TDR Targets

Basic information

Technical information

TDR Targets ID: 683969
Name: ZINC04370503
MW: 409.481 | Formula: C22H27N5O3
H donors: 0 H acceptors: 3 LogP: 3.89 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOCCn1c(=O)n(C)c2c(c1=O)n1c(n2)n(c(c1C)C)c1ccc(cc1C)C
InChi: 1S/C22H27N5O3/c1-7-30-11-10-25-20(28)18-19(24(6)22(25)29)23-21-26(15(4)16(5)27(18)21)17-9-8-13(2)12-14(17)3/h8-9,12H,7,10-11H2,1-6H3
InChiKey: MGMICLNKDXGJRV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

BAS 13030021

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0441	0.0404
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0451	0.4816
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0754	0.099
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0289	0.0352
Mycobacterium tuberculosis	Probable hydrolase	0.004	0.0639	0.1058
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0039	0.5
Loa Loa (eye worm)	MH1 domain-containing protein	0.0025	0.0278	0.0339
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0069	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.075	0.341
Mycobacterium tuberculosis	Probable esterase LipL	0.004	0.0639	0.1058
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0039	0.0025
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0266	0.1089
Brugia malayi	major facilitator superfamily protein	0.0014	0.0039	0.0025
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0754	0.099
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0324	0.0394
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0015	0.0051	0.0137
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0894	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0547	0.594
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0039	0.0051
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0039	0.0051
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0044	0.075	0.4454
Loa Loa (eye worm)	hypothetical protein	0.004	0.0639	0.0777
Brugia malayi	MH2 domain containing protein	0.0025	0.0278	0.0316
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0033	0.0018
Brugia malayi	beta-lactamase	0.004	0.0639	0.0756
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0441	0.0579
Entamoeba histolytica	hypothetical protein	0.0071	0.1387	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.1387	0.1821
Brugia malayi	latrophilin 2 splice variant baaae	0.0208	0.4626	0.5618
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0535	0.2378
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0033	0.004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0481	0.2117
Loa Loa (eye worm)	beta-lactamase	0.004	0.0639	0.0777
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0451	0.4816
Loa Loa (eye worm)	hypothetical protein	0.004	0.0639	0.0777
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0754	0.1558
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0321	0.1349
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0754	0.099
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0426	0.0844
Brugia malayi	hypothetical protein	0.0014	0.0039	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0451	0.1973
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0033	0.0481	0.0678
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0015	0.0051	0.0137
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0441	0.0536
Schistosoma mansoni	glucose transport protein	0.0103	0.2125	0.4548
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.004	0.0639	0.1058
Echinococcus granulosus	solute carrier family 22	0.0014	0.0039	0.0051
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0096	0.1979	0.2599
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0441	0.0617
Loa Loa (eye worm)	hypothetical protein	0.004	0.0639	0.0777
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0265	0.1085
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0025	0.0278	0.0366
Entamoeba histolytica	protein kinase, putative	0.0031	0.0441	0.1756
Echinococcus granulosus	short transient receptor potential channel 6	0.0137	0.2945	0.3868
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0451	0.4816
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0441	0.0404
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0044	0.075	0.4454
Echinococcus multilocularis	lamin	0.0026	0.0324	0.0426
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0265	0.1085
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0069	0.0355
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0278	0.0522
Mycobacterium tuberculosis	Probable lipase LipD	0.004	0.0639	0.1058
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0096	0.1979	0.239
Schistosoma mansoni	hypothetical protein	0.0096	0.1979	0.4229
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0481	0.2117
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.075	0.0913
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0441	0.4704
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0395	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0015	0.0051	0.0137
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0441	0.0404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0266	0.1089
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0451	0.1973
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0035	0.0536	0.5815
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0044	0.075	0.8325
Schistosoma mansoni	hypothetical protein	0.0103	0.2125	0.4548
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2125	0.2791
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0535	0.2378
Brugia malayi	Sugar transporter family protein	0.0103	0.2125	0.2568
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0044	0.075	0.8325
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0278	0.0522
Schistosoma mansoni	glucose transport protein	0.0103	0.2125	0.4548
Echinococcus multilocularis	transient receptor potential ion channel A	0.02	0.4443	0.5837
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0069	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0426	0.0518
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0639	0.0602
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0234	0.0307
Brugia malayi	beta-lactamase family protein	0.004	0.0639	0.0756
Schistosoma mansoni	hypothetical protein	0.0071	0.1387	0.2938
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0441	0.0579
Loa Loa (eye worm)	hypothetical protein	0.004	0.0639	0.0777
Mycobacterium tuberculosis	Conserved protein	0.004	0.0639	0.1058
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0451	0.4816
Schistosoma mansoni	protein kinase	0.0031	0.0441	0.0876
Plasmodium vivax	hexose transporter	0.0103	0.2125	0.2094
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0441	0.0404
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0639	0.1307
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0441	0.0404
Brugia malayi	Cam kinase protein 1	0.0031	0.0441	0.0515
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0547	0.0779
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0039	0.0051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0404	0.1749
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0324	0.0394
Trypanosoma cruzi	hexose transporter	0.0032	0.0451	0.4816
Brugia malayi	MH2 domain containing protein	0.0025	0.0278	0.0316
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2125	0.2791
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0547	0.594
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0441	0.0579
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0426	0.0496
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2125	0.2791
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0305	0.6907	0.8403
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0173	0.0641
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0754	0.0896
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0021	0.0196	0.1832
Onchocerca volvulus		0.0026	0.0324	0.3488
Echinococcus granulosus	solute carrier family 22	0.0014	0.0039	0.0051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0596	0.2672
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0441	0.0579
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0547	0.594
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0069	0.0084
Schistosoma mansoni	hypothetical protein	0.0023	0.0234	0.0425
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0015	0.0051	0.0137
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0441	0.0404
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0441	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0019	0.0023
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0044	0.075	0.1551
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.075	0.341
Echinococcus granulosus	Smad4	0.0025	0.0278	0.0366
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0044	0.075	0.8325
Toxoplasma gondii	ABC1 family protein	0.004	0.0639	0.092
Loa Loa (eye worm)	sugar transporter	0.0103	0.2125	0.2585
Schistosoma mansoni	transient receptor potential channel 4	0.0207	0.4607	0.9958
Brugia malayi	Smad1	0.0025	0.0278	0.0316
Echinococcus granulosus	intermediate filament protein	0.0026	0.0324	0.0426
Schistosoma mansoni	transient receptor potential channel	0.0207	0.4607	0.9958
Brugia malayi	intermediate filament protein	0.0026	0.0324	0.0372
Loa Loa (eye worm)	MH2 domain-containing protein	0.0025	0.0278	0.0339
Loa Loa (eye worm)	hypothetical protein	0.007	0.136	0.1654
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0015	0.0051	0.0067
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.024	0.2346
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0894	0.1087
Echinococcus multilocularis	transient receptor potential gamma protein	0.0207	0.4607	0.6052
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0069	0.0091
Brugia malayi	Latrophilin receptor protein 2	0.0096	0.1979	0.239
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0266	0.1089
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0039	0.0025
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0639	0.2875
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0158	0.021
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0039	0.0051
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0547	0.594
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0441	0.0404
Echinococcus granulosus	geminin	0.0166	0.3625	0.4762
Loa Loa (eye worm)	hypothetical protein	0.0023	0.024	0.0291
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0451	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0313	0.038
Schistosoma mansoni	Smad4	0.0025	0.0278	0.0522
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0754	0.0917
Entamoeba histolytica	hypothetical protein	0.0071	0.1387	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0044	0.075	0.8325
Echinococcus multilocularis	geminin	0.0166	0.3625	0.4762
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0096	0.1979	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0856	0.1042
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0754	0.099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0051	0.0056
Onchocerca volvulus		0.0049	0.0856	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2125	0.2791
Loa Loa (eye worm)	MH2 domain-containing protein	0.036	0.822	1
Loa Loa (eye worm)	hypothetical protein	0.0305	0.6907	0.8403
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.2125	1
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.024	0.0201
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2125	0.2791
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0451	0.1973
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.024	0.5
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0451	0.4816
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0305	0.6907	0.8399
Loa Loa (eye worm)	hypothetical protein	0.0207	0.4607	0.5604
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1979	0.2407
Plasmodium falciparum	hexose transporter	0.0103	0.2125	0.2094
Loa Loa (eye worm)	Smad1	0.0025	0.0278	0.0339
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0441	0.0579
Echinococcus multilocularis	short transient receptor potential channel 6	0.0137	0.2945	0.3868
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0481	0.2117
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0025	0.0278	0.0522
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.024	0.0437
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.024	0.0269
Leishmania major	protein kinase, putative	0.0031	0.0441	0.4704
Schistosoma mansoni	transient receptor potential channel	0.0137	0.2945	0.6335
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.0069	0.0355
Mycobacterium ulcerans	lipase LipD	0.004	0.0639	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0381	0.164
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0451	0.4816
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0535	0.2378
Brugia malayi	MH1 domain containing protein	0.0025	0.0278	0.0316
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0441	0.0536
Schistosoma mansoni	hypothetical protein	0.0096	0.1979	0.4229
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.024	0.0961
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0754	0.1558
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0254	0.571	1
Brugia malayi	hypothetical protein	0.0014	0.0039	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0441	0.0536
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0441	0.0515
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0015	0.0051	0.0026
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0639	0.7018
Brugia malayi	hypothetical protein	0.0014	0.0039	0.0025
Schistosoma mansoni	hypothetical protein	0.0096	0.1979	0.4229
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0051	0.0056
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0039	0.0051
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.0856	0.1782
Loa Loa (eye worm)	phosphatidylinositol 3	0.0015	0.0051	0.0062
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0481	0.2117
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0096	0.1979	0.2407
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0426	0.056
Onchocerca volvulus		0.004	0.0639	0.7338
Brugia malayi	follicle stimulating hormone receptor	0.0242	0.5436	0.6605
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0639	0.2875
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0441	0.1927
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0426	0.1855
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0639	0.1307
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0044	0.075	0.8325
Onchocerca volvulus		0.0026	0.0324	0.3488
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1524	0.1853
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0039	0.0051
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0639	0.2875
Leishmania major	glucose transporter, lmgt3	0.0032	0.0451	0.4816
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0266	0.1089
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0096	0.1979	0.2599
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0242	0.5436	0.6613
Echinococcus multilocularis	General substrate transporter	0.0088	0.1784	0.2343
Mycobacterium tuberculosis	Probable lipase LipE	0.004	0.0639	0.1058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0535	0.2378
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.1387	0.2938
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0441	0.0579
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0426	0.5575
Echinococcus granulosus	lamin dm0	0.0026	0.0324	0.0426
Schistosoma mansoni	hypothetical protein	0.0166	0.3625	0.7818
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0451	0.4816
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0481	0.2117
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0894	0.1311
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0069	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0039	0.0051
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0166	0.362	0.3595
Loa Loa (eye worm)	sugar transporter	0.0014	0.0039	0.0047
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0639	0.0839
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0894	0.0858
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0451	0.4816
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0044	0.075	0.0986
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0894	1
Leishmania major	hypothetical protein, conserved	0.0051	0.0894	1
Echinococcus multilocularis	musashi	0.0026	0.0324	0.0426
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0547	0.051
Echinococcus granulosus	solute carrier family 22	0.0014	0.0039	0.0051
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0015	0.0051	0.0039
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0324	0.0621
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.075	0.341
Brugia malayi	hypothetical protein	0.0051	0.0894	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.075	0.0892
Echinococcus granulosus	GPCR family 2	0.0096	0.1979	0.2599
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0039	0.0047
Brugia malayi	hypothetical protein	0.0033	0.047	0.055
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0639	0.0756
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0451	0.4816
Echinococcus multilocularis	lamin dm0	0.0026	0.0324	0.0426
Mycobacterium tuberculosis	Conserved protein	0.004	0.0639	0.1058
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2125	0.2791
Schistosoma mansoni	glucose transport protein	0.0103	0.2125	0.4548
Trichomonas vaginalis	esterase, putative	0.004	0.0639	0.2875
Trypanosoma cruzi	target of rapamycin kinase 3	0.0035	0.0536	0.5815
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0096	0.1979	0.2599
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0069	0.0066
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0481	0.2117
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0321	0.1349
Echinococcus multilocularis	smad	0.0025	0.0278	0.0366
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.024	0.2346
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0441	0.0404
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0044	0.075	0.0986
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0481	0.2117
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0639	1
Echinococcus granulosus	solute carrier family 22	0.0014	0.0039	0.0051
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.024	0.0201
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0069	0.0062
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0069	0.0062
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.024	0.3343
Plasmodium falciparum	protein kinase 7	0.029	0.6556	0.6542
Schistosoma mansoni	protein kinase	0.0031	0.0441	0.0876
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0426	0.056
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0158	0.021
Leishmania major	glucose transporter, lmgt2	0.0032	0.0451	0.4816
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0426	0.0844
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0426	0.0496
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0015	0.0051	0.0137
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0754	0.1558
Onchocerca volvulus		0.004	0.0639	0.7338
Echinococcus granulosus	lamin	0.0026	0.0324	0.0426
Toxoplasma gondii	protein kinase, putative	0.029	0.6556	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0441	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0426	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0451	0.4816
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0166	0.362	0.5495
Brugia malayi	Sugar transporter family protein	0.0014	0.0039	0.0025
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0451	0.4816
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0435	1	1
Mycobacterium tuberculosis	Conserved protein	0.004	0.0639	0.1058
Echinococcus granulosus	transient receptor potential ion channel A	0.02	0.4443	0.5837
Toxoplasma gondii	facilitative glucose transporter GT1	0.0103	0.2125	0.3201
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0051	0.0056
Leishmania major	glucose transporter, lmgt1	0.0032	0.0451	0.4816
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0639	1
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0278	0.0522
Entamoeba histolytica	hypothetical protein	0.0071	0.1387	1
Echinococcus granulosus	smad	0.0025	0.0278	0.0366
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.024	0.1698
Entamoeba histolytica	hypothetical protein	0.0071	0.1387	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0327	0.1379
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0894	0.0858
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0039	0.0025
Schistosoma mansoni	hypothetical protein	0.0096	0.1979	0.4229
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0069	0.0046
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0441	0.0579
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0025	0.0278	0.0366
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0547	0.594
Echinococcus granulosus	mothers against decapentaplegic 5	0.0025	0.0278	0.0366
Schistosoma mansoni	hypothetical protein	0.0208	0.4626	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0441	0.0617
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0039	0.0051
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0441	0.0876
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0234	0.0307
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0069	0.0053
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0451	0.4816
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0109	0.0821
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0639	0.7018
Leishmania major	hypothetical protein, conserved	0.004	0.0639	0.7018
Schistosoma mansoni	smad	0.0025	0.0278	0.0522
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0451	0.4816
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0069	0.0091
Echinococcus granulosus	tumor protein p63	0.0334	0.7613	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0451	0.4816
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0639	0.2875
Loa Loa (eye worm)	hypothetical protein	0.004	0.0639	0.0777
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.024	0.3343
Loa Loa (eye worm)	hypothetical protein	0.0208	0.4626	0.5628
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0327	0.1379
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0069	0.0091
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0451	0.4816
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0077	0.1524	0.2001
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.024	0.0308
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0395	0.0519
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0327	0.1379
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0051	0.0056
Brugia malayi	Transient-receptor-potential like protein	0.0077	0.1524	0.1835
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.004	0.0639	0.1058
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0639	1
Schistosoma mansoni	protein kinase	0.0031	0.0441	0.0876
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0451	0.1973
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0103	0.2125	0.2791
Brugia malayi	hypothetical protein	0.0071	0.1387	0.1668
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2125	0.2791
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.024	0.2346
Loa Loa (eye worm)	transcription factor SMAD2	0.036	0.822	1
Mycobacterium leprae	Probable lipase LipE	0.004	0.0639	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0039	0.0047
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.004	0.0639	0.1058
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0451	0.4816
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0069	0.0355
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0426	0.1625
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0324	0.0372
Echinococcus granulosus	short transient receptor potential channel 6	0.0137	0.2945	0.3868
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0894	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0018	0.0135	0.1123
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0015	0.0051	0.0137
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0265	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0047
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0069	0.0091
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0044	0.075	0.8325
Mycobacterium ulcerans	beta-lactamase	0.004	0.0639	1
Schistosoma mansoni	lamin	0.0026	0.0324	0.0621
Echinococcus multilocularis	short transient receptor potential channel 6	0.0137	0.2945	0.3868
Mycobacterium ulcerans	hypothetical protein	0.004	0.0639	1
Echinococcus multilocularis	GPCR, family 2	0.0096	0.1979	0.2599
Schistosoma mansoni	transient receptor potential channel	0.0137	0.2945	0.6335
Entamoeba histolytica	protein kinase, putative	0.0031	0.0441	0.1756
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0535	0.2378
Schistosoma mansoni	lamin	0.0026	0.0324	0.0621
Echinococcus multilocularis	tumor protein p63	0.0334	0.7613	1
Schistosoma mansoni	hypothetical protein	0.0166	0.3625	0.7818
Echinococcus granulosus	General substrate transporter	0.0088	0.1784	0.2343
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0894	0.0858
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0547	0.051
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0305	0.6907	0.8399
Brugia malayi	beta-lactamase family protein	0.004	0.0639	0.0756
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0025	0.0278	0.0366
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0639	0.0777
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0166	0.362	0.3595
Brugia malayi	MH1 domain containing protein	0.0025	0.0278	0.0316
Loa Loa (eye worm)	nuclear factor I	0.0014	0.0019	0.0023
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0051	0.0056
Giardia lamblia	GTOR	0.0044	0.075	1
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0451	0.1973
Onchocerca volvulus		0.004	0.0639	0.7338
Loa Loa (eye worm)	hypothetical protein	0.004	0.0639	0.0777
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0069	0.0355
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0324	0.0394
Brugia malayi	Sugar transporter family protein	0.0014	0.0039	0.0025
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0451	0.4816
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0016	0.0069	0.003
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0639	0.2875
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.0069	0.003
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0451	0.1973
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0069	0.0046
Echinococcus granulosus	transient receptor potential gamma protein	0.0207	0.4607	0.6052
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.024	0.0315
Echinococcus multilocularis	Smad4	0.0025	0.0278	0.0366
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.024	0.2818
Echinococcus granulosus	TRP transient receptor potential channel	0.0077	0.1524	0.2001
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0015	0.0051	0.0067
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0441	0.0404
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0639	0.7018
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0426	0.5439
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0639	0.0839
Brugia malayi	major facilitator superfamily protein	0.0014	0.0039	0.0025
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0035	0.0536	0.5815
Loa Loa (eye worm)	hypothetical protein	0.013	0.2781	0.3383
Brugia malayi	MH2 domain containing protein	0.036	0.822	1
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.024	0.0315
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.024	0.0437
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.1387	0.1821

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 683969