Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0065 | 0 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0073 | 0.0083 | 0.0083 |
Echinococcus granulosus | protein jagged 2 | 0.0067 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0084 | 0.0194 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0065 | 0 | 0.5 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0176 | 0.1138 | 0.2359 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0067 | 0.0021 | 0.0041 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0095 | 0.031 | 0.0316 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0421 | 0.3661 | 0.3661 |
Brugia malayi | Cadherin domain containing protein | 0.0067 | 0.0021 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0176 | 0.1138 | 0.2359 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0067 | 0.0021 | 0.0021 |
Brugia malayi | Cadherin domain containing protein | 0.0067 | 0.0021 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0073 | 0.0083 | 0.0083 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0067 | 0.0021 | 0.0041 |
Brugia malayi | EGF-like domain containing protein | 0.0067 | 0.0021 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0021 | 0.0021 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0083 | 0.0085 |
Echinococcus multilocularis | Receptor type tyrosine protein phosphatase O | 0.0095 | 0.031 | 0.031 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0067 | 0.0021 | 0.0021 |
Echinococcus multilocularis | protein jagged 2 | 0.0067 | 0.0021 | 0.0021 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0067 | 0.0021 | 0.0021 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0067 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0095 | 0.031 | 0.031 |
Echinococcus granulosus | neural cadherin | 0.0067 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1448 | 0.3001 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0067 | 0.0021 | 0.0047 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0067 | 0.0021 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.4827 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0073 | 0.0083 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0084 | 0.0194 | 0.0194 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0095 | 0.031 | 0.031 |
Onchocerca volvulus | Arrow homolog | 0.0176 | 0.1138 | 0.2548 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Onchocerca volvulus | 0.0067 | 0.0021 | 0.0047 | |
Brugia malayi | EGF-like domain containing protein | 0.0067 | 0.0021 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0067 | 0.0021 | 0.0021 |
Onchocerca volvulus | 0.0067 | 0.0021 | 0.0047 | |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Echinococcus multilocularis | slit 2 protein | 0.0067 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | fibronectin type III domain-containing protein | 0.0095 | 0.031 | 0.0642 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0421 | 0.3661 | 0.7128 |
Brugia malayi | Muscle positioning protein 4 | 0.0067 | 0.0021 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0469 | 0.4158 | 0.8615 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0067 | 0.0021 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Schistosoma mansoni | notch | 0.0067 | 0.0021 | 0.0021 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0067 | 0.0021 | 0.0041 |
Onchocerca volvulus | 0.0067 | 0.0021 | 0.0047 | |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0095 | 0.031 | 0.0316 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0176 | 0.1138 | 0.2217 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Echinococcus granulosus | notch | 0.0067 | 0.0021 | 0.0021 |
Giardia lamblia | High cysteine protein | 0.0067 | 0.0021 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Schistosoma mansoni | notch | 0.0067 | 0.0021 | 0.0021 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase zeta | 0.0095 | 0.031 | 0.031 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Echinococcus granulosus | protein jagged 2 | 0.0067 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0084 | 0.0194 | 0.0194 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0067 | 0.0021 | 0.0021 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0421 | 0.3661 | 0.3732 |
Onchocerca volvulus | Putative cubilin | 0.0067 | 0.0021 | 0.0047 |
Echinococcus multilocularis | laminin | 0.0176 | 0.1138 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Brugia malayi | EGF-like domain containing protein | 0.0067 | 0.0021 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1138 | 0.2359 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0084 | 0.0194 | 0.0194 |
Onchocerca volvulus | Slit protein homolog | 0.0067 | 0.0021 | 0.0047 |
Echinococcus multilocularis | protein jagged 1 | 0.0067 | 0.0021 | 0.0021 |
Echinococcus multilocularis | protein jagged 1 | 0.0067 | 0.0021 | 0.0021 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0421 | 0.3661 | 0.3661 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Schistosoma mansoni | notch | 0.0067 | 0.0021 | 0.0021 |
Onchocerca volvulus | 0.0499 | 0.4468 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.1018 | 0.9811 | 1 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0572 | 0.5214 | 0.5214 |
Brugia malayi | Protein kinase domain containing protein | 0.0078 | 0.0138 | 0.0268 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0067 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0421 | 0.3661 | 0.7586 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0067 | 0.0021 | 0.0021 |
Schistosoma mansoni | notch | 0.0067 | 0.0021 | 0.0021 |
Brugia malayi | EGF-like domain containing protein | 0.0067 | 0.0021 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0469 | 0.4158 | 0.8615 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Onchocerca volvulus | 0.0067 | 0.0021 | 0.0047 | |
Toxoplasma gondii | kringle domain-containing protein | 0.0073 | 0.0083 | 0.0558 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0095 | 0.031 | 0.031 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0572 | 0.5214 | 0.5214 |
Brugia malayi | Fibulin-1 precursor | 0.0176 | 0.1138 | 0.2217 |
Echinococcus multilocularis | notch | 0.0067 | 0.0021 | 0.0021 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0602 | 0.5523 | 0.5523 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0176 | 0.1138 | 1 |
Loa Loa (eye worm) | Notch2 | 0.0067 | 0.0021 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1138 | 0.2359 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0095 | 0.031 | 0.031 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0021 | 0.0021 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0084 | 0.0194 | 0.0377 |
Trypanosoma brucei | protein tyrosine phosphatase 1 | 0.0065 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1138 | 0.2359 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0095 | 0.031 | 0.0316 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0067 | 0.0021 | 0.0021 |
Brugia malayi | Delta serrate ligand family protein | 0.0067 | 0.0021 | 0.0041 |
Echinococcus granulosus | protein jagged 1 | 0.0067 | 0.0021 | 0.0021 |
Echinococcus multilocularis | neural cadherin | 0.0067 | 0.0021 | 0.0021 |
Echinococcus multilocularis | fibrillin 1 | 0.0176 | 0.1138 | 0.1138 |
Echinococcus granulosus | delta-like protein 1 | 0.0067 | 0.0021 | 0.0021 |
Echinococcus granulosus | laminin | 0.0176 | 0.1138 | 0.1138 |
Brugia malayi | EGF-like domain containing protein | 0.0067 | 0.0021 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0469 | 0.4158 | 0.8615 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.1138 | 0.2359 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0067 | 0.0021 | 0.0021 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0095 | 0.031 | 0.0316 |
Echinococcus granulosus | slit 2 protein | 0.0067 | 0.0021 | 0.0021 |
Echinococcus granulosus | protein jagged 1 | 0.0067 | 0.0021 | 0.0021 |
Schistosoma mansoni | egf-like domain protein | 0.0176 | 0.1138 | 0.116 |
Schistosoma mansoni | septate junction protein | 0.0067 | 0.0021 | 0.0021 |
Entamoeba histolytica | Pten 3-phosphoinositide phosphatase, putative | 0.0065 | 0 | 0.5 |
Schistosoma mansoni | slit | 0.0067 | 0.0021 | 0.0021 |
Echinococcus granulosus | fibropellin Ia | 0.0067 | 0.0021 | 0.0021 |
Brugia malayi | EGF-like domain containing protein | 0.0067 | 0.0021 | 0.0041 |
Brugia malayi | notch-like transmembrane receptor | 0.0067 | 0.0021 | 0.0041 |
Brugia malayi | EGF-like domain containing protein | 0.0067 | 0.0021 | 0.0041 |
Brugia malayi | Protein-tyrosine phosphatase | 0.0564 | 0.5136 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0078 | 0.0138 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0083 | 0.0172 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0084 | 0.0194 | 0.0194 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0067 | 0.0021 | 0.0021 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0073 | 0.0083 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0176 | 0.1138 | 0.1138 |
Schistosoma mansoni | protein tyrosine phosphatase | 0.0095 | 0.031 | 0.0316 |
Leishmania major | hypothetical protein, conserved | 0.0073 | 0.0083 | 1 |
Trichomonas vaginalis | pten, drome, putative | 0.0065 | 0 | 0.5 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0095 | 0.031 | 0.031 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0176 | 0.1138 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Onchocerca volvulus | 0.0073 | 0.0083 | 0.0186 | |
Schistosoma mansoni | receptor protein tyrosine phosphatase | 0.0095 | 0.031 | 0.0316 |
Brugia malayi | Kringle domain containing protein | 0.0073 | 0.0083 | 0.0162 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type | 0.0095 | 0.031 | 0.031 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0176 | 0.1138 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0176 | 0.1138 | 0.116 |
Schistosoma mansoni | notch | 0.0067 | 0.0021 | 0.0021 |
Schistosoma mansoni | protein tyrosine phosphatase n11 (shp2) | 0.0084 | 0.0194 | 0.0197 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0067 | 0.0021 | 0.0021 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.1037 | 1 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0176 | 0.1138 | 0.2359 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | notch protein | 0.0067 | 0.0021 | 0.0043 |
Schistosoma mansoni | notch | 0.0067 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Onchocerca volvulus | 0.0067 | 0.0021 | 0.0047 | |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase zeta | 0.0095 | 0.031 | 0.031 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0067 | 0.0021 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0021 | 0.0043 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0073 | 0.0083 | 1 |
Schistosoma mansoni | cell polarity protein | 0.0067 | 0.0021 | 0.0021 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0021 | 0.0021 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0176 | 0.1138 | 0.2217 |
Echinococcus multilocularis | fibropellin Ia | 0.0067 | 0.0021 | 0.0021 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0021 | 0.0021 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.362 uM | In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes. | ChEMBL. | 10229631 |
Increase (functional) | = 6 % | Agonist activity for stimulation of PLC at P2Y purinoceptor 1 in the turkey erythrocyte membranes. | ChEMBL. | 10229631 |
Inhibition (functional) | = 94 % | Antagonist activity for inhibition of PLC elicited by 10 nM 2-MeSADP at P2Y purinoceptor 1 in turkey erythrocyte membranes | ChEMBL. | 10229631 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.