Detailed information for compound 627789

Basic information

Technical information
  • TDR Targets ID: 627789
  • Name: 7-butyl-5-[(2-fluorophenyl)methylsulfanyl]-1, 3-dimethylpyrimido[5,6-e]pyrimidine-2,4-dione
  • MW: 388.459 | Formula: C19H21FN4O2S
  • H donors: 0 H acceptors: 4 LogP: 3.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCc1nc(SCc2ccccc2F)c2c(n1)n(C)c(=O)n(c2=O)C
  • InChi: 1S/C19H21FN4O2S/c1-4-5-10-14-21-16-15(18(25)24(3)19(26)23(16)2)17(22-14)27-11-12-8-6-7-9-13(12)20/h6-9H,4-5,10-11H2,1-3H3
  • InChiKey: LTSINMPJQHFLNV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-butyl-5-[(2-fluorophenyl)methylsulfanyl]-1,3-dimethyl-pyrimido[5,6-e]pyrimidine-2,4-dione
  • 7-butyl-5-[(2-fluorophenyl)methylthio]-1,3-dimethylpyrimido[5,6-e]pyrimidine-2,4-dione
  • 7-butyl-5-[(2-fluorobenzyl)thio]-1,3-dimethyl-pyrimido[5,6-e]pyrimidine-2,4-quinone
  • ZINC04341244

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0029 0.0497 0.0685
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0215 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0773
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.1605 0.5668
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0048 0.1115 0.092
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0048 0.1115 0.3857
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0215 0.0304
Brugia malayi MH2 domain containing protein 0.0129 0.3803 0.5976
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0074 0.1955 0.3951
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1605 0.5776
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0023 0.0276 0.0763
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0813 0.1557
Echinococcus granulosus dna polymerase kappa 0.0021 0.0215 0.0304
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0098 0.2779 0.5679
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.1425 0.5001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0215 0.0232
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.4841 0.7638
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0703 0.1328
Trypanosoma brucei glucosidase, putative 0.0036 0.0703 0.2529
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0215 0.0536
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0098 0.2779 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0773
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 1 1
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0074 0.1955 0.5
Giardia lamblia Fructose-bisphosphate aldolase 0.0317 1 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0155 0.4641 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0703 0.0638
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0215 0.0773
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0074 0.1955 0.1898
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.1955 0.6957
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0773
Loa Loa (eye worm) hypothetical protein 0.0021 0.0215 0.0232
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0098 0.2779 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0215 0.0304
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1016 0.2348
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0025 0.0361 0.0294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1605 0.5776
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0098 0.2779 0.4338
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0703 0.1014
Trypanosoma brucei unspecified product 0.0021 0.0215 0.0773
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0074 0.1955 0.1898
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0074 0.1955 0.3951
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0074 0.1955 0.4677
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0074 0.1955 0.6957
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0155 0.4641 1
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0074 0.1955 0.7033
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.6316 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0023 0.0276 0.0763
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0773
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0813 0.1557
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 1 1
Onchocerca volvulus 0.0029 0.0497 0.0595
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0497 0.0897
Leishmania major cathepsin L-like protease 0.0063 0.1605 0.5668
Entamoeba histolytica hypothetical protein 0.0039 0.0813 0.0748
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0074 0.1955 0.6957
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0215 0.0773
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0074 0.1955 0.6957
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0215 0.0146
Plasmodium vivax SET domain protein, putative 0.0029 0.0497 0.1579
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.1955 0.1898
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0098 0.2779 1
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.3803 0.5976
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0703 0.1328
Onchocerca volvulus 0.0093 0.2599 0.352
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1016 0.1515
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.4841 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0703 0.0638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1605 0.5776
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.116 0.4023
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.4841 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0074 0.1955 0.6957
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0773
Entamoeba histolytica hypothetical protein 0.0039 0.0813 0.0748
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0215 0.036
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0703 0.0638
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0813 0.1843
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0215 0.0536
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0051 0.1201 0.1812
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0074 0.1955 0.7033
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.1955 0.6957
Brugia malayi hypothetical protein 0.0039 0.0813 0.119
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.1955 0.6957
Brugia malayi fructose-bisphosphate aldolase 2 0.0098 0.2779 0.4338
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0773
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0703 0.0638
Plasmodium falciparum fructose-bisphosphate aldolase 0.0098 0.2779 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1605 0.5776
Trichomonas vaginalis set domain proteins, putative 0.0234 0.7255 0.7236
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1605 0.5668
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0703 0.0638
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0048 0.1116 0.2193
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0773
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1016 0.1984
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0074 0.1955 0.3951
Echinococcus multilocularis dna polymerase eta 0.0021 0.0215 0.0304
Onchocerca volvulus 0.0234 0.7255 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.1955 0.1898
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0497 0.1061
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0048 0.1115 0.3857
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0317 1 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.4841 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1605 0.5776
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.4841 0.7638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1605 0.5776
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0098 0.2779 0.6723
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0023 0.0276 0.0763
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1016 0.2348
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1605 0.5776
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0461 0.0822
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0215 0.0773
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0074 0.1955 0.6957
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0155 0.4641 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0215 0.0146
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0703 0.0638
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0098 0.2779 1
Entamoeba histolytica hypothetical protein 0.0039 0.0813 0.0748
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0497 0.0897
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0023 0.0276 0.0763
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0025 0.0361 0.0467
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1605 0.5776
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0703 0.0638
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0098 0.2779 0.5679
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0497 0.1061
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0215 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0773
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0074 0.1955 0.1898
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0215 0.0536
Leishmania major fructose-1,6-bisphosphate aldolase 0.0098 0.2779 1
Entamoeba histolytica hypothetical protein 0.0039 0.0813 0.0748
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0074 0.1955 0.4677
Schistosoma mansoni alpha-glucosidase 0.0138 0.4101 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1605 0.5668
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0074 0.1955 0.3018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1605 0.5776
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0215 0.036
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0098 0.2779 0.5679
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0074 0.1955 0.4677
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0703 0.1014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0497 0.1061
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0098 0.2779 0.6723
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0098 0.2779 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0703 0.0638
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0703 0.2338
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.1955 0.6957
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0074 0.1955 0.6957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1605 0.5776
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0703 0.0638
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0051 0.1201 0.1812
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1016 0.1984
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1605 0.5776
Schistosoma mansoni alpha-glucosidase 0.0138 0.4101 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1016 0.1984
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0098 0.2779 1
Leishmania major cathepsin L-like protease 0.0063 0.1605 0.5668
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0023 0.0276 0.0763
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 1 1
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0098 0.2779 1
Echinococcus granulosus dna polymerase eta 0.0021 0.0215 0.0304
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0098 0.2779 0.4338
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0074 0.1955 0.5
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0703 0.0638
Leishmania major DNA polymerase eta, putative 0.0021 0.0215 0.0536
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0074 0.1955 0.4677
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0025 0.0363 0.0335
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1016 0.1515
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0098 0.2779 0.5679
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0048 0.1116 0.1675
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.1955 0.1898
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0074 0.1955 0.3931
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0098 0.2779 0.5679
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.1955 0.1898
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0074 0.1955 0.6957
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0215 0.0536
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0497 0.1579
Treponema pallidum fructose-bisphosphate aldolase 0.0317 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0497 0.1061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1016 0.2348
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 1 1
Schistosoma mansoni hypothetical protein 0.0039 0.0813 0.1843
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0215 0.0304
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0074 0.1955 0.6957
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0074 0.1955 0.3951
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0703 0.2338
Schistosoma mansoni alpha glucosidase 0.0036 0.0703 0.1572
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0773
Leishmania major DNA polymerase kappa, putative 0.0021 0.0215 0.0536
Schistosoma mansoni DNA polymerase eta 0.0021 0.0215 0.036
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0048 0.1116 0.1054
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0074 0.1955 0.6957
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0098 0.2779 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0703 0.2338
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0703 0.2338
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0074 0.1955 0.7033
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0098 0.2779 0.5679
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0048 0.1116 0.1054
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0074 0.1955 0.1898
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1016 0.1984
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0497 0.0897
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0703 0.0638
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0048 0.1115 0.4011
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0098 0.2779 0.5679
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0098 0.2779 0.5679
Loa Loa (eye worm) hypothetical protein 0.0048 0.1116 0.1675
Brugia malayi fructose-bisphosphate aldolase 1 0.0098 0.2779 0.4338
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0215 0.0536
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0098 0.2779 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0048 0.1116 0.2193
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0215 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0215 0.0773
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0048 0.1115 0.3857
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0074 0.1955 0.1778
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.3803 0.5976
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0023 0.0276 0.0331
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0215 0.0536
Brugia malayi Pre-SET motif family protein 0.0029 0.0497 0.0685
Leishmania major cathepsin L-like protease 0.0063 0.1605 0.5668
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0048 0.1116 0.1675
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0317 1 1
Brugia malayi Pre-SET motif family protein 0.0205 0.6316 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1605 0.5668
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0215 0.0773

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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