TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 508.462 | Formula: C25H24F4N2O5
H donors: 2 H acceptors: 3 LogP: 2.95 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(F)(F)F.Fc1ccc(cc1)CN1CCC(C1)Oc1ccc(cc1C)NC(=O)c1ccco1
InChi: 1S/C23H23FN2O3.C2HF3O2/c1-16-13-19(25-23(27)22-3-2-12-28-22)8-9-21(16)29-20-10-11-26(15-20)14-17-4-6-18(24)7-5-17;3-2(4,5)1(6)7/h2-9,12-13,20H,10-11,14-15H2,1H3,(H,25,27);(H,6,7)
InChiKey: CNAZWDTZXDCQOZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	manganese resistance 1 protein, putative	0.0121	0.0222	1
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0051	0.0268
Echinococcus multilocularis	sodium calcium exchanger	0.4781	1	1
Schistosoma mansoni	lamin	0.0028	0.0027	0.0022
Loa Loa (eye worm)	transcription factor SMAD2	0.0135	0.0252	0.0252
Schistosoma mansoni	potassium-dependent sodium-calcium exchanger 3 4	0.0121	0.0222	0.0217
Brugia malayi	TAR-binding protein	0.0066	0.0106	0.0267
Toxoplasma gondii	ABC1 family protein	0.004	0.0051	0.2145
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0107	0.7403
Leishmania major	hypothetical protein, conserved	0.004	0.0051	0.3811
Schistosoma mansoni	na/ca exchanger	0.0121	0.0222	0.0217
Brugia malayi	Pre-SET motif family protein	0.0065	0.0105	0.0264
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0051	0.3811
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0148	0.0279	0.0274
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0005	0.0013
Loa Loa (eye worm)	MH2 domain-containing protein	0.0135	0.0252	0.0252
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0005	0.0013
Trypanosoma brucei	PAB1-binding protein , putative	0.0076	0.0127	1
Echinococcus granulosus	tar DNA binding protein	0.0066	0.0106	0.0101
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0107	0.7403
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0107	0.8393
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0026	0.0026
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0058	0.0091	0.3967
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0107	0.7403
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Mycobacterium leprae	Probable ionic transporter integral membrane protein ChaA	0.0121	0.0222	1
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0051	0.0268
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0005	0.0005
Onchocerca volvulus		0.004	0.0051	0.0443
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0148	0.0279	0.0274
Onchocerca volvulus		0.0517	0.1054	1
Loa Loa (eye worm)	solute carrier family 8	0.4781	1	1
Onchocerca volvulus		0.0028	0.0027	0.0212
Treponema pallidum	hypothetical protein	0.0121	0.0222	1
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0051	0.0268
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0058	0.0091	0.7048
Onchocerca volvulus		0.004	0.0051	0.0443
Echinococcus granulosus	sodium:potassium:calcium exchanger 6	0.0121	0.0222	0.0217
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0065	0.0105	0.4627
Echinococcus granulosus	lamin dm0	0.0028	0.0027	0.0022
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0065	0.0105	0.01
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.0222	0.1251
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0005	0.0013
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0034	0.004	0.0035
Schistosoma mansoni	hypothetical protein	0.0034	0.004	0.0035
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0027	0.0027
Schistosoma mansoni	hypothetical protein	0.0121	0.0222	0.0217
Plasmodium falciparum	cation/H+ antiporter	0.0121	0.0222	1
Brugia malayi	intermediate filament protein	0.0028	0.0027	0.0068
Loa Loa (eye worm)	hypothetical protein	0.1912	0.3981	0.3981
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0058	0.0091	0.7048
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Echinococcus multilocularis	lamin	0.0028	0.0027	0.0022
Loa Loa (eye worm)	RNA binding protein	0.0066	0.0106	0.0106
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.0106	0.0267
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.0095	0.7406
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0065	0.0105	0.01
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0051	0.3811
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0027	0.0022
Schistosoma mansoni	potassium-dependent sodium-calcium exchanger 3 4	0.0121	0.0222	0.0217
Brugia malayi	RNA binding protein	0.0066	0.0106	0.0267
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0148	0.0279	0.0274
Echinococcus multilocularis	lamin dm0	0.0028	0.0027	0.0022
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.0106	0.0106
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0005	0.0005
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0106	0.0101
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0107	0.7403
Entamoeba histolytica	sodium/calcium exchanger protein, putative	0.0121	0.0222	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.0078	0.5957
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0222	0.0222
Onchocerca volvulus		0.0314	0.0628	0.5944
Leishmania major	hypothetical protein, conserved	0.0076	0.0127	1
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0106	0.0101
Loa Loa (eye worm)	ctsf protein	0.0017	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0076	0.0127	0.0319
Leishmania major	cathepsin L-like protease	0.0066	0.0107	0.8393
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0065	0.0105	0.01
Schistosoma mansoni	cellular tumor antigen P53	0.0314	0.0628	0.0624
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0107	0.7403
Brugia malayi	MH2 domain containing protein	0.0135	0.0252	0.0632
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.0107	0.8393
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0058	0.0091	0.5
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0063	0.01	0.0095
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0065	0.0105	0.01
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.0222	0.1251
Brugia malayi	K+-dependent Na+/Ca+ exchanger related-protein	0.0121	0.0222	0.0557
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0107	0.8393
Plasmodium vivax	cation/H+ antiporter, putative	0.0121	0.0222	1
Loa Loa (eye worm)	Na/Ca eXchangers family member	0.0121	0.0222	0.0222
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0005	0.0013
Onchocerca volvulus		0.004	0.0051	0.0443
Onchocerca volvulus		0.0028	0.0027	0.0212
Brugia malayi	beta-lactamase family protein	0.004	0.0051	0.0129
Brugia malayi	Pre-SET motif family protein	0.0454	0.0922	0.2315
Echinococcus multilocularis	tumor protein p63	0.2148	0.4475	0.4473
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0107	0.7403
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0051	0.0047
Toxoplasma gondii	exonuclease III APE	0.0058	0.0091	0.3967
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0107	0.7403
Loa Loa (eye worm)	cysteine protease	0.0017	0.0005	0.0005
Plasmodium falciparum	ataxin-2 like protein, putative	0.0076	0.0127	0.5629
Trichomonas vaginalis	esterase, putative	0.004	0.0051	0.0268
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0106	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0222	0.0222
Trichomonas vaginalis	ap endonuclease, putative	0.0058	0.0091	0.0496
Schistosoma mansoni	lamin	0.0028	0.0027	0.0022
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0027	0.0027
Trichomonas vaginalis	set domain proteins, putative	0.0517	0.1054	0.6051
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0051	0.0268
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0058	0.0091	0.0086
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0843	0.1738	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0148	0.0279	0.0274
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0106	0.0101
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0027	0.0068
Trypanosoma cruzi	PAB1-binding protein , putative	0.0076	0.0127	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0105	0.0105
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0005	0.0013
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0454	0.0922	0.0922
Echinococcus granulosus	lamin	0.0028	0.0027	0.0022
Schistosoma mansoni	ap endonuclease	0.0058	0.0091	0.0086
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0106	0.0101
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0148	0.0279	0.0279
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0253	0.0498	1
Brugia malayi	hypothetical protein	0.0049	0.0071	0.0178
Onchocerca volvulus	Sodium\/potassium\/calcium exchanger	0.0121	0.0222	0.2067
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0843	0.1738	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0058	0.0091	0.0086
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0058	0.0091	0.3967
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0034	0.004	0.0035
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0107	0.7403
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0058	0.0091	0.0884
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0107	0.7403
Leishmania major	cathepsin L-like protease	0.0066	0.0107	0.8393
Onchocerca volvulus		0.0065	0.0105	0.0956
Plasmodium vivax	SET domain protein, putative	0.0065	0.0105	0.4627
Brugia malayi	beta-lactamase family protein	0.004	0.0051	0.0129
Echinococcus granulosus	intermediate filament protein	0.0028	0.0027	0.0022
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.0106	0.0101
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0051	0.0268
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0005	0.0013
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0148	0.0279	0.0274
Schistosoma mansoni	sodium/calcium exchanger	0.4781	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0076	0.0127	0.5629
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0051	0.2145
Echinococcus multilocularis	musashi	0.0028	0.0027	0.0022
Echinococcus multilocularis	sodium:potassium:calcium exchanger 6	0.0121	0.0222	0.0217
Echinococcus granulosus	tumor protein p63	0.2148	0.4475	0.4473
Echinococcus granulosus	histone lysine methyltransferase setb	0.0065	0.0105	0.01
Mycobacterium tuberculosis	Probable ionic transporter integral membrane protein ChaA	0.0121	0.0222	0.381
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0058	0.0091	0.0091
Brugia malayi	Sodium/calcium exchanger protein	0.1912	0.3981	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0107	0.7403
Loa Loa (eye worm)	fibroinase	0.0017	0.0005	0.0005
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0065	0.0105	0.01
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0058	0.0091	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0076	0.0127	0.5629
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0051	0.0129
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0058	0.0091	0.5
Loa Loa (eye worm)	beta-lactamase	0.004	0.0051	0.0051
Brugia malayi	exodeoxyribonuclease III family protein	0.0058	0.0091	0.0229
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0058	0.0091	0.7048
Trypanosoma cruzi	PAB1-binding protein , putative	0.0076	0.0127	1
Brugia malayi	beta-lactamase	0.004	0.0051	0.0129
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0051	0.0047
Loa Loa (eye worm)	hypothetical protein	0.004	0.0051	0.0051
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0051	0.0047
Schistosoma mansoni	ap endonuclease	0.0058	0.0091	0.0086
Trichomonas vaginalis	ap endonuclease, putative	0.0058	0.0091	0.0496
Echinococcus granulosus	sodium:potassium:calcium exchanger	0.0121	0.0222	0.0217
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0051	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0127	0.0127
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0058	0.0091	0.3967
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0005	0.0005
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0107	0.7403
Toxoplasma gondii	LsmAD domain-containing protein	0.0076	0.0127	0.5629
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0005	0.0013
Brugia malayi	Na/Ca eXchangers family member (ncx-4)	0.0121	0.0222	0.0557
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0148	0.0279	0.0274
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0107	0.8393
Loa Loa (eye worm)	hypothetical protein	0.0314	0.0628	0.0628
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0051	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.0222	0.1251
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.0106	0.0106
Leishmania major	cathepsin L-like protease	0.0066	0.0107	0.8393
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0065	0.0105	0.01
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0148	0.0279	0.07
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0148	0.0279	0.0274
Echinococcus multilocularis	sodium:potassium:calcium exchanger	0.0121	0.0222	0.0217
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0058	0.0091	0.523

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 0.1 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 0.21 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 0.41 %	ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro	ChEMBL.	No reference
Inhibition (functional)	= 5 %	GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.	ChEMBL.	20485427
Inhibition (functional)	= 5 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 92 %	GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition (functional)	= 96 %	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM	ChEMBL.	20485427
Inhibition frequency index (IFI) (functional)	= 1.64	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= 5 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 5 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 92 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 96 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 6.19	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427
XC50 (functional)	= 0.6441 uM	GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.	ChEMBL.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL529199
Search by GSK

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 603717