Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1716 | 0.6015 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0962 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0051 | 0.2146 | 0.7525 |
Echinococcus multilocularis | cyclic AMP responsive element binding protein | 0.0002 | 0.003 | 0.0044 |
Onchocerca volvulus | Netrin receptor homolog | 0.0031 | 0.1258 | 0.4568 |
Onchocerca volvulus | 0.0024 | 0.0962 | 0.3493 | |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.0234 | 0.0546 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0007 | 0.0234 | 0.0819 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0659 | 0.6071 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0962 | 0.0962 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0234 | 0.0546 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0234 | 0.0546 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0234 | 0.0234 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0031 | 0.1258 | 0.187 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0962 | 0.4187 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0031 | 0.1258 | 0.441 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0962 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0234 | 0.0234 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0007 | 0.0234 | 0.0347 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0234 | 0.0234 |
Echinococcus granulosus | Ankyrin | 0.0031 | 0.1269 | 0.1887 |
Toxoplasma gondii | propionate-CoA ligase | 0.0007 | 0.0234 | 0.0614 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0701 | 0.6617 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.1471 | 0.2187 |
Echinococcus multilocularis | Ankyrin | 0.0031 | 0.1269 | 0.1887 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0701 | 0.0701 |
Brugia malayi | MAP kinase sur-1 | 0.0051 | 0.2146 | 0.2146 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.0234 | 0.0614 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.0234 | 0.0614 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0659 | 0.6071 |
Brugia malayi | hypothetical protein | 0.0002 | 0.003 | 0.003 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0051 | 0.2146 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0962 | 1 |
Brugia malayi | Hypothetical 84.0 kDa protein T23G5.2 in chromosome III | 0.0004 | 0.0109 | 0.0109 |
Echinococcus multilocularis | cyclic AMP dependent transcription factor ATF 6 | 0.0002 | 0.003 | 0.0044 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2146 | 1 |
Loa Loa (eye worm) | bZIP transcription factor family protein | 0.0002 | 0.003 | 0.003 |
Brugia malayi | bZIP transcription factor family protein | 0.0002 | 0.003 | 0.003 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0031 | 0.1258 | 0.1258 |
Echinococcus granulosus | expressed protein | 0.0002 | 0.003 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0234 | 0.0234 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0051 | 0.2146 | 0.2146 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.1471 | 0.5158 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0002 | 0.003 | 0.0044 |
Echinococcus multilocularis | cAMP responsive element binding protein 3 | 0.0002 | 0.003 | 0.0044 |
Schistosoma mansoni | hypothetical protein | 0.0002 | 0.003 | 0.0104 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0962 | 0.4187 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0234 | 0.0234 |
Brugia malayi | bZIP transcription factor family protein | 0.0083 | 0.3526 | 0.3526 |
Schistosoma mansoni | camp-response element binding protein-related | 0.0002 | 0.003 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0962 | 0.0962 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0962 | 0.5884 |
Brugia malayi | hypothetical protein | 0.0065 | 0.2754 | 0.2754 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.2146 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0002 | 0.003 | 0.0044 |
Echinococcus multilocularis | jun protein | 0.0083 | 0.3526 | 0.5241 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0007 | 0.0234 | 0.0234 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0007 | 0.0234 | 0.0614 |
Echinococcus multilocularis | expressed protein | 0.0002 | 0.003 | 0.0044 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0234 | 0.0234 |
Onchocerca volvulus | 0.0002 | 0.003 | 0.0108 | |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0.0234 | 0.0614 |
Brugia malayi | Uncoordinated protein 44 | 0.0031 | 0.1258 | 0.1258 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0962 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1471 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.2852 | 1 |
Schistosoma mansoni | camp-response element binding protein-related | 0.0002 | 0.003 | 0.0104 |
Schistosoma mansoni | camp-response element binding protein-related | 0.0002 | 0.003 | 0.0104 |
Onchocerca volvulus | 0.0007 | 0.0234 | 0.0849 | |
Brugia malayi | bZIP transcription factor family protein | 0.0002 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0701 | 0.0701 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0701 | 0.0701 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2146 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0051 | 0.2146 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0962 | 0.4187 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0007 | 0.0234 | 0.0614 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0158 | 0.6726 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0962 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0962 | 0.0962 |
Onchocerca volvulus | 0.0007 | 0.0234 | 0.0849 | |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1269 | 0.1269 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1471 | 1 |
Loa Loa (eye worm) | bZIP transcription factor family protein | 0.0002 | 0.003 | 0.003 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0701 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0051 | 0.2146 | 0.3191 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.0234 | 0.0546 |
Onchocerca volvulus | 0.0065 | 0.2754 | 1 | |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0007 | 0.0234 | 0.0614 |
Loa Loa (eye worm) | hypothetical protein | 0.0002 | 0.003 | 0.003 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0007 | 0.0234 | 0.0614 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0031 | 0.1258 | 0.187 |
Brugia malayi | bZIP transcription factor family protein | 0.0002 | 0.003 | 0.003 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.1471 | 0.2187 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0962 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0051 | 0.2146 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1471 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0018 | 0.0701 | 0.6421 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0051 | 0.2146 | 0.3191 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0051 | 0.2146 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0701 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0004 | 0.0103 | 0.036 |
Echinococcus granulosus | fos transcription factor | 0.0002 | 0.003 | 0.0044 |
Schistosoma mansoni | camp-response element binding protein | 0.0002 | 0.003 | 0.0104 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0007 | 0.0234 | 0.0234 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0962 | 0.5884 |
Schistosoma mansoni | retinaldehyde binding protein-related | 0.0004 | 0.0109 | 0.0381 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.0234 | 0.0614 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1471 | 0.5158 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0962 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0962 | 1 |
Loa Loa (eye worm) | bZIP transcription factor family protein | 0.0002 | 0.003 | 0.003 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.0234 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0004 | 0.0109 | 0.0109 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0007 | 0.0234 | 0.0347 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.0234 | 0.0546 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0962 | 0.0962 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0962 | 0.0962 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0007 | 0.0234 | 0.0614 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0701 | 0.0701 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0234 | 1 | 1 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.0234 | 0.0546 |
Echinococcus granulosus | cyclic AMP responsive element binding protein | 0.0002 | 0.003 | 0.0044 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0051 | 0.2146 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0234 | 0.0234 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0962 | 0.5884 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.0234 | 0.0546 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0051 | 0.2146 | 1 |
Schistosoma mansoni | fos transcription factor-related | 0.0002 | 0.003 | 0.0104 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0007 | 0.0234 | 0.0614 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0031 | 0.1269 | 0.4449 |
Echinococcus multilocularis | fos transcription factor | 0.0002 | 0.003 | 0.0044 |
Echinococcus granulosus | jun protein | 0.0083 | 0.3526 | 0.5241 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0659 | 0.6071 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0962 | 1 |
Onchocerca volvulus | 0.0007 | 0.0234 | 0.0849 | |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0051 | 0.2146 | 0.3191 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0007 | 0.0234 | 0.0614 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0659 | 0.6071 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0031 | 0.1258 | 0.187 |
Echinococcus granulosus | cAMP responsive element binding protein 3 | 0.0002 | 0.003 | 0.0044 |
Loa Loa (eye worm) | oxidoreductase | 0.0007 | 0.0234 | 0.0234 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0083 | 0.3526 | 0.5241 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0051 | 0.2146 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.1258 | 0.441 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1258 | 0.1258 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0962 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0962 | 0.0962 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0051 | 0.2146 | 0.3191 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0234 | 0.0234 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0962 | 1 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.0234 | 0.0546 |
Schistosoma mansoni | netrin receptor unc5 | 0.0031 | 0.1258 | 0.441 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0234 | 0.0546 |
Trypanosoma brucei | protein kinase, putative | 0.0051 | 0.2146 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0962 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0051 | 0.2146 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0083 | 0.3526 | 0.5241 |
Onchocerca volvulus | 0.0007 | 0.0234 | 0.0849 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0234 | 0.0546 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0158 | 0.6726 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.3427 | 0.3427 |
Brugia malayi | Protein kinase domain containing protein | 0.0031 | 0.1278 | 0.1278 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0031 | 0.1258 | 0.187 |
Brugia malayi | Death domain containing protein | 0.0031 | 0.1258 | 0.1258 |
Schistosoma mansoni | jun-related protein | 0.0068 | 0.2852 | 1 |
Echinococcus granulosus | death domain containing protein | 0.0031 | 0.1258 | 0.187 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0031 | 0.1258 | 0.1258 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0701 | 1 |
Echinococcus granulosus | cyclic AMP dependent transcription factor ATF 6 | 0.0002 | 0.003 | 0.0044 |
Brugia malayi | bZIP transcription factor family protein | 0.0002 | 0.003 | 0.003 |
Echinococcus granulosus | cyclic AMP responsive element binding protein | 0.0002 | 0.003 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0701 | 0.0701 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0051 | 0.2146 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.1471 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0002 | 0.003 | 0.003 |
Brugia malayi | hypothetical protein | 0.0036 | 0.1471 | 0.1471 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 1.77 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.68 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.81 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 9 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 30 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 36 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 96 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 9.65 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 9 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 30 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 36 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 96 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.14 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.71816 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.