Detailed information for compound 588706

Basic information

Technical information
  • TDR Targets ID: 588706
  • Name: 1-methyl-3-(1-methylallylcarbamothioylamino)t hiourea
  • MW: 218.343 | Formula: C7H14N4S2
  • H donors: 4 H acceptors: 0 LogP: 0.95 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CC(NC(=S)NNC(=S)NC)C
  • InChi: 1S/C7H14N4S2/c1-4-5(2)9-7(13)11-10-6(12)8-3/h4-5H,1H2,2-3H3,(H2,8,10,12)(H2,9,11,13)
  • InChiKey: CGFFKDRVHZIQHL-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 1-methyl-3-[[(1-methylallylamino)-thioxomethyl]amino]thiourea
  • 1-but-3-en-2-yl-3-(methylcarbamothioylamino)thiourea
  • 1-methyl-3-(1-methylallylthiocarbamoylamino)thiourea
  • Methallibure
  • almagate
  • 3-(methylcarbamothioylamino)-1-(1-methylprop-2-enyl)thiourea
  • 3-[(methylamino-thioxomethyl)amino]-1-(1-methylprop-2-enyl)thiourea
  • 1-(1-methylprop-2-enyl)-3-(methylthiocarbamoylamino)thiourea
  • 926-93-2
  • BRN 1212512
  • Compound 33,828
  • EINECS 213-146-7
  • I.C.I. 33,828
  • I.C.I. Compound 33828
  • ICI 33,828
  • Metalibura [INN-Spanish]
  • Metalibura [Spanish]
  • Metalliburum [INN-Latin]
  • Metalliburum [Latin]
  • Methallibure [USAN:BAN]
  • 1,2-Hydrazinedicarbothioamide, N-methyl-N'-(1-methyl-2-propenyl)-
  • 1-Methyl-6-(1-methylallyl)-2,5-dithiobiurea
  • 1-Methyl-6-(1-methylallyl)dithiobiurea
  • 1-[(.alpha.-Methylallyl)thiocarbamoyl]-2-(methylthiocarbamoyl)hydrazine
  • 2,5-Dithio-1-methyl-6-(1-methyl-2-propenyl)biurea
  • AY-61122
  • Aimax
  • Biurea, 1-methyl-6-(1-methylallyl)-2,5-dithio-
  • Biurea, 2,5-dithio-1-methyl-6-(1-methyl-2-propenyl)-
  • ICI 33828
  • ICI-33,828
  • Match
  • Metallibure
  • N-[(1-Methylallyl)thiocarbamoyl]-N'-(methylthiocarbamoyl)hydrazine
  • NSC69536
  • Suisynchron
  • Turisynchron
  • WLN: SUYM1&MMYUS&MY1U1
  • NCIOpen2_003498
  • N-((1-Methylallyl)thiocarbamoyl)-N'-(methylthiocarbamoyl)hydrazine
  • NSC 69536
  • NSC-69536
  • D04975
  • Methallibure (USAN)
  • .meta.Llibure
  • 1, 2-Hydrazinedicarbothioamide, N-methyl-N'-(1-methyl-2-propenyl)-
  • AIDS-125344
  • AIDS125344
  • Biurea, 1-methyl-6-(1-methylallyl)-2, 5-dithio-
  • Biurea, 2, 5-dithio-1-methyl-6-(1-methyl-2-propenyl)-
  • N~1~-Methyl-N~2~-(1-methyl-2-propenyl)-1,2-hydrazinedicarbothioamide
  • {1-[(.Alpha.-Methylallyl)thiocarbamoyl]-2-(methylthiocarbamoyl)hydr} azine
  • {N-[(1-Methylallyl)thiocarbamoyl]-N'-(methylthiocarbamoyl)hydrazine}
  • 1-alpha-Methylallylthiocarbamoyl-2-methylthiocarbamoylhydrazine
  • 1alpha-Methylallylthiocarbamoyl-2-methylthiocarbamoylhydrazine
  • AI3-51056
  • AY 61122

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0169 0.0497 0.046
Brugia malayi Furin-like cysteine rich region family protein 0.0059 0.0043 0.0043
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.2485 1 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.0772 0.0732
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Brugia malayi hypothetical protein 0.0095 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0167 0.0486 0.0486
Schistosoma mansoni tyrosine kinase 0.013 0.0333 0.0296
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0936 0.3642 1
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0936 0.3642 0.3642
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0095 0.0189 0.0147
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0095 0.0189 0.0147
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.0772 0.0732
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.0772 0.0732
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.017 0.0128
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0099 0.0208 0.017
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0811 0.313 0.31
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0099 0.0208 0.0166
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0099 0.0208 0.0166
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.0772 0.0732
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0936 0.3642 0.3642
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0099 0.0208 0.0166
Brugia malayi hypothetical protein 0.0095 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0237 0.0772 0.0772
Onchocerca volvulus 0.0095 0.0189 0.0206
Brugia malayi Protein kinase domain containing protein 0.013 0.0333 0.0333
Loa Loa (eye worm) TK/INSR protein kinase 0.013 0.0333 0.0333
Echinococcus granulosus protein tyrosine phosphatase n9 0.0095 0.0189 0.0147
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0095 0.0189 0.0147
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0237 0.0772 0.0736
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0288 0.0985 0.2305
Schistosoma mansoni tyrosine kinase 0.0059 0.0043 0.0004
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0079 0.0125 0.0082
Loa Loa (eye worm) hypothetical protein 0.0071 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0237 0.0772 0.0772
Schistosoma mansoni serine/threonine protein kinase 0.0311 0.1076 0.1041
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.2485 1 1
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0095 0.0189 0.0147
Schistosoma mansoni tyrosine kinase 0.0059 0.0043 0.0004
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Echinococcus granulosus insulin receptor 0.013 0.0333 0.0291
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0099 0.0208 0.017
Onchocerca volvulus 0.0095 0.0189 0.0206
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0134 0.0352 0.0311
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0237 0.0772 0.0736
Brugia malayi Protein kinase domain containing protein 0.0311 0.1076 0.1076
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0936 0.3642 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0095 0.0189 0.0147
Echinococcus granulosus ectonucleotide 0.0199 0.0619 0.0579
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0285 0.0243
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0199 0.0619 0.0579
Onchocerca volvulus 0.0095 0.0189 0.0206
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0095 0.0189 0.0147
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.2485 1 1
Onchocerca volvulus 0.0237 0.0772 0.1859
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0095 0.0189 0.0147
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0095 0.0189 0.0189
Echinococcus granulosus Endonuclease G 0.0142 0.0384 0.0343
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0237 0.0772 0.0736
Schistosoma mansoni protein tyrosine phosphatase 0.0095 0.0189 0.0151
Loa Loa (eye worm) TK/EGFR protein kinase 0.0059 0.0043 0.0043
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0099 0.0208 0.0166
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Echinococcus granulosus neuropeptide s receptor 0.0462 0.1699 0.1664
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.017 0.0128
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0099 0.0208 0.0166
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0095 0.0189 0.0147
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0095 0.0189 0.0189
Brugia malayi hypothetical protein 0.0095 0.0189 0.0189
Schistosoma mansoni protein tyrosine phosphatase 0.0095 0.0189 0.0151
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0072 0.0097 0.0097
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0095 0.0189 0.0147
Schistosoma mansoni protein tyrosine phosphatase 0.0099 0.0208 0.017
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0095 0.0189 0.0147
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0142 0.0384 0.2453
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0936 0.3642 1
Onchocerca volvulus 0.0237 0.0772 0.1859
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0079 0.0125 0.0125
Schistosoma mansoni lipoxygenase 0.0082 0.0139 0.0101
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0311 0.1076 0.1037
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Onchocerca volvulus 0.0095 0.0189 0.0206
Echinococcus multilocularis 0.0095 0.0189 0.0147
Onchocerca volvulus 0.0095 0.0189 0.0206
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0099 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Leishmania major hypothetical protein, conserved 0.0288 0.0985 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0095 0.0189 0.0147
Schistosoma mansoni hypothetical protein 0.0169 0.0497 0.046
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Echinococcus multilocularis geminin 0.0169 0.0497 0.0455
Schistosoma mansoni tyrosine kinase 0.013 0.0333 0.0296
Onchocerca volvulus 0.0095 0.0189 0.0206
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0095 0.0189 0.0151
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0095 0.0189 0.0151
Brugia malayi Thrombospondin type 1 domain containing protein 0.0511 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.0199 0.0619 0.0619
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0095 0.0189 0.0147
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0285 0.0243
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0095 0.0189 0.0147
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0936 0.3642 0.5
Onchocerca volvulus 0.0936 0.3642 1
Trypanosoma brucei endonuclease G, putative 0.0142 0.0384 0.2453
Echinococcus multilocularis insulin receptor 0.013 0.0333 0.0291
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0142 0.0384 1
Onchocerca volvulus 0.0095 0.0189 0.0206
Brugia malayi Protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Onchocerca volvulus 0.0095 0.0189 0.0206
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Onchocerca volvulus 0.0095 0.0189 0.0206
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0095 0.0189 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0288 0.0985 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Schistosoma mansoni hypothetical protein 0.0511 0.1897 0.1866
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0099 0.0208 0.0166
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0288 0.0985 1
Echinococcus multilocularis Endonuclease G 0.0142 0.0384 0.0343
Leishmania major endonuclease G, putative 0.0142 0.0384 0.2453
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0936 0.3642 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.0772 0.0732
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0311 0.1076 0.1076
Loa Loa (eye worm) hypothetical protein 0.0072 0.0097 0.0097
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Brugia malayi Protein kinase domain containing protein 0.0072 0.0095 0.0095
Trypanosoma cruzi endonuclease G, putative 0.0142 0.0384 0.2453
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0511 0.1897 0.1897
Echinococcus multilocularis hypothetical protein 0.0095 0.0189 0.0147
Schistosoma mansoni pcd6 interacting protein-related 0.0095 0.0189 0.0151
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0288 0.0985 0.2305
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0099 0.0208 0.017
Brugia malayi endonuclease G, mitochondrial precursor 0.0142 0.0384 0.0384
Giardia lamblia Protein tyrosine phosphatase 0.0095 0.0189 0.0054
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Trypanosoma brucei endonuclease G, putative 0.0142 0.0384 0.2453
Trypanosoma brucei endonuclease G, putative 0.0142 0.0384 0.2453
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.0772 0.0732
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0095 0.0189 0.0147
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Onchocerca volvulus 0.0095 0.0189 0.0206
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0142 0.0384 0.2453
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.0772 0.0732
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Onchocerca volvulus 0.0095 0.0189 0.0206
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Onchocerca volvulus 0.0095 0.0189 0.0206
Loa Loa (eye worm) protein tyrosine phosphatase 0.0095 0.0189 0.0189
Brugia malayi hypothetical protein 0.0095 0.0189 0.0189
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0095 0.0189 0.0147
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.009 0.017 0.0132
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0099 0.0208 0.0166
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0099 0.0208 0.0166
Onchocerca volvulus 0.0095 0.0189 0.0206
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0095 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.009 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Trypanosoma cruzi endonuclease G, putative 0.0142 0.0384 0.2453
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0311 0.1076 0.2721
Onchocerca volvulus 0.0095 0.0189 0.0206
Onchocerca volvulus 0.0095 0.0189 0.0206
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0095 0.0189 0.0147
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0095 0.0189 0.0147
Brugia malayi hypothetical protein 0.0095 0.0189 0.0189
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.017 0.0128
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0095 0.0189 0.0147
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0142 0.0384 0.2453
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0936 0.3642 1
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0095 0.0189 0.0151
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0095 0.0189 0.0189
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0936 0.3642 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Onchocerca volvulus 0.0095 0.0189 0.0206
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.0772 0.0732
Loa Loa (eye worm) hypothetical protein 0.0237 0.0772 0.0772
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0099 0.0208 0.017
Schistosoma mansoni lipoxygenase 0.0118 0.0285 0.0247
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Onchocerca volvulus 0.0095 0.0189 0.0206
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0095 0.0189 0.0147
Onchocerca volvulus 0.0095 0.0189 0.0206
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0095 0.0189 0.0147
Brugia malayi Protein-tyrosine phosphatase 1 0.0095 0.0189 0.0189
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0311 0.1076 0.1076
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0936 0.3642 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0095 0.0189 0.0147
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0095 0.0189 0.0147
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0936 0.3642 1
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0095 0.0189 0.0151
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0095 0.0189 0.0147
Loa Loa (eye worm) protein-tyrosine phosphatase 0.2485 1 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0311 0.1076 0.1076
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.0772 0.0732
Onchocerca volvulus 0.0095 0.0189 0.0206
Schistosoma mansoni tyrosine kinase 0.0059 0.0043 0.0004
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0237 0.0772 0.0772
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0647 0.2458 0.5
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0099 0.0208 0.017
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0099 0.0208 0.0166
Onchocerca volvulus 0.0511 0.1897 0.5051
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0099 0.0208 0.0166
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0095 0.0189 0.0151
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0199 0.0619 0.0579
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0095 0.0189 0.0147
Echinococcus multilocularis neuropeptide s receptor 0.0462 0.1699 0.1664
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0095 0.0189 0.0147
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0095 0.0189 0.0189
Onchocerca volvulus 0.0095 0.0189 0.0206
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.0288 0.0985 1
Schistosoma mansoni endonuclease related 0.0142 0.0384 0.0347
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0095 0.0189 0.0189
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0095 0.0189 0.0151
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0936 0.3642 1
Onchocerca volvulus 0.0095 0.0189 0.0206
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0072 0.0097 0.0097
Echinococcus multilocularis neuropeptide receptor A26 0.0462 0.1699 0.1664
Echinococcus granulosus geminin 0.0169 0.0497 0.0455
Echinococcus granulosus neuropeptide receptor A26 0.0462 0.1699 0.1664
Echinococcus multilocularis ectonucleotide 0.0199 0.0619 0.0579
Onchocerca volvulus 4.1 G protein, putative homolog 0.0095 0.0189 0.0206
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0095 0.0189 0.0147
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0311 0.1076 0.1037
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0095 0.0189 0.0189
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0237 0.0772 0.0736
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.0772 0.0732
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0079 0.0125 0.0082
Onchocerca volvulus 0.0095 0.0189 0.0206
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0237 0.0772 0.0732
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0079 0.0125 0.0125
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0095 0.0189 0.0151
Brugia malayi Protein-tyrosine phosphatase 0.0171 0.0505 0.0505
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0095 0.0189 0.0189
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0095 0.0189 0.0147
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.017 0.0128
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0134 0.0352 0.0311
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0095 0.0189 0.0147
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0095 0.0189 0.0151
Onchocerca volvulus 0.0095 0.0189 0.0206

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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