Detailed information for compound 579191

Basic information

Technical information
  • TDR Targets ID: 579191
  • Name: 2-dimethylaminoethyl (2S,5R,6R)-3,3-dimethyl- 7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azab icyclo[3.2.0]heptane-2-carboxylate hydroiodid e
  • MW: 533.423 | Formula: C20H28IN3O4S
  • H donors: 1 H acceptors: 3 LogP: 2.53 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN(CCOC(=O)[C@@H]1N2C(=O)[C@H]([C@H]2SC1(C)C)NC(=O)Cc1ccccc1)C.I
  • InChi: 1S/C20H27N3O4S.HI/c1-20(2)16(19(26)27-11-10-22(3)4)23-17(25)15(18(23)28-20)21-14(24)12-13-8-6-5-7-9-13;/h5-9,15-16,18H,10-12H2,1-4H3,(H,21,24);1H/t15-,16+,18-;/m1./s1
  • InChiKey: NGASWANRINDJST-PNQHFFRLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(1-oxo-2-phenylethyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 2-dimethylaminoethyl ester hydroiodide
  • 2-dimethylaminoethyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylethanoylamino)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate hydroiodide
  • (2S,5R,6R)-7-keto-3,3-dimethyl-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 2-dimethylaminoethyl ester hydroiodide
  • lactopen
  • 71798-32-8
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2S-(2alpha,5alpha,6beta))-, 2-(dimethylamino)ethyl ester, monohydriodide
  • Benzylpenicillin-dimethylamino-ethylester hydroiodide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0085 0.0471
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.0834 0.0951
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.0834 0.0951
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0912 0.2622
Loa Loa (eye worm) hypothetical protein 0.0253 0.0916 0.2712
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0085 0.0438
Loa Loa (eye worm) glutaminase 2 0.0855 0.3367 1
Brugia malayi MH2 domain containing protein 0.0133 0.0426 0.1255
Onchocerca volvulus 0.0049 0.0085 0.0994
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0912 0.2622
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0039 0.0022
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0056 0.0051
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0059 0.0163
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.02 0.0699 0.2067
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0085 0.0094
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.01 0.0293 0.0859
Echinococcus multilocularis microtubule associated protein 2 0.2184 0.8775 0.8775
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1346 0.5364 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0057 0.0173
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.0481 0.0837
Trichomonas vaginalis set domain proteins, putative 0.023 0.0821 0.2349
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0023 0.0055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.0834 0.0946
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.0834 0.083
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.0916 0.1044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0035 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0595 0.1672
Onchocerca volvulus 0.0052 0.0097 0.1131
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0293 0.2414
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0085 0.0438
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.1103 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0461 0.3977
Loa Loa (eye worm) hypothetical protein 0.0058 0.0121 0.0347
Brugia malayi hypothetical protein 0.0253 0.0916 0.2712
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0008 0.0004
Schistosoma mansoni hypothetical protein 0.0041 0.0055 0.0057
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0092
Mycobacterium ulcerans transcriptional regulator 0.1346 0.5364 1
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0061 0.007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0086 0.0243
Schistosoma mansoni hypothetical protein 0.003 0.0008 0.0004
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1346 0.5364 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0034 0.0033
Schistosoma mansoni hypothetical protein 0.034 0.127 0.1443
Schistosoma mansoni survival motor neuron protein 0.0052 0.0097 0.0105
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0035 0.0035
Brugia malayi Pre-SET motif family protein 0.0202 0.0707 0.209
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Schistosoma mansoni hypothetical protein 0.0036 0.0035 0.0035
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0166 0.0563 0.0559
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0233 0.0834 0.2468
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.1101 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0011
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.0467 0.0463
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0284 0.0324
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0912 0.2622
Entamoeba histolytica hypothetical protein 0.0047 0.0077 0.0389
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0293 0.0334
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.0912 0.2698
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0121 0.0772
Mycobacterium ulcerans hypothetical protein 0.0049 0.0085 0.0094
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0085 0.0471
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0061 0.0066
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0137 0.0395
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.1103 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0169
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0039 0.5
Brugia malayi jmjC domain containing protein 0.0036 0.0034 0.0087
Trichomonas vaginalis ran, putative 0.0042 0.0059 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.0834 0.0946
Onchocerca volvulus Alhambra homolog 0.003 0.0008 0.0045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0526 0.0935
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0095 0.0525
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0233 0.0834 0.2468
Loa Loa (eye worm) hypothetical protein 0.0049 0.0085 0.0241
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0059 0.019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0092
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0097 0.0275
Loa Loa (eye worm) hypothetical protein 0.0033 0.0023 0.0055
Plasmodium falciparum importin beta, putative 0.0058 0.0121 1
Echinococcus granulosus importin subunit beta 1 0.0058 0.0121 0.0138
Onchocerca volvulus 0.023 0.0821 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0085 0.0094
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0008 0.0316
Loa Loa (eye worm) hypothetical protein 0.02 0.0699 0.2067
Toxoplasma gondii exonuclease III APE 0.0037 0.0039 0.297
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.0481 0.0851
Echinococcus granulosus snurportin 1 0.0615 0.2388 0.2722
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0299 0.0336
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0008 0.0004
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0077 0.0355
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.0426 0.1255
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0092
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0061 0.0169
Loa Loa (eye worm) hypothetical protein 0.0126 0.0399 0.1175
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0034 0.0038
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.0895 0.2649
Leishmania major importin beta-1 subunit, putative 0.0047 0.0077 0.0355
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Echinococcus multilocularis snurportin 1 0.0615 0.2388 0.2385
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0615 0.2388 0.709
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0092
Echinococcus granulosus expressed conserved protein 0.0094 0.0268 0.0306
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0008 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0912 0.2622
Loa Loa (eye worm) hypothetical protein 0.0126 0.0399 0.1175
Entamoeba histolytica Ran family GTPase 0.0042 0.0059 0.0224
Schistosoma mansoni ap endonuclease 0.0037 0.0039 0.004
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0461 0.3977
Leishmania major GTP-binding protein, putative 0.0042 0.0059 0.019
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0039 0.0036
Echinococcus multilocularis protein patched 0.0043 0.0061 0.0057
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.0481 0.0749
Schistosoma mansoni hypothetical protein 0.0041 0.0055 0.0057
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0085 0.0471
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Plasmodium vivax hypothetical protein, conserved 0.003 0.0008 0.0316
Schistosoma mansoni ran 0.0042 0.0059 0.0062
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.1101 1
Echinococcus multilocularis expressed conserved protein 0.0094 0.0268 0.0264
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0039 0.0007
Brugia malayi Bromodomain containing protein 0.003 0.0008 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0085 0.0094
Mycobacterium ulcerans TetR family transcriptional regulator 0.1346 0.5364 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0034 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0085 0.0241
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0086 0.0243
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0085 0.0094
Mycobacterium ulcerans glutaminase 0.0855 0.3367 0.6252
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.0426 0.1255
Schistosoma mansoni glutaminase 0.0855 0.3367 0.3834
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0061 0.0057
Echinococcus granulosus microtubule associated protein 2 0.2184 0.8775 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0085 0.0241
Mycobacterium ulcerans hypothetical protein 0.0157 0.0526 0.0921
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1101 1
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0293 0.0859
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0059 0.0467
Schistosoma mansoni hypothetical protein 0.0041 0.0055 0.0057
Schistosoma mansoni ap endonuclease 0.0037 0.0039 0.004
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0085 0.0241
Brugia malayi Importin beta-1 subunit 0.0058 0.0121 0.0347
Brugia malayi RNA, U transporter 1 0.0164 0.0553 0.1632
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0085 0.0094
Onchocerca volvulus Huntingtin homolog 0.0126 0.0399 0.4841
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0293 0.0289
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.1103 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0035 0.0031
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0061 0.007
Echinococcus granulosus peregrin 0.003 0.0008 0.0009
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0059 0.4523
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0056 0.0063
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0004 0.0005
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0035 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0166 0.0563 0.0642
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0077 0.0113
Echinococcus multilocularis peregrin 0.003 0.0008 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Trichomonas vaginalis glutaminase, putative 0.0855 0.3367 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0034 0.0029
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0035 0.0015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.0834 0.083
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0085 0.0094
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0059 0.0067
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0059 0.4696
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0059 0.4696
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0202 0.0226
Echinococcus multilocularis geminin 0.034 0.127 0.1266
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0085 0.0241
Loa Loa (eye worm) hypothetical protein 0.0052 0.01 0.0285
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0059 0.0055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0057 0.0173
Toxoplasma gondii hypothetical protein 0.0048 0.0082 0.6699
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0008 0.0009
Schistosoma mansoni hypothetical protein 0.0033 0.0023 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Schistosoma mansoni hypothetical protein 0.0041 0.0055 0.0057
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0039 0.0103
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.0467 0.0533
Plasmodium vivax importin-beta 2, putative 0.0058 0.0121 1
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0059 0.0163
Schistosoma mansoni ran 0.0042 0.0059 0.0062
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0559 0.6798
Loa Loa (eye worm) hypothetical protein 0.0051 0.0095 0.0269
Brugia malayi follicle stimulating hormone receptor 0.0248 0.0895 0.2649
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0039 0.0283
Schistosoma mansoni microtubule-associated protein tau 0.2184 0.8775 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0461 0.3977
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.0595 0.1672
Echinococcus multilocularis protein dispatched 1 0.0049 0.0086 0.0081
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0035 0.2407
Brugia malayi hypothetical protein 0.0036 0.0035 0.0092
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0039 0.297
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0121 0.0772
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0085 0.0094
Schistosoma mansoni importin beta-1 0.0058 0.0121 0.0133
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0284 0.028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.0834 0.0946
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0707 0.209
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0121 0.0117
Echinococcus granulosus geminin 0.034 0.127 0.1447
Schistosoma mansoni hypothetical protein 0.0052 0.0097 0.0105
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.1101 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0008 0.0316
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0039 0.0035
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0059 0.019
Onchocerca volvulus Huntingtin homolog 0.0126 0.0399 0.4841
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0057 0.0173
Loa Loa (eye worm) hypothetical protein 0.0049 0.0085 0.0241
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0039 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0912 0.2622
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0057 0.0173
Brugia malayi jmjC domain containing protein 0.0098 0.0284 0.0832
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.0912 0.2622
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0077 0.0113
Brugia malayi glutaminase DH11.1 0.0855 0.3367 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.0912 0.2698
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.1103 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0085 0.0438
Loa Loa (eye worm) glutaminase 0.0855 0.3367 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0039 0.2741
Brugia malayi hypothetical protein 0.0126 0.0399 0.1175
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0039 0.0103
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1346 0.5364 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0035 0.2646
Brugia malayi PHD-finger family protein 0.003 0.0008 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0085 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0559 0.1563
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0059 0.019
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.0916 0.0912
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Schistosoma mansoni patched 1 0.0043 0.0061 0.0065
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0085 0.0109
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0121 1
Schistosoma mansoni hypothetical protein 0.0615 0.2388 0.2718
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.1103 0.3199
Brugia malayi CHE-14 protein 0.0043 0.0061 0.0169
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0077 0.0113
Schistosoma mansoni hypothetical protein 0.034 0.127 0.1443

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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