TDR Targets

Basic information

Technical information

TDR Targets ID: 610461
Name: 2-[[3-cyano-4-(3-nitrophenyl)-6-oxo-4,5-dihyd ro-1H-pyridin-2-yl]sulfanyl]-N-(3-methylpheny l)acetamide
MW: 422.457 | Formula: C21H18N4O4S
H donors: 2 H acceptors: 5 LogP: 2.65 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: N#CC1=C(SCC(=O)Nc2cccc(c2)C)NC(=O)CC1c1cccc(c1)[N+](=O)[O-]
InChi: 1S/C21H18N4O4S/c1-13-4-2-6-15(8-13)23-20(27)12-30-21-18(11-22)17(10-19(26)24-21)14-5-3-7-16(9-14)25(28)29/h2-9,17H,10,12H2,1H3,(H,23,27)(H,24,26)
InChiKey: ZETLNNIVQLSASW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[[3-cyano-4-(3-nitrophenyl)-6-oxo-4,5-dihydro-1H-pyridin-2-yl]thio]-N-(3-methylphenyl)acetamide
2-[[3-cyano-6-keto-4-(3-nitrophenyl)-4,5-dihydro-1H-pyridin-2-yl]thio]-N-(3-methylphenyl)acetamide
2-[[3-cyano-4-(3-nitrophenyl)-6-oxo-4,5-dihydro-1H-pyridin-2-yl]sulfanyl]-N-(3-methylphenyl)ethanamide
Oprea1_842515
Oprea1_768560

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0046	0.0335	0.5689
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Brugia malayi	RNA recognition motif domain containing protein	0.0249	0.2339	0.3845
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Echinococcus multilocularis	lysyl tRNA synthetase	0.0046	0.0335	0.0335
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0071	0.0589	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Brugia malayi	major facilitator superfamily protein	0.0029	0.0169	0.0278
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0509	0.8651
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0071	0.0589	1
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0037	0.006
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0108	0.0945	0.1554
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0169	0.0278
Echinococcus multilocularis	microtubule associated protein 2	0.0677	0.6553	0.6553
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0062	0.0502	0.0597
Onchocerca volvulus		0.0029	0.0169	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Echinococcus granulosus	lamin dm0	0.0028	0.0166	0.0166
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Echinococcus multilocularis	calcium dependent protein kinase	0.0059	0.0463	0.0463
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0061	0.0489	0.0804
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0169	0.0278
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0062	0.0501	0.0501
Trypanosoma cruzi	hexose transporter, putative	0.0063	0.0509	0.8651
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0022	0.01	0.2978
Toxoplasma gondii	protein kinase, putative	0.0576	0.5555	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.0027
Mycobacterium ulcerans	sugar transporter	0.0029	0.0169	0.5052
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0169	0.0244
Brugia malayi	hypothetical protein	0.0029	0.0169	0.0278
Onchocerca volvulus		0.0029	0.0169	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0169	0.0244
Onchocerca volvulus		0.0029	0.0169	0.0005
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.1051	0.1727
Schistosoma mansoni	tar DNA-binding protein	0.0249	0.2339	0.357
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0169	0.0278
Onchocerca volvulus		0.0029	0.0169	0.0005
Onchocerca volvulus		0.0029	0.0169	0.0005
Plasmodium falciparum	protein kinase 7	0.0576	0.5555	0.6612
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0204	0.1893	0.1893
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Schistosoma mansoni	lysyl-tRNA synthetase	0.0046	0.0335	0.0511
Echinococcus multilocularis	tumor protein p63	0.1028	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0062	0.0501	0.0723
Onchocerca volvulus		0.009	0.0776	0.09
Onchocerca volvulus		0.0029	0.0169	0.0005
Chlamydia trachomatis	lysine--tRNA ligase	0.0046	0.0335	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0222	0.0339
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0509	0.0734
Leishmania major	glucose transporter, lmgt3	0.0063	0.0509	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0501	0.0824
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0222	0.0365
Onchocerca volvulus		0.0029	0.0169	0.0005
Echinococcus multilocularis	lamin	0.0028	0.0166	0.0166
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0062	0.0502	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0022	0.0036
Echinococcus multilocularis	General substrate transporter	0.0175	0.1611	0.1611
Leishmania major	lysyl-tRNA synthetase, putative	0.0046	0.0335	0.5689
Trichomonas vaginalis	sugar transport protein, putative	0.0029	0.0169	0.0244
Brugia malayi	hypothetical protein	0.0167	0.1531	0.2517
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0108	0.0945	0.1554
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0501	0.0765
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0222	0.0222
Brugia malayi	Sugar transporter family protein	0.0029	0.0169	0.0278
Schistosoma mansoni	hypothetical protein	0.0034	0.0222	0.0339
Brugia malayi	RNA binding protein	0.0249	0.2339	0.3845
Brugia malayi	Cam kinase protein 1	0.0062	0.0501	0.0824
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0039	0.0267	0.5469
Giardia lamblia	Lysyl-tRNA synthetase	0.0046	0.0335	0.6849
Plasmodium falciparum	proline--tRNA ligase	0.0071	0.0589	0.0701
Onchocerca volvulus		0.0029	0.0169	0.0005
Trypanosoma cruzi	hexose transporter, putative	0.0029	0.0169	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Brugia malayi	TAR-binding protein	0.0249	0.2339	0.3845
Toxoplasma gondii	sugar transporter ST3	0.0029	0.0169	0.0305
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0063	0.0509	0.8651
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0222	0.0222
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0509	0.8651
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0509	0.8651
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0063	0.0509	0.8651
Toxoplasma gondii	lysine-tRNA ligase	0.0046	0.0335	0.0603
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0509	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0073	0.061	0.1003
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0166	0.0253
Schistosoma mansoni	lysyl-tRNA synthetase	0.0046	0.0335	0.0511
Trypanosoma cruzi	sugar transporter, putative	0.0029	0.0169	0.2874
Treponema pallidum	prolyl-tRNA synthetase	0.0022	0.01	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0025	0.0134	0.0221
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0865	0.8402	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0071	0.0589	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0166	0.0273
Schistosoma mansoni	protein kinase	0.0062	0.0501	0.0765
Echinococcus granulosus	synaptic vesicle 2 protein	0.0029	0.0169	0.0169
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0222	0.0222
Toxoplasma gondii	facilitative glucose transporter GT1	0.0204	0.1893	0.3408
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0039	0.0267	1
Brugia malayi	Pre-SET motif family protein	0.063	0.6084	1
Brugia malayi	lysyl-tRNA synthetase	0.0046	0.0335	0.0551
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0061	0.0489	0.0746
Loa Loa (eye worm)	TAR-binding protein	0.0249	0.2339	0.3845
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0222	0.0365
Trypanosoma cruzi	glucose transporter, putative	0.0029	0.0169	0.2874
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.009	0.0776	0.1184
Onchocerca volvulus		0.0717	0.694	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0204	0.1893	0.1893
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0063	0.0509	0.8651
Trichomonas vaginalis	myo-inositol transporter, putative	0.0029	0.0169	0.0244
Onchocerca volvulus	Putative transporter	0.0029	0.0169	0.0005
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0062	0.0501	0.0501
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Schistosoma mansoni	tar DNA-binding protein	0.0249	0.2339	0.357
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0169	0.0169
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0062	0.0501	0.0824
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0062	0.0502	0.0597
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0061	0.0489	1
Schistosoma mansoni	sugar transporter	0.0029	0.0169	0.0258
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0204	0.1893	0.1893
Toxoplasma gondii	transporter, major facilitator family protein	0.0029	0.0169	0.0305
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0509	0.8651
Echinococcus granulosus	calcium dependent protein kinase	0.0059	0.0463	0.0463
Entamoeba histolytica	hypothetical protein	0.0046	0.0335	0.6679
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0169	0.0244
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0062	0.0502	0.0903
Schistosoma mansoni	glucose transport protein	0.0204	0.1893	0.2889
Plasmodium falciparum	hexose transporter	0.0204	0.1893	0.2253
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0108	0.0945	0.1554
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0161	0.0265
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0062	0.0502	0.0597
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0062	0.0501	0.0501
Loa Loa (eye worm)	sugar transporter	0.0029	0.0169	0.0278
Schistosoma mansoni	hypothetical protein	0.0073	0.061	0.0931
Brugia malayi	Sugar transporter family protein	0.0029	0.0169	0.0278
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0029	0.0169	0.2874
Echinococcus granulosus	lamin	0.0028	0.0166	0.0166
Chlamydia trachomatis	proline--tRNA ligase	0.0022	0.01	0.2978
Giardia lamblia	Prolyl-tRNA synthetase	0.0061	0.0489	1
Brugia malayi	major facilitator superfamily protein	0.0029	0.0169	0.0278
Loa Loa (eye worm)	RNA binding protein	0.0249	0.2339	0.3845
Loa Loa (eye worm)	hypothetical protein	0.0167	0.1531	0.2517
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0071	0.0589	1
Trichomonas vaginalis	conserved hypothetical protein	0.0204	0.1893	0.2728
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0169	0.0169
Brugia malayi	intermediate filament protein	0.0028	0.0166	0.0273
Trichomonas vaginalis	set domain proteins, putative	0.0717	0.694	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0087	0.0743	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0335	0.0551
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0062	0.0501	0.8517
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0029	0.0169	0.0169
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0046	0.0335	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0046	0.0335	1
Schistosoma mansoni	lamin	0.0028	0.0166	0.0253
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0061	0.0489	0.0489
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0062	0.0502	0.0903
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0029	0.0169	0.5052
Plasmodium vivax	proline--tRNA ligase, putative	0.0071	0.0589	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0227	0.386
Schistosoma mansoni	cellular tumor antigen P53	0.015	0.1367	0.2087
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0062	0.0501	0.0824
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Onchocerca volvulus		0.015	0.1367	0.1773
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0204	0.1893	0.1893
Schistosoma mansoni	tar DNA-binding protein	0.0249	0.2339	0.357
Leishmania major	myo-inositol/proton symporter (MIT)	0.0029	0.0169	0.2874
Onchocerca volvulus		0.0029	0.0169	0.0005
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Brugia malayi	hypothetical protein	0.0029	0.0169	0.0278
Onchocerca volvulus		0.0029	0.0169	0.0005
Echinococcus granulosus	lysyl tRNA synthetase	0.0046	0.0335	0.0335
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.1051	0.1727
Plasmodium vivax	sugar transporter, putative	0.0029	0.0169	0.0201
Loa Loa (eye worm)	hypothetical protein	0.015	0.1367	0.2248
Echinococcus granulosus	solute carrier family 22	0.0029	0.0169	0.0169
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0029	0.0169	0.0258
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0062	0.0502	0.0597
Plasmodium falciparum	lysine--tRNA ligase	0.0046	0.0335	0.0399
Leishmania major	hypothetical protein, conserved	0.0029	0.0169	0.2874
Toxoplasma gondii	sugar transporter ST1	0.0029	0.0169	0.0305
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0062	0.0501	0.0501
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Echinococcus multilocularis	lamin dm0	0.0028	0.0166	0.0166
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0062	0.0501	0.0824
Giardia lamblia	Sugar-proton symporter	0.0029	0.0169	0.346
Onchocerca volvulus		0.0029	0.0169	0.0005
Schistosoma mansoni	hypothetical protein	0.0204	0.1893	0.2889
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0029	0.0169	0.6328
Onchocerca volvulus		0.0029	0.0169	0.0005
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Echinococcus granulosus	solute carrier family 22	0.0029	0.0169	0.0169
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0204	0.1893	0.1893
Entamoeba histolytica	protein kinase, putative	0.0062	0.0501	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Echinococcus granulosus	GPCR family 2	0.0034	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0945	0.1554
Schistosoma mansoni	hypothetical protein	0.0034	0.0222	0.0339
Echinococcus granulosus	histone lysine methyltransferase setb	0.009	0.0776	0.0776
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0062	0.0502	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0222	0.0365
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0061	0.0489	0.0746
Mycobacterium ulcerans	integral membrane transport protein	0.0029	0.0169	0.5052
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0061	0.0489	0.0804
Schistosoma mansoni	hypothetical protein	0.0034	0.0222	0.0339
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0509	0.0734
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.005	0.0376	0.0618
Schistosoma mansoni	tar DNA-binding protein	0.0249	0.2339	0.357
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0509	0.8651
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0071	0.0589	0.106
Schistosoma mansoni	sugar transporter	0.0029	0.0169	0.0258
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0046	0.0335	0.5689
Schistosoma mansoni	glucose transport protein	0.0204	0.1893	0.2889
Echinococcus granulosus	solute carrier family 22	0.0029	0.0169	0.0169
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.009	0.0776	0.1184
Trichomonas vaginalis	glucose transporter, putative	0.0029	0.0169	0.0244
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0061	0.0489	0.0489
Trypanosoma cruzi	hexose transporter, putative	0.0063	0.0509	0.8651
Giardia lamblia	Hexose transporter	0.0029	0.0169	0.346
Onchocerca volvulus		0.0029	0.0169	0.0005
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0222	0.0222
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0062	0.0501	0.0501
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0062	0.0502	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Schistosoma mansoni	glucose transporter	0.0029	0.0169	0.0258
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0509	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0062	0.0502	0.0597
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0169	0.0244
Trypanosoma brucei	sugar transporter, putative	0.0029	0.0169	0.2874
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0062	0.0501	0.0501
Leishmania major	glucose transporter, lmgt2	0.0063	0.0509	0.8651
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0029	0.0169	0.0201
Trypanosoma cruzi	hexose transporter, putative	0.0063	0.0509	0.8651
Trypanosoma brucei	glucose transporter 1E	0.0063	0.0509	0.8651
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0046	0.0335	0.0483
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0062	0.0502	0.0597
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0222	0.0222
Plasmodium vivax	SET domain protein, putative	0.009	0.0776	0.0923
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0329	0.3129	0.3724
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0062	0.0501	0.0501
Schistosoma mansoni	sugar transporter	0.0029	0.0169	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0489	0.0804
Brugia malayi	Pre-SET motif family protein	0.009	0.0776	0.1275
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0509	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Loa Loa (eye worm)	hypothetical protein	0.009	0.0776	0.1275
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.009	0.0776	0.0776
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0329	0.3129	0.3724
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0061	0.0489	0.9752
Onchocerca volvulus		0.0029	0.0169	0.0005
Onchocerca volvulus		0.0029	0.0169	0.0005
Schistosoma mansoni	protein kinase	0.0062	0.0501	0.0765
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.061	0.1003
Brugia malayi	hypothetical protein	0.0029	0.0169	0.0278
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0029	0.0169	0.0169
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0061	0.0489	0.0705
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0204	0.1893	0.1893
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.009	0.0776	0.1397
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.063	0.6084	1
Echinococcus multilocularis	tar DNA binding protein	0.0249	0.2339	0.2339
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Loa Loa (eye worm)	sugar transporter	0.0204	0.1893	0.3112
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0222	0.0365
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0166	0.0273
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0037	0.006
Echinococcus granulosus	microtubule associated protein 2	0.0677	0.6553	0.6553
Plasmodium falciparum	protein kinase 6	0.0865	0.8402	1
Echinococcus granulosus	General substrate transporter	0.0175	0.1611	0.1611
Brugia malayi	MH2 domain containing protein	0.0118	0.1051	0.1727
Schistosoma mansoni	glucose transport protein	0.0204	0.1893	0.2889
Echinococcus multilocularis	musashi	0.0028	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Onchocerca volvulus		0.0029	0.0169	0.0005
Schistosoma mansoni	lamin	0.0028	0.0166	0.0253
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.009	0.0776	0.0776
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0022	0.0022
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0509	0.8651
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0329	0.3129	0.5632
Schistosoma mansoni	sugar transporter	0.0029	0.0169	0.0258
Leishmania major	protein kinase, putative	0.0062	0.0501	0.8517
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0204	0.1893	0.1893
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0029	0.0169	0.5052
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0029	0.0169	0.6328
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0039	0.0267	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0062	0.0502	0.0597
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0029	0.0169	0.0169
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.004	0.028	0.0403
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0169	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0166	0.0273
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0204	0.1893	0.1893
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0169	0.0169
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0509	0.0734
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0509	0.0734
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0166	0.0273
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.009	0.0776	0.1184
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0169	0.0244
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0249	0.2339	0.3845
Trypanosoma cruzi	hexose transporter	0.0063	0.0509	0.8651
Leishmania major	glucose transporter, lmgt1	0.0063	0.0509	0.8651
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0063	0.0509	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Schistosoma mansoni	protein kinase	0.0062	0.0501	0.0765
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0071	0.0589	1
Trichomonas vaginalis	glucose transporter, putative	0.0063	0.0509	0.0734
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.009	0.0776	0.1184
Brugia malayi	Sugar transporter family protein	0.0204	0.1893	0.3112
Toxoplasma gondii	sugar transporter ST2	0.0029	0.0169	0.0305
Plasmodium vivax	lysine--tRNA ligase, putative	0.0046	0.0335	0.0399
Echinococcus granulosus	solute carrier family 22	0.0029	0.0169	0.0169
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Schistosoma mansoni	microtubule-associated protein tau	0.0677	0.6553	1
Plasmodium vivax	hexose transporter	0.0204	0.1893	0.2253
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0017	0.0027
Trichomonas vaginalis	glucose transporter, putative	0.0063	0.0509	0.0734
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Onchocerca volvulus		0.0167	0.1531	0.2016
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0489	0.0804
Entamoeba histolytica	protein kinase, putative	0.0062	0.0501	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Echinococcus granulosus	tar DNA binding protein	0.0249	0.2339	0.2339
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Schistosoma mansoni	tar DNA-binding protein	0.0249	0.2339	0.357
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0169	0.0278
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0169	0.0244
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0029	0.0169	1
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0046	0.0335	0.6849
Echinococcus granulosus	intermediate filament protein	0.0028	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0169	0.0278
Trypanosoma brucei	glucose transporter 2A	0.0063	0.0509	0.8651
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0062	0.0501	0.0501

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 610461