
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0037 0.0441
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.077 0.9275
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0116 0.0485
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0031 0.0193
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0116 0.0713
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.015
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0037 0.0441
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0132 0.0075
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0116 0.0485
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.1871
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0116 0.0713
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0116 0.1398
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0037 0.0441
Loa Loa (eye worm) hypothetical protein 0.0056 0.0565 0.3443
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0015 0.0037 0.0029
Onchocerca volvulus 0.0015 0.0037 0.0357
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0076 0.083 0.1971
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0116 0.0485
Onchocerca volvulus 0.0021 0.0116 0.1323
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0116 0.0485
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0138 0.1627 1
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0015 0.0037 0.0357
Onchocerca volvulus 0.0015 0.0037 0.0357
Loa Loa (eye worm) hypothetical protein 0.0021 0.0116 0.0672
Brugia malayi PAN domain containing protein 0.0036 0.031 0.1907
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0132 0.0075
Brugia malayi PAN domain containing protein 0.0036 0.031 0.1907
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0031 0.0193
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0186 0.2252 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0116 0.0713
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0014 0.0031 0.015
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0076 0.083 1
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0019 0.0088 0.0541
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0116 0.0485
Brugia malayi Fibulin-1 precursor 0.0014 0.0031 0.0193
Loa Loa (eye worm) TK/ROR protein kinase 0.0056 0.0565 0.3443
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0116 0.0485
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0498 0.2188
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.015
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.031 0.1871
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0116 0.0485
Loa Loa (eye worm) hypothetical protein 0.0072 0.077 0.4711
Toxoplasma gondii microneme protein MIC17C 0.0036 0.031 0.0726
Loa Loa (eye worm) hypothetical protein 0.0054 0.0536 0.3265
Echinococcus granulosus Tolloid protein 1 0.0014 0.0031 0.0295
Onchocerca volvulus Arrow homolog 0.0014 0.0031 0.0295
Brugia malayi casein kinase II, putaitve 0.0022 0.0132 0.0812
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Loa Loa (eye worm) hypothetical protein 0.0054 0.0536 0.3265
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0037 0.0441
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0116 0.0672
Echinococcus granulosus glycoprotein Antigen 5 0.0015 0.0037 0.0357
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.077 0.3399
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0116 0.0485
Echinococcus multilocularis tissue type plasminogen activator 0.0056 0.0565 0.0558
Echinococcus multilocularis fibrillin 1 0.0014 0.0031 0.0024
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0186 0.2252 1
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0565 0.6779
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.002 0.0103 0.0229
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0056 0.0565 0.2485
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0019 0.0088 0.036
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.077 0.9275
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.002 0.0103 0.0096
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.077 0.3399
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0014 0.0031 0.015
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0037 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.077 0.3399
Echinococcus multilocularis enteropeptidase 0.0015 0.0037 0.0029
Schistosoma mansoni phospholipase C beta 0.0019 0.0088 0.1061
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.002 0.0103 0.1161
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0022 0.0132 0.1518
Onchocerca volvulus 0.0036 0.031 0.3683
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0116 0.0261
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0181
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.1871
Loa Loa (eye worm) hypothetical protein 0.0054 0.0536 0.3265
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0132 0.0075
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0536 0.2356
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0116 0.0485
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0116 0.0485
Brugia malayi PAN domain containing protein 0.0036 0.031 0.1907
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.031 0.1871
Brugia malayi PAN domain containing protein 0.0036 0.031 0.1907
Onchocerca volvulus 0.0021 0.0116 0.1323
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0116 0.0485
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0116 0.0713
Brugia malayi hypothetical protein 0.0015 0.0037 0.0225
Leishmania major phospholipase c-like protein 0.002 0.0103 0.1161
Echinococcus multilocularis casein kinase ii subunit beta 0.0076 0.083 0.0824
Schistosoma mansoni hypothetical protein 0.0056 0.0565 0.6807
Toxoplasma gondii hypothetical protein 0.0036 0.031 0.0726
Plasmodium falciparum casein kinase II beta chain 0.0076 0.083 0.3665
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.031 0.1871
Loa Loa (eye worm) Plcb4 protein 0.0019 0.0088 0.0499
Onchocerca volvulus 0.0036 0.031 0.3683
Loa Loa (eye worm) hypothetical protein 0.002 0.0103 0.059
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0116 0.0261
Echinococcus multilocularis glycoprotein Antigen 5 0.0015 0.0037 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0116 0.0485
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0116 0.1323
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0536 0.2356
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.083 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0132 0.0075
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342
Plasmodium vivax casein kinase II beta chain, putative 0.0076 0.083 0.3665
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0498 0.2188
Schistosoma mansoni hypothetical protein 0.0015 0.0037 0.0441
Mycobacterium ulcerans hypothetical protein 0.0072 0.077 0.3399
Loa Loa (eye worm) PAN domain-containing protein 0.0036 0.031 0.1871
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0014 0.0031 0.0379
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0116 0.0109
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0132 0.0075
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.083 1
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.0132 0.0075
Brugia malayi PAN domain containing protein 0.0036 0.031 0.1907
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0116 0.0485
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0116 0.0485
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0186 0.2252 1
Toxoplasma gondii PAN domain-containing protein 0.0036 0.031 0.0726
Toxoplasma gondii subtilisin SUB12 0.0036 0.031 0.0726
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.077 0.3399
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0037 0.0441
Toxoplasma gondii microneme protein, putative 0.0036 0.031 0.0726
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.077 0.9275
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0037 0.0441
Echinococcus granulosus Mastin 0.0015 0.0037 0.0357
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0031 0.015
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0015 0.0037 0.0357
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0116 0.1323
Toxoplasma gondii hypothetical protein 0.0036 0.031 0.0726
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.077 0.9275
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.1871
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0499
Loa Loa (eye worm) hypothetical protein 0.0054 0.0536 0.3265
Loa Loa (eye worm) hypothetical protein 0.0014 0.0031 0.015
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0116 0.0485
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0037 0.0441
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.077 0.3399
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0037 0.0441
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.083 0.3342

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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