TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 323.346 | Formula: C18H17N3O3
H donors: 2 H acceptors: 3 LogP: 2.79 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1O)/C=N/c1c(C)n(n(c1=O)c1ccccc1)C
InChi: 1S/C18H17N3O3/c1-12-17(19-11-13-8-9-15(22)16(23)10-13)18(24)21(20(12)2)14-6-4-3-5-7-14/h3-11,22-23H,1-2H3/b19-11+
InChiKey: WQLJNMMVTZYNSO-YBFXNURJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	AMP-binding enzyme family protein	0.0059	0.0058	0.0428
Entamoeba histolytica	Flap nuclease, putative	0.003	0.0018	0.0455
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0059	0.0058	0.0152
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0059	0.0058	0.1433
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0202	0.0251	0.0679
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.0065	1
Toxoplasma gondii	propionate-CoA ligase	0.0059	0.0058	0.1796
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0252	0.0321	0.0866
Giardia lamblia	Flap structure-specific endonuclease	0.003	0.0018	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0003	0.0003
Schistosoma mansoni	ferritin light chain	0.0018	0.0002	0.0002
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0059	0.0058	0.0152
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0059	0.0058	0.8893
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0182	0.1353
Mycobacterium ulcerans	acyl-CoA synthetase	0.0059	0.0058	0.0152
Entamoeba histolytica	hypothetical protein	0.0312	0.0402	1
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0087	0.0095	0.0254
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0252	0.0321	1
Plasmodium vivax	flap endonuclease 1, putative	0.003	0.0018	0.057
Onchocerca volvulus		0.0059	0.0058	0.0574
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0252	0.0321	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0059	0.0058	0.0428
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0252	0.0321	0.0866
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0059	0.0058	0.0152
Onchocerca volvulus		0.0095	0.0106	0.106
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0059	0.0058	0.0152
Echinococcus multilocularis	tumor protein p63	0.1803	0.2432	0.2432
Brugia malayi	Pre-SET motif family protein	0.0663	0.0879	0.6532
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0151	0.0182	0.049
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0202	0.0251	0.0679
Echinococcus granulosus	histone lysine methyltransferase setb	0.0095	0.0106	0.0106
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0059	0.0058	0.0152
Entamoeba histolytica	acyl-coA synthetase, putative	0.0202	0.0251	0.6261
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0165	0.0202	0.0545
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0059	0.0058	0.0152
Echinococcus multilocularis	expressed protein	0.0018	0.0002	0.0002
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0252	0.0321	1
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0059	0.0058	0.0152
Onchocerca volvulus		0.0264	0.0336	0.3351
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0202	0.0251	0.0679
Mycobacterium ulcerans	acyl-CoA synthetase	0.0202	0.0251	0.0679
Trichomonas vaginalis	ferritin, putative	0.0018	0.0002	0.0017
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0202	0.0251	0.0679
Entamoeba histolytica	hypothetical protein	0.0312	0.0402	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0095	0.0106	0.0106
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0059	0.0057	0.8824
Schistosoma mansoni	apoferritin-2	0.0018	0.0002	0.0002
Echinococcus multilocularis	ferritin	0.0018	0.0002	0.0002
Brugia malayi	Flap endonuclease-1	0.003	0.0018	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0251	0.1869
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0059	0.0058	0.0428
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.003	0.0018	0.057
Leishmania major	4-coumarate:coa ligase-like protein	0.0202	0.0251	1
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0059	0.0058	0.2289
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0059	0.0058	0.0152
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0312	0.0402	0.0402
Brugia malayi	AMP-binding enzyme family protein	0.0059	0.0058	0.0428
Schistosoma mansoni	ferritin	0.0018	0.0002	0.0002
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0059	0.0058	0.0152
Schistosoma mansoni	acetyl-CoA synthetase	0.0059	0.0058	0.0058
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0165	0.0202	0.0202
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0059	0.0058	0.0152
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0065	1
Echinococcus granulosus	flap endonuclease 1	0.003	0.0018	0.0018
Schistosoma mansoni	ferritin	0.0018	0.0002	0.0002
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0059	0.0058	0.0152
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0663	0.0879	0.6532
Schistosoma mansoni	hypothetical protein	0.0019	0.0003	0.0003
Plasmodium falciparum	acyl-CoA synthetase	0.0151	0.0182	0.568
Echinococcus granulosus	tumor protein p63	0.1803	0.2432	0.2432
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0252	0.0321	1
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0059	0.0058	0.0152
Onchocerca volvulus		0.0059	0.0058	0.0574
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0059	0.0058	0.0152
Schistosoma mansoni	cellular tumor antigen P53	0.0264	0.0336	0.0336
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0252	0.0321	0.0866
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0058	0.0434
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0202	0.0251	0.0679
Loa Loa (eye worm)	flap endonuclease-1	0.003	0.0018	0.0136
Entamoeba histolytica	hypothetical protein	0.0312	0.0402	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0095	0.0106	0.0106
Echinococcus granulosus	expressed protein	0.0018	0.0002	0.0002
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0087	0.0095	0.2936
Entamoeba histolytica	hypothetical protein	0.0312	0.0402	1
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0059	0.0058	0.1796
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0087	0.0095	0.2974
Echinococcus multilocularis	flap endonuclease 1	0.003	0.0018	0.0018
Mycobacterium ulcerans	acyl-CoA synthetase	0.0202	0.0251	0.0679
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0059	0.0058	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0058	0.0428
Brugia malayi	AMP-binding enzyme family protein	0.0059	0.0058	0.0428
Toxoplasma gondii	hypothetical protein	0.0087	0.0095	0.2974
Schistosoma mansoni	hypothetical protein	0.0312	0.0402	0.0402
Plasmodium falciparum	flap endonuclease 1	0.003	0.0018	0.057
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0065	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0252	0.0321	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0058	0.0434
Schistosoma mansoni	transcription factor LCR-F1	0.0312	0.0402	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0106	0.079
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0065	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0059	0.0058	0.0428
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0003	0.0003
Schistosoma mansoni	ferritin	0.0018	0.0002	0.0002
Mycobacterium ulcerans	acyl-CoA synthetase	0.0059	0.0058	0.0152
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0202	0.0251	0.0679
Mycobacterium tuberculosis	PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0051	0.0046	0.0121
Mycobacterium ulcerans	acyl-CoA synthetase	0.0059	0.0058	0.0152
Schistosoma mansoni	flap endonuclease-1	0.0027	0.0014	0.0014
Mycobacterium ulcerans	acyl-CoA synthetase	0.0059	0.0058	0.0152
Echinococcus multilocularis	microtubule associated protein 2	0.7363	1	1
Schistosoma mansoni	hypothetical protein	0.0205	0.0256	0.0256
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0065	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0059	0.0058	0.0152
Trichomonas vaginalis	antibiotic synthetase, putative	0.0059	0.0058	0.0574
Echinococcus granulosus	survival motor neuron protein 1	0.1005	0.1345	0.1345
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0058	0.0434
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0059	0.0058	0.0152
Echinococcus granulosus	peptidase Clp S14 family	0.0165	0.0202	0.0202
Loa Loa (eye worm)	hypothetical protein	0.006	0.0058	0.0434
Mycobacterium ulcerans	AcrR family transcriptional regulator	0.2721	0.3681	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0003	0.0003
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0205	0.0256	0.1903
Mycobacterium leprae	Probable transcriptional regulatory repressor protein (TetR-family) EthR	0.2721	0.3681	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0003	0.0003
Trichomonas vaginalis	flap endonuclease-1, putative	0.003	0.0018	0.0182
Schistosoma mansoni	hypothetical protein	0.0041	0.0033	0.0033
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0095	0.0106	0.0106
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0095	0.0106	0.0106
Mycobacterium leprae	POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE)	0.0059	0.0058	0.0152
Mycobacterium ulcerans	acyl-CoA synthetase	0.0059	0.0058	0.0152
Leishmania major	cathepsin L-like protease	0.0064	0.0065	0.2574
Leishmania major	acetyl-CoA synthetase, putative	0.0059	0.0058	0.2289
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0059	0.0058	0.0152
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0059	0.0058	0.0058
Mycobacterium ulcerans	hypothetical protein	0.0202	0.0251	0.0679
Loa Loa (eye worm)	hypothetical protein	0.0264	0.0336	0.2499
Leishmania major	cathepsin L-like protease	0.0064	0.0065	0.2574
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0059	0.0058	0.1796
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0142	0.0171	0.046
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0065	1
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0059	0.0058	0.0152
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0142	0.0171	0.046
Leishmania major	acetyl-CoA synthetase, putative	0.0059	0.0058	0.2289
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0202	0.0251	0.0679
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0252	0.0321	1
Schistosoma mansoni	peptidase Clp (S14 family)	0.0252	0.0321	0.0321
Loa Loa (eye worm)	hypothetical protein	0.1005	0.1345	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0202	0.0251	0.0679
Brugia malayi	Pre-SET motif family protein	0.0095	0.0106	0.079
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.003	0.0018	0.2825
Leishmania major	4-coumarate:coa ligase-like protein	0.0202	0.0251	1
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.003	0.0018	0.0727
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0003	0.002
Echinococcus granulosus	ferritin	0.0018	0.0002	0.0002
Schistosoma mansoni	survival motor neuron protein	0.0205	0.0256	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0252	0.0321	0.2382
Echinococcus multilocularis	survival motor neuron protein 1	0.1005	0.1345	0.1345
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0202	0.0251	0.6261
Brugia malayi	AMP-binding enzyme family protein	0.0059	0.0058	0.0428
Brugia malayi	Probable ClpP-like protease	0.0252	0.0321	0.2382
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0033	0.0242
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	0.2721	0.3681	1
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0252	0.0321	0.0321
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0059	0.0058	0.0058
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0059	0.0058	0.8893
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0095	0.0106	0.0106
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0003	0.0003
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0142	0.0171	0.046
Trichomonas vaginalis	antibiotic synthetase, putative	0.0059	0.0058	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0003	0.002
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0033	0.0242
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0065	1
Onchocerca volvulus		0.0059	0.0058	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0182	0.1353
Schistosoma mansoni	hypothetical protein	0.0019	0.0003	0.0003
Mycobacterium ulcerans	transcriptional regulator	0.2721	0.3681	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0065	1
Plasmodium vivax	SET domain protein, putative	0.0095	0.0106	0.3317
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0065	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0065	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0059	0.0058	0.0152
Loa Loa (eye worm)	oxidoreductase	0.0059	0.0058	0.0428
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0092	0.0102	0.0102
Mycobacterium leprae	POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0059	0.0058	0.0152
Schistosoma mansoni	ferritin light chain	0.0018	0.0002	0.0002
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0059	0.0058	0.8893
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0202	0.0251	0.0679
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0059	0.0058	0.1796
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0059	0.0058	0.0152
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0151	0.0182	0.049
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0059	0.0058	0.0428
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0202	0.0251	0.6261
Onchocerca volvulus		0.0202	0.0251	0.2506
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0087	0.0095	0.2974
Brugia malayi	hypothetical protein	0.0312	0.0402	0.2985
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0059	0.0058	0.8457
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0059	0.0058	0.8457
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0065	1
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0059	0.0058	0.8893
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0095	0.0106	0.3317
Onchocerca volvulus		0.0205	0.0256	0.2552
Schistosoma mansoni	ferritin	0.0018	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0019	0.0003	0.0003
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0059	0.0058	0.0152
Onchocerca volvulus		0.0754	0.1003	1
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0059	0.0058	0.1796
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0142	0.0171	0.046
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0065	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0003	0.002
Schistosoma mansoni	apoferritin-2	0.0018	0.0002	0.0002
Mycobacterium ulcerans	TetR family transcriptional regulator	0.2721	0.3681	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0182	0.1353
Plasmodium vivax	acyl-CoA synthetase, putative	0.0151	0.0182	0.568
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0252	0.0321	0.0321
Trichomonas vaginalis	set domain proteins, putative	0.0754	0.1003	1
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0059	0.0058	0.0152
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0003	0.0003
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0059	0.0058	0.0152
Onchocerca volvulus		0.0059	0.0058	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0182	0.1353
Mycobacterium ulcerans	acyl-CoA synthetase	0.0059	0.0058	0.0152
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0003	0.002
Brugia malayi	AMP-binding enzyme family protein	0.0202	0.0251	0.1869
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0065	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0165	0.0202	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0251	0.1869
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0165	0.0202	0.0545
Brugia malayi	AMP-binding enzyme family protein	0.0202	0.0251	0.1869
Brugia malayi	hypothetical protein	0.1005	0.1345	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0252	0.0321	1
Leishmania major	cathepsin L-like protease	0.0064	0.0065	0.2574
Schistosoma mansoni	microtubule-associated protein tau	0.7363	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0182	0.1353
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0065	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0312	0.0402	0.0402
Brugia malayi	AMP-binding enzyme family protein	0.0202	0.0251	0.1869
Trypanosoma cruzi	major cysteine proteinase, putative	0.0051	0.0046	0.7098
Echinococcus granulosus	GPCR family 2	0.0019	0.0003	0.0003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0065	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0058	0.0428
Leishmania major	4-coumarate:coa ligase-like protein	0.0202	0.0251	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0252	0.0321	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0095	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0251	0.1869

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 651574