TDR Targets

Basic information

Technical information

TDR Targets ID: 659136
Name: 1-[(3-bromophenyl)methyl]-4-[(2,3-dimethoxyph enyl)methyl]piperazine
MW: 405.329 | Formula: C20H25BrN2O2
H donors: 0 H acceptors: 0 LogP: 3.7 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1c(cccc1OC)CN1CCN(CC1)Cc1cccc(c1)Br
InChi: 1S/C20H25BrN2O2/c1-24-19-8-4-6-17(20(19)25-2)15-23-11-9-22(10-12-23)14-16-5-3-7-18(21)13-16/h3-8,13H,9-12,14-15H2,1-2H3
InChiKey: FABUNCRPUMHTPR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(3-bromobenzyl)-4-(2,3-dimethoxybenzyl)piperazine
5873-12-1
Oprea1_736982
1-(3-Bromo-benzyl)-4-(2,3-dimethoxy-benzyl)-piperazine
BAS 01235029
AK-968/13149973
STK145415
Oprea1_865861

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0287	0.6141	0.6932
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0179	0.2954
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0296	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0451	0.0683
Schistosoma mansoni	ap endonuclease	0.0021	0.0296	0.0334
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0179	0.0202
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0604	0.0941
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0585	0.8107
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0296	0.2339
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0296	0.0427
Trichomonas vaginalis	glucosylceramidase, putative	0.0284	0.6071	1
Loa Loa (eye worm)	sugar transporter	0.0015	0.0179	0.0233
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0576	0.065
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0463	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0451	0.0276
Trichomonas vaginalis	glucosylceramidase, putative	0.0186	0.3929	0.6365
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0377	0.3046
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0451	0.5423
Trichomonas vaginalis	glucosylceramidase, putative	0.0186	0.3929	0.6365
Echinococcus granulosus	General substrate transporter	0.0094	0.1899	0.2144
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0179	0.0237
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0115	0.013
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0864	0.0975
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0033	0.0561	0.7788
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0296	0.0119
Echinococcus multilocularis	General substrate transporter	0.0094	0.1899	0.2144
Schistosoma mansoni	sugar transporter	0.0015	0.0179	0.0202
Entamoeba histolytica	hypothetical protein	0.0036	0.0636	1
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0864	0.0975
Trichomonas vaginalis	glucosylceramidase, putative	0.0284	0.6071	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0561	0.0866
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0296	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0377	0.0561
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0296	0.2339
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0451	0.5423
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0576	0.0404
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0576	0.0404
Schistosoma mansoni	hypothetical protein	0.0352	0.756	0.8534
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0377	0.0201
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0576	0.065
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0296	0.0199
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0576	0.7919
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0033	0.0561	0.0647
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0864	0.0975
Schistosoma mansoni	cpg binding protein	0.003	0.0512	0.0578
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.068	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0377	0.395
Onchocerca volvulus	Glucosylceramidase homolog	0.0186	0.3929	1
Echinococcus granulosus	solute carrier family 22	0.0015	0.0179	0.0202
Trypanosoma cruzi	hexose transporter	0.0034	0.0585	0.8107
Trichomonas vaginalis	glucosylceramidase, putative	0.0186	0.3929	0.6365
Brugia malayi	hypothetical protein	0.0036	0.0636	0.0994
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0377	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.068	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.068	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0604	0.0937
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0561	0.0633
Brugia malayi	hypothetical protein	0.0015	0.0179	0.0237
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0179	0.2954
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.068	1
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0604	0.0682
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.1005	0.1135
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0585	0.8107
Entamoeba histolytica	hypothetical protein	0.0024	0.0377	0.2375
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0476	0.0725
Leishmania major	protein kinase, putative	0.0033	0.0576	0.7919
Schistosoma mansoni	hypothetical protein	0.0109	0.2236	0.2524
Plasmodium vivax	hexose transporter	0.0109	0.2236	0.2094
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0576	0.065
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Echinococcus multilocularis	cpg binding protein	0.003	0.0512	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0576	0.0404
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.1487	0.2405
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0576	0.0617
Schistosoma mansoni	cpg binding protein	0.0029	0.0476	0.0537
Schistosoma mansoni	hypothetical protein	0.0035	0.0604	0.0682
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0296	0.0119
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0585	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0576	0.089
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0636	0.0718
Echinococcus multilocularis	geminin	0.0352	0.756	0.8534
Trichomonas vaginalis	glucosylceramidase, putative	0.0186	0.3929	0.6365
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0179	0.2954
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0864	0.0975
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0576	0.065
Toxoplasma gondii	protein kinase, putative	0.0308	0.6604	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0186	0.3929	0.6365
Entamoeba histolytica	protein kinase, putative	0.0033	0.0576	0.8225
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0576	0.0617
Brugia malayi	hypothetical protein	0.0028	0.0451	0.0687
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0585	0.0689
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0179	0.0237
Entamoeba histolytica	protein kinase, putative	0.0033	0.0576	0.8225
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0585	0.0689
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0377	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.4149	0.6738
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0451	0.0422
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0561	0.0633
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0864	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0561	0.0633
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.053	0.0599
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0576	0.0404
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0296	0.2339
Brugia malayi	Sugar transporter family protein	0.0109	0.2236	0.3645
Brugia malayi	mbt repeat family protein	0.0047	0.0864	0.1371
Echinococcus granulosus	dnaJ subfamily B	0.0411	0.8859	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0576	0.065
Schistosoma mansoni	glucose transporter	0.0015	0.0179	0.0202
Trichomonas vaginalis	glucosylceramidase, putative	0.0284	0.6071	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0864	0.1825
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0377	0.0425
Schistosoma mansoni	sugar transporter	0.0015	0.0179	0.0202
Schistosoma mansoni	sugar transporter	0.0015	0.0179	0.0202
Schistosoma mansoni	protein kinase	0.0033	0.0576	0.065
Brugia malayi	mbt repeat family protein	0.0047	0.0864	0.1371
Echinococcus granulosus	solute carrier family 22	0.0015	0.0179	0.0202
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0585	0.0689
Toxoplasma gondii	facilitative glucose transporter GT1	0.0109	0.2236	0.3201
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0109	0.2236	0.2524
Plasmodium vivax	proline--tRNA ligase, putative	0.0038	0.068	0.051
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0377	0.395
Echinococcus multilocularis	dnaJ subfamily B	0.0411	0.8859	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0033	0.0561	0.0869
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0033	0.0561	0.0869
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0377	0.395
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0176	0.371	0.5495
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0179	0.0202
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0179	0.0202
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0636	0.0718
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0585	0.8107
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0585	0.8107
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0585	0.8107
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.011	0.2248	0.3666
Brugia malayi	Sugar transporter family protein	0.0015	0.0179	0.0237
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.011	0.2248	0.3663
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1487	0.2401
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0377	0.0336
Loa Loa (eye worm)	hypothetical protein	0.011	0.2248	0.3663
Brugia malayi	hypothetical protein	0.0015	0.0179	0.0237
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0179	0.0237
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0585	0.8107
Echinococcus granulosus	solute carrier family 22	0.0015	0.0179	0.0202
Trypanosoma brucei	glucose transporter 2A	0.0034	0.0585	0.8107
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0039	0.0044
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.1005	0.1135
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0476	0.0729
Schistosoma mansoni	hypothetical protein	0.0075	0.1487	0.1679
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0585	0.8107
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0179	0.0233
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0296	0.3068
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0585	0.8107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0109	0.2236	0.2524
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0451	0.0276
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.053	0.0599
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0296	0.2339
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0115	0.013
Echinococcus granulosus	GPCR family 2	0.0035	0.0604	0.0682
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0109	0.2236	0.2524
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0576	0.065
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0109	0.2236	0.2524
Trichomonas vaginalis	glucosylceramidase, putative	0.0186	0.3929	0.6365
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0109	0.2236	0.2524
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0585	0.8107
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0576	0.0404
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0864	0.1368
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0377	0.0425
Brugia malayi	Cam kinase protein 1	0.0033	0.0576	0.0894
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0576	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0179	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0426	0.0642
Plasmodium falciparum	hexose transporter	0.0109	0.2236	0.2094
Brugia malayi	Sugar transporter family protein	0.0015	0.0179	0.0237
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0179	0.0202
Schistosoma mansoni	sugar transporter	0.0015	0.0179	0.0202
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0576	0.065
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0296	0.0334
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0585	0.8107
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0377	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0179	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Schistosoma mansoni	protein kinase	0.0033	0.0576	0.065
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0296	0.7126
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0109	0.2236	0.2524
Schistosoma mansoni	hypothetical protein	0.0035	0.0604	0.0682
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0377	0.0425
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0296	0.9991
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0137	0.0164
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0585	0.8107
Leishmania major	glucose transporter, lmgt1	0.0034	0.0585	0.8107
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0585	0.0689
Brugia malayi	hypothetical protein	0.0015	0.0179	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0604	0.0937
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0576	0.065
Schistosoma mansoni	hypothetical protein	0.0036	0.0636	0.0718
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0585	0.8107
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0604	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Plasmodium falciparum	proline--tRNA ligase	0.0038	0.068	0.051
Trichomonas vaginalis	glucosylceramidase, putative	0.0284	0.6071	1
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0864	0.0975
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0296	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0561	0.0866
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0576	0.0404
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0576	0.0404
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0377	0.0425
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0451	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0576	0.089
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0604	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0179	0.0202
Schistosoma mansoni	hypothetical protein	0.0035	0.0604	0.0682
Onchocerca volvulus		0.0029	0.0476	0.0791
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0377	0.0308
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0576	0.0404
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0109	0.2236	0.2524
Brugia malayi	hypothetical protein	0.0018	0.0235	0.033
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0576	0.0617
Mycobacterium ulcerans	sugar transporter	0.0015	0.0179	0.2954
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1005	0.1602
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0109	0.2236	0.2524
Schistosoma mansoni	glucose transport protein	0.0109	0.2236	0.2524
Echinococcus granulosus	geminin	0.0352	0.756	0.8534
Schistosoma mansoni	hypothetical protein	0.0411	0.8859	1
Schistosoma mansoni	glucose transport protein	0.0109	0.2236	0.2524
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0451	0.5423
Leishmania major	hypothetical protein, conserved	0.0028	0.0451	0.5423
Brugia malayi	major facilitator superfamily protein	0.0015	0.0179	0.0237
Schistosoma mansoni	cpg binding protein	0.003	0.0512	0.0578
Brugia malayi	Calcitonin receptor-like protein seb-1	0.011	0.2248	0.3666
Loa Loa (eye worm)	sugar transporter	0.0109	0.2236	0.3643
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.1005	0.1135
Schistosoma mansoni	hypothetical protein	0.0012	0.0115	0.013
Plasmodium falciparum	protein kinase 7	0.0308	0.6604	0.6542
Trichomonas vaginalis	glucosylceramidase, putative	0.0196	0.4149	0.6738
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0179	0.0202
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0377	0.5182
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Leishmania major	glucose transporter, lmgt3	0.0034	0.0585	0.8107
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0176	0.371	0.3595
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0576	0.065
Schistosoma mansoni	hypothetical protein	0.0035	0.0604	0.0682
Trichomonas vaginalis	glucosylceramidase, putative	0.0284	0.6071	1
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.1005	0.1135
Toxoplasma gondii	exonuclease III APE	0.0021	0.0296	0.0182
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0576	0.0673
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0248	0.1383
Entamoeba histolytica	hypothetical protein	0.0036	0.0636	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1186	0.1338
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0585	0.0689
Echinococcus granulosus	cpg binding protein	0.003	0.0512	0.0578
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0296	1
Loa Loa (eye worm)	MBCTL1	0.0053	0.1005	0.1602
Leishmania major	glucose transporter, lmgt2	0.0034	0.0585	0.8107
Trichomonas vaginalis	glucosylceramidase, putative	0.0284	0.6071	1
Trypanosoma brucei	glucose transporter 1E	0.0034	0.0585	0.8107
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0561	0.0633
Schistosoma mansoni	ap endonuclease	0.0021	0.0296	0.0334
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0296	1
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0377	0.0201
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0576	0.089
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Onchocerca volvulus		0.0047	0.0864	0.1825
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0864	0.0975
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0284	0.6071	1
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.1005	0.1135
Brugia malayi	major facilitator superfamily protein	0.0015	0.0179	0.0237
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0604	0.0682
Schistosoma mansoni	hypothetical protein	0.0352	0.756	0.8534
Schistosoma mansoni	glucose transport protein	0.0109	0.2236	0.2524
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0179	0.0202
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0033	0.0561	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0311	0.0224
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0296	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Schistosoma mansoni	protein kinase	0.0033	0.0576	0.065
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0585	0.0689
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0604	0.0682
Giardia lamblia	Prolyl-tRNA synthetase	0.0033	0.0561	1
Trichomonas vaginalis	conserved hypothetical protein	0.0109	0.2236	0.3491
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0585	0.8107
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0039	0.0044
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0179	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0179	0.0233
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0188	0.3958	0.4467
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0284	0.6071	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0038	0.068	0.0779
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.068	1
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.1005	0.1606
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0188	0.3958	0.4467
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0296	0.0199
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0576	0.0404
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0034	0.0585	0.8107
Echinococcus granulosus	solute carrier family 22	0.0015	0.0179	0.0202
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0377	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0176	0.371	0.3595
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.1042	0.1343
Trichomonas vaginalis	glucosylceramidase, putative	0.0186	0.3929	0.6365
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0585	0.0689
Entamoeba histolytica	hypothetical protein	0.0036	0.0636	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0864	0.1368
Entamoeba histolytica	hypothetical protein	0.0036	0.0636	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0636	0.0718
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0604	0.0682

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 659136