Detailed information for compound 622702

Basic information

Technical information
  • TDR Targets ID: 622702
  • Name: (5Z)-5-[(4-bromophenyl)methylidene]-1,3-thiaz olidine-2,4-dione
  • MW: 284.129 | Formula: C10H6BrNO2S
  • H donors: 1 H acceptors: 2 LogP: 2.89 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)S/C/1=C\c1ccc(cc1)Br
  • InChi: 1S/C10H6BrNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)/b8-5-
  • InChiKey: WOJYBXTWFNRUTA-YVMONPNESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[(4-bromophenyl)methylidene]-1,3-thiazolidine-2,4-dione
  • (5Z)-5-[(4-bromophenyl)methylene]thiazolidine-2,4-dione
  • 5-[(4-bromophenyl)methylene]thiazolidine-2,4-dione
  • (5Z)-5-(4-bromobenzylidene)thiazolidine-2,4-quinone
  • 5-(4-bromobenzylidene)thiazolidine-2,4-quinone
  • ZINC01909784
  • T5664683
  • CBMicro_048148

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Pim-2 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei protein lipid droplet kinase (LDK) Pim-2 proto-oncogene, serine/threonine kinase 311 aa 278 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.016 0.0733
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0153 0.2535
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0079 0.0487 0.1388
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0153 0.2535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0079 0.0487 0.1445
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0079 0.0487 0.3709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Leishmania major mitochondrial DNA polymerase beta 0.0318 0.2656 0.7613
Echinococcus multilocularis serine protein kinase ATM 0.0044 0.0176 0.0173
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0153 0.2535
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0315 0.0311
Loa Loa (eye worm) hypothetical protein 0.0122 0.0883 0.4104
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0153 0.0495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0025 0.0003 0.5
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0079 0.0487 0.0484
Brugia malayi hypothetical protein 0.0025 0.0003 0.0016
Brugia malayi SWIRM domain containing protein 0.0025 0.0003 0.0016
Toxoplasma gondii hypothetical protein 0.0051 0.0239 0.4881
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0241 0.4494
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0085 0.1025
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0241 0.1819
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0153 0.0447
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.019 0.1431
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0079 0.0487 0.2269
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0859 1
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0241 0.0237
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0202 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0315 0.0311
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0262 0.2146 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0079 0.0487 0.2257
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0202 0.0199
Loa Loa (eye worm) hypothetical protein 0.0044 0.0176 0.0808
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0241 0.0709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.019 0.0885
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0079 0.0487 0.1335
Loa Loa (eye worm) phosphatidylinositol 3 0.0079 0.0487 0.2257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Loa Loa (eye worm) glutathione reductase 0.0047 0.0202 0.0928
Leishmania major hypothetical protein, conserved 0.041 0.3488 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.019 0.1431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Brugia malayi MAP kinase sur-1 0.0051 0.0241 0.1121
Brugia malayi Inositol-1 0.0042 0.0153 0.0712
Schistosoma mansoni bromodomain containing protein 0.0063 0.0347 0.2635
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0044 0.0176 0.0705
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0241 0.0237
Brugia malayi FAT domain containing protein 0.0034 0.0085 0.0397
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1138 0.3391
Brugia malayi follicle stimulating hormone receptor 0.0262 0.2146 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.075 0.8728
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.075 0.2676
Toxoplasma gondii FATC domain-containing protein 0.0044 0.0176 0.3578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0122 0.0552
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0176 0.0822
Mycobacterium tuberculosis Probable reductase 0.0108 0.075 0.2676
Schistosoma mansoni inositol monophosphatase 0.0042 0.0153 0.1146
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0202 0.0713
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.019 0.0871
Leishmania major trypanothione reductase 0.0047 0.0202 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Echinococcus multilocularis geminin 0.0169 0.1307 0.1304
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0079 0.0487 0.0484
Brugia malayi Thioredoxin reductase 0.0047 0.0202 0.0943
Onchocerca volvulus Huntingtin homolog 0.0122 0.0883 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0079 0.0487 0.1335
Echinococcus granulosus serine protein kinase ATM 0.0044 0.0176 0.0173
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0859 0.3067
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0113 0.1284
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0153 0.3091
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0079 0.0487 0.1388
Mycobacterium ulcerans hypothetical protein 0.0168 0.1293 0.427
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0153 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.075 0.2676
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.075 0.2676
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0113 0.0394
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0029 0.0039 0.0108
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0079 0.0487 0.2269
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.2656 0.7925
Brugia malayi amine oxidase, flavin-containing family protein 0.0025 0.0003 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0079 0.0487 0.1388
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0153 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0044 0.0176 0.0173
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0241 0.4494
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0176 0.0822
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0241 0.4904
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.018 0.0527
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0227 0.1059
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0318 0.2656 1
Schistosoma mansoni hypothetical protein 0.0169 0.1307 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0222 0.4087
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0153 0.015
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0044 0.0176 0.0517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0084 0.0392
Schistosoma mansoni hypothetical protein 0.0034 0.0084 0.0619
Toxoplasma gondii target of rapamycin (TOR), putative 0.0079 0.0487 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0241 0.0681
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0241 0.0681
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0079 0.0487 0.1335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trypanosoma brucei trypanothione reductase 0.0047 0.0202 0.0198
Brugia malayi Bromodomain containing protein 0.0075 0.0453 0.2111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.019 0.0187
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1138 0.3257
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0241 0.0709
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0044 0.0176 0.0094
Trypanosoma cruzi target of rapamycin kinase 3 0.0079 0.0487 0.1445
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0044 0.0176 0.0517
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0241 0.0709
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0227 0.1059
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0079 0.0487 0.1445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Brugia malayi Bromodomain containing protein 0.0038 0.0121 0.0564
Brugia malayi hypothetical protein 0.0122 0.0883 0.4113
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0079 0.0487 0.1445
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0153 0.0429
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0241 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Brugia malayi glutathione reductase 0.0047 0.0202 0.0943
Schistosoma mansoni hypothetical protein 0.0169 0.1307 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0241 0.1107
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.01 0.0096
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0859 0.3067
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0079 0.0487 0.0484
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.3023 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0883 0.4104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.018 0.0108
Loa Loa (eye worm) inositol-1 0.0042 0.0153 0.0698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0079 0.0487 0.1388
Entamoeba histolytica protein kinase rad3, putative 0.0044 0.0176 0.0705
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0241 0.0237
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0079 0.0487 0.3709
Toxoplasma gondii thioredoxin reductase 0.0047 0.0202 0.4113
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0079 0.0487 0.1335
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0079 0.0487 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0241 0.0709
Schistosoma mansoni fkbp-rapamycin associated protein 0.0044 0.0176 0.1327
Loa Loa (eye worm) hypothetical protein 0.005 0.0227 0.1045
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0034 0.0085 0.0082
Loa Loa (eye worm) hypothetical protein 0.0034 0.0084 0.0377
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1129 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0079 0.0487 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0034 0.0085 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.075 0.2676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0079 0.0487 0.1335
Loa Loa (eye worm) hypothetical protein 0.0049 0.0222 0.1022
Echinococcus granulosus geminin 0.0169 0.1307 0.1304
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0049 0.0222 0.4527
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0227 0.1045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.2656 0.7925
Trypanosoma cruzi hypothetical protein, conserved 0.0395 0.3351 1
Plasmodium falciparum glutathione reductase 0.0047 0.0202 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.019 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0143 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.075 0.2676
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0241 0.4494
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.019 0.0187
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0382
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0044 0.0176 0.1327
Loa Loa (eye worm) hypothetical protein 0.0071 0.0414 0.1918
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Schistosoma mansoni hypothetical protein 0.0034 0.0085 0.0628
Trypanosoma brucei protein kinase, putative 0.0051 0.0241 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.018 0.0527
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0269 0.0792
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0859 0.3067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.3023 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0044 0.0176 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0222 0.4087
Plasmodium vivax glutathione reductase, putative 0.0047 0.0202 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Schistosoma mansoni inositol monophosphatase 0.0042 0.0153 0.1146
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0079 0.0487 0.1445
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.01 0.0096
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0049 0.0222 0.0277
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.019 0.0187
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.1138 0.3937
Leishmania major phosphatidylinositol 3-kinase, putative 0.0079 0.0487 0.1388
Giardia lamblia GTOR 0.0079 0.0487 1
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0202 0.0928
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0333 0.2794 1
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0202 0.0594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.1293 0.462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.019 0.1431
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0202 0.0199
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0153 0.015
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0079 0.0487 0.0484
Plasmodium falciparum thioredoxin reductase 0.0047 0.0202 1
Onchocerca volvulus Huntingtin homolog 0.0122 0.0883 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.018 0.0527
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0241 0.4494
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0241 0.0237
Entamoeba histolytica hypothetical protein 0.0044 0.0176 0.0705

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.09 uM Inhibition of human recombinant Pim2 by ATP depletion assay ChEMBL. 19072652
IC50 (binding) = 28 uM Inhibition of human recombinant Pim1 by ATP depletion assay ChEMBL. 19072652
IC50 (functional) = 85 uM Antiproliferative activity against human PC3 cells after 48 hrs by MTS assay ChEMBL. 19072652
Inhibition (functional) = 16.9 % Inhibition of MCP1-induced chemotaxis in mouse RAW264.7 cells at 25 ug/mL relative to control ChEMBL. 19904929

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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