Detailed information for compound 578453

Basic information

Technical information
  • TDR Targets ID: 578453
  • Name: 1-[(4,4-dimethyl-1-oxo-2,6-dioxa-1$l^{5}-phos phacyclohex-1-yl)oxy]-4,4-dimethyl-2,6-dioxa- 1$l^{5}-phosphacyclohexane 1-oxide
  • MW: 314.209 | Formula: C10H20O7P2
  • H donors: 0 H acceptors: 2 LogP: 0.89 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1(C)COP(=O)(OC1)OP1(=O)OCC(CO1)(C)C
  • InChi: 1S/C10H20O7P2/c1-9(2)5-13-18(11,14-6-9)17-19(12)15-7-10(3,4)8-16-19/h5-8H2,1-4H3
  • InChiKey: ABOQUUWIIIVSEK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(1-keto-4,4-dimethyl-2,6-dioxa-1$l^{5}-phosphacyclohex-1-yl)oxy]-4,4-dimethyl-2,6-dioxa-1$l^{5}-phosphacyclohexane 1-oxide
  • 2-[(5,5-dimethyl-2-oxo-1,3-dioxa-2$l^{5}-phosphacyclohex-2-yl)oxy]-5,5-dimethyl-1,3-dioxa-2$l^{5}-phosphacyclohexane 2-oxide
  • 2-[(2-keto-5,5-dimethyl-1,3-dioxa-2$l^{5}-phosphacyclohex-2-yl)oxy]-5,5-dimethyl-1,3-dioxa-2$l^{5}-phosphacyclohexane 2-oxide
  • 4090-52-2
  • EINECS 223-830-7
  • 2,2'-Oxybis(5,5-dimethyl-1,3,2-dioxaphosphorinane) 2,2'-dioxide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0044 0.0435 0.0546
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.3975 0.7484
Chlamydia trachomatis malate dehydrogenase 0.0111 0.2548 1
Schistosoma mansoni cathepsin F (C01 family) 0.0058 0.0878 0.1652
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0435 0.0818
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0094 0.2013 0.5084
Brugia malayi Cathepsin L-like precursor 0.0058 0.0878 0.1652
Loa Loa (eye worm) hypothetical protein 0.0111 0.2546 0.4792
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.2342 0.6029
Echinococcus granulosus cathepsin l1 0.0058 0.0878 0.0878
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0044 0.0435 0.0546
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.0435 0.0818
Loa Loa (eye worm) hypothetical protein 0.0111 0.2546 0.4792
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0044 0.0435 0.0546
Loa Loa (eye worm) malate dehydrogenase 0.0111 0.2548 0.4795
Leishmania major cathepsin L-like protease 0.0157 0.3975 0.7302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0878 0.3444
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0044 0.0435 0.0188
Echinococcus granulosus cytosolic malate dehydrogenase 0.0111 0.2548 0.2548
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0435 0.0546
Trichomonas vaginalis malate dehydrogenase, putative 0.0111 0.2548 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0058 0.0878 0.2002
Leishmania major cathepsin L-like protease 0.0157 0.3975 0.7302
Leishmania major 4-coumarate:coa ligase-like protein 0.0149 0.3723 0.6794
Trichomonas vaginalis malate dehydrogenase, putative 0.0111 0.2548 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0111 0.2546 0.6617
Echinococcus granulosus lactate dehydrogenase a 0.017 0.4383 0.4383
Echinococcus granulosus carbonic anhydrase 0.0108 0.2449 0.2449
Trypanosoma brucei carbonic anhydrase-like protein 0.02 0.5311 1
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0359 0.0819
Toxoplasma gondii malate dehydrogenase MDH 0.017 0.4383 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.3975 0.7484
Trypanosoma cruzi major cysteine proteinase, putative 0.011 0.2499 0.4705
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0812 0.1529
Echinococcus granulosus intermediate filament protein 0.0056 0.0812 0.0812
Leishmania major 4-coumarate:coa ligase-like protein 0.0149 0.3723 0.6794
Brugia malayi Cathepsin L-like precursor 0.0039 0.0279 0.0526
Brugia malayi AMP-binding enzyme family protein 0.0149 0.3723 0.701
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0359 0.0676
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0058 0.0878 0.2002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.2356 0.6071
Schistosoma mansoni malate dehydrogenase 0.0111 0.2548 0.4797
Echinococcus multilocularis cathepsin L cysteine protease 0.0058 0.0878 0.0878
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0111 0.2548 0.2548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Leishmania major cathepsin L-like protease 0.0058 0.0878 0.1047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0878 0.3444
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0435 0.0818
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0105 0.2343 0.4412
Schistosoma mansoni carbonic anhydrase 0.0108 0.2449 0.4611
Onchocerca volvulus 0.0044 0.0435 0.0451
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0111 0.2548 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Loa Loa (eye worm) hypothetical protein 0.0044 0.0435 0.0814
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0435 0.0546
Plasmodium vivax vivapain-2 0.0058 0.0878 0.2002
Plasmodium vivax vivapain-2 0.0058 0.0878 0.2002
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0435 0.0546
Plasmodium falciparum lactate dehydrogenase, putative 0.0087 0.1799 0.4103
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0087 0.1799 0.4103
Leishmania major malate dehydrogenase 0.0105 0.2343 0.4008
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0044 0.0435 0.0546
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.02 0.5311 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0108 0.2449 0.4611
Leishmania major cathepsin L-like protease 0.0058 0.0878 0.1047
Onchocerca volvulus 0.0058 0.0878 0.1737
Loa Loa (eye worm) hypothetical protein 0.0044 0.0435 0.0814
Trichomonas vaginalis malate dehydrogenase, putative 0.0111 0.2548 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0878 0.3444
Loa Loa (eye worm) hypothetical protein 0.0056 0.0812 0.1526
Plasmodium falciparum thioredoxin reductase 0.0041 0.0359 0.0819
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0094 0.2013 0.5084
Brugia malayi glutathione reductase 0.0041 0.0359 0.0676
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0138 0.3376 0.6358
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.02 0.5311 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0878 0.1649
Echinococcus multilocularis malate dehydrogenase 0.0105 0.2343 0.2343
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0105 0.2343 0.4412
Brugia malayi Cathepsin L-like precursor 0.0058 0.0878 0.1652
Schistosoma mansoni L-lactate dehydrogenase 0.017 0.4383 0.8254
Loa Loa (eye worm) hypothetical protein 0.017 0.4383 0.8253
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0044 0.0435 0.0435
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.2342 0.5799
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.2356 0.6071
Schistosoma mansoni malate dehydrogenase 0.0105 0.2343 0.4412
Trypanosoma brucei trypanothione reductase 0.0041 0.0359 0.0676
Leishmania major mitochondrial malate dehydrogenase 0.0105 0.2343 0.4008
Echinococcus granulosus carbonic anhydrase 0.0108 0.2449 0.2449
Toxoplasma gondii propionate-CoA ligase 0.0044 0.0435 0.0188
Onchocerca volvulus 0.0058 0.0878 0.1737
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0111 0.2548 0.4797
Entamoeba histolytica acyl-CoA synthetase, putative 0.0149 0.3723 0.8493
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0111 0.2548 0.5812
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0108 0.2449 0.4611
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0149 0.3723 1
Echinococcus granulosus cathepsin l1 0.0039 0.0279 0.0279
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.0435 0.0814
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.2356 0.6071
Schistosoma mansoni intermediate filament proteins 0.0056 0.0812 0.1529
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0105 0.2343 0.4412
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.0435 0.1706
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0111 0.2548 0.4797
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0002 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0149 0.3723 0.701
Toxoplasma gondii lactate dehydrogenase LDH2 0.017 0.4383 1
Brugia malayi Putative carbonic anhydrase 5 precursor 0.02 0.5311 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0058 0.0878 0.0878
Loa Loa (eye worm) hypothetical protein 0.0039 0.0279 0.0522
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.02 0.5311 1
Onchocerca volvulus 0.0044 0.0435 0.0451
Echinococcus multilocularis cysteine protease 0.0058 0.0878 0.0878
Echinococcus granulosus carbonic anhydrase II 0.02 0.5311 0.5311
Brugia malayi Cathepsin L-like precursor 0.0039 0.0279 0.0526
Loa Loa (eye worm) glutathione reductase 0.0041 0.0359 0.0672
Schistosoma mansoni carbonic anhydrase-related 0.0108 0.2449 0.4611
Schistosoma mansoni carbonic anhydrase-related 0.0108 0.2449 0.4611
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0044 0.0435 0.0546
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0435 0.0818
Trypanosoma cruzi cysteine peptidase, putative 0.0157 0.3975 0.7484
Loa Loa (eye worm) hypothetical protein 0.0039 0.0279 0.0522
Plasmodium falciparum glutathione reductase 0.0041 0.0359 0.0819
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0044 0.0435 0.0818
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0279 0.1096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Brugia malayi Thioredoxin reductase 0.0041 0.0359 0.0676
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.2356 0.6071
Trypanosoma brucei malate dehydrogenase-related 0.0087 0.1799 0.3387
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0108 0.2449 0.4611
Mycobacterium tuberculosis Probable reductase 0.0094 0.2013 0.5084
Plasmodium falciparum malate dehydrogenase 0.017 0.4383 1
Onchocerca volvulus 0.0058 0.0878 0.1737
Plasmodium falciparum L-lactate dehydrogenase 0.017 0.4383 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0111 0.2548 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0668 0.1254
Leishmania major cytosolic malate dehydrogenase 0.0111 0.2548 0.442
Loa Loa (eye worm) cysteine protease 0.0058 0.0878 0.1649
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0149 0.3723 1
Echinococcus multilocularis lactate dehydrogenase a 0.017 0.4383 0.4383
Onchocerca volvulus 0.0044 0.0435 0.0451
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0111 0.2548 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0279 0.0522
Entamoeba histolytica acyl-CoA synthetase, putative 0.0149 0.3723 0.8493
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0878 0.3444
Echinococcus granulosus malate dehydrogenase 0.0105 0.2343 0.2343
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0108 0.2449 0.4611
Mycobacterium ulcerans acyl-CoA synthetase 0.0149 0.3723 1
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0668 0.1258
Echinococcus multilocularis lactate dehydrogenase protein 0.017 0.4383 0.4383
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.0435 0.1706
Onchocerca volvulus 0.0056 0.0812 0.1548
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0878 0.1652
Echinococcus granulosus lactate dehydrogenase protein 0.017 0.4383 0.4383
Loa Loa (eye worm) hypothetical protein 0.0149 0.3723 0.7009
Echinococcus multilocularis L lactate dehydrogenase B chain 0.017 0.4383 0.4383
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.2342 0.6029
Onchocerca volvulus Cathepsin F homolog 0.0058 0.0878 0.1737
Entamoeba histolytica cysteine protease, putative 0.0058 0.0878 0.2002
Leishmania major 4-coumarate:coa ligase-like protein 0.0149 0.3723 0.6794
Onchocerca volvulus 0.0058 0.0878 0.1737
Trypanosoma cruzi malate dehydrogenase, putative 0.0105 0.2343 0.4412
Loa Loa (eye worm) hypothetical protein 0.0111 0.2546 0.4792
Echinococcus granulosus malate dehydrogenase 0.0105 0.2343 0.2343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Loa Loa (eye worm) hypothetical protein 0.0108 0.2449 0.4608
Echinococcus multilocularis musashi 0.0056 0.0812 0.0812
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0058 0.0878 0.1649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Entamoeba histolytica acyl-coA synthetase, putative 0.0149 0.3723 0.8493
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.0435 0.0814
Mycobacterium ulcerans acyl-CoA synthetase 0.0149 0.3723 1
Trypanosoma brucei glycosomal malate dehydrogenase 0.0105 0.2343 0.4412
Echinococcus multilocularis lamin 0.0056 0.0812 0.0812
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.3975 0.7484
Echinococcus multilocularis carbonic anhydrase 0.0108 0.2449 0.2449
Schistosoma mansoni malate dehydrogenase 0.017 0.4383 0.8254
Echinococcus granulosus cathepsin L cysteine proteinase 0.0058 0.0878 0.0878
Plasmodium vivax acetyl-CoA synthetase, putative 0.0044 0.0435 0.0991
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.3975 0.7484
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0044 0.0435 0.0991
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.017 0.4383 0.5
Toxoplasma gondii cathepsin CPL 0.0058 0.0878 0.1289
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.0435 0.0153
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0094 0.2013 0.5084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Leishmania major malate dehydrogenase, putative 0.0087 0.1799 0.2908
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0279 0.1096
Loa Loa (eye worm) oxidoreductase 0.0044 0.0435 0.0814
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0279 0.0526
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.02 0.5311 1
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0111 0.2548 0.4797
Brugia malayi Cathepsin L-like precursor 0.0058 0.0878 0.1652
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Onchocerca volvulus 0.0058 0.0878 0.1737
Loa Loa (eye worm) hypothetical protein 0.0149 0.3723 0.7009
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.02 0.5311 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.3975 0.7484
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0878 0.2002
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.0435 0.0818
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0149 0.3723 1
Onchocerca volvulus 0.0056 0.0812 0.1548
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0149 0.3723 1
Leishmania major glycosomal malate dehydrogenase 0.0105 0.2343 0.4008
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0044 0.0435 0.0818
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0435 0.0818
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0359 0.0329
Trichomonas vaginalis malate dehydrogenase, putative 0.0111 0.2548 1
Schistosoma mansoni carbonic anhydrase-related 0.0108 0.2449 0.4611
Trichomonas vaginalis malate dehydrogenase, putative 0.0111 0.2548 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0108 0.2449 0.4611
Echinococcus multilocularis lactate dehydrogenase a 0.017 0.4383 0.4383
Onchocerca volvulus 0.0044 0.0435 0.0451
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0111 0.2548 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.3975 0.7484
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0878 0.2002
Trypanosoma brucei cytosolic malate dehydrogenase 0.0111 0.2548 0.4797
Brugia malayi lactate dehydrogenase. 0.017 0.4383 0.8254
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0111 0.2548 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0058 0.0878 0.1649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.3975 0.7484
Loa Loa (eye worm) hypothetical protein 0.0149 0.3723 0.7009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Plasmodium vivax lactate dehydrogenase 0.017 0.4383 1
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0359 0.0672
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.02 0.5311 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0878 0.3444
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0279 0.0637
Schistosoma mansoni lamin 0.0056 0.0812 0.1529
Schistosoma mansoni lamin 0.0056 0.0812 0.1529
Loa Loa (eye worm) hypothetical protein 0.0055 0.078 0.1466
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0149 0.3723 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.3975 0.7484
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0812 0.1526
Echinococcus granulosus L lactate dehydrogenase B chain 0.017 0.4383 0.4383
Echinococcus multilocularis lamin dm0 0.0056 0.0812 0.0812
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0044 0.0435 0.0546
Brugia malayi Papain family cysteine protease containing protein 0.0058 0.0878 0.1652
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0058 0.0878 0.3444
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0435 0.0818
Brugia malayi Cathepsin L-like cysteine proteinase 0.0039 0.0279 0.0526
Loa Loa (eye worm) fibroinase 0.0058 0.0878 0.1649
Plasmodium vivax acyl-CoA synthetase, putative 0.0111 0.2546 0.5809
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.0435 0.0153
Onchocerca volvulus 0.0058 0.0878 0.1737
Echinococcus granulosus cytosolic malate dehydrogenase 0.0111 0.2548 0.2548
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0398 0.1563
Mycobacterium ulcerans acyl-CoA synthetase 0.0149 0.3723 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0878 0.3444
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0111 0.2548 0.2548
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0058 0.0878 0.0878
Mycobacterium ulcerans hypothetical protein 0.0149 0.3723 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0044 0.0435 0.0991
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.3975 0.7484
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0435 0.0818
Plasmodium vivax malate dehydrogenase, putative 0.017 0.4383 1
Leishmania major carbonic anhydrase-like protein 0.02 0.5311 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0111 0.2548 1
Schistosoma mansoni malate dehydrogenase 0.0111 0.2548 0.4797
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.2342 0.6029
Loa Loa (eye worm) hypothetical protein 0.0111 0.2546 0.4792
Schistosoma mansoni hypothetical protein 0.0108 0.2449 0.4611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0435 0.0818
Echinococcus multilocularis carbonic anhydrase 0.0108 0.2449 0.2449
Plasmodium falciparum cysteine proteinase falcipain 3 0.0058 0.0878 0.2002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0878 0.3444
Leishmania major cathepsin L-like protease 0.0058 0.0878 0.1047
Echinococcus multilocularis carbonic anhydrase 0.0108 0.2449 0.2449
Echinococcus granulosus carbonic anhydrase 0.0108 0.2449 0.2449
Echinococcus granulosus lactate dehydrogenase a 0.017 0.4383 0.4383
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Trichomonas vaginalis malate dehydrogenase, putative 0.0111 0.2548 1
Echinococcus granulosus lamin dm0 0.0056 0.0812 0.0812
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0111 0.2548 0.6621
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Echinococcus multilocularis cysteine protease 0.0058 0.0878 0.0878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.3975 0.7484
Onchocerca volvulus Cathepsin L homolog 0.0058 0.0878 0.1737
Echinococcus granulosus L lactate dehydrogenase 0.0083 0.1652 0.1652
Trichomonas vaginalis malate dehydrogenase, putative 0.0111 0.2548 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0108 0.2449 0.4608
Brugia malayi AMP-binding enzyme family protein 0.0149 0.3723 0.701
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0105 0.2343 0.4412
Echinococcus multilocularis tumor protein p63 0.0349 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.3975 0.7484
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0435 0.0818
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0435 0.0546
Entamoeba histolytica malate dehydrogenase, putative 0.017 0.4383 1
Toxoplasma gondii hypothetical protein 0.0108 0.2449 0.5192
Brugia malayi intermediate filament protein 0.0056 0.0812 0.1529
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0812 0.1526
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0878 0.3444
Plasmodium vivax glutathione reductase, putative 0.0041 0.0359 0.0819
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0111 0.2546 0.6421
Loa Loa (eye worm) carbonic anhydrase 3 0.02 0.5311 1
Trypanosoma cruzi cysteine peptidase, putative 0.0157 0.3975 0.7484
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0058 0.0878 0.3444
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0111 0.2548 0.6426
Onchocerca volvulus 0.0051 0.0668 0.1129
Leishmania major cathepsin L-like protease 0.0058 0.0878 0.1047
Onchocerca volvulus 0.0058 0.0878 0.1737
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.0435 0.0188
Echinococcus granulosus lamin 0.0056 0.0812 0.0812
Brugia malayi cathepsin L-like precursor 0.0039 0.0279 0.0526
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0058 0.0878 0.0878
Plasmodium falciparum carbonic anhydrase 0.0108 0.2449 0.5586
Trichomonas vaginalis malate dehydrogenase, putative 0.0066 0.1147 0.4503
Echinococcus granulosus cathepsin l cysteine peptidase 0.0058 0.0878 0.0878
Onchocerca volvulus Cathepsin L homolog 0.0058 0.0878 0.1737
Toxoplasma gondii lactate dehydrogenase LDH1 0.017 0.4383 1
Onchocerca volvulus 0.0149 0.3723 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0094 0.2013 0.5084
Plasmodium falciparum acyl-CoA synthetase 0.0111 0.2546 0.5809
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0044 0.0435 0.0546
Echinococcus multilocularis malate dehydrogenase 0.0105 0.2343 0.2343
Brugia malayi Cathepsin L-like precursor 0.0058 0.0878 0.1652
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0376 0.0376
Brugia malayi Cathepsin L-like precursor 0.0058 0.0878 0.1652
Loa Loa (eye worm) ctsf protein 0.0058 0.0878 0.1649
Leishmania major cathepsin L-like protease 0.0058 0.0878 0.1047
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0149 0.3723 1
Trypanosoma cruzi cruzipain precursor, putative 0.0157 0.3975 0.7484
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0149 0.3723 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.2449 0.4608
Schistosoma mansoni cathepsin F (C01 family) 0.0058 0.0878 0.1652
Schistosoma mansoni L-lactate dehydrogenase 0.0087 0.1799 0.3387
Entamoeba histolytica malate dehydrogenase, putative 0.0111 0.2548 0.5812
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0094 0.2013 0.5084
Leishmania major cysteine peptidase A (CPA) 0.0058 0.0878 0.1047
Loa Loa (eye worm) malate dehydrogenase 0.0105 0.2343 0.441
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0108 0.2449 0.4608
Leishmania major malate dehydrogenase, putative 0.017 0.4383 0.8127
Trichomonas vaginalis malate dehydrogenase, putative 0.0111 0.2548 1
Leishmania major cathepsin L-like protease 0.0157 0.3975 0.7302
Trypanosoma cruzi malate dehydrogenase, putative 0.0087 0.1799 0.3387
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0044 0.0435 0.0435
Schistosoma mansoni acetyl-CoA synthetase 0.0044 0.0435 0.0818
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0435 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0878 0.3444
Brugia malayi Cathepsin L-like precursor 0.0058 0.0878 0.1652
Trypanosoma cruzi cysteine peptidase, putative 0.0157 0.3975 0.7484
Echinococcus multilocularis L lactate dehydrogenase 0.0083 0.1652 0.1652
Trichomonas vaginalis malate dehydrogenase, putative 0.0087 0.1799 0.706
Trichomonas vaginalis malate dehydrogenase, putative 0.0111 0.2548 1
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0105 0.2343 0.4412
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0149 0.3723 1
Echinococcus multilocularis lactate dehydrogenase a 0.017 0.4383 0.4383
Echinococcus multilocularis carbonic anhydrase II 0.02 0.5311 0.5311
Loa Loa (eye worm) hypothetical protein 0.0111 0.2546 0.4792
Mycobacterium ulcerans malate dehydrogenase 0.0111 0.2548 0.6426
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0878 0.3444
Giardia lamblia Malate dehydrogenase 0.0111 0.2548 0.5
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0094 0.2013 0.48

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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