Detailed information for compound 673053

Basic information

Technical information
  • TDR Targets ID: 673053
  • Name: 2-chloro-4-methyl-N-(1-phenylethyl)benzamide
  • MW: 273.757 | Formula: C16H16ClNO
  • H donors: 1 H acceptors: 1 LogP: 4.09 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)Cl)C(=O)NC(c1ccccc1)C
  • InChi: 1S/C16H16ClNO/c1-11-8-9-14(15(17)10-11)16(19)18-12(2)13-6-4-3-5-7-13/h3-10,12H,1-2H3,(H,18,19)
  • InChiKey: NVLZPNJOJOLVCX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • STK222213

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii transporter, cation channel family protein 0.0019 0.0108 0.1472
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.047
Schistosoma mansoni hypothetical protein 0.0047 0.0657 0.2006
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0432 0.093
Echinococcus granulosus voltage dependent calcium channel 0.0019 0.0108 0.0067
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0432 0.093
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.1066 0.1161
Echinococcus multilocularis voltage dependent calcium channel 0.0092 0.1551 0.1516
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0432 0.093
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.2671 0.2908
Onchocerca volvulus 0.0036 0.0432 0.044
Schistosoma mansoni intermediate filament proteins 0.0026 0.0238 0.0639
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0534 0.0887
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0039 0.05 0.046
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0432 1
Schistosoma mansoni hypothetical protein 0.0047 0.0657 0.2006
Trypanosoma brucei CAAX amino terminal protease, putative 0.0082 0.134 1
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0066 0.0072
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0492 0.0453
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1739 0.1894
Echinococcus granulosus caspase 2 0.0035 0.0412 0.0372
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.5349 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0322 0.0282
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0082 0.134 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0102 0.006
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0102 0.0463
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0238 0.0259
Echinococcus granulosus CAAX prenyl protease 2 0.0082 0.134 0.1304
Echinococcus multilocularis geminin 0.0171 0.3113 0.3084
Loa Loa (eye worm) hypothetical protein 0.0019 0.0108 0.0117
Schistosoma mansoni hypothetical protein 0.0047 0.0657 0.2006
Loa Loa (eye worm) voltage-dependent calcium channel 0.0019 0.0108 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Echinococcus multilocularis high voltage activated calcium channel beta 0.0139 0.2471 0.244
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0432 0.1544
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0082 0.134 0.2413
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0092 0.1551 0.1516
Loa Loa (eye worm) hypothetical protein 0.003 0.0315 0.0343
Schistosoma mansoni ap endonuclease 0.0019 0.0102 0.0196
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0066 0.0079
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.022 0.4573
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0673 0.0733
Entamoeba histolytica CAAX prenyl protease family 0.0082 0.134 0.2423
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0041 0.0045
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.5349 1
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0082 0.134 0.4229
Loa Loa (eye worm) hypothetical protein 0.0478 0.9183 1
Echinococcus granulosus dna polymerase eta 0.0017 0.0066 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0432 0.0693
Toxoplasma gondii hypothetical protein 0.0017 0.0059 0.0386
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0066 0.0058
Onchocerca volvulus 0.003 0.0315 0.0175
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0102 0.006
Brugia malayi Pre-SET motif family protein 0.0031 0.0345 0.0376
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0082 0.134 1
Schistosoma mansoni survival motor neuron protein 0.0098 0.1655 0.5253
Echinococcus multilocularis caspase 2 0.0035 0.0412 0.0372
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0432 0.0096
Brugia malayi beta-lactamase family protein 0.0036 0.0432 0.047
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0432 0.093
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0432 0.3004
Leishmania major DNA polymerase eta, putative 0.0017 0.0066 0.0187
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0102 0.0111
Echinococcus granulosus lamin dm0 0.0026 0.0238 0.0197
Loa Loa (eye worm) hypothetical protein 0.0038 0.0477 0.0519
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0059 0.0041
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.2472 1
Leishmania major hypothetical protein, conserved 0.0036 0.0432 0.3004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0432 0.093
Echinococcus granulosus neuropeptide receptor A26 0.0519 1 1
Schistosoma mansoni hypothetical protein 0.0027 0.0268 0.0738
Echinococcus granulosus high voltage activated calcium channel beta 0.0139 0.2471 0.244
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0432 0.0693
Loa Loa (eye worm) hypothetical protein 0.0025 0.0228 0.0249
Loa Loa (eye worm) hypothetical protein 0.0149 0.2671 0.2908
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0345 0.0305
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0432 0.3004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0412 0.0449
Onchocerca volvulus 0.0035 0.0412 0.0396
Echinococcus granulosus geminin 0.0171 0.3113 0.3084
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.5349 1
Schistosoma mansoni voltage-gated cation channel 0.0092 0.1551 0.4915
Schistosoma mansoni chromobox protein 0.0068 0.1066 0.3336
Brugia malayi CAAX amino terminal protease family protein 0.0082 0.134 0.1459
Echinococcus multilocularis chromobox protein 1 0.0068 0.1066 0.1029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0492 0.347
Echinococcus granulosus chromobox protein 1 0.0068 0.1066 0.1029
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0432 0.0693
Loa Loa (eye worm) hypothetical protein 0.0017 0.0066 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0673 0.0635
Onchocerca volvulus 0.0098 0.1655 0.3218
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.022 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0432 0.0392
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.5349 1
Echinococcus multilocularis neuropeptide receptor A26 0.0519 1 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0432 0.093
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0092 0.1551 0.1516
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.047
Loa Loa (eye worm) hypothetical protein 0.0102 0.1739 0.1894
Echinococcus granulosus survival motor neuron protein 1 0.0478 0.9183 0.918
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0673 0.0733
Brugia malayi hypothetical protein 0.0035 0.0412 0.0449
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0092 0.1551 0.1516
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0432 0.3004
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0066 0.0187
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0432 0.0693
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0056 0.0836 0.6117
Onchocerca volvulus 0.0248 0.4641 1
Echinococcus multilocularis neuropeptide s receptor 0.0519 1 1
Loa Loa (eye worm) calcium channel 0.0092 0.1551 0.1689
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0477 0.0779
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0066 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0258 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0534 0.0673
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0492 0.347
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.047
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0477 0.0543
Echinococcus multilocularis voltage dependent calcium channel 0.0092 0.1551 0.1516
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0102 0.0463
Toxoplasma gondii hypothetical protein 0.0017 0.0062 0.045
Echinococcus multilocularis lamin 0.0026 0.0238 0.0197
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0492 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0432 0.047
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0102 0.0068
Schistosoma mansoni inositol monophosphatase 0.0039 0.0492 0.1467
Brugia malayi Inositol-1 0.0039 0.0492 0.0536
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0102 0.0177
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0092 0.1551 0.1516
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0657 0.0716
Brugia malayi intermediate filament protein 0.0026 0.0238 0.0259
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0092 0.1551 0.4915
Echinococcus multilocularis apoptotic protease activating factor 1 0.0035 0.0412 0.0372
Loa Loa (eye worm) hypothetical protein 0.0026 0.0238 0.0259
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0102 0.0081
Echinococcus multilocularis chromobox protein 1 0.0068 0.1066 0.1029
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0564 0.1703
Brugia malayi hypothetical protein 0.0016 0.0045 0.0049
Schistosoma mansoni hypothetical protein 0.0102 0.1739 0.5527
Loa Loa (eye worm) hypothetical protein 0.0031 0.0345 0.0376
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0238 0.0259
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0092 0.1551 0.1689
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0102 0.0463
Schistosoma mansoni high voltage-activated calcium channel beta subunit 2 0.0139 0.2471 0.7911
Mycobacterium ulcerans lipase LipD 0.0036 0.0432 0.1544
Brugia malayi Cell death protein 3 precursor 0.0035 0.0412 0.0449
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0432 0.047
Echinococcus multilocularis dna polymerase eta 0.0017 0.0066 0.0024
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0432 0.0392
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0345 0.0989
Brugia malayi beta-lactamase 0.0036 0.0432 0.047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.1655 0.1802
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0345 0.0305
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0102 0.337
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.2671 0.2908
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0066 0.0079
Mycobacterium ulcerans beta-lactamase 0.0036 0.0432 0.1544
Echinococcus multilocularis dna polymerase kappa 0.0017 0.0066 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.5349 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0102 0.1334
Trichomonas vaginalis set domain proteins, putative 0.0248 0.4641 0.8661
Echinococcus granulosus intermediate filament protein 0.0026 0.0238 0.0197
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0673 0.0635
Loa Loa (eye worm) inositol-1 0.0039 0.0492 0.0536
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0066 0.0029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0067
Brugia malayi hypothetical protein 0.0025 0.022 0.0239
Onchocerca volvulus 0.0036 0.0432 0.044
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0432 0.093
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.5349 1
Echinococcus granulosus apoptotic protease activating factor 1 0.0035 0.0412 0.0372
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0066 0.0187
Loa Loa (eye worm) hypothetical protein 0.0025 0.022 0.0239
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0238 0.0259
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0432 0.093
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0017 0.0066 0.0187
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0102 0.1541
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0017 0.0059 0.0041
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0492 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0102 0.0068
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0056 0.0836 0.6117
Brugia malayi isocitrate dehydrogenase 0.0016 0.0041 0.0045
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.047
Echinococcus multilocularis GPCR, family 2 0.0047 0.0657 0.0619
Schistosoma mansoni hypothetical protein 0.0171 0.3113 1
Schistosoma mansoni lamin 0.0026 0.0238 0.0639
Giardia lamblia Hypothetical protein 0.0082 0.134 0.2413
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.5349 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0066 0.0072
Onchocerca volvulus 0.0036 0.0432 0.044
Echinococcus multilocularis survival motor neuron protein 1 0.0478 0.9183 0.918
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0066 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0673 0.0635
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0092 0.1551 0.1516
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0017 0.0059 0.0041
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0412 0.0883
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0066 0.0013
Mycobacterium leprae Probable lipase LipE 0.0036 0.0432 0.0096
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0673 0.2058
Plasmodium falciparum protease, putative 0.0017 0.0059 0.0974
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0345 0.0305
Schistosoma mansoni hypothetical protein 0.005 0.0708 0.217
Schistosoma mansoni inositol monophosphatase 0.0039 0.0492 0.1467
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0657 0.0619
Echinococcus granulosus voltage dependent calcium channel 0.0092 0.1551 0.1516
Schistosoma mansoni caspase-7 (C14 family) 0.0035 0.0412 0.1207
Echinococcus granulosus chromobox protein 1 0.0068 0.1066 0.1029
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.2472 0.5796
Toxoplasma gondii CAAX amino terminal protease family protein 0.0017 0.0059 0.0386
Echinococcus multilocularis CAAX prenyl protease 2 0.0082 0.134 0.1304
Plasmodium vivax protease, putative 0.0017 0.0059 0.0446
Echinococcus multilocularis sodium channel protein 0.0039 0.05 0.046
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Mycobacterium tuberculosis Conserved protein 0.0036 0.0432 0.093
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0066 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.5349 1
Schistosoma mansoni DNA polymerase eta 0.0017 0.0066 0.0079
Schistosoma mansoni hypothetical protein 0.0171 0.3113 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.2671 0.2908
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0673 0.0635
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1066 0.1894
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0066 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0345 0.0989
Echinococcus multilocularis lamin dm0 0.0026 0.0238 0.0197
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.022 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0657 0.0619
Leishmania major hypothetical protein, conserved 0.0025 0.022 0.1374
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0345 0.6738
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0477 0.0779
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0017 0.0066 0.0058
Plasmodium vivax SET domain protein, putative 0.0031 0.0345 0.7784
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0102 0.0068
Leishmania major DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.047
Onchocerca volvulus Cell death protein 3 homolog 0.0035 0.0412 0.0396
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0345 0.0989
Chlamydia trachomatis hypothetical protein 0.0017 0.0059 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0432 0.1544
Brugia malayi chromobox protein homolog 3 0.0038 0.0477 0.0519
Brugia malayi beta-lactamase family protein 0.0036 0.0432 0.047
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0492 0.0453
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.2472 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0432 0.127
Echinococcus granulosus GPCR family 2 0.0047 0.0657 0.0619
Loa Loa (eye worm) hypothetical protein 0.0035 0.0412 0.0449
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.5349 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0102 0.0081
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0534 0.0887
Brugia malayi hypothetical protein 0.0478 0.9183 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0067
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1066 0.1894
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0657 0.0619
Mycobacterium ulcerans hypothetical protein 0.0036 0.0432 0.1544
Toxoplasma gondii hypothetical protein 0.0017 0.0059 0.0386
Toxoplasma gondii ABC1 family protein 0.0036 0.0432 0.8656
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0102 0.0111
Schistosoma mansoni ap endonuclease 0.0019 0.0102 0.0196
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0492 0.347
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0092 0.1551 0.4915
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0657 0.0716
Echinococcus granulosus lamin 0.0026 0.0238 0.0197
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0492 0.0807
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.022 0.1374
Trypanosoma brucei unspecified product 0.0017 0.0066 0.0187
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.022 0.1374
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0066 0.0187
Schistosoma mansoni lamin 0.0026 0.0238 0.0639
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0432 0.0693
Echinococcus granulosus dna polymerase kappa 0.0017 0.0066 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0258 0.0363
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0492 0.0807
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.5349 1
Trichomonas vaginalis esterase, putative 0.0036 0.0432 0.0693
Schistosoma mansoni hypothetical protein 0.0098 0.1655 0.5253
Schistosoma mansoni hypothetical protein 0.0035 0.0412 0.1207
Brugia malayi Heterochromatin protein 1 0.0068 0.1066 0.1161
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0657 0.0619
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.4045 0.4404
Brugia malayi Pre-SET motif family protein 0.0218 0.4045 0.4404
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0066 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0673 0.2058
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0066 0.0024
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0041 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.5349 1
Schistosoma mansoni chromobox protein 0.0068 0.1066 0.3336
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0102 0.0143
Onchocerca volvulus 0.0042 0.0564 0.0742
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.5349 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0092 0.1551 0.1516
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0082 0.134 1
Schistosoma mansoni hypothetical protein 0.0047 0.0657 0.2006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0432 0.047
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0492 0.347
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.0286 0.5384 0.5862
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.022 0.3959
Mycobacterium tuberculosis Conserved protein 0.0036 0.0432 0.093
Loa Loa (eye worm) hypothetical protein 0.0092 0.1551 0.1689
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0102 0.0463
Mycobacterium tuberculosis Probable integral membrane protein 0.0017 0.0059 0.0041
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0092 0.1551 0.1516
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0492 0.1795
Loa Loa (eye worm) hypothetical protein 0.0082 0.134 0.1459
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.4236 1
Echinococcus multilocularis musashi 0.0026 0.0238 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Loa Loa (eye worm) hypothetical protein 0.0047 0.0657 0.0716
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0492 0.0819
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.022 0.1374
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.0286 0.5384 0.5862
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0066 0.0187
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0492 0.0807
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0432 0.047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0432 0.127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0673 0.2058
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0657 0.0716
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0082 0.134 0.4229

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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