Detailed information for compound 624570

Basic information

Technical information
  • TDR Targets ID: 624570
  • Name: 2,6,8-trimethyl-4-(pyridin-3-ylmethylsulfanyl )pyrimido[5,6-e]pyrimidine-5,7-dione
  • MW: 329.377 | Formula: C15H15N5O2S
  • H donors: 0 H acceptors: 5 LogP: 1.09 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc(SCc2cccnc2)c2c(n1)n(C)c(=O)n(c2=O)C
  • InChi: 1S/C15H15N5O2S/c1-9-17-12-11(14(21)20(3)15(22)19(12)2)13(18-9)23-8-10-5-4-6-16-7-10/h4-7H,8H2,1-3H3
  • InChiKey: NXKUNJXSFMLESH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,6,8-trimethyl-4-(3-pyridylmethylsulfanyl)pyrimido[5,6-e]pyrimidine-5,7-dione
  • 2,6,8-trimethyl-4-(3-pyridylmethylthio)pyrimido[5,6-e]pyrimidine-5,7-dione
  • 2,6,8-trimethyl-4-(3-pyridylmethylthio)pyrimido[5,6-e]pyrimidine-5,7-quinone
  • EU-0060304
  • ZINC04061645

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0029 0.0199 0.0265
Schistosoma mansoni coup transcription factor 0.0015 0.0063 0.0084
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0124 0.111 0.4157
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0313 0.0417
Echinococcus multilocularis ecdysone induced protein 78C 0.0015 0.0063 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0397 0.0529
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0124 0.111 0.148
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.005 0.0397 0.0529
Brugia malayi Serotonin/octopamine receptor family protein 7 0.005 0.0397 0.0548
Echinococcus multilocularis dro:myosuppressin receptor 0.005 0.0397 0.0529
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.005 0.0397 0.0529
Loa Loa (eye worm) neuropeptide F receptor 0.005 0.0397 0.306
Leishmania major hypothetical protein, conserved 0.0012 0.0034 0.0126
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.0397 0.0529
Schistosoma mansoni opsin-like receptor 0.005 0.0397 0.0529
Echinococcus multilocularis somatostatin receptor 0.005 0.0397 0.0529
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.005 0.0397 0.306
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0048 0.0063
Schistosoma mansoni amine GPCR 0.005 0.0397 0.0529
Onchocerca volvulus 0.0124 0.111 0.1053
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0397 0.0529
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0015 0.0063 0.0488
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0248 0.0331
Trichomonas vaginalis aldo-keto reductase, putative 0.0036 0.0261 0.2098
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0015 0.0063 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0063 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0397 0.0529
Schistosoma mansoni neuropeptide receptor 0.005 0.0397 0.0529
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.0199 0.1535
Trypanosoma brucei ABC transporter, putative 0.0027 0.0177 0.0663
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus granulosus 7tm_1 domain containing protein 0.005 0.0397 0.0529
Echinococcus granulosus lipoxygenase domain containing protein 0.0064 0.053 0.0706
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0488
Echinococcus multilocularis aldo keto reductase 0.0124 0.111 0.148
Echinococcus multilocularis ATP binding cassette sub family G 0.0027 0.0177 0.0236
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0488
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0124 0.111 0.148
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus multilocularis g protein coupled receptor 0.005 0.0397 0.0529
Giardia lamblia Kinase, CMGC MAPK 0.0089 0.0774 0.2403
Brugia malayi G protein-coupled receptor 0.005 0.0397 0.0548
Schistosoma mansoni lipoxygenase 0.0382 0.3589 0.4786
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0124 0.111 0.148
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Brugia malayi hypothetical protein 0.005 0.0397 0.0548
Trypanosoma brucei telomerase reverse transcriptase 0.0287 0.267 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Schistosoma mansoni hypothetical protein 0.003 0.0199 0.0265
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.005 0.0397 0.0548
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0089 0.0774 0.2898
Brugia malayi follicle stimulating hormone receptor 0.005 0.0397 0.0548
Echinococcus granulosus aldo keto reductase 0.0124 0.111 0.148
Echinococcus multilocularis JmjC domain containing protein 4 0.0012 0.0034 0.0045
Plasmodium vivax ABC transporter G family member 2, putative 0.0027 0.0177 0.0544
Schistosoma mansoni biogenic amine (5HT) receptor 0.005 0.0397 0.0529
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Brugia malayi neuropeptide F receptor 0.005 0.0397 0.0548
Schistosoma mansoni neuropeptide F-like receptor 0.005 0.0397 0.0529
Brugia malayi Isocitrate dehydrogenase 0.0029 0.0199 0.0274
Loa Loa (eye worm) ABC transporter 0.0023 0.0137 0.1059
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.0199 0.0265
Schistosoma mansoni loxhd1 0.0064 0.053 0.0706
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus granulosus lipoxygenase domain containing protein 0.0064 0.053 0.0706
Loa Loa (eye worm) hypothetical protein 0.0064 0.053 0.4084
Brugia malayi CXXC zinc finger family protein 0.0055 0.0448 0.0618
Echinococcus multilocularis allatostatin A receptor 0.005 0.0397 0.0529
Echinococcus granulosus g-protein coupled receptor 0.005 0.0397 0.0529
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.0199 0.0265
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.048 0.1797
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0036 0.0261 0.0863
Brugia malayi ORL1-like opioid receptor 0.005 0.0397 0.0548
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0397 0.0529
Brugia malayi jmjC domain containing protein 0.0046 0.0359 0.0496
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Schistosoma mansoni histamine h1 receptor 0.005 0.0397 0.0529
Echinococcus granulosus thyrotropin releasing hormone receptor 0.005 0.0397 0.0529
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0089 0.0774 0.2898
Loa Loa (eye worm) jmjC domain-containing protein 0.0049 0.039 0.3006
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0089 0.0774 0.5967
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0271 0.0361
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.048 0.1797
Brugia malayi Latrophilin receptor protein 2 0.003 0.0199 0.0275
Plasmodium falciparum aldehyde reductase, putative 0.0036 0.0261 0.0863
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0124 0.111 0.148
Trichomonas vaginalis aldo-keto reductase, putative 0.0036 0.0261 0.2098
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0124 0.111 0.1532
Echinococcus multilocularis G-protein coupled receptor, putative 0.005 0.0397 0.0529
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0063 0.0084
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0093 0.0812 0.6262
Echinococcus multilocularis RUN 0.0064 0.053 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0261 0.2098
Echinococcus granulosus peptide allatostatin:somatostatin 0.005 0.0397 0.0529
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Trypanosoma cruzi aldo-keto reductase 0.0124 0.111 0.4157
Echinococcus granulosus jumonji domain containing 1A 0.0012 0.0034 0.0045
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0036 0.0261 0.0979
Brugia malayi jmjC domain containing protein 0.0012 0.0034 0.0047
Loa Loa (eye worm) doublecortin family protein 0.0064 0.053 0.4084
Brugia malayi hypothetical protein 0.005 0.0397 0.0548
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.008 0.0107
Brugia malayi nuclear receptor NHR-88 0.0015 0.0063 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0015 0.0063 0.0488
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.0397 0.0529
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0063 0.0084
Schistosoma mansoni hypothetical protein 0.005 0.0397 0.0529
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0015 0.0063 0.0488
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0029 0.0199 0.0265
Echinococcus granulosus aldehyde reductase 0.0088 0.0764 0.1018
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.048 0.064
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.005 0.0397 0.0529
Schistosoma mansoni RAR-like nuclear receptor 0.0015 0.0063 0.0084
Echinococcus granulosus hypothetical protein 0.005 0.0397 0.0529
Schistosoma mansoni neuropeptide F-like receptor 0.005 0.0397 0.0529
Echinococcus granulosus dnaJ subfamily B 0.0789 0.75 1
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0397 0.0529
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0015 0.0063 0.0084
Brugia malayi Melatonin receptor type 1A 0.005 0.0397 0.0548
Onchocerca volvulus 0.0124 0.111 0.1053
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus multilocularis ATP binding cassette sub family G 0.0027 0.0177 0.0236
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0124 0.111 0.1532
Loa Loa (eye worm) hypothetical protein 0.0144 0.1297 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0124 0.111 0.148
Plasmodium vivax telomerase reverse transcriptase, putative 0.0287 0.267 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0029 0.0199 0.0265
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0063 0.0087
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0015 0.0063 0.0084
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.048 0.4323
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0964
Schistosoma mansoni cpg binding protein 0.0059 0.0478 0.0638
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0488
Brugia malayi hypothetical protein 0.0064 0.053 0.0731
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0015 0.0063 0.0087
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0029 0.0199 0.0744
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.0199 0.0265
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0313 0.0417
Echinococcus multilocularis fmrfamide receptor 0.005 0.0397 0.0529
Brugia malayi ABC transporter family protein 0.0023 0.0137 0.019
Loa Loa (eye worm) follicle stimulating hormone receptor 0.005 0.0397 0.306
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.005 0.0397 0.0529
Loa Loa (eye worm) jmjC domain-containing protein 0.0012 0.0034 0.026
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0029 0.0199 0.0744
Brugia malayi jmjC domain containing protein 0.0012 0.0034 0.0047
Brugia malayi latrophilin 2 splice variant baaae 0.0064 0.0528 0.0729
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.026
Onchocerca volvulus 0.005 0.0397 0.0336
Brugia malayi jmjC domain containing protein 0.0012 0.0034 0.0047
Mycobacterium leprae Possible oxidoreductase 0.0036 0.0261 0.2354
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0271 0.0361
Brugia malayi hypothetical protein 0.005 0.0397 0.0548
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0023 0.0134 0.121
Brugia malayi photoreceptor-specific nuclear receptor 0.0015 0.0063 0.0087
Loa Loa (eye worm) melatonin receptor type 1A 0.005 0.0397 0.306
Brugia malayi Dopamine receptor protein 2 0.005 0.0397 0.0548
Trypanosoma cruzi ABC transporter, putative 0.0027 0.0177 0.0663
Brugia malayi G-protein coupled receptor 0.005 0.0397 0.0548
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0027 0.0177 0.0663
Echinococcus multilocularis biogenic amine (5HT) receptor 0.005 0.0397 0.0529
Onchocerca volvulus 0.005 0.0397 0.0336
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Schistosoma mansoni ABC transporter 0.0023 0.0137 0.0183
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.005 0.0397 0.0529
Leishmania major aldo-keto reductase-like protein 0.0124 0.111 0.4157
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0027 0.0177 0.0663
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.005 0.0397 0.0529
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0015 0.0063 0.0084
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.005 0.0397 0.0529
Echinococcus granulosus g protein coupled receptor 0.005 0.0397 0.0529
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Brugia malayi NADH-dependent xylose reductase 0.0036 0.0261 0.0361
Echinococcus granulosus tachykinin peptides receptor 99D 0.005 0.0397 0.0529
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0313 0.0417
Loa Loa (eye worm) steroid hormone receptor 0.0015 0.0063 0.0488
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0124 0.111 0.148
Schistosoma mansoni adenoreceptor 0.005 0.0397 0.0529
Echinococcus multilocularis fmrfamide receptor 0.005 0.0397 0.0529
Onchocerca volvulus 0.005 0.0397 0.0336
Entamoeba histolytica alcohol dehydrogenase, putative 0.0036 0.0261 0.0903
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0397 0.0529
Schistosoma mansoni amine GPCR 0.005 0.0397 0.0529
Toxoplasma gondii aldose reductase, putative 0.0124 0.111 0.4157
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0012 0.0034 0.0126
Onchocerca volvulus 0.005 0.0397 0.0336
Brugia malayi neuropeptide F receptor 0.005 0.0397 0.0548
Plasmodium falciparum ABC transporter G family member 2 0.0027 0.0177 0.0544
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus granulosus neuropeptide s receptor 0.005 0.0397 0.0529
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0015 0.0063 0.0084
Schistosoma mansoni hypothetical protein 0.005 0.0397 0.0529
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0029 0.0199 0.0626
Loa Loa (eye worm) hypothetical protein 0.0064 0.0528 0.4074
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0015 0.0063 0.0488
Echinococcus multilocularis muscleblind protein 1 0.0144 0.1297 0.1729
Brugia malayi AKH receptor 0.005 0.0397 0.0548
Trichomonas vaginalis aldo-keto reductase, putative 0.0124 0.111 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0015 0.0063 0.0084
Echinococcus granulosus FTZ F1 alpha 0.0015 0.0063 0.0084
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.005 0.0397 0.0548
Schistosoma mansoni microtubule-associated protein tau 0.0664 0.6297 0.8395
Echinococcus multilocularis G protein coupled receptor 139 0.005 0.0397 0.0529
Brugia malayi nuclear hormone receptor 0.0015 0.0063 0.0087
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0488
Echinococcus multilocularis mitogen activated protein kinase 3 0.0089 0.0774 0.1032
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0124 0.111 0.148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0397 0.0529
Toxoplasma gondii histone lysine methyltransferase SET1 0.0105 0.0924 0.3462
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0488
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0488
Echinococcus granulosus microtubule associated protein 2 0.0664 0.6297 0.8395
Onchocerca volvulus 0.005 0.0397 0.0336
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0089 0.0774 0.2898
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0063 0.0084
Loa Loa (eye worm) hypothetical protein 0.0064 0.053 0.4084
Echinococcus multilocularis microtubule associated protein 2 0.0664 0.6297 0.8395
Schistosoma mansoni neuropeptide receptor 0.005 0.0397 0.0529
Loa Loa (eye worm) hypothetical protein 0.003 0.0199 0.1535
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0015 0.0063 0.0488
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0078 0.0108
Echinococcus multilocularis lipoxygenase domain containing protein 0.0064 0.053 0.0706
Loa Loa (eye worm) TYRA-2 protein 0.005 0.0397 0.306
Schistosoma mansoni cpg binding protein 0.0059 0.0478 0.0638
Echinococcus granulosus RUN 0.0064 0.053 0.0706
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.005 0.0397 0.0529
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0397 0.0529
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0015 0.0063 0.0084
Echinococcus multilocularis neuropeptide Y receptor 0.005 0.0397 0.0529
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0397 0.0529
Loa Loa (eye worm) transcription factor SMAD2 0.0108 0.0953 0.7348
Mycobacterium tuberculosis Conserved protein 0.0036 0.0261 0.2354
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0012 0.0034 0.0126
Echinococcus multilocularis voltage gated potassium channel subunit 0.0036 0.0261 0.0348
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0029 0.0199 0.0744
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0529 0.0705
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0397 0.0529
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.021 0.1889
Loa Loa (eye worm) oxidoreductase 0.0124 0.111 0.8559
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0313 0.0417
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0397 0.0529
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.005 0.0397 0.0529
Echinococcus granulosus ATP binding cassette sub family G 0.0027 0.0177 0.0236
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.005 0.0397 0.0529
Plasmodium vivax multidomain scavenger receptor, putative 0.0064 0.053 0.1881
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.039 0.052
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.005 0.0397 0.0529
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0029 0.0199 0.179
Plasmodium falciparum telomerase reverse transcriptase 0.0287 0.267 1
Schistosoma mansoni rab6-interacting 0.0064 0.053 0.0706
Echinococcus multilocularis Polycystic kidney disease protein 0.0064 0.053 0.0706
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.005 0.0397 0.0529
Onchocerca volvulus 0.0124 0.111 0.1053
Onchocerca volvulus 0.005 0.0397 0.0336
Onchocerca volvulus Neuropeptide F receptor homolog 0.005 0.0397 0.0336
Echinococcus granulosus fmrfamide receptor 0.005 0.0397 0.0529
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0248 0.0331
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.005 0.0397 0.306
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.005 0.0397 0.0529
Echinococcus multilocularis neuropeptides capa receptor 0.005 0.0397 0.0529
Trypanosoma cruzi aldo/keto reductase, putative 0.0124 0.111 0.4157
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0089 0.0774 0.2898
Trypanosoma cruzi aldo/keto reductase, putative 0.0036 0.0261 0.0979
Echinococcus granulosus ecdysone induced protein 78C 0.0015 0.0063 0.0084
Schistosoma mansoni phd/f-box containing protein 0.0012 0.0034 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0063 0.0087
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0015 0.0063 0.0087
Echinococcus multilocularis phd:f box containing protein 0.0012 0.0034 0.0045
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0287 0.267 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0027 0.0177 0.1596
Echinococcus multilocularis aldehyde reductase 0.0088 0.0764 0.1018
Echinococcus granulosus neuropeptide receptor A26 0.005 0.0397 0.0529
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Toxoplasma gondii aldo-keto reductase 0.0036 0.0261 0.0979
Brugia malayi Muscleblind-like protein 0.0144 0.1297 0.179
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.026
Schistosoma mansoni hypothetical protein 0.0064 0.0528 0.0704
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0048 0.0063
Echinococcus granulosus 7TM GPCR rhodopsin 0.005 0.0397 0.0529
Brugia malayi Steroid receptor seven-up type 2 0.0015 0.0063 0.0087
Echinococcus granulosus somatostatin receptor 0.005 0.0397 0.0529
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0029 0.0199 0.0265
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Schistosoma mansoni hypothetical protein 0.0789 0.75 1
Loa Loa (eye worm) histone methyltransferase 0.0017 0.008 0.0617
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0397 0.0529
Brugia malayi hypothetical protein 0.0035 0.0248 0.0342
Echinococcus multilocularis dnaJ subfamily B 0.0789 0.75 1
Echinococcus granulosus neuropeptide Y receptor 0.005 0.0397 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0015 0.0063 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0397 0.0529
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0089 0.0774 0.2898
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus granulosus Polycystic kidney disease protein 0.0064 0.053 0.0706
Onchocerca volvulus 0.005 0.0397 0.0336
Onchocerca volvulus 0.0036 0.0261 0.0199
Brugia malayi sulfakinin receptor protein 0.005 0.0397 0.0548
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0488
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.005 0.0397 0.0529
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0027 0.0177 0.0663
Onchocerca volvulus 0.005 0.0397 0.0336
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0048 0.0063
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.005 0.0397 0.0336
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0529 0.1981
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0124 0.111 0.4157
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0015 0.0063 0.0087
Echinococcus granulosus g protein coupled receptor 0.005 0.0397 0.0529
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.111 1
Entamoeba histolytica hypothetical protein 0.0035 0.0248 0.076
Echinococcus granulosus geminin 0.0316 0.2955 0.394
Schistosoma mansoni aldo-keto reductase 0.0124 0.111 0.148
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.0313 0.0432
Loa Loa (eye worm) jmjC domain-containing protein 0.0012 0.0034 0.026
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0774 0.687
Echinococcus multilocularis mitogen activated protein kinase 0.0089 0.0774 0.1032
Brugia malayi Serotonin receptor 0.005 0.0397 0.0548
Echinococcus granulosus G protein coupled receptor 139 0.005 0.0397 0.0529
Echinococcus granulosus JmjC domain containing protein 4 0.0012 0.0034 0.0045
Schistosoma mansoni biogenic amine (5HT) receptor 0.005 0.0397 0.0529
Echinococcus multilocularis lysine specific demethylase 6a 0.0012 0.0034 0.0045
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.0397 0.0529
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Entamoeba histolytica hypothetical protein 0.0035 0.0248 0.076
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0124 0.111 0.148
Schistosoma mansoni biogenic amine receptor 0.005 0.0397 0.0529
Echinococcus multilocularis g protein coupled receptor 0.005 0.0397 0.0529
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0029 0.0199 0.0744
Schistosoma mansoni myosin xvIII 0.005 0.0397 0.0529
Onchocerca volvulus 0.005 0.0397 0.0336
Echinococcus multilocularis serotonin receptor 0.005 0.0397 0.0529
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0029 0.0199 0.0626
Trypanosoma brucei ATP-binding cassette protein, putative 0.0027 0.0177 0.0663
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0089 0.0774 0.2898
Brugia malayi hypothetical protein 0.005 0.0397 0.0548
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.0313 0.2412
Trichomonas vaginalis aldo-keto reductase, putative 0.0124 0.111 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0124 0.111 0.148
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0063 0.0084
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0012 0.0034 0.0045
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0124 0.111 0.148
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0124 0.111 0.148
Echinococcus granulosus aldo keto reductase 0.0124 0.111 0.148
Echinococcus multilocularis neuropeptide FF receptor 2 0.005 0.0397 0.0529
Echinococcus multilocularis cpg binding protein 0.0059 0.0478 0.0638
Echinococcus multilocularis aldo keto reductase 0.0124 0.111 0.148
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0124 0.111 0.148
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0774 0.687
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0063 0.0087
Echinococcus multilocularis neuropeptide receptor 0.005 0.0397 0.0529
Loa Loa (eye worm) G-protein coupled receptor 0.005 0.0397 0.306
Brugia malayi G-protein coupled receptor 0.005 0.0397 0.0548
Trypanosoma brucei prostaglandin f synthase 0.0124 0.111 0.4157
Brugia malayi gonadotropin-releasing hormone receptor 2 0.005 0.0397 0.0548
Trichomonas vaginalis aldo/keto reductase, putative 0.0124 0.111 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.0397 0.0529
Schistosoma mansoni jumonji domain containing protein 0.0012 0.0034 0.0045
Onchocerca volvulus 0.0055 0.0448 0.0387
Loa Loa (eye worm) CXXC zinc finger family protein 0.0055 0.0448 0.3454
Echinococcus multilocularis serotonin receptor 0.005 0.0397 0.0529
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.0313 0.0417
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.005 0.0397 0.306
Brugia malayi isocitrate dehydrogenase 0.0029 0.0199 0.0274
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0063 0.0084
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.048 0.4323
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.021 0.0785
Trypanosoma brucei aldo/keto reductase, putative 0.0036 0.0261 0.0979
Leishmania major cytochrome p450-like protein 0.0031 0.021 0.0785
Echinococcus multilocularis neuropeptide Y receptor 0.005 0.0397 0.0529
Echinococcus multilocularis neuropeptide receptor 0.005 0.0397 0.0529
Brugia malayi Cytochrome P450 family protein 0.0031 0.021 0.0289
Brugia malayi hypothetical protein 0.005 0.0397 0.0548
Loa Loa (eye worm) neuropeptide F receptor 0.005 0.0397 0.306
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0063 0.0084
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.021 0.1617
Schistosoma mansoni biogenic amine receptor 0.005 0.0397 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0015 0.0063 0.0087
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0784 0.7453 0.9938
Onchocerca volvulus 0.0124 0.111 0.1053
Brugia malayi Tachykinin-like peptides receptor 99D 0.005 0.0397 0.0548
Mycobacterium ulcerans oxidoreductase 0.0124 0.111 1
Echinococcus granulosus ATP binding cassette sub family G 0.0027 0.0177 0.0236
Echinococcus granulosus muscleblind protein 0.0144 0.1297 0.1729
Brugia malayi putative neuropeptide receptor NPR1 0.005 0.0397 0.0548
Schistosoma mansoni neuropeptide receptor 0.005 0.0397 0.0529
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.005 0.0397 0.0529
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0529 0.0705
Echinococcus granulosus lysine specific demethylase 6a 0.0012 0.0034 0.0045
Echinococcus multilocularis neuropeptide receptor A26 0.005 0.0397 0.0529
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0397 0.0529
Brugia malayi hypothetical protein 0.005 0.0397 0.0548
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Brugia malayi Dopamine receptor 0.005 0.0397 0.0548
Schistosoma mansoni opsin-like receptor 0.005 0.0397 0.0529
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0529 0.1981
Schistosoma mansoni neuropeptide f receptor 76f 0.005 0.0397 0.0529
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.008 0.0107
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0048 0.0063
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.005 0.0397 0.0529
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0029 0.0199 0.0744
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0124 0.111 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0093 0.0812 0.1121
Echinococcus multilocularis g-protein coupled receptor 0.005 0.0397 0.0529
Mycobacterium ulcerans hypothetical protein 0.0036 0.0261 0.2354
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.048 0.4323
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0063 0.0087
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0529 0.3772
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0029 0.0199 0.0265
Brugia malayi GnHR receptor homolog 0.005 0.0397 0.0548
Brugia malayi hypothetical protein 0.005 0.0397 0.0548
Echinococcus granulosus neuropeptides capa receptor 0.005 0.0397 0.0529
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0036 0.0261 0.0361
Trichomonas vaginalis aldo-keto reductase, putative 0.0124 0.111 1
Brugia malayi MH2 domain containing protein 0.0108 0.0953 0.1315
Echinococcus multilocularis geminin 0.0316 0.2955 0.394
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.005 0.0397 0.0548
Echinococcus granulosus cpg binding protein 0.0059 0.0478 0.0638
Entamoeba histolytica aldose reductase, putative 0.0124 0.111 1
Echinococcus granulosus sex peptide receptor 0.005 0.0397 0.0529
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0036 0.0261 0.0979
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0064 0.0085
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Trichomonas vaginalis aldo-keto reductase, putative 0.0124 0.111 1
Echinococcus granulosus phd:f box containing protein 0.0012 0.0034 0.0045
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0124 0.111 1
Echinococcus multilocularis orexin receptor type 2 0.005 0.0397 0.0529
Echinococcus granulosus neuropeptide receptor 0.005 0.0397 0.0529
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0015 0.0063 0.0084
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.0313 0.0417
Echinococcus multilocularis tachykinin peptides receptor 99D 0.005 0.0397 0.0529
Trichomonas vaginalis aldo-keto reductase, putative 0.0124 0.111 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0029 0.0199 0.0265
Echinococcus granulosus GPCR family 2 0.003 0.0199 0.0265
Plasmodium falciparum LCCL domain-containing protein 0.0064 0.053 0.1881
Echinococcus granulosus serotonin receptor 0.005 0.0397 0.0529
Brugia malayi hypothetical protein 0.0064 0.053 0.0731
Echinococcus granulosus mitogen activated protein kinase 0.0089 0.0774 0.1032
Echinococcus granulosus allatostatin A receptor 0.005 0.0397 0.0529
Schistosoma mansoni hypothetical protein 0.0316 0.2955 0.394
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.0397 0.0529
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0012 0.0034 0.0126
Schistosoma mansoni lipoxygenase 0.0267 0.2484 0.3312
Brugia malayi Telomerase reverse transcriptase 0.0763 0.7245 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0027 0.0177 0.1596
Schistosoma mansoni hypothetical protein 0.003 0.0199 0.0265
Schistosoma mansoni phosphatidylserine receptor 0.0012 0.0034 0.0045
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Schistosoma mansoni amine GPCR 0.005 0.0397 0.0529
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0774 0.687
Echinococcus multilocularis neuropeptides capa receptor 0.005 0.0397 0.0529
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus granulosus biogenic amine 5HT receptor 0.005 0.0397 0.0529
Giardia lamblia Telomerase catalytic subunit 0.0287 0.267 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.048 0.4323
Loa Loa (eye worm) MH2 domain-containing protein 0.0108 0.0953 0.7348
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0015 0.0063 0.0084
Loa Loa (eye worm) oxidoreductase 0.0124 0.111 0.8559
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.005 0.0397 0.0529
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.048 0.064
Schistosoma mansoni pol-related 0.0124 0.111 0.148
Schistosoma mansoni retinoic acid receptor RXR 0.0015 0.0063 0.0084
Loa Loa (eye worm) hypothetical protein 0.0093 0.0812 0.6262
Echinococcus granulosus neuropeptide receptor 0.005 0.0397 0.0529
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0015 0.0063 0.0084
Brugia malayi jmjC domain containing protein 0.0012 0.0034 0.0047
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0015 0.0063 0.0084
Plasmodium vivax aldehyde reductase, putative 0.0036 0.0261 0.0863
Echinococcus granulosus lysine specific demethylase 5A 0.0049 0.039 0.052
Schistosoma mansoni amine GPCR 0.005 0.0397 0.0529
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0036 0.0261 0.2098
Echinococcus multilocularis alpha 1A adrenergic receptor 0.005 0.0397 0.0529
Schistosoma mansoni amine GPCR 0.005 0.0397 0.0529
Schistosoma mansoni neuropeptide receptor 0.005 0.0397 0.0529
Trichomonas vaginalis aldo-keto reductase, putative 0.0124 0.111 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.026
Loa Loa (eye worm) oxidoreductase 0.0124 0.111 0.8559
Entamoeba histolytica aldose reductase, putative 0.0124 0.111 1
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.0397 0.0529
Echinococcus granulosus dro:myosuppressin receptor 0.005 0.0397 0.0529
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0015 0.0063 0.0084
Brugia malayi RE15519p 0.005 0.0397 0.0548
Giardia lamblia Aldose reductase 0.0124 0.111 0.3749
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus multilocularis muscleblind protein 0.0144 0.1297 0.1729
Trypanosoma brucei protein kinase, putative 0.0089 0.0774 0.2898
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0046 0.0359 0.0479
Onchocerca volvulus 0.005 0.0397 0.0336
Onchocerca volvulus 0.005 0.0397 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0015 0.0063 0.0087
Brugia malayi putative neuropeptide receptor 0.005 0.0397 0.0548
Brugia malayi hypothetical protein 0.005 0.0397 0.0548
Loa Loa (eye worm) hypothetical protein 0.0124 0.111 0.8559
Echinococcus multilocularis lipoxygenase domain containing protein 0.0064 0.053 0.0706
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0089 0.0774 0.2898
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Brugia malayi G protein-coupled receptor F59B2.13 0.005 0.0397 0.0548
Echinococcus granulosus g protein coupled receptor 0.005 0.0397 0.0529
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.048 0.064
Schistosoma mansoni growth hormone secretagogue receptor 0.005 0.0397 0.0529
Leishmania major telomerase reverse transcriptase, putative 0.0287 0.267 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Brugia malayi steroid hormone receptor 0.0015 0.0063 0.0087
Echinococcus granulosus mitogen activated protein kinase 3 0.0089 0.0774 0.1032
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0529 0.1981
Schistosoma mansoni steroid hormone receptor ad4bp 0.0015 0.0063 0.0084
Schistosoma mansoni hypothetical protein 0.003 0.0199 0.0265
Toxoplasma gondii isocitrate dehydrogenase 0.0029 0.0199 0.0744
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0124 0.111 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0124 0.111 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0124 0.111 0.148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0397 0.0529
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0027 0.0177 0.0236
Toxoplasma gondii isocitrate dehydrogenase 0.0029 0.0199 0.0744
Onchocerca volvulus 0.005 0.0397 0.0336
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0063 0.0084
Trypanosoma brucei aldo-keto reductase, putative 0.0124 0.111 0.4157
Echinococcus granulosus orexin receptor type 2 0.005 0.0397 0.0529
Schistosoma mansoni hypothetical protein 0.005 0.0397 0.0529
Echinococcus multilocularis lysine specific demethylase 5A 0.0046 0.0359 0.0479
Echinococcus multilocularis ATP binding cassette sub family G 0.0027 0.0177 0.0236
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0124 0.111 0.148
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.021 0.1617
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0287 0.267 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0015 0.0063 0.0087
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.005 0.0397 0.0529
Onchocerca volvulus 0.005 0.0397 0.0336
Brugia malayi ecdysteroid receptor 0.0015 0.0063 0.0087
Loa Loa (eye worm) CYP4Cod1 0.0031 0.021 0.1617
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0015 0.0063 0.0084
Entamoeba histolytica hypothetical protein 0.0035 0.0248 0.076
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0529 0.0705
Onchocerca volvulus 0.0064 0.053 0.0469
Entamoeba histolytica aldose reductase, putative 0.0124 0.111 1
Echinococcus multilocularis neuropeptide s receptor 0.005 0.0397 0.0529
Trichomonas vaginalis CMGC family protein kinase 0.0089 0.0774 0.687
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0124 0.111 0.148
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Schistosoma mansoni hypothetical protein 0.005 0.0397 0.0529
Echinococcus multilocularis GPCR, family 2 0.003 0.0199 0.0265
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.0397 0.0529
Schistosoma mansoni hypothetical protein 0.003 0.0199 0.0265
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0382 0.3589 0.4786
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0036 0.0261 0.2015
Giardia lamblia Aldose reductase 0.0124 0.111 0.3749
Loa Loa (eye worm) isocitrate dehydrogenase 0.0029 0.0199 0.1532
Schistosoma mansoni rab6-interacting 0.0064 0.053 0.0706
Entamoeba histolytica hypothetical protein 0.0035 0.0248 0.076
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.005 0.0397 0.306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0397 0.0529
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0089 0.0774 0.2898
Echinococcus granulosus aldo keto reductase 0.0124 0.111 0.148
Toxoplasma gondii RNA-directed DNA polymerase 0.0287 0.267 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0248 0.0331
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.005 0.0397 0.0529
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.005 0.0397 0.0529
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0382 0.3589 0.4786
Schistosoma mansoni hypothetical protein 0.0035 0.0248 0.0331
Echinococcus multilocularis g protein coupled receptor 0.005 0.0397 0.0529
Loa Loa (eye worm) oxidoreductase 0.0124 0.111 0.8559
Onchocerca volvulus 0.0124 0.111 0.1053
Echinococcus granulosus alpha 1A adrenergic receptor 0.005 0.0397 0.0529
Schistosoma mansoni potassium channel beta 0.0036 0.0261 0.0348
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0397 0.0529
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0124 0.111 0.148
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0124 0.111 0.148
Schistosoma mansoni hypothetical protein 0.0064 0.053 0.0706
Echinococcus multilocularis aldo keto reductase 0.0124 0.111 0.148
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0397 0.0529
Trichomonas vaginalis aldo-keto reductase, putative 0.0124 0.111 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0124 0.111 1
Brugia malayi Cytochrome P450 family protein 0.0031 0.021 0.0289
Echinococcus granulosus biogenic amine 5HT receptor 0.005 0.0397 0.0529
Trichomonas vaginalis aldo-keto reductase, putative 0.0124 0.111 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0063 0.0488
Leishmania major prostaglandin f synthase, putative 0.0124 0.111 0.4157
Schistosoma mansoni hypothetical protein 0.0316 0.2955 0.394
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0397 0.0529
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0012 0.0034 0.0126
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0015 0.0063 0.0488
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0124 0.111 0.148
Echinococcus granulosus neuropeptides capa receptor 0.005 0.0397 0.0529
Trichomonas vaginalis aldo-keto reductase, putative 0.0124 0.111 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0064 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0774 0.1032
Trichomonas vaginalis aldo-keto reductase, putative 0.0036 0.0261 0.2098
Echinococcus granulosus neuropeptide Y receptor 0.005 0.0397 0.0529
Brugia malayi hypothetical protein 0.005 0.0397 0.0548
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0012 0.0034 0.0126
Brugia malayi Serotonin receptor 0.005 0.0397 0.0548
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0046 0.0359 0.0479
Echinococcus multilocularis thyroid hormone receptor alpha 0.0015 0.0063 0.0084
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.048 0.064
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0529 0.1981
Brugia malayi Dopamine receptor protein 1 0.005 0.0397 0.0548
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.005 0.0397 0.0529
Echinococcus granulosus hypothetical protein 0.0124 0.111 0.148
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.0199 0.0275
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.0199 0.0265
Trichomonas vaginalis aldo-keto reductase, putative 0.0124 0.111 1
Onchocerca volvulus 0.005 0.0397 0.0336
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0048 0.0063
Brugia malayi Doublecortin family protein 0.0064 0.053 0.0731
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.0313 0.0417
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0063 0.0084
Brugia malayi hypothetical protein 0.005 0.0397 0.0548
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0015 0.0063 0.0084
Trichomonas vaginalis aldo-keto reductase, putative 0.0124 0.111 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0063 0.0087
Trichomonas vaginalis aldo/keto reductase, putative 0.0124 0.111 1
Schistosoma mansoni hypothetical protein 0.0023 0.0134 0.0179
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0036 0.0261 0.0348
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0397 0.0529
Schistosoma mansoni alpha-1 adrenergic receptor 0.005 0.0397 0.0529
Echinococcus granulosus voltage gated potassium channel subunit 0.0036 0.0261 0.0348
Schistosoma mansoni polycystin 1-related 0.0064 0.053 0.0706
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0397 0.0529
Loa Loa (eye worm) G-protein coupled receptor 0.005 0.0397 0.306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0397 0.0529
Echinococcus granulosus ATP binding cassette sub family G 0.0027 0.0177 0.0236
Brugia malayi MAP kinase sur-1 0.0089 0.0774 0.1068
Mycobacterium leprae Conserved hypothetical protein 0.0088 0.0764 0.6882
Echinococcus multilocularis FTZ F1 alpha 0.0015 0.0063 0.0084
Schistosoma mansoni jumonji/arid domain-containing protein 0.0049 0.039 0.052
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0529 0.4079
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Plasmodium falciparum aldo-keto reductase, putative 0.0036 0.0261 0.0863
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.005 0.0397 0.0529
Schistosoma mansoni jumonji domain containing protein 0.0046 0.0359 0.0479
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0124 0.111 0.148
Entamoeba histolytica alcohol dehydrogenase, putative 0.0036 0.0261 0.0903
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0027 0.0177 0.1596
Schistosoma mansoni protein phosphatase 2C 0.0012 0.0034 0.0045
Trichomonas vaginalis aldo-keto reductase, putative 0.0124 0.111 1
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.021 0.0785
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0397 0.0529
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0036 0.0261 0.0979
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0529 0.073
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0118 0.1045 0.1393
Echinococcus multilocularis aldo keto reductase 0.0124 0.111 0.148
Schistosoma mansoni cpg binding protein 0.0055 0.0448 0.0597
Brugia malayi larval opioid receptor 0.005 0.0397 0.0548
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.0397 0.0529
Trypanosoma brucei cytochrome P450, putative 0.0031 0.021 0.0785
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0015 0.0063 0.0488
Onchocerca volvulus 0.0064 0.053 0.0469
Loa Loa (eye worm) hypothetical protein 0.0144 0.1297 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.306
Brugia malayi jmjC domain containing protein 0.0049 0.039 0.0538
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0397 0.0529
Schistosoma mansoni peptide (allatostatin)-like receptor 0.005 0.0397 0.0529
Schistosoma mansoni opsin-like receptor 0.005 0.0397 0.0529
Echinococcus multilocularis sex peptide receptor 0.005 0.0397 0.0529
Brugia malayi Calcitonin receptor-like protein seb-1 0.0093 0.0812 0.1121
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0027 0.0177 0.0663
Schistosoma mansoni aldo-keto reductase 0.0124 0.111 0.148
Onchocerca volvulus 0.005 0.0397 0.0336
Echinococcus granulosus neuropeptide FF receptor 2 0.005 0.0397 0.0529
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0124 0.111 0.1532
Schistosoma mansoni biogenic amine receptor 0.005 0.0397 0.0529
Loa Loa (eye worm) jmjC domain-containing protein 0.0012 0.0034 0.026
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0124 0.111 0.148
Echinococcus multilocularis jumonji domain containing 1A 0.0012 0.0034 0.0045
Onchocerca volvulus 0.005 0.0397 0.0336
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.0397 0.0529
Onchocerca volvulus 0.005 0.0397 0.0336
Onchocerca volvulus 0.0124 0.111 0.1053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0063 0.0087
Loa Loa (eye worm) oxidoreductase 0.0124 0.111 0.8559
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0124 0.111 0.1532
Echinococcus multilocularis isocitrate dehydrogenase 0.0029 0.0199 0.0265

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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