Detailed information for compound 680014

Basic information

Technical information
  • TDR Targets ID: 680014
  • Name: N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen -2-yl)-2-(3-oxo-4H-1,4-benzothiazin-2-yl)acet amide
  • MW: 383.487 | Formula: C19H17N3O2S2
  • H donors: 2 H acceptors: 3 LogP: 3.77 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(NC(=O)CC2Sc3ccccc3NC2=O)sc2c1CCCC2
  • InChi: 1S/C19H17N3O2S2/c20-10-12-11-5-1-3-7-14(11)26-19(12)22-17(23)9-16-18(24)21-13-6-2-4-8-15(13)25-16/h2,4,6,8,16H,1,3,5,7,9H2,(H,21,24)(H,22,23)
  • InChiKey: AKNJWENBBGECNR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-cyano-4,5,6,7-tetrahydrobenzothiophen-2-yl)-2-(3-oxo-4H-1,4-benzothiazin-2-yl)acetamide
  • N-(3-cyano-4,5,6,7-tetrahydrobenzothiophen-2-yl)-2-(3-keto-4H-1,4-benzothiazin-2-yl)acetamide
  • N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-(3-oxo-4H-1,4-benzothiazin-2-yl)ethanamide
  • Oprea1_504330
  • BAS 03571796
  • Oprea1_625152
  • A2462/0104496
  • EU-0052648

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0088 0.1627
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0346 0.4996 0.91
Toxoplasma gondii facilitative glucose transporter GT1 0.0114 0.1553 0.3263
Toxoplasma gondii LsmAD domain-containing protein 0.008 0.1037 0.2148
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0138
Schistosoma mansoni nAChR subunit 0.0346 0.4996 1
Brugia malayi hypothetical protein 0.0159 0.2223 0.2907
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1308 0.8381
Plasmodium falciparum flap endonuclease 1 0.003 0.0298 0.0362
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0088 0.0348
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.1308 1
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0377 0.2633
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0587 0.3603
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0138 0.018
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0228 0.0518
Schistosoma mansoni glucose transport protein 0.0114 0.1553 0.3108
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0159 0.2223 0.2907
Loa Loa (eye worm) glutathione reductase 0.0038 0.0412 0.0412
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.1136 0.8703
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0359 0.0719
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0175 0.0175
Trichomonas vaginalis myo-inositol transporter, putative 0.0016 0.0088 0.0292
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0138 0.0275
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0138 0.0275
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.1136 0.8837
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Schistosoma mansoni glucose transporter 0.0016 0.0088 0.0175
Schistosoma mansoni inositol monophosphatase 0.0036 0.0391 0.0783
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.1553 0.2828
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0035 0.0375 0.0716
Brugia malayi Inositol-1 0.0036 0.0391 0.0512
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.1553 0.2828
Trypanosoma brucei glucose transporter 2A 0.0035 0.0377 0.2633
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0043 0.0057
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0346 0.4996 0.91
Onchocerca volvulus 0.0016 0.0088 0.0175
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0521 0.0681
Giardia lamblia Hexose transporter 0.0016 0.0088 0.0348
Trypanosoma brucei PAB1-binding protein , putative 0.008 0.1037 0.7856
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.1136 0.8837
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0375 0.0682
Brugia malayi hypothetical protein 0.0159 0.2223 0.2907
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0375 0.075
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0138 0.0251
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0138 0.018
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0159 0.2223 0.4048
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0138 0.0624
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0035 0.0375 0.0682
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.042 0.0765
Brugia malayi hypothetical protein 0.0019 0.0138 0.018
Entamoeba histolytica protein kinase, putative 0.0035 0.0375 0.0954
Entamoeba histolytica hypothetical protein 0.0042 0.047 0.134
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.047 0.0941
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0088 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0138 0.0624
Onchocerca volvulus 0.0159 0.2223 0.4449
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0391 0.2305
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0346 0.4996 0.91
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0181 0.0914
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0587 0.3603
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0228 0.0262
Trichomonas vaginalis glucose transporter, putative 0.0016 0.0088 0.0292
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0524 0.7645 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.1553 0.2828
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0088 0.0348
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.1308 0.2619
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0159 0.2223 0.2907
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0138 0.0275
Echinococcus multilocularis calcium dependent protein kinase 0.0033 0.0338 0.0615
Brugia malayi hypothetical protein 0.0159 0.2223 0.2907
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.042 0.0765
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0346 0.4996 0.6535
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0375 0.0682
Schistosoma mansoni sugar transporter 0.0016 0.0088 0.0175
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Trypanosoma cruzi hexose transporter, putative 0.0019 0.0137 0.0738
Entamoeba histolytica hypothetical protein 0.0186 0.2622 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0346 0.4996 1
Trichomonas vaginalis sugar transport protein, putative 0.0016 0.0088 0.0292
Echinococcus granulosus glycine receptor subunit alpha 1 0.0346 0.4996 0.91
Plasmodium falciparum calcium-dependent protein kinase 5 0.0035 0.0375 0.047
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0088 0.0088
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0034 0.0359 0.2093
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0346 0.4996 0.91
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0138 0.0251
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0391 0.0713
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0391 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Entamoeba histolytica Flap nuclease, putative 0.003 0.0298 0.0648
Echinococcus multilocularis glycine receptor subunit beta 0.0346 0.4996 0.91
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.1553 0.2828
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.004 0.0444 0.0866
Onchocerca volvulus Putative transporter 0.0016 0.0088 0.0175
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.1279 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0346 0.4996 0.91
Plasmodium vivax CDK-related protein kinase 6, putative 0.0486 0.7089 1
Giardia lamblia Sugar-proton symporter 0.0016 0.0088 0.0348
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0088 0.0159
Trypanosoma brucei glucose transporter, putative 0.0035 0.0377 0.2633
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0138 0.0624
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0346 0.4996 0.91
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0298 0.2016
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Onchocerca volvulus 0.0159 0.2223 0.4449
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0088 0.0348
Onchocerca volvulus 0.0016 0.0088 0.0175
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0138 0.0251
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0138 0.0138
Plasmodium vivax calcium-dependent protein kinase, putative 0.0035 0.0375 0.047
Onchocerca volvulus 0.0346 0.4996 1
Trypanosoma cruzi hexose transporter 0.0035 0.0377 0.2633
Schistosoma mansoni hypothetical protein 0.0114 0.1553 0.3108
Echinococcus granulosus expressed protein 0.0379 0.549 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0377 0.2207
Onchocerca volvulus 0.0346 0.4996 1
Loa Loa (eye worm) LGC-31 protein 0.0346 0.4996 0.4996
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0159 0.2223 0.2907
Echinococcus multilocularis solute carrier family 22 0.0016 0.0088 0.0159
Leishmania major protein kinase, putative 0.0035 0.0375 0.2617
Loa Loa (eye worm) hypothetical protein 0.0026 0.0228 0.0228
Echinococcus granulosus General substrate transporter 0.0098 0.1313 0.2391
Schistosoma mansoni acetylcholine receptor subunit beta 0.0159 0.2223 0.4449
Onchocerca volvulus 0.0016 0.0088 0.0175
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0375 0.0682
Entamoeba histolytica hypothetical protein 0.0026 0.0228 0.0365
Onchocerca volvulus 0.0016 0.0088 0.0175
Echinococcus granulosus calcium dependent protein kinase 0.0033 0.0338 0.0615
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0034 0.0359 0.0893
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1308 0.2619
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0359 0.0719
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0088 0.0348
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Loa Loa (eye worm) sugar transporter 0.0016 0.0088 0.0088
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0088 0.0159
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0521 0.0949
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Brugia malayi PXA domain containing protein 0.0019 0.0138 0.018
Plasmodium falciparum hexose transporter 0.0114 0.1553 0.2142
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0171 0.1032
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0159 0.2223 0.2223
Loa Loa (eye worm) hypothetical protein 0.008 0.1037 0.1037
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0186 0.2622 0.5247
Trypanosoma brucei glucose transporter, putative 0.0035 0.0377 0.2633
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0175 0.0229
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0016 0.0088 0.0357
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0138 0.0251
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0088 0.0292
Echinococcus granulosus flap endonuclease 1 0.003 0.0298 0.0544
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Schistosoma mansoni nAChR subunit 0.0346 0.4996 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0175 0.0318
Trypanosoma brucei glucose transporter, putative 0.0035 0.0377 0.2633
Echinococcus granulosus nAChR subunit 0.0186 0.2622 0.4775
Schistosoma mansoni neurotransmitter gated ion channel 0.0159 0.2223 0.4449
Brugia malayi hypothetical protein 0.0019 0.0138 0.018
Loa Loa (eye worm) hypothetical protein 0.0186 0.2622 0.2622
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0228 0.1462
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0377 0.2633
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0138 0.0275
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0298 0.0362
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0228 0.1462
Echinococcus granulosus solute carrier family 22 0.0016 0.0088 0.0159
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0186 0.2622 0.3429
Plasmodium vivax hexose transporter 0.0114 0.1553 0.2142
Echinococcus granulosus glycine receptor subunit alpha 1 0.0346 0.4996 0.91
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0377 0.2633
Loa Loa (eye worm) hypothetical protein 0.0186 0.2622 0.2622
Schistosoma mansoni nAChR subunit 0.0346 0.4996 1
Brugia malayi Sugar transporter family protein 0.0016 0.0088 0.0114
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Onchocerca volvulus 0.0159 0.2223 0.4449
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.1279 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0444 0.3167
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Brugia malayi hypothetical protein 0.0042 0.047 0.0615
Schistosoma mansoni sugar transporter 0.0016 0.0088 0.0175
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0175 0.035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0138
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0391 0.2305
Trypanosoma brucei THT1 - hexose transporter, putative 0.0035 0.0377 0.2633
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.1279 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Onchocerca volvulus 0.0016 0.0088 0.0175
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0088 0.1627
Plasmodium falciparum glutathione reductase 0.0038 0.0412 0.0524
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.1037 0.7856
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0088 0.0088
Brugia malayi Thioredoxin reductase 0.0038 0.0412 0.0539
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0391 0.0713
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0334 0.2354
Echinococcus granulosus glycine receptor subunit alpha 1 0.0346 0.4996 0.91
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1308 0.8381
Loa Loa (eye worm) inositol-1 0.0036 0.0391 0.0391
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0228 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0138 0.0251
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.1308 0.2383
Loa Loa (eye worm) hypothetical protein 0.0186 0.2622 0.2622
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0088 0.0114
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0298 0.2016
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0175 0.035
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0034 0.0359 0.047
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0043 0.0749
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0228 0.1462
Echinococcus multilocularis solute carrier family 22 0.0016 0.0088 0.0159
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.1553 0.2828
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.1136 0.8837
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0035 0.0375 0.047
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0391 0.2751
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Toxoplasma gondii protein kinase, putative 0.0324 0.467 1
Echinococcus multilocularis solute carrier family 22 0.0016 0.0088 0.0159
Echinococcus multilocularis nAChR subunit 0.0186 0.2622 0.4775
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0088 0.0348
Plasmodium vivax proline--tRNA ligase, putative 0.004 0.0444 0.0569
Brugia malayi follicle stimulating hormone receptor 0.0229 0.3256 0.4259
Schistosoma mansoni sugar transporter 0.0016 0.0088 0.0175
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0043 0.0087
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0391 0.0752
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0175 0.0318
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0114 0.1553 0.2828
Leishmania major glucose transporter, lmgt1 0.0035 0.0377 0.2633
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0298 0.2016
Echinococcus multilocularis flap endonuclease 1 0.003 0.0298 0.0544
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Onchocerca volvulus 0.0186 0.2622 0.5247
Loa Loa (eye worm) hypothetical protein 0.0186 0.2622 0.2622
Loa Loa (eye worm) ACC-1 protein 0.0346 0.4996 0.4996
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0391 0.1022
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0346 0.4996 0.4996
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0444 0.3167
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0228 0.0457
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0228 0.0457
Brugia malayi hypothetical protein 0.0016 0.0088 0.0114
Echinococcus granulosus glycine receptor subunit beta 0.0346 0.4996 0.91
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0298 0.1689
Toxoplasma gondii sugar transporter ST2 0.0016 0.0088 0.0095
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0228 0.0299
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0346 0.4996 0.6535
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0159 0.2223 0.4048
Brugia malayi hypothetical protein 0.0052 0.0616 0.0805
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Loa Loa (eye worm) hypothetical protein 0.0186 0.2622 0.2622
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0391 0.2751
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0228 0.5508
Schistosoma mansoni neurotransmitter gated ion channel 0.0159 0.2223 0.4449
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0016 0.0088 0.1267
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0035 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Brugia malayi Cation transporter family protein 0.0346 0.4996 0.6535
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0138 0.0624
Trypanosoma brucei glucose transporter, putative 0.0035 0.0377 0.2633
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0138 0.0251
Trypanosoma brucei polo-like protein kinase 0.0098 0.1308 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0346 0.4996 0.6535
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0377 0.2207
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0346 0.4996 0.6535
Echinococcus multilocularis nAChR subunit 0.0346 0.4996 0.91
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0377 0.2207
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0138 0.0624
Plasmodium falciparum calcium-dependent protein kinase 1 0.0035 0.0375 0.047
Echinococcus granulosus glycine receptor subunit beta 0.0346 0.4996 0.91
Loa Loa (eye worm) hypothetical protein 0.0034 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Brugia malayi PXA domain containing protein 0.0019 0.0138 0.018
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0391 0.2751
Plasmodium vivax ataxin-2 like protein, putative 0.008 0.1037 0.141
Brugia malayi hypothetical protein 0.0016 0.0088 0.0114
Schistosoma mansoni glucose transport protein 0.0114 0.1553 0.3108
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0138 0.0275
Trypanosoma brucei trypanothione reductase 0.0038 0.0412 0.2917
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0375 0.0682
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0346 0.4996 0.6535
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0228 0.5508
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.047 0.0857
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0228 1
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0377 0.2207
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0186 0.2622 0.3429
Onchocerca volvulus 0.0346 0.4996 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0138
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0185 0.2607 0.5543
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0138 0.0275
Onchocerca volvulus 0.0016 0.0088 0.0175
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0175 0.0175
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1308 0.8381
Schistosoma mansoni hypothetical protein 0.0036 0.0381 0.0763
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0346 0.4996 0.6535
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0346 0.4996 0.91
Plasmodium vivax sugar transporter, putative 0.0016 0.0088 0.0063
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0391 0.2305
Plasmodium falciparum calcium-dependent protein kinase 2 0.0035 0.0375 0.047
Loa Loa (eye worm) hypothetical protein 0.0186 0.2622 0.2622
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1308 0.8381
Loa Loa (eye worm) hypothetical protein 0.0034 0.0359 0.0359
Plasmodium falciparum calcium-dependent protein kinase 3 0.0035 0.0375 0.047
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0138
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0138 0.0251
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0346 0.4996 0.91
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0521 0.0521
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0381 0.0694
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0088 0.0175
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0346 0.4996 0.6535
Onchocerca volvulus 0.0346 0.4996 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1308 0.8381
Brugia malayi Cation transporter family protein 0.0346 0.4996 0.6535
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Echinococcus granulosus solute carrier family 22 0.0016 0.0088 0.0159
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0088 0.1627
Onchocerca volvulus 0.0186 0.2622 0.5247
Onchocerca volvulus 0.0346 0.4996 1
Mycobacterium ulcerans sugar transporter 0.0016 0.0088 0.1627
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0228 0.1462
Brugia malayi hypothetical protein 0.0159 0.2223 0.2907
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0375 0.0682
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0035 0.0375 0.0716
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0043 0.0413
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0346 0.4996 0.91
Onchocerca volvulus 0.0346 0.4996 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0298 0.0551
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0228 0.0416
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0346 0.4996 0.6535
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.047 0.0857
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Trypanosoma brucei glucose transporter, putative 0.0035 0.0377 0.2633
Toxoplasma gondii transporter, major facilitator family protein 0.0016 0.0088 0.0095
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0228 0.0416
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0034 0.0359 0.0654
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0035 0.0375 0.049
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0159 0.2223 0.2223
Treponema pallidum NADH oxidase 0.0013 0.0043 1
Giardia lamblia Kinase, PLK 0.0098 0.1308 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0034 0.0359 0.1699
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0138 0.0251
Echinococcus multilocularis expressed protein 0.0379 0.549 1
Leishmania major hypothetical protein, conserved 0.008 0.1037 0.7856
Echinococcus multilocularis solute carrier family 22 0.0016 0.0088 0.0159
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0334 0.1474
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.1308 0.2383
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0412 0.2985
Brugia malayi major facilitator superfamily protein 0.0016 0.0088 0.0114
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0138 0.0251
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0298 0.2016
Onchocerca volvulus 0.0016 0.0088 0.0175
Schistosoma mansoni neurotransmitter gated ion channel 0.0186 0.2622 0.5247
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0016 0.0088 0.0357
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0521 0.0949
Mycobacterium tuberculosis Probable reductase 0.0086 0.1136 0.8837
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1308 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0346 0.4996 0.6535
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0138 0.018
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0346 0.4996 0.6535
Schistosoma mansoni flap endonuclease-1 0.0027 0.0255 0.0511
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.1279 1
Onchocerca volvulus 0.0016 0.0088 0.0175
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0391 1
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Loa Loa (eye worm) hypothetical protein 0.0028 0.0263 0.0263
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Leishmania major glucose transporter, lmgt2 0.0035 0.0377 0.2633
Giardia lamblia Prolyl-tRNA synthetase 0.0034 0.0359 0.2497
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Onchocerca volvulus 0.0016 0.0088 0.0175
Schistosoma mansoni inositol monophosphatase 0.0036 0.0391 0.0783
Loa Loa (eye worm) acetylcholine receptor protein 0.0159 0.2223 0.2223
Schistosoma mansoni nAChR subunit 0.0346 0.4996 1
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0159 0.2223 0.4048
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0346 0.4996 0.6535
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0391 0.2751
Brugia malayi hypothetical protein 0.008 0.1037 0.1357
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0138 0.0624
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0088 0.0292
Trypanosoma brucei glucose transporter, putative 0.0035 0.0377 0.2633
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0043 0.0413
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0088 0.0114
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0346 0.4996 0.4996
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0346 0.4996 0.6535
Leishmania major glucose transporter, lmgt3 0.0035 0.0377 0.2633
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0035 0.0375 0.047
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0377 0.2207
Brugia malayi hypothetical protein 0.0016 0.0088 0.0114
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0088 0.0159
Trypanosoma brucei sugar transporter, putative 0.0016 0.0088 0.0348
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Schistosoma mansoni glucose transport protein 0.0114 0.1553 0.3108
Plasmodium falciparum thioredoxin reductase 0.0038 0.0412 0.0524
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0138 0.0275
Entamoeba histolytica hypothetical protein 0.0042 0.047 0.134
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1308 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Onchocerca volvulus 0.0016 0.0088 0.0175
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0346 0.4996 1
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0138 0.0251
Plasmodium falciparum protein kinase 6 0.0486 0.7089 1
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0114 0.1553 0.2828
Leishmania major hypothetical protein, conserved 0.0016 0.0088 0.0348
Brugia malayi Cam kinase protein 1 0.0035 0.0375 0.049
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Onchocerca volvulus 0.0016 0.0088 0.0175
Brugia malayi excitatory GABA receptor EXP-1A 0.0346 0.4996 0.6535
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0171 0.1032
Loa Loa (eye worm) hypothetical protein 0.0186 0.2622 0.2622
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0138 0.0251
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Brugia malayi Flap endonuclease-1 0.003 0.0298 0.039
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.1037 0.7856
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0346 0.4996 0.4996
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0228 0.1225
Trypanosoma brucei glucose transporter, putative 0.0035 0.0377 0.2633
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0159 0.2223 0.2907
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0346 0.4996 0.91
Brugia malayi Cation transporter family protein 0.0346 0.4996 0.6535
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0138 0.0275
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.1308 0.1711
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0088 0.0159
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.3256 0.3256
Brugia malayi glutathione reductase 0.0038 0.0412 0.0539
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.1136 0.8837
Echinococcus granulosus solute carrier family 22 0.0016 0.0088 0.0159
Brugia malayi Sugar transporter family protein 0.0016 0.0088 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1308 0.8381
Plasmodium falciparum proline--tRNA ligase 0.004 0.0444 0.0569
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0159 0.2223 0.2907
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0346 0.4996 0.91
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0444 0.3167
Schistosoma mansoni acetylcholine receptor-related 0.0159 0.2223 0.4449
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0035 0.0375 0.0375
Entamoeba histolytica hypothetical protein 0.0042 0.047 0.134
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.1037 0.141
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0043 0.0079
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0035 0.0375 0.2617
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0138 0.0275
Schistosoma mansoni protein kinase 0.0035 0.0375 0.075
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0016 0.0088 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0088 0.0292
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0034 0.0359 0.0654
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0138 0.0138
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0186 0.2622 0.5247
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0381 0.0694
Onchocerca volvulus 0.0016 0.0088 0.0175
Loa Loa (eye worm) sugar transporter 0.0114 0.1553 0.1553
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0088 0.0292
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0228 0.04
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0346 0.4996 0.91
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0346 0.4996 0.4996
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0034 0.0359 0.047
Toxoplasma gondii thioredoxin reductase 0.0038 0.0412 0.0798
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0377 0.2207
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0159 0.2223 0.2907
Brugia malayi hypothetical protein 0.0159 0.2223 0.2907
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0346 0.4996 0.91
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.1037 0.141
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0138 0.018
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0444 0.3167
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0346 0.4996 0.91
Onchocerca volvulus 0.0016 0.0088 0.0175
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1553 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0138
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0412 0.2917
Plasmodium vivax glutathione reductase, putative 0.0038 0.0412 0.0524
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0346 0.4996 0.91
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0521 0.1043
Brugia malayi Sugar transporter family protein 0.0114 0.1553 0.2031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0138
Toxoplasma gondii sugar transporter ST3 0.0016 0.0088 0.0095
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0346 0.4996 0.6535
Plasmodium falciparum mitogen-activated protein kinase 2 0.0185 0.2607 0.3639
Trypanosoma brucei glucose transporter, putative 0.0035 0.0377 0.2633
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0138 0.0624
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0035 0.0375 0.0716
Echinococcus granulosus solute carrier family 22 0.0016 0.0088 0.0159
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0185 0.2607 0.3639
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0346 0.4996 0.91
Loa Loa (eye worm) hypothetical protein 0.0186 0.2622 0.2622
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0521 0.1043
Entamoeba histolytica hypothetical protein 0.0042 0.047 0.134
Loa Loa (eye worm) hypothetical protein 0.0035 0.0375 0.0375
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1308 0.8381
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0346 0.4996 1
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Plasmodium falciparum calcium-dependent protein kinase 4 0.0035 0.0375 0.047
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0346 0.4996 0.4996
Trypanosoma brucei glucose transporter 1E 0.0035 0.0377 0.2633
Echinococcus multilocularis glycine receptor subunit beta 0.0346 0.4996 0.91
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Entamoeba histolytica protein kinase, putative 0.0035 0.0375 0.0954
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0138 0.0251
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0521 0.0949
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0346 0.4996 0.6535
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0377 0.2207
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0138 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0088 0.0292
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0138 0.0251
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0186 0.2622 0.3429
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0346 0.4996 0.6535
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0346 0.4996 0.91
Plasmodium falciparum protein kinase 7 0.0324 0.467 0.6566
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Onchocerca volvulus Putative nachr subunit 0.0346 0.4996 1
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0298 0.0298
Onchocerca volvulus 0.0016 0.0088 0.0175
Schistosoma mansoni nAChR subunit 0.0346 0.4996 1
Loa Loa (eye worm) hypothetical protein 0.0364 0.527 0.527
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0375 0.2193
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0375 0.0682
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0043 0.0413
Schistosoma mansoni hypothetical protein 0.0042 0.047 0.0941
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0114 0.1553 0.2828
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0412 0.0524
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0138 0.0251
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0521 0.1043
Leishmania major glucose transporter/membrane transporter D2, putative 0.0035 0.0377 0.2633
Loa Loa (eye worm) GABA receptor subunit 0.0186 0.2622 0.2622
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0346 0.4996 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0159 0.2223 0.4048
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0377 0.2633
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0377 0.2633
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0043 0.0079
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0375 0.0682
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0159 0.2223 0.4048
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0138 0.0275
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0346 0.4996 0.4996
Echinococcus multilocularis General substrate transporter 0.0098 0.1313 0.2391
Schistosoma mansoni kinase 0.0051 0.0606 0.1213
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Schistosoma mansoni nAChR subunit 0.0159 0.2223 0.4449
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0138 0.0251
Onchocerca volvulus 0.0016 0.0088 0.0175
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0138 0.0251
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0521 0.0949
Schistosoma mansoni nAChR subunit 0.0159 0.2223 0.4449
Toxoplasma gondii sugar transporter ST1 0.0016 0.0088 0.0095
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0346 0.4996 0.91
Onchocerca volvulus 0.0016 0.0088 0.0175
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.1136 0.8837
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0138 0.018
Brugia malayi major facilitator superfamily protein 0.0016 0.0088 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0175 0.035
Loa Loa (eye worm) hypothetical protein 0.0346 0.4996 0.4996
Schistosoma mansoni nAChR subunit 0.0346 0.4996 1
Loa Loa (eye worm) ACC-1 protein 0.0346 0.4996 0.4996
Loa Loa (eye worm) hypothetical protein 0.0524 0.7645 0.7645
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0346 0.4996 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0138 0.0251
Echinococcus granulosus nAChR subunit 0.0346 0.4996 0.91
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.1308 0.4713
Schistosoma mansoni protein kinase 0.0035 0.0375 0.075
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0444 0.3167
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.1308 0.1308
Schistosoma mansoni nAChR subunit 0.0346 0.4996 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0375 0.047
Leishmania major trypanothione reductase 0.0038 0.0412 0.2917
Loa Loa (eye worm) hypothetical protein 0.0159 0.2223 0.2223
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0088
Trichomonas vaginalis sugar transporter, putative 0.0016 0.0088 0.0292
Schistosoma mansoni protein kinase 0.0035 0.0375 0.075
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0346 0.4996 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0186 0.2622 0.3429
Schistosoma mansoni sugar transporter 0.0016 0.0088 0.0175
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0058 0.0058

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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