TDR Targets

Basic information

Technical information

TDR Targets ID: 623014
Name: (2-chlorophenyl)-[2-(phenylmethylsulfanyl)-4, 5-dihydroimidazol-1-yl]methanone
MW: 330.832 | Formula: C17H15ClN2OS
H donors: 0 H acceptors: 1 LogP: 3.91 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccccc1C(=O)N1CCN=C1SCc1ccccc1
InChi: 1S/C17H15ClN2OS/c18-15-9-5-4-8-14(15)16(21)20-11-10-19-17(20)22-12-13-6-2-1-3-7-13/h1-9H,10-12H2
InChiKey: ZQKJLYWWNIQPMQ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(2-chlorophenyl)-[2-(phenylmethylthio)-4,5-dihydroimidazol-1-yl]methanone
[2-(benzylthio)-4,5-dihydroimidazol-1-yl]-(2-chlorophenyl)methanone
ZINC04119809

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	acyl-CoA synthetase	0.004	0.0131	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0454	0.0442
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.004	0.0131	0.1616
Loa Loa (eye worm)	hypothetical protein	0.004	0.0131	0.0118
Schistosoma mansoni	hypothetical protein	0.0095	0.0808	0.0827
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.0502	1
Schistosoma mansoni	ap endonuclease	0.0038	0.0105	0.0096
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0105	0.0093
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.007	0.0502	0.0529
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0184	0.0172
Brugia malayi	AMP-binding enzyme family protein	0.004	0.0131	0.0118
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.004	0.0131	0.0026
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.007	0.0502	0.0529
Brugia malayi	beta-lactamase family protein	0.007	0.0502	0.049
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.004	0.0131	0.0137
Mycobacterium ulcerans	acyl-CoA synthetase	0.004	0.0131	0.0026
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0184	0.0178
Echinococcus granulosus	beta LACTamase domain containing family member	0.007	0.0502	0.0509
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.0806	0.9632	1
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.004	0.0131	0.0026
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.004	0.0131	0.0137
Mycobacterium ulcerans	acyl-CoA synthetase	0.004	0.0131	0.0026
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.004	0.0131	0.0027
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.004	0.0131	0.0118
Onchocerca volvulus		0.007	0.0502	0.5489
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.004	0.0131	0.0137
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.0502	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0502	0.049
Loa Loa (eye worm)	hypothetical protein	0.007	0.0502	0.049
Loa Loa (eye worm)	hypothetical protein	0.007	0.0502	0.049
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.004	0.0131	0.0123
Brugia malayi	MH2 domain containing protein	0.0372	0.425	0.4242
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.007	0.0502	0.0401
Loa Loa (eye worm)	hypothetical protein	0.004	0.0131	0.0118
Schistosoma mansoni	hypothetical protein	0.0328	0.3704	0.3837
Mycobacterium ulcerans	beta-lactamase	0.007	0.0502	0.0401
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.0502	0.0417
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0836	1	1
Schistosoma mansoni	acetyl-CoA synthetase	0.004	0.0131	0.0123
Trichomonas vaginalis	esterase, putative	0.007	0.0502	1
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.0502	1
Schistosoma mansoni	hypothetical protein	0.0328	0.3704	0.3837
Loa Loa (eye worm)	transcription factor SMAD2	0.0372	0.425	0.4242
Mycobacterium ulcerans	acyl-CoA synthetase	0.004	0.0131	0.0026
Brugia malayi	beta-lactamase family protein	0.007	0.0502	0.049
Mycobacterium leprae	conserved hypothetical protein	0.007	0.0502	0.0397
Loa Loa (eye worm)	MH2 domain-containing protein	0.0372	0.425	0.4242
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0262	0.3943
Brugia malayi	AMP-binding enzyme family protein	0.004	0.0131	0.0118
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.004	0.0131	0.0123
Mycobacterium tuberculosis	Probable lipase LipE	0.007	0.0502	0.0529
Echinococcus multilocularis	beta LACTamase domain containing family member	0.007	0.0502	0.0509
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.0835	0.0823
Mycobacterium leprae	possible long-chain acyl-CoA synthase	0.0796	0.9502	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.004	0.0131	0.0026
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0448	0.5191	0.5464
Loa Loa (eye worm)	hypothetical protein	0.004	0.0131	0.0118
Echinococcus granulosus	geminin	0.0328	0.3704	0.3837
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0105	0.0093
Toxoplasma gondii	propionate-CoA ligase	0.004	0.0131	0.0637
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.004	0.0131	0.0637
Mycobacterium tuberculosis	Probable hydrolase	0.007	0.0502	0.0529
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0105	0.0096
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0262	0.0164
Brugia malayi	hypothetical protein	0.0033	0.0039	0.0026
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0098	0.0089
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.004	0.0131	0.0137
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.004	0.0131	0.0137
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.004	0.0131	0.0027
Loa Loa (eye worm)	hypothetical protein	0.007	0.0502	0.049
Leishmania major	4-coumarate:coa ligase-like protein	0.004	0.0131	0.0027
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.0806	0.9632	1
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0836	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0796	0.9502	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.004	0.0131	0.0137
Brugia malayi	AMP-binding enzyme family protein	0.004	0.0131	0.0118
Leishmania major	fatty acid transporter protein-like protein	0.0796	0.9502	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0184	0.0172
Leishmania major	4-coumarate:coa ligase-like protein	0.004	0.0131	0.0027
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.004	0.0131	0.0026
Brugia malayi	hypothetical protein	0.0465	0.5396	0.5391
Trichomonas vaginalis	antibiotic synthetase, putative	0.004	0.0131	0.0637
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0262	1
Mycobacterium ulcerans	lipase LipD	0.007	0.0502	0.0401
Toxoplasma gondii	ABC1 family protein	0.007	0.0502	1
Echinococcus multilocularis	long chain fatty acid transport protein 4	0.0806	0.9632	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.0502	0.049
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0184	0.0178
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.0105	0.5
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0262	0.3943
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0095	0.0808	0.0796
Loa Loa (eye worm)	hypothetical protein	0.004	0.0131	0.0118
Plasmodium vivax	acetyl-CoA synthetase, putative	0.004	0.0131	0.0637
Loa Loa (eye worm)	beta-lactamase	0.007	0.0502	0.049
Mycobacterium ulcerans	esterase/lipase LipP	0.007	0.0502	0.0401
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.0502	0.0509
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0262	1
Echinococcus multilocularis	geminin	0.0328	0.3704	0.3837
Echinococcus granulosus	long chain fatty acid transport protein 4	0.0806	0.9632	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.0105	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.004	0.0131	0.0026
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.004	0.0131	0.0137
Loa Loa (eye worm)	oxidoreductase	0.004	0.0131	0.0118
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.007	0.0502	0.0529
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.0502	1
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.004	0.0131	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.0105	0.5
Leishmania major	acetyl-CoA synthetase, putative	0.004	0.0131	0.0027
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.004	0.0131	0.0637
Onchocerca volvulus		0.0095	0.0808	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0184	0.0178
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.004	0.0131	0.0026
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.0835	0.0823
Echinococcus granulosus	survival motor neuron protein 1	0.0465	0.5396	0.5597
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0184	0.0178
Echinococcus granulosus	microtubule associated protein 2	0.0671	0.7959	0.8261
Leishmania major	hypothetical protein, conserved	0.0051	0.0262	0.0167
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0262	0.0164
Mycobacterium tuberculosis	Conserved protein	0.007	0.0502	0.0529
Schistosoma mansoni	hypothetical protein	0.0038	0.0098	0.0089
Trichomonas vaginalis	antibiotic synthetase, putative	0.004	0.0131	0.0637
Onchocerca volvulus		0.007	0.0502	0.5489
Brugia malayi	latrophilin 2 splice variant baaae	0.0066	0.0454	0.0442
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.004	0.0131	0.0026
Loa Loa (eye worm)	hypothetical protein	0.004	0.0131	0.0118
Schistosoma mansoni	microtubule-associated protein tau	0.0671	0.7959	0.8261
Mycobacterium ulcerans	hypothetical protein	0.004	0.0131	0.0026
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0105	0.2162
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0184	0.0178
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.0502	1
Leishmania major	acetyl-CoA synthetase, putative	0.004	0.0131	0.0027
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0105	0.0096
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.0105	0.0111
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.004	0.0131	0.0026
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.004	0.0131	0.0137
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.004	0.0131	0.0118
Mycobacterium ulcerans	acyl-CoA synthetase	0.004	0.0131	0.0026
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.004	0.0131	0.0137
Echinococcus multilocularis	microtubule associated protein 2	0.0671	0.7959	0.8261
Mycobacterium ulcerans	acyl-CoA synthetase	0.004	0.0131	0.0026
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.004	0.0131	0.0137
Mycobacterium leprae	Probable lipase LipE	0.007	0.0502	0.0397
Mycobacterium ulcerans	acyl-CoA synthetase	0.004	0.0131	0.0026
Brugia malayi	AMP-binding enzyme family protein	0.004	0.0131	0.0118
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.004	0.0131	0.0027
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.0835	0.0823
Entamoeba histolytica	acyl-CoA synthetase, putative	0.004	0.0131	1
Trypanosoma brucei	hypothetical protein, conserved	0.007	0.0502	1
Mycobacterium tuberculosis	Probable esterase LipL	0.007	0.0502	0.0529
Brugia malayi	hypothetical protein	0.0051	0.0262	0.0249
Plasmodium vivax	hypothetical protein, conserved	0.007	0.0502	1
Brugia malayi	hypothetical protein	0.0038	0.0098	0.0086
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.007	0.0502	0.049
Mycobacterium ulcerans	acetyl-CoA synthetase	0.004	0.0131	0.0026
Entamoeba histolytica	acyl-CoA synthetase, putative	0.004	0.0131	1
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.004	0.0131	0.0027
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0262	0.3943
Brugia malayi	beta-lactamase	0.007	0.0502	0.049
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.004	0.0131	0.0026
Schistosoma mansoni	FFA transport protein	0.0806	0.9632	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0184	0.0178
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0184	0.0178
Echinococcus multilocularis	survival motor neuron protein 1	0.0465	0.5396	0.5597
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.004	0.0131	0.0637
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.004	0.0131	0.0637
Mycobacterium tuberculosis	Conserved protein	0.007	0.0502	0.0529
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.004	0.0131	0.0026
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.004	0.0131	0.0137
Schistosoma mansoni	hypothetical protein	0.0066	0.0454	0.0459
Brugia malayi	AMP-binding enzyme family protein	0.004	0.0131	0.0118
Schistosoma mansoni	survival motor neuron protein	0.0095	0.0808	0.0827
Schistosoma mansoni	ap endonuclease	0.0038	0.0105	0.0096
Mycobacterium ulcerans	hypothetical protein	0.007	0.0502	0.0401
Leishmania major	hypothetical protein, conserved	0.007	0.0502	0.0423
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.007	0.0502	0.049
Loa Loa (eye worm)	hypothetical protein	0.007	0.0502	0.049
Entamoeba histolytica	acyl-coA synthetase, putative	0.004	0.0131	1
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.0502	0.0417
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.004	0.0131	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0465	0.5396	0.5391
Mycobacterium ulcerans	acyl-CoA synthetase	0.004	0.0131	0.0026
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.004	0.0131	0.0026
Mycobacterium tuberculosis	Probable lipase LipD	0.007	0.0502	0.0529
Leishmania major	4-coumarate:coa ligase-like protein	0.004	0.0131	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0835	0.0823
Mycobacterium ulcerans	acyl-CoA synthetase	0.004	0.0131	0.0026
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0098	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0262	0.0249
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.0502	0.0509
Brugia malayi	AMP-binding enzyme family protein	0.004	0.0131	0.0118
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.004	0.0131	0.0027
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.004	0.0131	0.0026
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.004	0.0131	0.0137
Onchocerca volvulus		0.007	0.0502	0.5489
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.004	0.0131	0.0137
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.004	0.0131	0.0026
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0098	0.0089
Mycobacterium tuberculosis	Conserved protein	0.007	0.0502	0.0529

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 623014