Detailed information for compound 623105

Basic information

Technical information
  • TDR Targets ID: 623105
  • Name: (2-methylsulfanyl-4,5-dihydroimidazol-1-yl)-( 2-nitrophenyl)methanone
  • MW: 265.288 | Formula: C11H11N3O3S
  • H donors: 0 H acceptors: 3 LogP: 1.62 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSC1=NCCN1C(=O)c1ccccc1[N+](=O)[O-]
  • InChi: 1S/C11H11N3O3S/c1-18-11-12-6-7-13(11)10(15)8-4-2-3-5-9(8)14(16)17/h2-5H,6-7H2,1H3
  • InChiKey: HMRFQCROLKWWMX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-(methylthio)-4,5-dihydroimidazol-1-yl]-(2-nitrophenyl)methanone
  • ZINC04119734

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.178 0.358
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0156 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0092 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0092 0.0185
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0156 0.0261
Echinococcus multilocularis long chain fatty acid transport protein 4 0.018 0.5981 1
Trichomonas vaginalis CMGC family protein kinase 0.015 0.4972 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0156 0.0156
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0092 0.0185
Giardia lamblia Casein kinase II beta chain 0.0041 0.1266 0.2546
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Loa Loa (eye worm) oxidoreductase 0.0008 0.0156 0.0156
Trichomonas vaginalis casein kinase II beta chain, putative 0.0012 0.0284 0.0571
Schistosoma mansoni protein kinase 0.015 0.4972 0.8313
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.0049
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.4499 0.7523
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0008 0.0156 0.0252
Plasmodium falciparum casein kinase II beta chain 0.0041 0.1266 0.2305
Onchocerca volvulus 0.0028 0.0821 0.0821
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.4633 0.4633
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Mycobacterium ulcerans hypothetical protein 0.0008 0.0156 0.0252
Loa Loa (eye worm) hypothetical protein 0.0008 0.0156 0.0156
Treponema pallidum gamma-glutamyl phosphate reductase 0.0004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0156 0.0156
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0156 0.0252
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0156 0.0156
Trichomonas vaginalis CMGC family protein kinase 0.015 0.4972 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0008 0.0156 0.0252
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.017 0.0284
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0156 0.0261
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0005 0.0049 0.0082
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Brugia malayi Csnk2b protein 0.0041 0.1266 0.1266
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0092 0.0185
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0156 0.0264
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0156 0.0313
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0156 0.0313
Loa Loa (eye worm) hypothetical protein 0.0008 0.0156 0.0156
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Loa Loa (eye worm) casein kinase II 0.0012 0.0284 0.0284
Brugia malayi CXXC zinc finger family protein 0.0028 0.0821 0.0821
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0166 0.0166
Giardia lamblia Kinase, CMGC CK2 0.015 0.4972 1
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0041 0.1266 0.2546
Entamoeba histolytica acyl-CoA synthetase, putative 0.0008 0.0156 0.0313
Plasmodium vivax casein kinase II beta chain, putative 0.0041 0.1266 0.2523
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Loa Loa (eye worm) hypothetical protein 0.0008 0.0156 0.0156
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0156 0.0252
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0041 0.1266 0.2117
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.116 0.2334
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0092 0.0185
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0156 0.0156
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0004 0.0012 0.0024
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0008 0.0156 0.0264
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0092 0.0185
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0005 0.0049 0.0082
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0113 0.0188
Trichomonas vaginalis casein kinase II beta chain, putative 0.0012 0.0284 0.0571
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0156 0.0252
Trichomonas vaginalis casein kinase II beta chain, putative 0.0012 0.0284 0.0571
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0041 0.1266 0.1266
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0156 0.0264
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Onchocerca volvulus 0.0008 0.0156 0.0156
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0092 0.0185
Plasmodium falciparum casein kinase 2, alpha subunit 0.015 0.4972 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0092 0.0185
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.2084 0.3485
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.4633 0.7746
Brugia malayi AMP-binding enzyme family protein 0.0186 0.6178 0.6178
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.2084 0.3532
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0186 0.6178 1
Echinococcus granulosus casein kinase ii subunit alpha 0.015 0.4972 0.8313
Entamoeba histolytica protein kinase domain containing protein 0.015 0.4972 1
Echinococcus multilocularis casein kinase ii subunit alpha 0.015 0.4972 0.8313
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0156 0.0264
Entamoeba histolytica acyl-CoA synthetase, putative 0.0008 0.0156 0.0313
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.1266 0.2546
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0186 0.6178 0.6178
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0014 0.0023
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.018 0.5981 1
Onchocerca volvulus 0.0299 1 1
Onchocerca volvulus 0.0008 0.0156 0.0156
Trichomonas vaginalis CMGC family protein kinase 0.015 0.4972 1
Schistosoma mansoni bromodomain containing protein 0.0005 0.0049 0.0082
Schistosoma mansoni cpg binding protein 0.0028 0.0821 0.1372
Schistosoma mansoni zinc finger protein 0.0005 0.0049 0.0082
Echinococcus granulosus long chain fatty acid transport protein 4 0.018 0.5981 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0005 0.0049 0.0049
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0006 0.0076 0.0129
Trypanosoma brucei Casein kinase II 0.015 0.4972 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0821 0.0821
Mycobacterium ulcerans acetyl-CoA synthetase 0.0008 0.0156 0.0252
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.015 0.4972 0.4972
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0092 0.0185
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0156 0.0264
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.116 0.2334
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0156 0.0264
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.2084 0.3373
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0156 0.0264
Trypanosoma cruzi casein kinase II, putative 0.015 0.4972 0.8313
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0113 0.0188
Echinococcus multilocularis casein kinase ii subunit beta 0.0041 0.1266 0.2117
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0156 0.0156
Trichomonas vaginalis CMGC family protein kinase 0.015 0.4972 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.2084 0.3373
Leishmania major 4-coumarate:coa ligase-like protein 0.0008 0.0156 0.0264
Loa Loa (eye worm) acetyltransferase 0.014 0.4633 0.4633
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.1277 0.2568
Leishmania major 4-coumarate:coa ligase-like protein 0.0008 0.0156 0.0264
Schistosoma mansoni bromodomain containing protein 0.0005 0.0049 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0092 0.0185
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.018 0.5981 1
Schistosoma mansoni casein kinase II beta subunit 0.0041 0.1266 0.2117
Plasmodium vivax casein kinase II beta chain, putative 0.0041 0.1266 0.2523
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.1266 0.2546
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0012 0.0284 0.0571
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0156 0.0264
Schistosoma mansoni cpg binding protein 0.0029 0.0874 0.1462
Echinococcus granulosus cpg binding protein 0.0029 0.0874 0.1462
Trichomonas vaginalis helicase, putative 0.0006 0.0092 0.0185
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0156 0.0261
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0156 0.0156
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.2084 0.3485
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0008 0.0156 0.0252
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0156 0.0156
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0113 0.0188
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.1277 0.2568
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0156 0.0156
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0041 0.1266 0.1266
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0156 0.0313
Onchocerca volvulus 0.0008 0.0156 0.0156
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0156 0.0252
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0156 0.0264
Brugia malayi PHD-finger family protein 0.0005 0.0049 0.0049
Loa Loa (eye worm) Csnk2b protein 0.0041 0.1266 0.1266
Trichomonas vaginalis casein kinase II beta chain, putative 0.0012 0.0284 0.0571
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0113 0.0188
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0156 0.0252
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0041 0.1266 0.2117
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0156 0.0252
Echinococcus multilocularis zinc finger protein 0.0005 0.0049 0.0082
Echinococcus granulosus casein kinase ii subunit beta 0.0041 0.1266 0.2117
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0008 0.0156 0.0252
Toxoplasma gondii CMGC kinase, CK2 family 0.015 0.4972 1
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0156 0.0313
Trichomonas vaginalis casein kinase II beta chain, putative 0.0012 0.0284 0.0571
Trichomonas vaginalis casein kinase II beta chain, putative 0.0012 0.0284 0.0571
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.2084 0.3532
Echinococcus multilocularis cpg binding protein 0.0029 0.0874 0.1462
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.116 0.2086
Leishmania major casein kinase II, putative 0.015 0.4972 0.8425
Trichomonas vaginalis CMGC family protein kinase 0.015 0.4972 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0012 0.0284 0.0571
Plasmodium vivax unspecified product 0.015 0.4972 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.1277 0.2135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0178 0.5901 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0156 0.0252
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0008 0.0156 0.0264
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0156 0.0313
Giardia lamblia Casein kinase II beta chain 0.0012 0.0284 0.0571
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0041 0.1266 0.2546
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0008 0.0156 0.0252
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0008 0.0156 0.0252
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0156 0.0261
Brugia malayi Bromodomain containing protein 0.0005 0.0049 0.0049
Echinococcus granulosus zinc finger protein 0.0005 0.0049 0.0082
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0156 0.0261
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0178 0.5901 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0008 0.0156 0.0252
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0156 0.0264
Trichomonas vaginalis casein kinase II beta chain, putative 0.0012 0.0284 0.0571
Onchocerca volvulus 0.0008 0.0156 0.0156
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0156 0.0264
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0012 0.0284 0.0571
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.4633 0.7746
Trichomonas vaginalis casein kinase II beta chain, putative 0.0012 0.0284 0.0571
Trichomonas vaginalis casein kinase II beta chain, putative 0.0012 0.0284 0.0571
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.2084 0.3485
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0156 0.0252
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.017 0.0284
Leishmania major fatty acid transporter protein-like protein 0.0178 0.5901 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0156 0.0252
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0156 0.0261
Plasmodium falciparum casein kinase II beta chain 0.0041 0.1266 0.2305
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.015 0.4972 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0008 0.0156 0.0264
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1877 0.3138
Entamoeba histolytica acyl-coA synthetase, putative 0.0008 0.0156 0.0313
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0156 0.0264
Onchocerca volvulus 0.0008 0.0156 0.0156
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0008 0.0156 0.0252
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0156 0.0156
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0156 0.0283
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.2084 0.3485
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0008 0.0156 0.0252
Entamoeba histolytica casein kinase, putative 0.015 0.4972 1
Trichomonas vaginalis CMGC family protein kinase 0.015 0.4972 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0092 0.0185
Schistosoma mansoni FFA transport protein 0.018 0.5981 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0008 0.0156 0.0252
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0156 0.0313
Schistosoma mansoni cpg binding protein 0.0029 0.0874 0.1462
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.1277 0.2544
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0156 0.0313
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0004 0.0012 0.0024
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.0156 0.0252
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.1277 0.2568
Toxoplasma gondii ck2 beta subunit 0.0041 0.1266 0.2546
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0156 0.0264
Trichomonas vaginalis casein kinase II beta chain, putative 0.0012 0.0284 0.0571
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0156 0.0261
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0156 0.0264
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0113 0.0188
Brugia malayi casein kinase II, putaitve 0.0012 0.0284 0.0284
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0092 0.0185
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0156 0.0156
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0156 0.0313
Trichomonas vaginalis casein kinase II beta chain, putative 0.0012 0.0284 0.0571
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0008 0.0156 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0092 0.0185
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0041 0.1266 0.2145
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0092 0.0185
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0012 0.0284 0.0571
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Trichomonas vaginalis casein kinase II beta chain, putative 0.0012 0.0284 0.0571
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0092 0.0185
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0012 0.0284 0.0571
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.1277 0.2568
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0008 0.0156 0.0264
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.2084 0.4192
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.2084 0.3373
Brugia malayi Casein kinase II, alpha chain 0.015 0.4972 0.4972
Trichomonas vaginalis casein kinase II beta chain, putative 0.0041 0.1266 0.2546
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0092 0.0185
Trichomonas vaginalis CMGC family protein kinase 0.015 0.4972 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0092 0.0185
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0156 0.0264
Loa Loa (eye worm) hypothetical protein 0.0299 1 1
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0004 0 0.5
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0008 0.0156 0.0252
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0156 0.0264
Leishmania major 4-coumarate:coa ligase-like protein 0.0008 0.0156 0.0264
Loa Loa (eye worm) histone methyltransferase 0.0009 0.017 0.017
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0008 0.0156 0.0264
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0041 0.1266 0.2546

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.