Detailed information for compound 585455

Basic information

Technical information
  • TDR Targets ID: 585455
  • Name: 2-amino-6-trifluoromethylbenzonorbornene
  • MW: 227.226 | Formula: C12H12F3N
  • H donors: 1 H acceptors: 0 LogP: 2.3 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@@H]1C[C@@H]2C[C@H]1c1c2cc(cc1)C(F)(F)F
  • InChi: 1S/C12H12F3N/c13-12(14,15)7-1-2-8-9(5-7)6-3-10(8)11(16)4-6/h1-2,5-6,10-11H,3-4,16H2/t6-,10-,11+/m0/s1
  • InChiKey: YVQIQERXVFKDDA-NRZXQICZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 83118-50-7
  • 1,4-Methanonaphthalen-2-amine, 1,2,3,4-tetrahydro-6-(trifluoromethyl)-, (1alpha,2alpha,4alpha)-
  • 2-Atfmb

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0079 0.0289 1
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.022 0.0186
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0067 0.022 0.2337
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.097 0.097
Giardia lamblia Kinase, CMGC CLK 0.0079 0.0289 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.019 0.0183
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0069 0.023 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0063 0.0195 0.0195
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0079 0.0289 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.097 0.0964
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1697 1 1
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0064 0.0199 0.6823
Echinococcus granulosus inositol monophosphatase 1 0.0077 0.0279 0.0279
Brugia malayi mbt repeat family protein 0.0721 0.4145 0.4141
Brugia malayi Protein kinase domain containing protein 0.0079 0.0289 0.0282
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0064 0.0199 0.0192
Echinococcus multilocularis mitogen activated protein kinase 0.0067 0.022 0.0213
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.022 0.0213
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0195 0.6685
Loa Loa (eye worm) hypothetical protein 0.0108 0.0466 0.0459
Schistosoma mansoni hypothetical protein 0.0051 0.0124 0.0117
Brugia malayi hypothetical protein 0.0251 0.1323 0.1317
Echinococcus granulosus SAM and MBT domain containing protein 0.0258 0.1362 0.1362
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0182 0.0176
Echinococcus granulosus peregrin 0.0063 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0721 0.4145 0.4141
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0063 0.0195 0.0188
Schistosoma mansoni hypothetical protein 0.0063 0.0195 0.0188
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0079 0.0289 1
Trichomonas vaginalis set domain proteins, putative 0.0252 0.1326 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.019 0.0183
Plasmodium vivax glycogen synthase kinase 3, putative 0.0064 0.0199 0.6823
Loa Loa (eye worm) jmjC domain-containing protein 0.013 0.0598 0.0592
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0275 0.0268
Echinococcus multilocularis dual specificity protein kinase clk2 0.0079 0.0289 0.0282
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0279 0.8914
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.1239 0.1233
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.097 0.0964
Trypanosoma brucei protein kinase, putative 0.0067 0.022 0.2337
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0721 0.4145 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0064 0.0199 0.0192
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0195 0.0188
Echinococcus multilocularis inositol monophosphatase 1 0.0077 0.0279 0.0272
Trichomonas vaginalis inositol monophosphatase, putative 0.0077 0.0279 0.0708
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0124 0.0117
Loa Loa (eye worm) hypothetical protein 0.0063 0.0195 0.0188
Schistosoma mansoni sex comb on midleg homolog 0.0279 0.1491 0.1485
Brugia malayi Pre-SET motif family protein 0.0221 0.1143 0.1136
Echinococcus multilocularis mitogen activated protein kinase 3 0.0067 0.022 0.0213
Schistosoma mansoni inositol monophosphatase 0.0077 0.0279 0.0272
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0067 0.022 0.7565
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.097 0.0964
Echinococcus granulosus mitogen activated protein kinase 0.0067 0.022 0.022
Brugia malayi intracellular kinase 0.0064 0.0199 0.0192
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0279 0.9019
Onchocerca volvulus 0.0252 0.1326 0.3187
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0077 0.0279 0.5
Echinococcus multilocularis SAM and MBT domain containing protein 0.0258 0.1362 0.1356
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.022 0.0186
Echinococcus multilocularis lysine specific demethylase 5A 0.0076 0.0275 0.0268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.097 0.0964
Brugia malayi PHD-finger family protein 0.0063 0.0195 0.0188
Echinococcus granulosus hypothetical protein 0.0072 0.0249 0.0249
Brugia malayi Cytochrome P450 family protein 0.0061 0.0182 0.0176
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.0553 0.0553
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0067 0.022 0.0213
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.022 0.0186
Giardia lamblia Kinase, CMGC GSK 0.0064 0.0199 0.0417
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.097 0.0964
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0077 0.0279 0.9655
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0064 0.0199 0.0199
Brugia malayi mbt repeat family protein 0.0258 0.1362 0.1356
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0064 0.0199 0.0192
Schistosoma mansoni lipoxygenase 0.0086 0.0332 0.0325
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0079 0.0289 1
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0079 0.0289 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.097 0.0964
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1697 1 1
Plasmodium vivax serine/threonine kinase-1, putative 0.0079 0.0289 1
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.022 0.0186
Echinococcus multilocularis protein kinase shaggy 0.0064 0.0199 0.0192
Echinococcus multilocularis 0.0072 0.0249 0.0242
Echinococcus granulosus dual specificity protein kinase clk2 0.0079 0.0289 0.0289
Onchocerca volvulus 0.0064 0.0199 0.0464
Leishmania major protein kinase, putative 0.0079 0.0289 1
Echinococcus multilocularis peregrin 0.0063 0.0195 0.0188
Leishmania major protein kinase, putative 0.0079 0.0289 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0279 0.8914
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0079 0.0289 1
Schistosoma mansoni serine/threonine protein kinase 0.1697 1 1
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.1323 0.1317
Loa Loa (eye worm) inositol-1 0.0077 0.0279 0.0272
Schistosoma mansoni survival motor neuron protein 0.0051 0.0124 0.0117
Brugia malayi Bromodomain containing protein 0.0063 0.0195 0.0188
Onchocerca volvulus 0.0279 0.1491 0.3587
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0064 0.0199 0.0192
Echinococcus multilocularis jumonji domain containing protein 0.0088 0.0343 0.0337
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.1323 0.1323
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0275 0.0268
Echinococcus multilocularis PHD finger protein rhinoceros 0.0063 0.0195 0.0188
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.019 0.6485
Brugia malayi jmjC domain containing protein 0.0207 0.1056 0.105
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.097 0.097
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0207 0.1056 0.1056
Schistosoma mansoni lipoxygenase 0.0123 0.0553 0.0547
Loa Loa (eye worm) mbt repeat family protein 0.0258 0.1362 0.1356
Schistosoma mansoni sex comb on midleg homolog 0.0279 0.1491 0.1485
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0289 0.0794
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.022 0.2337
Brugia malayi MAP kinase sur-1 0.0067 0.022 0.0213
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0077 0.0279 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0069 0.023 0.5
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0406 0.2252 0.2252
Echinococcus granulosus polycomb protein SCMH1 0.0279 0.1491 0.1491
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0067 0.022 0.3073
Onchocerca volvulus 0.0051 0.0124 0.0283
Plasmodium falciparum glycogen synthase kinase 3 0.0064 0.0199 0.0417
Echinococcus granulosus mitogen activated protein kinase 3 0.0067 0.022 0.022
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0077 0.0279 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0406 0.2252 0.2247
Plasmodium falciparum protein serine/threonine kinase-1 0.0079 0.0289 1
Echinococcus granulosus lysine specific demethylase 5A 0.0076 0.0275 0.0275
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.097 0.0964
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0207 0.1056 0.105
Schistosoma mansoni inositol monophosphatase 0.0077 0.0279 0.0272
Brugia malayi jmjC domain containing protein 0.0076 0.0275 0.0268
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0258 0.1362 0.1356
Brugia malayi follicle stimulating hormone receptor 0.0237 0.1239 0.1233
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0067 0.022 0.2337
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0195 0.6685
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.019 0.019
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.1143 0.1136
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0275 0.0268
Giardia lamblia Kinase, CMGC GSK 0.0064 0.0199 0.0417
Giardia lamblia Kinase, CMGC MAPK 0.0067 0.022 0.2657
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0064 0.0199 0.096
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0279 0.0708
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0067 0.022 0.2337
Loa Loa (eye worm) hypothetical protein 0.0251 0.1323 0.1317
Schistosoma mansoni jumonji domain containing protein 0.0164 0.0801 0.0795
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.0553 0.0547
Schistosoma mansoni hypothetical protein 0.0663 0.3797 0.3792
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0279 0.8914
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0079 0.0289 0.0282
Brugia malayi Inositol-1 0.0077 0.0279 0.0272
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0079 0.0289 1
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1697 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.019 0.0183
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0007 0.0007
Echinococcus granulosus protein kinase shaggy 0.0064 0.0199 0.0199
Onchocerca volvulus Alhambra homolog 0.0063 0.0195 0.0455
Loa Loa (eye worm) hypothetical protein 0.0072 0.0249 0.0242
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0279 0.0708
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0289 0.0282
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0067 0.022 0.3073
Echinococcus granulosus jumonji domain containing protein 0.0088 0.0343 0.0343
Echinococcus multilocularis polycomb protein SCMH1 0.0279 0.1491 0.1485
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0289 0.0282
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0195 0.6685
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.022 0.2337

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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