Detailed information for compound 672603

Basic information

Technical information
  • TDR Targets ID: 672603
  • Name: 3,4-difluoro-N-(5-methyl-4-phenyl-1,3-thiazol -2-yl)benzamide
  • MW: 330.352 | Formula: C17H12F2N2OS
  • H donors: 1 H acceptors: 2 LogP: 4.38 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)F)F)Nc1sc(c(n1)c1ccccc1)C
  • InChi: 1S/C17H12F2N2OS/c1-10-15(11-5-3-2-4-6-11)20-17(23-10)21-16(22)12-7-8-13(18)14(19)9-12/h2-9H,1H3,(H,20,21,22)
  • InChiKey: UNWJFUSXLXAJPR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3,4-difluoro-N-(5-methyl-4-phenyl-thiazol-2-yl)benzamide
  • 3,4-difluoro-N-(5-methyl-4-phenyl-2-thiazolyl)benzamide
  • ZINC00468938

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0038 0.0748
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.0128
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0861 0.4373 0.4373
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0748
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0748
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0194 0.0649
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0194 0.3804
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0194 1
Onchocerca volvulus 0.0047 0.0184 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.0128
Echinococcus multilocularis inositol monophosphatase 1 0.011 0.0509 0.0509
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0035 0.0691
Schistosoma mansoni DNA polymerase eta 0.0019 0.0038 0.0038
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1136 0.1136
Schistosoma mansoni hypothetical protein 0.0176 0.0847 0.0847
Schistosoma mansoni survival motor neuron protein 0.0047 0.0184 0.0184
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0099 0.0449 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0194 0.0649
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0038 0.0038
Echinococcus granulosus geminin 0.0176 0.0847 0.0847
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.011 0.0509 1
Schistosoma mansoni hypothetical protein 0.0176 0.0847 0.0847
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.011 0.0509 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0184 0.0184
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0038 0.0038
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1953 1 1
Leishmania major hypothetical protein, conserved 0.0049 0.0194 0.3804
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0156 0.7635
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.011 0.0509 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.003 0.0667
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0067 0.132
Onchocerca volvulus 0.0025 0.0067 0.3646
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0024
Trypanosoma brucei unspecified product 0.0013 0.0008 0.0153
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0067 0.132
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.011 0.0509 0.1705
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0748
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0038
Echinococcus granulosus dna polymerase kappa 0.0019 0.0038 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0172 0.0172
Schistosoma mansoni hypothetical protein 0.0047 0.0184 0.0184
Trichomonas vaginalis myo inositol monophosphatase, putative 0.011 0.0509 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0038 0.0128
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0067
Echinococcus granulosus dna polymerase eta 0.0019 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0022 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0194 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1953 1 1
Loa Loa (eye worm) hypothetical protein 0.0603 0.3045 0.305
Schistosoma mansoni protein kinase 0.1953 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0588 0.2969 0.2974
Loa Loa (eye worm) hypothetical protein 0.0603 0.3045 0.305
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0067 0.132
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0054 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0748
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0067 0.132
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0194 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0024 0.0024
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0138 0.2715
Loa Loa (eye worm) hypothetical protein 0.195 0.9985 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.011 0.0509 1
Schistosoma mansoni inositol monophosphatase 0.011 0.0509 0.0509
Entamoeba histolytica myo-inositol monophosphatase, putative 0.011 0.0509 1
Schistosoma mansoni protein kinase 0.1953 1 1
Trichomonas vaginalis inositol monophosphatase, putative 0.011 0.0509 1
Echinococcus multilocularis geminin 0.0176 0.0847 0.0847
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.012 0.012
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0035 0.0782
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.011 0.0509 0.5
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0138 0.65
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0194 0.3804
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0748
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0081 0.0358 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0748
Trypanosoma brucei unspecified product 0.0019 0.0038 0.0748
Loa Loa (eye worm) hypothetical protein 0.0035 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0232 0.1136 0.1138
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Brugia malayi hypothetical protein 0.0232 0.1136 0.1136
Echinococcus granulosus muscleblind protein 0.0603 0.3045 0.3045
Loa Loa (eye worm) acetyltransferase 0.0142 0.0674 0.0675
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0038 0.0748
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0008 0.0153
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0067 0.132
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0674 0.0674
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0008 0.0153
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0358 0.7042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.0128
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0038 0.0038
Echinococcus granulosus GPCR family 2 0.0016 0.0024 0.0024
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.003 0.0667
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0054 0.0054
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0038 0.0748
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0156 0.3068
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0067 0.1495
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0067
Schistosoma mansoni inositol monophosphatase 0.011 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0748
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.0591 0.2984 0.2989
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0748
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0038 0.0748
Brugia malayi Muscleblind-like protein 0.0603 0.3045 0.3045
Leishmania major DNA polymerase kappa, putative 0.0019 0.0038 0.0748
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0067 0.132
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0024
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0067 0.0067
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0674 0.0674
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0172 0.0172
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0038 0.0848
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0138 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0203 0.0203
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.0128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0067 0.1495
Leishmania major DNA polymerase eta, putative 0.0019 0.0038 0.0748
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.011 0.0509 0.1705
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0038 0.0748
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0024 0.0024
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0024 0.0024
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0067 0.132
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0038 0.0038
Brugia malayi hypothetical protein 0.0049 0.0194 0.0194
Schistosoma mansoni hypothetical protein 0.0016 0.0024 0.0024
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0024 0.0024
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0038 0.0848
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0172 0.0172
Echinococcus multilocularis dna polymerase eta 0.0019 0.0038 0.0038
Mycobacterium ulcerans hypothetical protein 0.0025 0.0067 0.132
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0591 0.2984 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0067
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0674 0.0674
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0067 0.1495
Trichomonas vaginalis myo inositol monophosphatase, putative 0.011 0.0509 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0194 0.0194
Schistosoma mansoni hypothetical protein 0.0035 0.012 0.012
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0067 0.132
Echinococcus multilocularis muscleblind protein 1 0.0603 0.3045 0.3045
Echinococcus multilocularis GPCR, family 2 0.0016 0.0024 0.0024
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0156 0.3068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0172 0.0172
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.003 0.0667
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0038 0.0748
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0203 0.0203
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0035 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0653 0.0653
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0008 0.0153
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0067 0.132
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0067 0.0067
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0358 0.7042
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0038 0.0748
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0591 0.2984 1
Brugia malayi Inositol-1 0.011 0.0509 0.0509
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0038 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.003 0.0667
Brugia malayi hypothetical protein 0.0032 0.0104 0.0104
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0172 0.0172
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0024 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0038 0.0748
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0067 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0748
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0038 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0172 0.0172
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0038 0.0748
Echinococcus granulosus inositol monophosphatase 1 0.011 0.0509 0.0509
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0172 0.0172
Trypanosoma brucei unspecified product 0.0013 0.0008 0.0153
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0067 0.132
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0038 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.0748
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0156 0.3068
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0067 0.132
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0051 0.0203 0.0203
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0038 0.0748
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0067 0.132
Echinococcus multilocularis muscleblind protein 0.0603 0.3045 0.3045
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1136 0.1136
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0067 0.132
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0203 0.0203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0172 0.0172
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0099 0.0449 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0038 0.0038
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0067 0.1495
Giardia lamblia DINP protein human, muc B family 0.0019 0.0038 0.2757
Loa Loa (eye worm) inositol-1 0.011 0.0509 0.051
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0156 0.3068

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.