Detailed information for compound 651574

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 323.346 | Formula: C18H17N3O3
  • H donors: 2 H acceptors: 3 LogP: 2.79 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1O)/C=N/c1c(C)n(n(c1=O)c1ccccc1)C
  • InChi: 1S/C18H17N3O3/c1-12-17(19-11-13-8-9-15(22)16(23)10-13)18(24)21(20(12)2)14-6-4-3-5-7-14/h3-11,22-23H,1-2H3/b19-11+
  • InChiKey: WQLJNMMVTZYNSO-YBFXNURJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0003 0.002
Schistosoma mansoni hypothetical protein 0.0019 0.0003 0.0003
Mycobacterium ulcerans acetyl-CoA synthetase 0.0059 0.0058 0.0152
Brugia malayi AMP-binding enzyme family protein 0.0202 0.0251 0.1869
Onchocerca volvulus 0.0059 0.0058 0.0574
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0046 0.0121
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0003 0.0003
Brugia malayi Pre-SET motif family protein 0.0095 0.0106 0.079
Brugia malayi Pre-SET motif family protein 0.0663 0.0879 0.6532
Mycobacterium ulcerans TetR family transcriptional regulator 0.2721 0.3681 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0018 0.057
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0095 0.0106 0.0106
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0059 0.0058 0.1433
Schistosoma mansoni hypothetical protein 0.0205 0.0256 0.0256
Entamoeba histolytica acyl-CoA synthetase, putative 0.0202 0.0251 0.6261
Mycobacterium ulcerans acyl-CoA synthetase 0.0202 0.0251 0.0679
Echinococcus multilocularis flap endonuclease 1 0.003 0.0018 0.0018
Echinococcus granulosus expressed protein 0.0018 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0151 0.0182 0.1353
Loa Loa (eye worm) hypothetical protein 0.0019 0.0003 0.002
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0018 0.2825
Brugia malayi Probable ClpP-like protease 0.0252 0.0321 0.2382
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0059 0.0058 0.2289
Schistosoma mansoni ferritin light chain 0.0018 0.0002 0.0002
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0087 0.0095 0.0254
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0059 0.0058 0.0152
Brugia malayi AMP-binding enzyme family protein 0.0059 0.0058 0.0428
Trichomonas vaginalis antibiotic synthetase, putative 0.0059 0.0058 0.0574
Leishmania major 4-coumarate:coa ligase-like protein 0.0202 0.0251 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0252 0.0321 0.0866
Loa Loa (eye worm) hypothetical protein 0.0151 0.0182 0.1353
Loa Loa (eye worm) hypothetical protein 0.0095 0.0106 0.079
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0059 0.0058 0.0152
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0142 0.0171 0.046
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0059 0.0058 0.0058
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0059 0.0058 0.0152
Onchocerca volvulus 0.0059 0.0058 0.0574
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0252 0.0321 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0142 0.0171 0.046
Schistosoma mansoni flap endonuclease-1 0.0027 0.0014 0.0014
Toxoplasma gondii hypothetical protein 0.0087 0.0095 0.2974
Mycobacterium ulcerans acyl-CoA synthetase 0.0059 0.0058 0.0152
Loa Loa (eye worm) hypothetical protein 0.0059 0.0058 0.0428
Echinococcus granulosus peptidase Clp S14 family 0.0165 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0202 0.0251 0.1869
Loa Loa (eye worm) hypothetical protein 0.006 0.0058 0.0434
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0059 0.0058 0.0428
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0059 0.0058 0.0152
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0202 0.0251 0.0679
Mycobacterium ulcerans acyl-CoA synthetase 0.0059 0.0058 0.0152
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0202 0.0251 0.0679
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0095 0.2936
Trichomonas vaginalis antibiotic synthetase, putative 0.0059 0.0058 0.0574
Loa Loa (eye worm) hypothetical protein 0.0264 0.0336 0.2499
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0059 0.0058 0.0152
Schistosoma mansoni hypothetical protein 0.0041 0.0033 0.0033
Onchocerca volvulus 0.0754 0.1003 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0059 0.0058 0.8893
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0065 1
Brugia malayi AMP-binding enzyme family protein 0.0202 0.0251 0.1869
Entamoeba histolytica hypothetical protein 0.0312 0.0402 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0106 0.0106
Trichomonas vaginalis set domain proteins, putative 0.0754 0.1003 1
Onchocerca volvulus 0.0095 0.0106 0.106
Leishmania major cathepsin L-like protease 0.0064 0.0065 0.2574
Schistosoma mansoni peptidase Clp (S14 family) 0.0252 0.0321 0.0321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0065 1
Echinococcus granulosus flap endonuclease 1 0.003 0.0018 0.0018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0202 0.0251 0.6261
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0151 0.0182 0.049
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0059 0.0058 0.1796
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0059 0.0058 0.0152
Brugia malayi hypothetical protein 0.1005 0.1345 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0095 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0151 0.0182 0.1353
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0059 0.0058 0.0152
Schistosoma mansoni ferritin 0.0018 0.0002 0.0002
Leishmania major acetyl-CoA synthetase, putative 0.0059 0.0058 0.2289
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0095 0.2974
Plasmodium falciparum flap endonuclease 1 0.003 0.0018 0.057
Loa Loa (eye worm) hypothetical protein 0.0059 0.0058 0.0428
Mycobacterium ulcerans acyl-CoA synthetase 0.0059 0.0058 0.0152
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0059 0.0058 0.8457
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0033 0.0242
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0059 0.0058 0.0152
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0202 0.0251 0.0679
Loa Loa (eye worm) hypothetical protein 0.0202 0.0251 0.1869
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0092 0.0102 0.0102
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0058 0.0434
Loa Loa (eye worm) hypothetical protein 0.1005 0.1345 1
Leishmania major acetyl-CoA synthetase, putative 0.0059 0.0058 0.2289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0065 1
Trichomonas vaginalis ferritin, putative 0.0018 0.0002 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0065 1
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0059 0.0058 0.0152
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0059 0.0058 0.8457
Brugia malayi AMP-binding enzyme family protein 0.0202 0.0251 0.1869
Loa Loa (eye worm) hypothetical protein 0.0151 0.0182 0.1353
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0018 0.5
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0165 0.0202 0.0545
Mycobacterium ulcerans acyl-CoA synthetase 0.0059 0.0058 0.0152
Onchocerca volvulus 0.0264 0.0336 0.3351
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0059 0.0058 0.1796
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0059 0.0058 0.0152
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0095 0.2974
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0252 0.0321 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0059 0.0058 0.0428
Leishmania major cathepsin L-like protease 0.0064 0.0065 0.2574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0065 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.0182 0.1353
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0059 0.0058 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0095 0.0106 0.0106
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0252 0.0321 1
Loa Loa (eye worm) oxidoreductase 0.0059 0.0058 0.0428
Schistosoma mansoni ferritin 0.0018 0.0002 0.0002
Onchocerca volvulus 0.0059 0.0058 0.0574
Echinococcus multilocularis survival motor neuron protein 1 0.1005 0.1345 0.1345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0065 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0106 0.0106
Schistosoma mansoni ferritin 0.0018 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0059 0.0058 0.0428
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0059 0.0058 0.0152
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0059 0.0058 0.8893
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0059 0.0058 0.8893
Entamoeba histolytica acyl-coA synthetase, putative 0.0202 0.0251 0.6261
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0018 0.0136
Schistosoma mansoni hypothetical protein 0.0312 0.0402 0.0402
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0059 0.0058 0.0428
Leishmania major cathepsin L-like protease 0.0064 0.0065 0.2574
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0059 0.0058 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0065 1
Toxoplasma gondii propionate-CoA ligase 0.0059 0.0058 0.1796
Schistosoma mansoni hypothetical protein 0.0019 0.0003 0.0003
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0018 0.0182
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0059 0.0058 0.0152
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0058 0.0434
Echinococcus multilocularis peptidase Clp (S14 family) 0.0165 0.0202 0.0202
Schistosoma mansoni survival motor neuron protein 0.0205 0.0256 0.0256
Entamoeba histolytica hypothetical protein 0.0312 0.0402 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0142 0.0171 0.046
Mycobacterium ulcerans acyl-CoA synthetase 0.0059 0.0058 0.0152
Echinococcus granulosus ferritin 0.0018 0.0002 0.0002
Brugia malayi hypothetical protein 0.0312 0.0402 0.2985
Plasmodium vivax acetyl-CoA synthetase, putative 0.0059 0.0058 0.1796
Loa Loa (eye worm) hypothetical protein 0.0041 0.0033 0.0242
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0059 0.0058 0.0152
Echinococcus granulosus survival motor neuron protein 1 0.1005 0.1345 0.1345
Schistosoma mansoni ferritin light chain 0.0018 0.0002 0.0002
Schistosoma mansoni cellular tumor antigen P53 0.0264 0.0336 0.0336
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0059 0.0058 0.0428
Leishmania major 4-coumarate:coa ligase-like protein 0.0202 0.0251 1
Schistosoma mansoni hypothetical protein 0.0019 0.0003 0.0003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0252 0.0321 0.2382
Mycobacterium ulcerans transcriptional regulator 0.2721 0.3681 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0252 0.0321 0.0866
Plasmodium falciparum acyl-CoA synthetase 0.0151 0.0182 0.568
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0142 0.0171 0.046
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0252 0.0321 1
Schistosoma mansoni transcription factor LCR-F1 0.0312 0.0402 0.0402
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2721 0.3681 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0252 0.0321 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0202 0.0251 0.0679
Mycobacterium ulcerans acyl-CoA synthetase 0.0059 0.0058 0.0152
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0151 0.0182 0.049
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0059 0.0058 0.0152
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0252 0.0321 0.0321
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0018 0.0727
Mycobacterium ulcerans acyl-CoA synthetase 0.0059 0.0058 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0065 1
Schistosoma mansoni microtubule-associated protein tau 0.7363 1 1
Echinococcus granulosus tumor protein p63 0.1803 0.2432 0.2432
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0059 0.0058 0.0152
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2721 0.3681 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0202 0.0251 0.0679
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0018 0.057
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0003 0.002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0663 0.0879 0.6532
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0059 0.0058 0.0152
Mycobacterium ulcerans acyl-CoA synthetase 0.0059 0.0058 0.0152
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0065 1
Echinococcus multilocularis tumor protein p63 0.1803 0.2432 0.2432
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.0106 0.3317
Echinococcus multilocularis ferritin 0.0018 0.0002 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0058 0.0434
Echinococcus multilocularis GPCR, family 2 0.0019 0.0003 0.0003
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0046 0.7098
Schistosoma mansoni ferritin 0.0018 0.0002 0.0002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0202 0.0251 0.0679
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0165 0.0202 0.0545
Schistosoma mansoni apoferritin-2 0.0018 0.0002 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0003 0.0003
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0059 0.0058 0.8893
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0065 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0252 0.0321 1
Plasmodium vivax SET domain protein, putative 0.0095 0.0106 0.3317
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0065 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0252 0.0321 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0065 1
Schistosoma mansoni acetyl-CoA synthetase 0.0059 0.0058 0.0058
Plasmodium vivax acyl-CoA synthetase, putative 0.0151 0.0182 0.568
Echinococcus granulosus GPCR family 2 0.0019 0.0003 0.0003
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0065 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0003 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0106 0.0106
Brugia malayi AMP-binding enzyme family protein 0.0059 0.0058 0.0428
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0059 0.0058 0.1796
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0165 0.0202 0.0545
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0252 0.0321 0.0321
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0312 0.0402 0.0402
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0205 0.0256 0.1903
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0202 0.0251 0.0679
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0057 0.8824
Entamoeba histolytica hypothetical protein 0.0312 0.0402 1
Schistosoma mansoni hypothetical protein 0.0019 0.0003 0.0003
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0059 0.0058 0.0152
Onchocerca volvulus 0.0205 0.0256 0.2552
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0003 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0202 0.0251 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0202 0.0251 0.0679
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0003 0.0003
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0252 0.0321 0.0866
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0312 0.0402 0.0402
Entamoeba histolytica hypothetical protein 0.0312 0.0402 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0252 0.0321 1
Entamoeba histolytica Flap nuclease, putative 0.003 0.0018 0.0455
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0059 0.0058 0.0152
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0202 0.0251 0.0679
Echinococcus multilocularis microtubule associated protein 2 0.7363 1 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0059 0.0058 0.0152
Echinococcus multilocularis expressed protein 0.0018 0.0002 0.0002
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0059 0.0058 0.0152
Brugia malayi AMP-binding enzyme family protein 0.0059 0.0058 0.0428
Onchocerca volvulus 0.0059 0.0058 0.0574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0065 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0059 0.0058 0.0152
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2721 0.3681 1
Schistosoma mansoni apoferritin-2 0.0018 0.0002 0.0002
Brugia malayi Flap endonuclease-1 0.003 0.0018 0.0136
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0202 0.0251 0.0679
Mycobacterium ulcerans hypothetical protein 0.0202 0.0251 0.0679
Onchocerca volvulus 0.0202 0.0251 0.2506
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0065 1
Loa Loa (eye worm) hypothetical protein 0.0202 0.0251 0.1869

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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