Detailed information for compound 589186

Basic information

Technical information
  • TDR Targets ID: 589186
  • Name: carbamimidoyl(dimethyl)ammonium; [(E)-[1-[2-( 3-furyl)ethyl]-4b,8,8,10a-tetramethyl-1,3,4,4 a,5,6,7,8a,9,10-decahydrophenanthren-2-yliden e]methyl] hydrogen sulfate
  • MW: 538.763 | Formula: C28H48N3O5S+
  • H donors: 3 H acceptors: 3 LogP: 6.09 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OS(=O)(=O)OC=C1CCC2C(C1CCc1cocc1)(C)CCC1C2(C)CCCC1(C)C.NC(=N)[NH+](C)C
  • InChi: 1S/C25H38O5S.C3H9N3/c1-23(2)12-5-13-25(4)21(23)10-14-24(3)20(8-6-18-11-15-29-16-18)19(7-9-22(24)25)17-30-31(26,27)28;1-6(2)3(4)5/h11,15-17,20-22H,5-10,12-14H2,1-4H3,(H,26,27,28);1-2H3,(H3,4,5)/p+1/b19-17+;
  • InChiKey: MUGYGAQKMRBEQJ-ZJSKVYKZSA-O  


Substructure search Similarity search

Network

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Synonyms

  • carbamimidoyl(dimethyl)ammonium; sulfuric acid [(E)-[1-[2-(3-furyl)ethyl]-4b,8,8,10a-tetramethyl-1,3,4,4a,5,6,7,8a,9,10-decahydrophenanthren-2-ylidene]methyl] ester
  • carbamimidoyl(dimethyl)azanium; [(E)-[1-(2-furan-3-ylethyl)-4b,8,8,10a-tetramethyl-1,3,4,4a,5,6,7,8a,9,10-decahydrophenanthren-2-ylidene]methyl] hydrogen sulfate
  • amidino(dimethyl)ammonium; sulfuric acid [(E)-[1-[2-(3-furyl)ethyl]-4b,8,8,10a-tetramethyl-1,3,4,4a,5,6,7,8a,9,10-decahydrophenanthren-2-ylidene]methyl] ester
  • carbamimidoyl-dimethylazanium; [(E)-[1-(2-furan-3-ylethyl)-4b,8,8,10a-tetramethyl-1,3,4,4a,5,6,7,8a,9,10-decahydrophenanthren-2-ylidene]methyl] hydrogen sulfate
  • carbamimidoyl-dimethyl-ammonium; [(E)-[1-[2-(3-furyl)ethyl]-4b,8,8,10a-tetramethyl-1,3,4,4a,5,6,7,8a,9,10-decahydrophenanthren-2-ylidene]methyl] hydrogen sulfate
  • carbamimidoyl-dimethylammonium; [(E)-[1-[2-(3-furyl)ethyl]-4b,8,8,10a-tetramethyl-1,3,4,4a,5,6,7,8a,9,10-decahydrophenanthren-2-ylidene]methyl] hydrogen sulfate
  • amidino-dimethyl-ammonium; [(E)-[1-[2-(3-furyl)ethyl]-4b,8,8,10a-tetramethyl-1,3,4,4a,5,6,7,8a,9,10-decahydrophenanthren-2-ylidene]methyl] hydrogen sulfate
  • carbamimidoyl-dimethyl-azanium; [(E)-[1-(2-furan-3-ylethyl)-4b,8,8,10a-tetramethyl-1,3,4,4a,5,6,7,8a,9,10-decahydrophenanthren-2-ylidene]methyl] hydrogen sulfate
  • 94203-53-9
  • AIDS-156388
  • AIDS156388
  • NSC 613010
  • (14-(2-(3-Furyl)ethyl)-8-methylpodocarpan-13-ylidene)methyl hydrogen sulfate compound with N,N-dimethylguanidine (1:1)

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans mycothiol conjugate amidase Mca Get druggable targets OG5_178532 All targets in OG5_178532
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) Get druggable targets OG5_178532 All targets in OG5_178532
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) Get druggable targets OG5_178532 All targets in OG5_178532
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 290 aa 315 aa 31.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0044 0.0223
Loa Loa (eye worm) hypothetical protein 0.0147 0.0827 0.5696
Trypanosoma brucei heat shock protein, putative 0.0031 0.0132 0.107
Loa Loa (eye worm) beta-lactamase 0.0036 0.0158 0.1092
Trypanosoma brucei heat shock protein, putative 0.0031 0.0132 0.107
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Onchocerca volvulus 0.002 0.0063 0.0757
Schistosoma mansoni hypothetical protein 0.0832 0.4925 1
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0044 0.009
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0158 0.0065
Schistosoma mansoni thyroid hormone receptor 0.002 0.0063 0.0127
Echinococcus granulosus dual specificity 0.0186 0.106 0.2152
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0186 0.106 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0023 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0431
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0044 0.009
Brugia malayi jmjC domain containing protein 0.0017 0.0044 0.0306
Brugia malayi TAR-binding protein 0.0252 0.1452 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0158 0.1092
Entamoeba histolytica hypothetical protein 0.0036 0.0158 0.0821
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.0794 0.073
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0007 0.0014
Schistosoma mansoni heat shock protein 0.0031 0.0132 0.0269
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0158 0.0825
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0023 0.0013
Schistosoma mansoni cpg binding protein 0.0062 0.0314 0.0637
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0063 0.0127
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0055 0.0276 0.1531
Mycobacterium tuberculosis Conserved protein 0.0036 0.0158 0.0093
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0158 0.1322
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Brugia malayi heat shock protein 90 0.0031 0.0132 0.0912
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0063 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0063 0.0431
Onchocerca volvulus 0.0036 0.0158 0.1916
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0063 0.0431
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0044 0.009
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0055 0.0276 0.1279
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0252 0.1452 1
Echinococcus multilocularis cpg binding protein 0.0062 0.0314 0.0637
Mycobacterium tuberculosis Conserved protein 0.0036 0.0158 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0023 0.0013
Treponema pallidum heat shock protein 90 0.0025 0.0094 0.0153
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0094 0.0701
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0055 0.0276 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0063 0.0431
Entamoeba histolytica protein kinase, putative 0.0186 0.106 0.6244
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0094 0.0191
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.0127 0.0257
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0055 0.0276 0.2453
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0023 0.0013
Onchocerca volvulus 0.0058 0.0294 0.3553
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0023 0.0013
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0158 0.009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0306
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0063 0.0127
Brugia malayi Protein kinase domain containing protein 0.0186 0.106 0.7298
Brugia malayi hypothetical protein 0.001 0.0007 0.0046
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0094 0.0701
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0052 0.036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0063 0.0127
Trichomonas vaginalis helicase, putative 0.0013 0.0023 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0023 0.0013
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0132 0.107
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0094 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0063 0.0431
Trypanosoma brucei Heat shock protein 83, putative 0.0031 0.0132 0.107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0063 0.0431
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0063 0.0431
Onchocerca volvulus 0.0036 0.0158 0.1916
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0031 0.0063
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.032 0.065
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1684 1
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Schistosoma mansoni hypothetical protein 0.003 0.0127 0.0257
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.032 0.065
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0044 0.0395
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0007 0.0014
Plasmodium vivax heat shock protein 86, putative 0.0031 0.0132 0.4363
Echinococcus granulosus heat shock protein 90 0.0031 0.0132 0.0269
Loa Loa (eye worm) TAR-binding protein 0.0252 0.1452 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0046
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0132 0.0391
Schistosoma mansoni tar DNA-binding protein 0.0252 0.1452 0.2948
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0132 0.107
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0044 0.0306
Schistosoma mansoni thyroid hormone receptor 0.002 0.0063 0.0127
Trichomonas vaginalis heat shock protein, putative 0.0019 0.006 0.0231
Loa Loa (eye worm) endoplasmin 0.0031 0.0132 0.0912
Schistosoma mansoni ap endonuclease 0.0021 0.0069 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0063 0.0431
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0069 0.1887
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0044 0.009
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0186 0.106 0.7298
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0094 0.0438
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0063 0.0127
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0063 0.0431
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0046
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0158 0.032
Schistosoma mansoni heat shock protein 0.0031 0.0132 0.0269
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0044 0.0223
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0158 0.032
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0063 0.0127
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0158 0.0825
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0023 0.0013
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0063 0.0127
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0094 0.0025
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0063 0.0127
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0055 0.0276 0.0184
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0431
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0132 0.0668
Schistosoma mansoni hypothetical protein 0.0066 0.0339 0.0687
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0055 0.0276 0.2453
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0431
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0052 0.0106
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0021 0.0257
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0069 0.0463
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0249 0.1712
Treponema pallidum fructose-bisphosphate aldolase 0.0291 0.1684 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1684 1
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Schistosoma mansoni cpg binding protein 0.0062 0.0314 0.0637
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0007 0.0014
Toxoplasma gondii heat shock protein HSP90 0.0031 0.0132 0.1898
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0044 0.009
Trypanosoma cruzi Heat shock protein 83, putative 0.0031 0.0132 0.107
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0069 0.0289
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0023 0.0013
Brugia malayi hypothetical protein 0.0147 0.0827 0.5696
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0186 0.106 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0094 0.0153
Leishmania major hypothetical protein, conserved 0.0017 0.0044 0.0223
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0249 0.1712
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0063 0.0127
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0158 0.0093
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0158 0.0825
Leishmania major hypothetical protein, conserved 0.0036 0.0158 0.1322
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.0127 0.0257
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0158 0.1322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0063 0.0431
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0052 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0063 0.0431
Schistosoma mansoni cpg binding protein 0.0058 0.0294 0.0597
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.1314 0.1296
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0063 0.0757
Entamoeba histolytica hypothetical protein 0.0036 0.0158 0.0821
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0063 0.0431
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0339 0.2332
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0023 0.0013
Trichomonas vaginalis esterase, putative 0.0036 0.0158 0.0825
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0158 0.0322
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0007 0.0046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0158 0.0322
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0044 0.0306
Schistosoma mansoni tar DNA-binding protein 0.0252 0.1452 0.2948
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.034 0.0691
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.0127 0.0257
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0023 0.0013
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0094 0.0438
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Schistosoma mansoni tar DNA-binding protein 0.0252 0.1452 0.2948
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0055 0.0276 1
Brugia malayi RNA binding protein 0.0252 0.1452 1
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0044 0.009
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.1684 1
Schistosoma mansoni hypothetical protein 0.003 0.0127 0.0257
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0044 0.0223
Mycobacterium ulcerans lipase LipD 0.0036 0.0158 0.009
Echinococcus multilocularis dnaJ subfamily B 0.0832 0.4925 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0046
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0063 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0023 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0096 0.0521 0.359
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.0127 0.0257
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.034 0.0691
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.032 0.065
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0607 1
Entamoeba histolytica hypothetical protein 0.0186 0.106 0.6244
Loa Loa (eye worm) hypothetical protein 0.0096 0.0521 0.359
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Trypanosoma brucei heat shock protein, putative 0.0031 0.0132 0.107
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0069 0.0463
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0063 0.0431
Brugia malayi beta-lactamase family protein 0.0036 0.0158 0.1092
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0306
Schistosoma mansoni endoplasmin 0.0031 0.0132 0.0269
Loa Loa (eye worm) hypothetical protein 0.0036 0.0158 0.1092
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0044 0.009
Entamoeba histolytica hypothetical protein 0.0036 0.0158 0.0821
Toxoplasma gondii exonuclease III APE 0.0021 0.0069 0.0821
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0021 0.0043
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0096 0.0521 0.359
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.0739 0.5089
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0055 0.0276 0.0208
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0063 0.0127
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0021 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0063 0.0431
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0249 0.0505
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0044 0.0306
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0021 0.0146
Brugia malayi jmjC domain containing protein 0.0017 0.0044 0.0306
Echinococcus granulosus FTZ F1 alpha 0.002 0.0063 0.0127
Loa Loa (eye worm) hypothetical protein 0.0185 0.1054 0.7259
Toxoplasma gondii heat shock protein 90, putative 0.0031 0.0132 0.1898
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0063 0.0127
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0055 0.0276 0.056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0063 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1684 1
Echinococcus multilocularis heat shock protein 0.0031 0.0132 0.0269
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.1684 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0158 0.009
Echinococcus granulosus tar DNA binding protein 0.0252 0.1452 0.2948
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0007 0.0046
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0132 0.107
Trypanosoma brucei heat shock protein, putative 0.0031 0.0132 0.107
Schistosoma mansoni jumonji domain containing protein 0.0063 0.032 0.065
Entamoeba histolytica protein kinase, putative 0.0186 0.106 0.6244
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0158 0.0093
Brugia malayi Latrophilin receptor protein 2 0.003 0.0127 0.0873
Brugia malayi beta-lactamase 0.0036 0.0158 0.1092
Schistosoma mansoni tar DNA-binding protein 0.0252 0.1452 0.2948
Schistosoma mansoni coup transcription factor 0.002 0.0063 0.0127
Entamoeba histolytica hypothetical protein 0.0036 0.0158 0.0821
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0063 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1684 1
Echinococcus granulosus dnaJ subfamily B 0.0832 0.4925 1
Echinococcus granulosus cpg binding protein 0.0062 0.0314 0.0637
Echinococcus multilocularis heat shock protein 90 0.0031 0.0132 0.0269
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0306
Trypanosoma brucei heat shock protein 90, putative 0.0031 0.0132 0.107
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0044 0.009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0063 0.0127
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0158 0.0093
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0063 0.0127
Schistosoma mansoni endoplasmin 0.0031 0.0132 0.0269
Brugia malayi jmjC domain containing protein 0.0017 0.0044 0.0306
Brugia malayi nuclear receptor RXR 0.001 0.0007 0.0046
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.034 0.2342
Brugia malayi nuclear receptor NHR-88 0.002 0.0063 0.0431
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0094 0.0026
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0063 0.0431
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0063 0.0127
Brugia malayi jmjC domain containing protein 0.0066 0.034 0.2342
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0686 0.1393
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0249 0.0505
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0158 0.0322
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0023 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0046
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0063 0.0127
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0132 0.0668
Mycobacterium ulcerans beta-lactamase 0.0036 0.0158 0.009
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0055 0.0276 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0252 0.1452 0.2948
Onchocerca volvulus 0.0036 0.0158 0.1916
Plasmodium vivax endoplasmin, putative 0.0031 0.0132 0.4363
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0158 0.009
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0055 0.0276 0.2453
Loa Loa (eye worm) heat shock protein 90 0.0031 0.0132 0.0912
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0055 0.0327
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0064 0.0131
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0063 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0023 0.0013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.0127 0.0873
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0158 0.5388
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0031 0.0063
Trypanosoma brucei heat shock protein, putative 0.0031 0.0132 0.107
Trypanosoma brucei heat shock protein, putative 0.0031 0.0132 0.107
Brugia malayi Endoplasmin precursor 0.0031 0.0132 0.0912
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.0127 0.0873
Brugia malayi Calcitonin receptor-like protein seb-1 0.0096 0.0521 0.359
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0158 0.0093
Brugia malayi Hsp90 protein 0.0013 0.0021 0.0146
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0094 0.0701
Loa Loa (eye worm) RNA binding protein 0.0252 0.1452 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0044 0.009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0031 0.0063
Brugia malayi hypothetical protein 0.0036 0.0158 0.1086
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0094 0.0438
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0158 0.032
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0063 0.0431
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0249 0.0505
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0158 0.1092
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0055 0.0276 0.435
Loa Loa (eye worm) hypothetical protein 0.0036 0.0158 0.1092
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0055 0.0276 0.1531
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0023 0.0013
Trypanosoma brucei heat shock protein, putative 0.0031 0.0132 0.107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0249 0.0505
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0069 0.1887
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0132 0.107
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0294 0.2024
Brugia malayi ecdysteroid receptor 0.002 0.0063 0.0431
Brugia malayi beta-lactamase family protein 0.0036 0.0158 0.1092
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0431
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0158 0.0825
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0007 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1684 1
Echinococcus multilocularis heat shock protein 90 0.0025 0.0094 0.0191
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0158 0.0825
Schistosoma mansoni heat shock protein 0.0013 0.0021 0.0043
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1624 0.9668 1
Brugia malayi CXXC zinc finger family protein 0.0058 0.0294 0.2024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1684 1
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0055 0.0276 0.19
Trypanosoma brucei heat shock protein, putative 0.0031 0.0132 0.107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1684 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0031 0.0063
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0055 0.0276 0.19
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0158 0.1322
Schistosoma mansoni nuclear hormone receptor 0.002 0.0063 0.0127
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0063 0.0127
Echinococcus multilocularis tar DNA binding protein 0.0252 0.1452 0.2948
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0063 0.0431
Brugia malayi nuclear hormone receptor 0.002 0.0063 0.0431
Echinococcus granulosus heat shock protein 90 0.0025 0.0094 0.0191
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0051 0.0351
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0063 0.0757
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0063 0.0431
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.0794 0.0707
Schistosoma mansoni hypothetical protein 0.0036 0.0158 0.032
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0064 0.0131
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0069 0.0477
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0063 0.0127
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0055 0.0276 0.1531
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0069 0.0141
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0069 0.0141
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0031 0.0063
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0158 0.0093
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0069 0.0289
Trichomonas vaginalis endoplasmin, putative 0.0019 0.006 0.0231
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0069 0.0463
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0063 0.0431
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0044 0.0395
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0055 0.0276 0.2453
Onchocerca volvulus 0.0147 0.0827 1
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0044 0.009
Echinococcus multilocularis endoplasmin 0.0025 0.0094 0.0191
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.0794 0.0755
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0249 0.0505
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0158 0.0093
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0044 0.0909
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0063 0.0127
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0063 0.0127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0249 0.0505
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0055 0.0276 0.056
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0023 0.0013
Brugia malayi MH2 domain containing protein 0.0133 0.0739 0.5089
Echinococcus granulosus GPCR family 2 0.003 0.0127 0.0257
Entamoeba histolytica heat shock protein 90, putative 0.0031 0.0132 0.0668
Schistosoma mansoni hypothetical protein 0.003 0.0127 0.0257
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0069 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0063 0.0431
Loa Loa (eye worm) hypothetical protein 0.0036 0.0158 0.1092
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0063 0.0127
Loa Loa (eye worm) hypothetical protein 0.0036 0.0158 0.1092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0158 0.1092
Brugia malayi RNA recognition motif domain containing protein 0.0252 0.1452 1
Schistosoma mansoni ap endonuclease 0.0021 0.0069 0.0141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0063 0.0431
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0063 0.0127
Brugia malayi jmjC domain containing protein 0.0017 0.0044 0.0306
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.0739 0.5089
Leishmania major heat shock protein 83-1 0.0031 0.0132 0.107
Plasmodium falciparum heat shock protein 90 0.0031 0.0132 0.4363
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0044 0.009
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0063 0.0431
Mycobacterium tuberculosis Conserved protein 0.0036 0.0158 0.0093
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0063 0.0127
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0007 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0023 0.0013
Plasmodium falciparum endoplasmin, putative 0.0019 0.006 0.1505
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0249 0.0505
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0158 0.1092
Brugia malayi steroid hormone receptor 0.002 0.0063 0.0431
Echinococcus granulosus phd:f box containing protein 0.0017 0.0044 0.009
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0186 0.106 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0186 0.106 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0063 0.0127
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0158 0.0093
Plasmodium vivax JmjC domain containing protein 0.0017 0.0044 0.0909
Giardia lamblia Grp94/Hsp90 0.0025 0.0094 0.0153
Toxoplasma gondii ABC1 family protein 0.0036 0.0158 0.2344
Brugia malayi jmjC domain containing protein 0.0063 0.032 0.2205
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0063 0.0127
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0069 0.0463
Loa Loa (eye worm) hypothetical protein 0.003 0.0127 0.0873
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0158 0.0322
Brugia malayi hypothetical protein 0.001 0.0007 0.0046
Entamoeba histolytica protein kinase domain containing protein 0.0186 0.106 0.6244
Schistosoma mansoni serine/threonine protein kinase 0.0186 0.106 0.2152
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0063 0.0757
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0023 0.0013
Mycobacterium leprae Probable lipase LipE 0.0036 0.0158 0.0065
Echinococcus granulosus endoplasmin 0.0025 0.0094 0.0191
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0132 0.107
Loa Loa (eye worm) hypothetical protein 0.0185 0.1054 0.7259
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.1684 1
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0055 0.0276 0.056
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.168 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0276 0.0215
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0044 0.009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.034 0.0691
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0431
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0069 0.0477
Echinococcus multilocularis GPCR, family 2 0.003 0.0127 0.0257
Loa Loa (eye worm) hypothetical protein 0.0066 0.0339 0.2332
Schistosoma mansoni hypothetical protein 0.003 0.0127 0.0257
Loa Loa (eye worm) hypothetical protein 0.002 0.0063 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0063 0.0431
Echinococcus granulosus heat shock protein 0.0031 0.0132 0.0269
Echinococcus multilocularis dual specificity 0.0186 0.106 0.2152
Giardia lamblia Fructose-bisphosphate aldolase 0.0291 0.1684 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 257019  
Annotator: crowther@u.washington.edu Comment: 2007-12-26 References: 11388862 12538025
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium smegmatis 257019  
Annotator: crowther@u.washington.edu Comment: 2007-12-26 References: 12538025

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.