Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA topoisomerase type IB small subunit | 0.0052 | 0.1656 | 0.2774 |
Echinococcus granulosus | dna polymerase eta | 0.0067 | 0.2257 | 0.2827 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0125 | 0.4609 | 0.4606 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1062 | 0.1316 |
Onchocerca volvulus | 0.0242 | 0.9349 | 1 | |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0039 | 0.11 | 0.1378 |
Schistosoma mansoni | DNA polymerase eta | 0.0067 | 0.2257 | 0.2815 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0042 | 0.0037 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0017 | 0.0204 | 0.0244 |
Leishmania major | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0792 | 0.0992 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0039 | 0.11 | 0.1096 |
Echinococcus granulosus | jumonji domain containing protein | 0.0042 | 0.1257 | 0.1575 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0067 | 0.2257 | 0.2253 |
Brugia malayi | Pre-SET motif family protein | 0.0212 | 0.816 | 0.8159 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0204 | 0.0256 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.6738 | 0.8437 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0208 | 0.7984 | 1 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0031 | 0.0772 | 0.0967 |
Trypanosoma brucei | unspecified product | 0.0028 | 0.0664 | 0.107 |
Brugia malayi | Bromodomain containing protein | 0.0031 | 0.0772 | 0.0767 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0792 | 0.0787 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0017 | 0.0204 | 0.0256 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0212 | 0.816 | 0.8159 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.004 | 0.1173 | 0.1945 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0017 | 0.0204 | 0.0244 |
Trichomonas vaginalis | set domain proteins, putative | 0.0242 | 0.9349 | 1 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0208 | 0.7984 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0792 | 0.0977 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0013 | 0.0042 | 0.004 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.0772 | 0.092 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0037 | 0.1033 | 0.1294 |
Brugia malayi | MH2 domain containing protein | 0.0125 | 0.4609 | 0.4606 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0204 | 0.0256 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0204 | 0.0205 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.004 | 0.1173 | 1 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0156 | 0.586 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0017 | 0.0204 | 0.0205 |
Brugia malayi | jmjC domain containing protein | 0.01 | 0.3592 | 0.3589 |
Plasmodium vivax | topoisomerase I, putative | 0.0208 | 0.7984 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0604 | 0.0967 |
Trypanosoma brucei | unspecified product | 0.0028 | 0.0664 | 0.107 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.004 | 0.1173 | 0.147 |
Mycobacterium ulcerans | DNA polymerase IV | 0.004 | 0.1173 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0156 | 0.586 | 0.7336 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0017 | 0.0204 | 0.024 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1062 | 0.1316 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0156 | 0.586 | 1 |
Trypanosoma cruzi | DNA topoisomerase type IB small subunit, putative | 0.0052 | 0.1656 | 0.2774 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0156 | 0.586 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0604 | 0.0745 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.2092 | 0.2088 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0017 | 0.0204 | 0.0279 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0017 | 0.0204 | 0.0256 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0156 | 0.586 | 0.7336 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0042 | 0.1257 | 0.1575 |
Brugia malayi | polk-prov protein | 0.0013 | 0.0042 | 0.0037 |
Echinococcus granulosus | dna polymerase kappa | 0.004 | 0.1173 | 0.147 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0125 | 0.4609 | 0.4606 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.004 | 0.1173 | 0.1169 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Brugia malayi | PHD-finger family protein | 0.0031 | 0.0772 | 0.0767 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0604 | 0.0599 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0204 | 0.0279 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0208 | 0.7984 | 0.7982 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0719 | 0.0715 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0028 | 0.0664 | 0.107 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0067 | 0.2257 | 0.3807 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0772 | 0.0952 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0.0772 | 0.6452 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0719 | 0.0886 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0204 | 0.0256 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0792 | 0.0945 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.004 | 0.1173 | 0.147 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.004 | 0.1173 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0787 | 0.0986 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0052 | 0.1656 | 0.2774 |
Brugia malayi | jmjC domain containing protein | 0.0039 | 0.11 | 0.1096 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0792 | 0.0977 |
Leishmania major | DNA polymerase eta, putative | 0.0067 | 0.2257 | 0.3807 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0787 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0792 | 0.0787 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0604 | 0.0745 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0719 | 0.0715 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0604 | 0.0708 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.1173 | 0.1945 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.2257 | 0.2253 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0012 | 0.0013 | 0.0016 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0017 | 0.0204 | 0.0199 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1062 | 0.1058 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0013 | 0.0042 | 0.004 |
Schistosoma mansoni | jumonji domain containing protein | 0.0079 | 0.2758 | 0.3444 |
Echinococcus granulosus | peregrin | 0.0031 | 0.0772 | 0.0967 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0028 | 0.0664 | 0.107 |
Echinococcus granulosus | geminin | 0.0177 | 0.6738 | 0.8439 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.004 | 0.1173 | 0.1169 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0792 | 0.0977 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0012 | 0.0013 | 0.0016 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.002 | 0.0345 | 0.034 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.004 | 0.1173 | 0.1456 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.004 | 0.1173 | 0.1456 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.1173 | 0.1945 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.1173 | 0.1945 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0031 | 0.0772 | 0.0967 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0604 | 0.0967 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.11 | 0.1364 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0067 | 0.2257 | 0.3807 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0017 | 0.0204 | 0.0279 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0604 | 0.0745 |
Giardia lamblia | DINP protein human, muc B family | 0.004 | 0.1173 | 1 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0208 | 0.7984 | 1 |
Echinococcus multilocularis | peregrin | 0.0031 | 0.0772 | 0.0967 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0772 | 0.0767 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.6738 | 0.8437 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0204 | 0.0279 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1062 | 0.133 |
Brugia malayi | isocitrate dehydrogenase | 0.0017 | 0.0204 | 0.0199 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0787 | 0.0986 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0604 | 0.0599 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0056 | 0.1826 | 0.2247 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Mycobacterium ulcerans | DNA polymerase IV | 0.004 | 0.1173 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0018 | 0.0278 | 0.0332 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.01 | 0.3592 | 0.45 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0224 | 0.0219 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.1173 | 0.1945 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0039 | 0.1125 | 0.1364 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0031 | 0.0772 | 0.0952 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.2095 | 0.2613 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0604 | 0.0967 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0792 | 0.0992 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0017 | 0.0204 | 0.0256 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0787 | 0.0971 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0017 | 0.0204 | 0.0279 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0792 | 0.0992 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0028 | 0.0664 | 0.107 |
Plasmodium falciparum | topoisomerase I | 0.0208 | 0.7984 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.0772 | 0.092 |
Onchocerca volvulus | 0.0031 | 0.0792 | 0.0084 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1658 | 0.1653 |
Schistosoma mansoni | DNA polymerase IV / kappa | 0.0013 | 0.0042 | 0.0036 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0721 | 0.0903 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0208 | 0.7984 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0039 | 0.1125 | 0.1862 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0792 | 0.0981 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.004 | 0.1173 | 1 |
Brugia malayi | DNA topoisomerase I | 0.0208 | 0.7984 | 0.7982 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1062 | 0.133 |
Leishmania major | DNA polymerase eta, putative | 0.0039 | 0.1125 | 0.1862 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0039 | 0.11 | 0.1364 |
Plasmodium falciparum | phd finger protein, putative | 0.0031 | 0.0772 | 0.0956 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0031 | 0.0772 | 0.0767 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.01 | 0.3592 | 0.45 |
Onchocerca volvulus | Alhambra homolog | 0.0031 | 0.0772 | 0.0061 |
Echinococcus multilocularis | geminin | 0.0177 | 0.6738 | 0.8439 |
Echinococcus multilocularis | dna polymerase eta | 0.0067 | 0.2257 | 0.2827 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.0772 | 0.0956 |
Trypanosoma brucei | unspecified product | 0.004 | 0.1173 | 0.1945 |
Brugia malayi | Isocitrate dehydrogenase | 0.0017 | 0.0204 | 0.0199 |
Echinococcus multilocularis | dna polymerase kappa | 0.004 | 0.1173 | 0.147 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0604 | 0.0967 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0792 | 0.0977 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.