Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0045 | 0.0319 | 0.1173 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0045 | 0.0319 | 0.1173 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0409 | 0.0691 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0315 | 0.114 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0247 | 0.2717 | 0.9842 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0045 | 0.0319 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0045 | 0.0319 | 0.1173 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0315 | 0.0315 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0045 | 0.0319 | 0.1173 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0409 | 0.0691 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0315 | 0.8109 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0409 | 0.0691 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0045 | 0.0319 | 0.1155 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0247 | 0.2717 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0315 | 0.0533 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0045 | 0.0319 | 0.054 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0045 | 0.0319 | 0.1173 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0045 | 0.0319 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.276 | 0.4672 |
Brugia malayi | hypothetical protein | 0.025 | 0.276 | 0.4672 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0319 | 0.054 |
Onchocerca volvulus | 0.0051 | 0.0388 | 0.0689 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0045 | 0.0319 | 0.1173 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0045 | 0.0319 | 0.1173 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0045 | 0.0319 | 0.0319 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0045 | 0.0319 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0247 | 0.2717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0515 | 0.5909 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0045 | 0.0319 | 0.054 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.025 | 0.276 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.1324 | 0.2241 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0315 | 0.114 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0045 | 0.0319 | 0.1173 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0247 | 0.2717 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.1324 | 1 |
Brugia malayi | hypothetical protein | 0.013 | 0.1324 | 0.2241 |
Schistosoma mansoni | choline o-acyltransferase | 0.0045 | 0.0319 | 0.8214 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0315 | 0.0315 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0045 | 0.0319 | 0.8214 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0045 | 0.0319 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.1324 | 0.2241 |
Echinococcus granulosus | choline O acetyltransferase | 0.0045 | 0.0319 | 0.1155 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0045 | 0.0319 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0045 | 0.0319 | 0.1173 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.0388 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.021 | 0.5404 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0045 | 0.0319 | 0.1173 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0247 | 0.2717 | 0.2717 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0045 | 0.0319 | 0.1173 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0409 | 0.0691 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0045 | 0.0319 | 0.054 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0045 | 0.0319 | 0.054 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0045 | 0.0319 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.021 | 0.0355 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0045 | 0.0319 | 0.1173 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0315 | 0.8109 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.0388 | 0.0657 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0388 | 1 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0045 | 0.0319 | 0.1173 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0515 | 0.5909 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0045 | 0.0319 | 0.054 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.025 | 0.276 | 0.276 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0315 | 0.0533 |
Brugia malayi | Choline O-acetyltransferase | 0.0045 | 0.0319 | 0.054 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0045 | 0.0319 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0315 | 0.8109 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.021 | 0.0355 |
Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.1324 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.