TDR Targets

Basic information

Technical information

TDR Targets ID: 620517
Name: 6-[[4-(3-methoxyphenyl)-5-prop-2-enylsulfanyl -1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4 -dione
MW: 371.414 | Formula: C17H17N5O3S
H donors: 2 H acceptors: 6 LogP: 2.77 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: C=CCSc1nnc(n1c1cccc(c1)OC)Cc1cc(O)nc(n1)O
InChi: 1S/C17H17N5O3S/c1-3-7-26-17-21-20-14(8-11-9-15(23)19-16(24)18-11)22(17)12-5-4-6-13(10-12)25-2/h3-6,9-10H,1,7-8H2,2H3,(H2,18,19,23,24)
InChiKey: OTOYWCHNRRPGMT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[[5-allylsulfanyl-4-(3-methoxyphenyl)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione
6-[[5-(allylthio)-4-(3-methoxyphenyl)-1,2,4-triazol-3-yl]methyl]-1H-pyrimidine-2,4-dione
6-[[5-(allylthio)-4-(3-methoxyphenyl)-1,2,4-triazol-3-yl]methyl]uracil
ZINC04061402

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0201	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0474
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0201	0.0278
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0474
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0399	0.5689
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.4251	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0606	0.269
Schistosoma mansoni	smad	0.0008	0.0043	0.0102
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.0823
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0606	0.269
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Leishmania major	glucose transporter, lmgt3	0.0033	0.0606	0.8651
Giardia lamblia	Hexose transporter	0.0015	0.0201	0.346
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0474
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.4251	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.2253	0.3107
Brugia malayi	major facilitator superfamily protein	0.0015	0.0201	0.0474
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0449	1	1
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0474
Echinococcus multilocularis	smad	0.0008	0.0043	0.006
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0474
Loa Loa (eye worm)	TAR-binding protein	0.0194	0.4251	1
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0474
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0606	0.269
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0106	0.2253	0.3107
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.016	0.0376
Mycobacterium ulcerans	sugar transporter	0.0015	0.0201	0.5052
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0201	0.0305
Brugia malayi	RNA recognition motif domain containing protein	0.0194	0.4251	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0597	0.0597
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0597	0.1404
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0201	0.2874
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0606	0.8651
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0399	0.6849
Brugia malayi	Smad1	0.0008	0.0043	0.0102
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0278
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0701	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0701	0.0701
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0399	1
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0278
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0201	0.2874
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0597	0.8517
Brugia malayi	Cam kinase protein 1	0.0032	0.0597	0.1404
Entamoeba histolytica	protein kinase, putative	0.0032	0.0597	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0201	0.2874
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0597	0.0597
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0606	0.269
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.0823
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0474
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0597	0.0597
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0582	0.9752
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0582	0.1369
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0043	0.0102
Schistosoma mansoni	glucose transport protein	0.0106	0.2253	0.5302
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	protein kinase	0.0032	0.0597	0.1404
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0278
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0606	0.8651
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0043	0.0102
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Plasmodium falciparum	hexose transporter	0.0106	0.2253	0.2253
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0399	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.2253	0.3107
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0399	0.0399
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0201	0.6328
Echinococcus multilocularis	tumor protein p63	0.0327	0.7252	1
Schistosoma mansoni	protein kinase	0.0032	0.0597	0.1404
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0043	0.006
Leishmania major	glucose transporter, lmgt1	0.0033	0.0606	0.8651
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0552	0.0761
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0318	1
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0597	0.1404
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0201	0.5052
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0399	0.5689
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0171	0.3724	0.3724
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0201	0.5052
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0606	0.8651
Plasmodium falciparum	protein kinase 7	0.0299	0.6612	0.6612
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2253	0.3107
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0597	0.0823
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0119	0.2978
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0201	0.0278
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0318	0.5469
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Schistosoma mansoni	glucose transport protein	0.0106	0.2253	0.5302
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0194	0.4251	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0582	0.1369
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0597	0.1404
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0606	0.8651
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2253	0.3107
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0043	0.0102
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2253	0.3107
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0399	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0582	0.1369
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0201	0.0305
Brugia malayi	MH2 domain containing protein	0.0008	0.0043	0.0102
Schistosoma mansoni	glucose transport protein	0.0106	0.2253	0.5302
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0399	0.0938
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Toxoplasma gondii	protein kinase, putative	0.0299	0.6612	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0701	0.106
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.0823
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.2253	0.3107
Brugia malayi	RNA binding protein	0.0194	0.4251	1
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0043	0.0102
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0399	0.5689
Echinococcus granulosus	smad	0.0008	0.0043	0.006
Brugia malayi	MH1 domain containing protein	0.0008	0.0043	0.0102
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0278
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0606	0.8651
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0552	0.0761
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0043	0.0102
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0701	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	glucose transporter	0.0015	0.0201	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0606	0.8651
Loa Loa (eye worm)	Smad1	0.0008	0.0043	0.0102
Echinococcus multilocularis	Smad4	0.0008	0.0043	0.006
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Echinococcus multilocularis	General substrate transporter	0.0091	0.1918	0.2644
Brugia malayi	MH2 domain containing protein	0.0116	0.2475	0.5824
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0701	0.0701
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0201	0.2874
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0701	1
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0597	0.1404
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0201	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0474
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0474
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0278
Trypanosoma cruzi	hexose transporter	0.0033	0.0606	0.8651
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0399	0.055
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0399	0.055
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0582	1
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0606	0.8651
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0606	0.8651
Brugia malayi	major facilitator superfamily protein	0.0015	0.0201	0.0474
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0201	0.0305
Loa Loa (eye worm)	sugar transporter	0.0015	0.0201	0.0474
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0201	0.2874
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.0823
Toxoplasma gondii	facilitative glucose transporter GT1	0.0106	0.2253	0.3408
Echinococcus granulosus	Smad4	0.0008	0.0043	0.006
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Plasmodium vivax	sugar transporter, putative	0.0015	0.0201	0.0201
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2253	0.3107
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0582	1
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0119	0.2978
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0597	0.2648
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0043	0.006
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0201	0.0278
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.0823
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0606	0.8651
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0333	0.1477
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	General substrate transporter	0.0091	0.1918	0.2644
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0201	0.2874
Brugia malayi	Sugar transporter family protein	0.0015	0.0201	0.0474
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0474
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0582	0.0803
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.4251	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0606	0.8651
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0582	0.1369
Leishmania major	hypothetical protein, conserved	0.0015	0.0201	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0399	0.0938
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.1404
Brugia malayi	MH1 domain containing protein	0.0008	0.0043	0.0102
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0399	0.0938
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0597	0.0597
Entamoeba histolytica	hypothetical protein	0.0024	0.0399	0.6679
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	protein kinase	0.0032	0.0597	0.1404
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0399	0.6849
Leishmania major	protein kinase, putative	0.0032	0.0597	0.8517
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0043	0.006
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0606	0.8651
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0318	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0278
Giardia lamblia	Sugar-proton symporter	0.0015	0.0201	0.346
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.027	0.386
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0597	0.0903
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0606	0.269
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.4251	1
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0606	0.8651
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0606	0.8651
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.0823
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Schistosoma mansoni	tar DNA-binding protein	0.0194	0.4251	1
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0399	0.0603
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0201	0.6328
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0606	0.8651
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0201	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0448	0.1053
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0278
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.2253	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0399	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0043	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0606	0.269
Brugia malayi	TAR-binding protein	0.0194	0.4251	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0201	0.5052
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0947	0.2228
Echinococcus granulosus	tar DNA binding protein	0.0194	0.4251	0.5861
Echinococcus granulosus	tumor protein p63	0.0327	0.7252	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0947	0.2228
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0701	1
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0201	0.0894
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0171	0.3724	0.3724
Echinococcus multilocularis	tar DNA binding protein	0.0194	0.4251	0.5861
Plasmodium vivax	hexose transporter	0.0106	0.2253	0.2253
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0606	0.269
Brugia malayi	Sugar transporter family protein	0.0106	0.2253	0.5302
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0201	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Leishmania major	glucose transporter, lmgt2	0.0033	0.0606	0.8651
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0597	0.0903
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0582	0.1369
Schistosoma mansoni	hypothetical protein	0.0106	0.2253	0.5302
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0606	0.8651
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0597	0.0597
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0582	0.2583
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0582	0.0803
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.2475	0.5824
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0606	0.8651
Entamoeba histolytica	protein kinase, putative	0.0032	0.0597	1
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	sugar transporter	0.0106	0.2253	0.5302
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0043	0.0102
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0399	0.0938
Brugia malayi	Sugar transporter family protein	0.0015	0.0201	0.0474
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0201	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0582	0.1369
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0119	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0171	0.3724	0.5632
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.2475	0.5824
Schistosoma mansoni	Smad4	0.0008	0.0043	0.0102
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0597	0.0903
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0701	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0474
Onchocerca volvulus		0.0048	0.0947	1
Loa Loa (eye worm)	RNA binding protein	0.0194	0.4251	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0597	0.0597
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0201	0.0305
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0201	0.0474
Brugia malayi	MH2 domain containing protein	0.0008	0.0043	0.0102

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 620517