Detailed information for compound 603686

Basic information

Technical information
  • TDR Targets ID: 603686
  • Name: 1'-[2-(4-chlorophenyl)ethyl]-6,8-difluorospir o[2,4-dihydrobenzo[e][1,2,4]thiadiazine-3,4'- piperidine] 1,1-dioxide
  • MW: 427.896 | Formula: C19H20ClF2N3O2S
  • H donors: 2 H acceptors: 2 LogP: 3.94 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)CCN1CCC2(CC1)Nc1cc(F)cc(c1S(=O)(=O)N2)F
  • InChi: 1S/C19H20ClF2N3O2S/c20-14-3-1-13(2-4-14)5-8-25-9-6-19(7-10-25)23-17-12-15(21)11-16(22)18(17)28(26,27)24-19/h1-4,11-12,23-24H,5-10H2
  • InChiKey: DLHHHBONHYKLOR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1'-[2-(4-chlorophenyl)ethyl]-6,8-difluoro-spiro[2,4-dihydrobenzo[e][1,2,4]thiadiazine-3,4'-piperidine] 1,1-dioxide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tar DNA binding protein 0.0066 0.0099 0.0095
Schistosoma mansoni hypothetical protein 0.0129 0.0223 0.0219
Loa Loa (eye worm) hypothetical protein 0.0129 0.0223 0.0223
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0011
Onchocerca volvulus 0.004 0.0049 0.0447
Schistosoma mansoni na/ca exchanger 0.0129 0.0223 0.0219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.01 0.8266
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.01 0.8266
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.0222 0.0222
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.01 0.8383
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0099 0.0095
Schistosoma mansoni cellular tumor antigen P53 0.032 0.0598 0.0594
Leishmania major cathepsin L-like protease 0.0066 0.01 0.8383
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.01 0.0096
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0012 0.0676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.01 0.8266
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0119 0.5234
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0119 0.5234
Toxoplasma gondii exonuclease III APE 0.0021 0.0012 0.0354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.01 0.0096
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0049 0.0045
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0119 1
Echinococcus granulosus tumor protein p63 0.2187 0.426 0.4257
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0049 0.0798
Echinococcus multilocularis musashi 0.0028 0.0026 0.0022
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0462 0.0875 0.0875
Brugia malayi beta-lactamase family protein 0.004 0.0049 0.0123
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0012 0.0676
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0012 0.5
Plasmodium falciparum cation/H+ antiporter 0.0129 0.0223 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0049 0.0257
Echinococcus multilocularis lamin dm0 0.0028 0.0026 0.0022
Schistosoma mansoni hypothetical protein 0.0166 0.0296 0.0292
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.01 0.8266
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0026 0.0026
Brugia malayi RNA binding protein 0.0066 0.0099 0.025
Brugia malayi beta-lactamase family protein 0.004 0.0049 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.01 0.8266
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0223 0.1262
Echinococcus multilocularis lamin 0.0028 0.0026 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.01 0.0096
Brugia malayi TAR-binding protein 0.0066 0.0099 0.025
Onchocerca volvulus 0.0066 0.01 0.096
Brugia malayi Sodium/calcium exchanger protein 0.2046 0.3982 1
Onchocerca volvulus 0.0028 0.0026 0.0217
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0172 0.0168
Treponema pallidum hypothetical protein 0.0129 0.0223 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0049 0.0049
Brugia malayi hypothetical protein 0.0049 0.0066 0.0166
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0012 0.0354
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.032 0.0598 0.0598
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0049 1
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0223 0.1262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0172 0.0168
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0012 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0119 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0099 0.0095
Loa Loa (eye worm) fibroinase 0.0017 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0223 0.1262
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0012 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0049 0.3888
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0049 0.3888
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0049 0.0123
Loa Loa (eye worm) hypothetical protein 0.004 0.0049 0.0049
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.01 0.0096
Mycobacterium ulcerans beta-lactamase 0.004 0.0049 1
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0119 0.5234
Loa Loa (eye worm) ctsf protein 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0129 0.0223 0.0223
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0012 0.003
Echinococcus multilocularis geminin 0.0166 0.0296 0.0292
Schistosoma mansoni ap endonuclease 0.0021 0.0012 0.0008
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.01 0.0096
Echinococcus granulosus intermediate filament protein 0.0028 0.0026 0.0022
Loa Loa (eye worm) hypothetical protein 0.0076 0.0119 0.0119
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0099 0.0099
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0026 0.0065
Brugia malayi Pre-SET motif family protein 0.0066 0.01 0.0251
Schistosoma mansoni hypothetical protein 0.0034 0.0037 0.0033
Schistosoma mansoni ap endonuclease 0.0021 0.0012 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0099 0.0095
Brugia malayi MH2 domain containing protein 0.0128 0.0222 0.0557
Loa Loa (eye worm) beta-lactamase 0.004 0.0049 0.0049
Plasmodium vivax hypothetical protein, conserved 0.004 0.0049 0.2035
Brugia malayi K+-dependent Na+/Ca+ exchanger related-protein 0.0129 0.0223 0.0561
Schistosoma mansoni sodium/calcium exchanger 0.5114 1 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0026 0.0022
Toxoplasma gondii ABC1 family protein 0.004 0.0049 0.2035
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0103 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.0166 0.0296 0.0292
Onchocerca volvulus 0.0525 0.1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.01 0.8266
Brugia malayi beta-lactamase 0.004 0.0049 0.0123
Toxoplasma gondii manganese resistance 1 protein, putative 0.0129 0.0223 1
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.01 0.8383
Entamoeba histolytica sodium/calcium exchanger protein, putative 0.0129 0.0223 1
Echinococcus multilocularis sodium calcium exchanger 0.5114 1 1
Echinococcus granulosus lamin 0.0028 0.0026 0.0022
Leishmania major hypothetical protein, conserved 0.004 0.0049 0.3888
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0004 0.0011
Echinococcus granulosus sodium:potassium:calcium exchanger 6 0.0129 0.0223 0.0219
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.01 0.8383
Mycobacterium tuberculosis Conserved protein 0.004 0.0049 0.0798
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0129 0.0223 0.0219
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0049 0.0798
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.0172 0.0168
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0049 0.0045
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0012 0.0012
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0049 0.0045
Leishmania major cathepsin L-like protease 0.0066 0.01 0.8383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0172 0.0168
Loa Loa (eye worm) hypothetical protein 0.004 0.0049 0.0049
Mycobacterium ulcerans hypothetical protein 0.004 0.0049 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.01 0.01
Echinococcus multilocularis sodium:potassium:calcium exchanger 0.0129 0.0223 0.0219
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0073 0.595
Brugia malayi Na/Ca eXchangers family member (ncx-4) 0.0129 0.0223 0.0561
Mycobacterium leprae Probable ionic transporter integral membrane protein ChaA 0.0129 0.0223 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0049 0.0257
Onchocerca volvulus 0.032 0.0598 0.5959
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.01 0.8266
Loa Loa (eye worm) hypothetical protein 0.0129 0.0223 0.0223
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0012 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.01 0.8266
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0099 0.0099
Echinococcus granulosus geminin 0.0166 0.0296 0.0292
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.0172 0.0168
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.01 0.0096
Loa Loa (eye worm) cysteine protease 0.0017 0.0004 0.0004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0012 0.0676
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0129 0.0223 0.0219
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.01 0.8383
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0012 0.0354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.01 0.8266
Echinococcus multilocularis tumor protein p63 0.2187 0.426 0.4257
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0099 0.025
Onchocerca volvulus Sodium\/potassium\/calcium exchanger 0.0129 0.0223 0.2198
Onchocerca volvulus 0.004 0.0049 0.0447
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0103 0.0172 0.0432
Loa Loa (eye worm) hypothetical protein 0.2046 0.3982 0.3982
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0004 0.0004
Brugia malayi intermediate filament protein 0.0028 0.0026 0.0065
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0012 0.5
Echinococcus multilocularis sodium:potassium:calcium exchanger 6 0.0129 0.0223 0.0219
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0049 0.0798
Loa Loa (eye worm) RNA binding protein 0.0066 0.0099 0.0099
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0049 0.3445
Loa Loa (eye worm) solute carrier family 8 0.5114 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.0172 0.0168
Loa Loa (eye worm) hypothetical protein 0.004 0.0049 0.0049
Mycobacterium tuberculosis Conserved protein 0.004 0.0049 0.0798
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0049 0.0257
Trichomonas vaginalis esterase, putative 0.004 0.0049 0.0257
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0049 0.0049
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0049 0.0798
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0049 0.0798
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.01 0.0096
Mycobacterium ulcerans lipase LipD 0.004 0.0049 1
Leishmania major hypothetical protein, conserved 0.0076 0.0119 1
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.0222 0.0222
Mycobacterium tuberculosis Conserved protein 0.004 0.0049 0.0798
Loa Loa (eye worm) Na/Ca eXchangers family member 0.0129 0.0223 0.0223
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0012 0.0045
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.0473 1
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0049 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.01 0.8266
Loa Loa (eye worm) hypothetical protein 0.004 0.0049 0.0049
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0026 0.0026
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.01 0.4368
Loa Loa (eye worm) hypothetical protein 0.0028 0.0025 0.0025
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0049 0.0798
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.01 0.8266
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0049 0.0257
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0037 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0099 0.0095
Plasmodium vivax SET domain protein, putative 0.0066 0.01 0.4368
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0095 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0099 0.0095
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0049 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0902 0.1739 1
Schistosoma mansoni lamin 0.0028 0.0026 0.0022
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0049 0.0049
Schistosoma mansoni lamin 0.0028 0.0026 0.0022
Echinococcus granulosus lamin dm0 0.0028 0.0026 0.0022
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0011
Trichomonas vaginalis set domain proteins, putative 0.0525 0.1 0.5742
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0089 0.7397
Mycobacterium tuberculosis Probable ionic transporter integral membrane protein ChaA 0.0129 0.0223 0.458
Brugia malayi hypothetical protein 0.0076 0.0119 0.0299
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.0172 0.0168
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0049 0.0045
Brugia malayi Pre-SET motif family protein 0.0462 0.0875 0.2198
Echinococcus granulosus sodium:potassium:calcium exchanger 0.0129 0.0223 0.0219
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0011
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0012 0.0354
Leishmania major cathepsin L-like protease 0.0066 0.01 0.8383
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0119 0.5234
Onchocerca volvulus 0.0028 0.0026 0.0217
Onchocerca volvulus 0.004 0.0049 0.0447
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0049 0.0798
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0099 0.0095
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0902 0.1739 1
Plasmodium vivax cation/H+ antiporter, putative 0.0129 0.0223 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 5 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 7 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 7.55 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 7.66 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 8.79 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 86 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 2.04 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -1 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 5 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 7 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 86 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 5.83 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 1.4643 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.