TDR Targets

Basic information

Technical information

TDR Targets ID: 620608
Name: N-(4-chlorophenyl)-2-[[5-[(2,6-dioxo-3H-pyrim idin-4-yl)methyl]-4-(3-methylphenyl)-1,2,4-tr iazol-3-yl]sulfanyl]acetamide
MW: 482.943 | Formula: C22H19ClN6O3S
H donors: 3 H acceptors: 7 LogP: 4.06 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1)Cl)CSc1nnc(n1c1cccc(c1)C)Cc1cc(O)nc(n1)O
InChi: 1S/C22H19ClN6O3S/c1-13-3-2-4-17(9-13)29-18(10-16-11-19(30)26-21(32)25-16)27-28-22(29)33-12-20(31)24-15-7-5-14(23)6-8-15/h2-9,11H,10,12H2,1H3,(H,24,31)(H2,25,26,30,32)
InChiKey: IZUYKVKJTXGOFQ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-(4-chlorophenyl)-2-[[5-[(2,6-dioxo-3H-pyrimidin-4-yl)methyl]-4-(3-methylphenyl)-1,2,4-triazol-3-yl]thio]acetamide
N-(4-chlorophenyl)-2-[[5-[(2,6-diketo-3H-pyrimidin-4-yl)methyl]-4-(3-methylphenyl)-1,2,4-triazol-3-yl]thio]acetamide
N-(4-chlorophenyl)-2-[[5-[(2,6-dioxo-3H-pyrimidin-4-yl)methyl]-4-(3-methylphenyl)-1,2,4-triazol-3-yl]sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	RNA binding protein	0.0189	0.4238	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Schistosoma mansoni	glucose transport protein	0.0103	0.2253	0.5317
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0399	0.0941
Entamoeba histolytica	hypothetical protein	0.0023	0.0399	0.6679
Loa Loa (eye worm)	Smad1	0.0008	0.0049	0.0115
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0201	0.0305
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma cruzi	hexose transporter	0.0032	0.0606	0.8651
Schistosoma mansoni	hypothetical protein	0.0103	0.2253	0.5317
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Entamoeba histolytica	protein kinase, putative	0.0032	0.0597	1
Echinococcus granulosus	tar DNA binding protein	0.0189	0.4238	1
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0201	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.2554	0.6025
Onchocerca volvulus		0.0015	0.0201	0.5
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0552	0.1301
Onchocerca volvulus		0.0015	0.0201	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0574	0.1354
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0119	0.2978
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0399	0.6849
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0574	0.1354
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0201	0.5052
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Brugia malayi	MH1 domain containing protein	0.0008	0.0049	0.0115
Schistosoma mansoni	protein kinase	0.0032	0.0597	0.1408
Toxoplasma gondii	protein kinase, putative	0.0292	0.6612	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0582	0.1373
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2253	0.5317
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Brugia malayi	major facilitator superfamily protein	0.0015	0.0201	0.0475
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Plasmodium vivax	sugar transporter, putative	0.0015	0.0201	0.0201
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0399	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0167	0.3724	0.5632
Toxoplasma gondii	facilitative glucose transporter GT1	0.0103	0.2253	0.3408
Schistosoma mansoni	protein kinase	0.0032	0.0597	0.1408
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	1
Onchocerca volvulus		0.0015	0.0201	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0189	0.4238	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0333	0.1477
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0597	0.1408
Schistosoma mansoni	glucose transporter	0.0015	0.0201	0.0475
Echinococcus granulosus	GPCR family 2	0.0031	0.0574	0.1354
Schistosoma mansoni	glucose transport protein	0.0103	0.2253	0.5317
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Leishmania major	glucose transporter, lmgt1	0.0032	0.0606	0.8651
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0399	0.0603
Onchocerca volvulus		0.0015	0.0201	0.5
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0582	0.1373
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2253	0.5317
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0475
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.2253	1
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0574	0.1354
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0574	0.1354
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0582	0.9752
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1408
Schistosoma mansoni	tar DNA-binding protein	0.0189	0.4238	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Onchocerca volvulus		0.0015	0.0201	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0475
Onchocerca volvulus		0.0015	0.0201	0.5
Plasmodium falciparum	hexose transporter	0.0103	0.2253	0.2253
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0701	0.0701
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0201	0.2874
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0201	0.0475
Schistosoma mansoni	tar DNA-binding protein	0.0189	0.4238	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0438	1	1
Onchocerca volvulus	Putative transporter	0.0015	0.0201	0.5
Brugia malayi	Sugar transporter family protein	0.0103	0.2253	0.5317
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0475
Brugia malayi	TAR-binding protein	0.0189	0.4238	1
Echinococcus multilocularis	Smad4	0.0008	0.0049	0.0115
Brugia malayi	Sugar transporter family protein	0.0015	0.0201	0.0475
Echinococcus multilocularis	smad	0.0008	0.0049	0.0115
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0201	0.0475
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0119	0.2978
Schistosoma mansoni	Smad4	0.0008	0.0049	0.0115
Schistosoma mansoni	protein kinase	0.0032	0.0597	0.1408
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0399	0.0399
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0597	0.1408
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0597	0.2648
Onchocerca volvulus		0.0015	0.0201	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0189	0.4238	1
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0582	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0475
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0201	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0049	0.0115
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0399	0.0399
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.0941
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0574	0.1354
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2253	0.5317
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0201	0.0894
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0318	0.5469
Brugia malayi	major facilitator superfamily protein	0.0015	0.0201	0.0475
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Leishmania major	glucose transporter, lmgt3	0.0032	0.0606	0.8651
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2253	0.5317
Onchocerca volvulus		0.0015	0.0201	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0597	0.0597
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0597	0.0597
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0597	0.1408
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0475
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0201	0.0305
Onchocerca volvulus		0.0015	0.0201	0.5
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8651
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0582	0.1373
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0201	0.0475
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0201	0.0475
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.027	0.386
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0606	0.8651
Brugia malayi	Cam kinase protein 1	0.0032	0.0597	0.1408
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0597	0.1408
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0475
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0201	0.2874
Brugia malayi	MH1 domain containing protein	0.0008	0.0049	0.0115
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0582	0.1373
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0701	0.106
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0318	1
Schistosoma mansoni	hypothetical protein	0.0066	0.1396	0.3293
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0552	0.1301
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0597	0.0597
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0201	0.0305
Schistosoma mansoni	smad	0.0008	0.0049	0.0115
Brugia malayi	Sugar transporter family protein	0.0015	0.0201	0.0475
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2253	0.5317
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0201	0.0475
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0049	0.0115
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.2104	0.4964
Brugia malayi	MH2 domain containing protein	0.0116	0.2554	0.6025
Loa Loa (eye worm)	TAR-binding protein	0.0189	0.4238	1
Giardia lamblia	Sugar-proton symporter	0.0015	0.0201	0.346
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0701	1
Echinococcus granulosus	General substrate transporter	0.0089	0.1918	0.4525
Plasmodium falciparum	protein kinase 7	0.0292	0.6612	0.6612
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0189	0.4238	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0066	0.1396	0.3293
Onchocerca volvulus		0.0015	0.0201	0.5
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0475
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8651
Brugia malayi	RNA binding protein	0.0189	0.4238	1
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0475
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0574	0.1354
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0103	0.2253	0.5317
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0049	0.0115
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	sugar transporter	0.0015	0.0201	0.0475
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0582	0.1373
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0606	0.8651
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0475
Leishmania major	hypothetical protein, conserved	0.0015	0.0201	0.2874
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0574	0.1354
Schistosoma mansoni	tar DNA-binding protein	0.0189	0.4238	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0399	0.0941
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0475
Leishmania major	protein kinase, putative	0.0032	0.0597	0.8517
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0597	0.0597
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0049	0.0115
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1408
Schistosoma mansoni	tar DNA-binding protein	0.0189	0.4238	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.1769
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0201	0.0475
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0399	0.0941
Onchocerca volvulus		0.0015	0.0201	0.5
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0606	0.8651
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0475
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Mycobacterium ulcerans	sugar transporter	0.0015	0.0201	0.5052
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0475
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0597	0.0597
Schistosoma mansoni	tar DNA-binding protein	0.0189	0.4238	1
Echinococcus multilocularis	General substrate transporter	0.0089	0.1918	0.4525
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1396	0.3293
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0597	0.0903
Brugia malayi	MH2 domain containing protein	0.0008	0.0049	0.0115
Echinococcus granulosus	smad	0.0008	0.0049	0.0115
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.2554	0.6025
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0049	0.0115
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0167	0.3724	0.3724
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Schistosoma mansoni	hypothetical protein	0.0031	0.0574	0.1354
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0597	0.0903
Onchocerca volvulus		0.0015	0.0201	0.5
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0582	0.2583
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Plasmodium vivax	hexose transporter	0.0103	0.2253	0.2253
Onchocerca volvulus		0.0015	0.0201	0.5
Leishmania major	glucose transporter, lmgt2	0.0032	0.0606	0.8651
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1408
Brugia malayi	MH2 domain containing protein	0.0008	0.0049	0.0115
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1408
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2253	0.5317
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1408
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0049	0.0115
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0597	0.0597
Loa Loa (eye worm)	sugar transporter	0.0103	0.2253	0.5317
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0597	0.0903
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1408
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0582	0.1373
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0582	1
Echinococcus granulosus	Smad4	0.0008	0.0049	0.0115
Schistosoma mansoni	glucose transport protein	0.0103	0.2253	0.5317
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0201	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0201	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0097	0.2104	0.4964
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0582	0.1373
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Entamoeba histolytica	protein kinase, putative	0.0032	0.0597	1
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.1408
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	1
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0574	0.1354
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0475
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0399	0.6849
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0399	0.0941
Giardia lamblia	Hexose transporter	0.0015	0.0201	0.346
Onchocerca volvulus		0.0015	0.0201	0.5
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0597	0.8517
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0049	0.0115
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0701	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2253	0.5317
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.2104	0.4964
Onchocerca volvulus		0.0015	0.0201	0.5
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0119	1
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0201	0.2874
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0201	0.0305
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0201	0.5052
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0201	0.6328
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0701	0.0701
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0475
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0475
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0582	0.1373
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0574	0.1354
Schistosoma mansoni	hypothetical protein	0.0031	0.0574	0.1354
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0049	0.0115
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0201	0.2874
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0049	0.0115
Brugia malayi	Smad1	0.0008	0.0049	0.0115
Schistosoma mansoni	hypothetical protein	0.0031	0.0574	0.1354
Schistosoma mansoni	hypothetical protein	0.0031	0.0574	0.1354
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0597	0.1408
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0597	0.0597
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0201	0.5052
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0448	0.1056
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	1
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0201	0.2874
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1408
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.016	0.0377
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0167	0.3724	0.3724
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8651
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0201	0.6328
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.0941
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0318	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.2104	0.4964
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0049	0.0115
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0475
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0475
Onchocerca volvulus		0.0015	0.0201	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 620608