TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 386.832 | Formula: C19H19ClN4O3
H donors: 2 H acceptors: 2 LogP: 2.99 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COCC(n1c(=O)[nH]c2c(c1=NC(=O)Nc1cccc(c1)Cl)cccc2)C
InChi: 1S/C19H19ClN4O3/c1-12(11-27-2)24-17(15-8-3-4-9-16(15)22-19(24)26)23-18(25)21-14-7-5-6-13(20)10-14/h3-10,12H,11H2,1-2H3,(H,21,25)(H,22,26)/b23-17+
InChiKey: YOWAWNAYNOAOIP-HAVVHWLPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Papain family cysteine protease containing protein	0.015	0.1717	0.1712
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0105	0.1078	0.1072
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0637	0.8577	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0642	0.073
Onchocerca volvulus		0.015	0.1717	1
Plasmodium falciparum	serine repeat antigen 4	0.0074	0.0642	0.3715
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0108	0.113	0.1094
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0137	0.0131
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0317	0.0311
Giardia lamblia	Cathepsin B precursor	0.0074	0.0642	0.073
Trypanosoma cruzi	cysteine peptidase, putative	0.0105	0.1078	0.1041
Entamoeba histolytica	cysteine proteinase, putative	0.0105	0.1078	0.624
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0039	0.0159	0.0159
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.015	0.1717	0.1996
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0007	0.0001
Schistosoma mansoni	cathepsin C	0.0074	0.0642	0.0636
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0494	0.0488
Loa Loa (eye worm)	hypothetical protein	0.015	0.1717	0.1717
Echinococcus multilocularis	snurportin 1	0.0304	0.3891	0.3887
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0642	0.0642
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0074	0.0642	0.3676
Echinococcus multilocularis	cathepsin L	0.0105	0.1078	0.1072
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0304	0.0304
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0031	0.0041	0.0041
Plasmodium falciparum	serine repeat antigen 6	0.0074	0.0642	0.3715
Trypanosoma cruzi	cysteine protease, putative	0.0105	0.1078	0.1041
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0039	0.0159	0.0166
Plasmodium falciparum	cysteine proteinase falcipain 3	0.015	0.1717	1
Schistosoma mansoni	high-affinity choline transporter	0.0346	0.4481	0.4478
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0074	0.0642	0.073
Echinococcus granulosus	solute carrier family 5	0.0038	0.0143	0.0136
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0304	0.3891	0.3891
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0494	0.0488
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0074	0.0642	0.0642
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0031	0.0041	0.0034
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0074	0.0642	0.3715
Brugia malayi	cathepsin F-like cysteine proteinase	0.0031	0.0041	0.0034
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0304	0.0298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1281	0.1477
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1078	0.1239
Onchocerca volvulus		0.015	0.1717	1
Schistosoma mansoni	ap endonuclease	0.0039	0.0159	0.0153
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.113	0.13
Giardia lamblia	Hypothetical protein	0.0074	0.0642	0.073
Echinococcus multilocularis	lamin	0.0029	0.0007	0.0001
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0317	0.0311
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0137	0.0131
Brugia malayi	Cathepsin L-like precursor	0.015	0.1717	0.1712
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0494	0.0494
Trypanosoma cruzi	cysteine peptidase, putative	0.015	0.1717	0.1683
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0074	0.0642	0.0636
Entamoeba histolytica	cysteine proteinase, putative	0.0105	0.1078	0.624
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.015	0.1717	0.1986
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1078	0.624
Loa Loa (eye worm)	6-phosphofructokinase	0.0108	0.113	0.113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.015	0.1717	0.1996
Entamoeba histolytica	cysteine protease, putative	0.0074	0.0642	0.3676
Trypanosoma cruzi	major cysteine proteinase, putative	0.0074	0.0642	0.0603
Onchocerca volvulus		0.015	0.1717	1
Brugia malayi	Cathepsin L-like precursor	0.015	0.1717	0.1712
Giardia lamblia	Encystation-specific protease	0.0074	0.0642	0.073
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.015	0.1717	0.1996
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0074	0.0642	0.0741
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1078	0.624
Brugia malayi	6-phosphofructokinase	0.0108	0.113	0.1124
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0006	0.0006
Loa Loa (eye worm)	6-phosphofructokinase	0.0108	0.113	0.113
Entamoeba histolytica	cysteine protease, putative	0.0074	0.0642	0.3676
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0039	0.0159	0.0153
Brugia malayi	cathepsin L-like cysteine proteinase	0.0074	0.0642	0.0636
Loa Loa (eye worm)	cathepsin B	0.0637	0.8577	0.8577
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0642	0.073
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0039	0.0159	0.0119
Brugia malayi	Cathepsin L-like precursor	0.015	0.1717	0.1712
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1078	0.125
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.113	0.13
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0074	0.0642	0.3715
Giardia lamblia	Cathepsin L precursor	0.0074	0.0642	0.073
Brugia malayi	RNA, U transporter 1	0.0081	0.0747	0.0741
Echinococcus granulosus	geminin	0.0367	0.4769	0.4766
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0074	0.0642	0.073
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0738	1	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1281	0.1281
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0017	0.0061
Echinococcus multilocularis	cathepsin b	0.0738	1	1
Toxoplasma gondii	cathepsin CPC1	0.0074	0.0642	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0007	0.0007
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1078	0.624
Onchocerca volvulus		0.015	0.1717	1
Plasmodium falciparum	serine repeat antigen 2	0.0074	0.0642	0.3715
Echinococcus multilocularis	high affinity choline transporter 1	0.0346	0.4481	0.4478
Echinococcus granulosus	cathepsin l cysteine peptidase	0.015	0.1717	0.1712
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.015	0.1717	0.1712
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0074	0.0642	0.0636
Echinococcus granulosus	cathepsin l1	0.015	0.1717	0.1712
Echinococcus granulosus	cathepsin L	0.0074	0.0642	0.0636
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0637	0.8577	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.015	0.1717	0.1996
Schistosoma mansoni	inositol transporter	0.0038	0.0143	0.0136
Schistosoma mansoni	cathepsin S (C01 family)	0.0074	0.0642	0.0636
Echinococcus multilocularis	cathepsin L cysteine protease	0.015	0.1717	0.1712
Brugia malayi	GH02984p	0.0346	0.4481	0.4478
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0642	0.073
Trypanosoma cruzi	cysteine peptidase, putative	0.015	0.1717	0.1683
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0637	0.8577	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0143	0.0143
Schistosoma mansoni	cathepsin s	0.0031	0.0041	0.0034
Brugia malayi	Cathepsin L-like precursor	0.015	0.1717	0.1712
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.015	0.1717	1
Plasmodium vivax	vivapain-2	0.015	0.1717	1
Entamoeba histolytica	cysteine protease, putative	0.0074	0.0642	0.3676
Schistosoma mansoni	sodium/solute symporter	0.0038	0.0143	0.0136
Plasmodium vivax	unspecified product	0.0031	0.0041	0.0201
Brugia malayi	fibroinase precursor	0.0074	0.0642	0.0636
Echinococcus multilocularis	geminin	0.0367	0.4769	0.4766
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0159	0.0166
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0317	0.0311
Giardia lamblia	Cathepsin B precursor	0.0074	0.0642	0.073
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0074	0.0642	0.073
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0039	0.0159	0.5
Echinococcus granulosus	6 phosphofructokinase	0.0108	0.113	0.1124
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0137	0.0131
Echinococcus multilocularis	solute carrier family 5	0.0038	0.0143	0.0136
Schistosoma mansoni	6-phosphofructokinase	0.0108	0.113	0.1124
Brugia malayi	Sodium:solute symporter family protein	0.0038	0.0143	0.0136
Schistosoma mansoni	cathepsin F (C01 family)	0.0119	0.1281	0.1275
Toxoplasma gondii	exonuclease III APE	0.0039	0.0159	0.0178
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0494	0.0494
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0159	0.0178
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.015	0.1717	0.1996
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0017	0.0012
Plasmodium vivax	vivapain-1	0.0105	0.1078	0.6263
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.015	0.1717	0.1986
Echinococcus multilocularis	musashi	0.0029	0.0007	0.0001
Trypanosoma cruzi	major cysteine proteinase, putative	0.0074	0.0642	0.0603
Leishmania major	ATP-dependent phosphofructokinase	0.0108	0.113	0.1153
Echinococcus granulosus	cysteine protease	0.0105	0.1078	0.1072
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0074	0.0642	0.3715
Onchocerca volvulus	Cathepsin F homolog	0.015	0.1717	1
Brugia malayi	6-phosphofructokinase	0.0108	0.113	0.1124
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1078	0.624
Brugia malayi	hypothetical protein	0.0038	0.0137	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0041	0.0041
Brugia malayi	cathepsin L precursor	0.0074	0.0642	0.0636
Plasmodium vivax	vivapain-3	0.0105	0.1078	0.6263
Entamoeba histolytica	cysteine proteinase, putative	0.0105	0.1078	0.624
Schistosoma mansoni	lamin	0.0029	0.0007	0.0001
Onchocerca volvulus		0.0038	0.0143	0.0792
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0007	0.0007
Brugia malayi	intermediate filament protein	0.0029	0.0007	0.0001
Giardia lamblia	Cathepsin B precursor	0.0074	0.0642	0.073
Entamoeba histolytica	cysteine proteinase 2	0.0105	0.1078	0.624
Giardia lamblia	Cathepsin B precursor	0.0637	0.8577	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0304	0.0304
Echinococcus granulosus	cathepsin l1	0.0119	0.1281	0.1275
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0074	0.0642	0.073
Brugia malayi	Cathepsin L-like precursor	0.0119	0.1281	0.1275
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.015	0.1717	0.1712
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.015	0.1717	0.1996
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0038	0.0143	0.0136
Plasmodium falciparum	serine repeat antigen 1	0.0074	0.0642	0.3715
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0105	0.1078	0.1041
Onchocerca volvulus	Cathepsin L homolog	0.015	0.1717	1
Plasmodium vivax	vivapain-2	0.015	0.1717	1
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0017	0.0061
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0017	0.5
Brugia malayi	Cathepsin L-like precursor	0.015	0.1717	0.1712
Brugia malayi	Cathepsin L-like precursor	0.0119	0.1281	0.1275
Plasmodium falciparum	serine repeat antigen 9	0.0074	0.0642	0.3715
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0074	0.0642	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0041	0.0041
Entamoeba histolytica	cysteine protease, putative	0.0074	0.0642	0.3676
Entamoeba histolytica	cysteine proteinase, putative	0.015	0.1717	1
Plasmodium vivax	unspecified product	0.0074	0.0642	0.3715
Onchocerca volvulus	Cathepsin L homolog	0.0074	0.0642	0.3711
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0105	0.1078	0.1239
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0074	0.0642	0.0636
Giardia lamblia	Cathepsin L-like protease	0.0074	0.0642	0.073
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0105	0.1078	0.125
Plasmodium falciparum	serine repeat antigen 7	0.0074	0.0642	0.3715
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0074	0.0642	0.0636
Trypanosoma cruzi	cysteine proteinase, putative	0.0105	0.1078	0.1041
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0017	0.0012
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0159	0.0892
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0074	0.0642	0.073
Brugia malayi	Papain family cysteine protease containing protein	0.0074	0.0642	0.0636
Loa Loa (eye worm)	ctsf protein	0.015	0.1717	0.1717
Giardia lamblia	Cysteine protease	0.0074	0.0642	0.073
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0038	0.0143	0.0159
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0039	0.0159	0.0119
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0738	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0494	0.0488
Echinococcus granulosus	lamin dm0	0.0029	0.0007	0.0001
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0317	0.0311
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0494	0.0488
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0108	0.113	0.5
Echinococcus granulosus	lamin	0.0029	0.0007	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0041	0.0041
Leishmania major	cathepsin L-like protease	0.015	0.1717	0.1851
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0317	0.0311
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0642	0.073
Giardia lamblia	Cathepsin L precursor	0.0074	0.0642	0.073
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0074	0.0642	0.0636
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.0159	0.0892
Mycobacterium ulcerans	6-phosphofructokinase	0.0108	0.113	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0105	0.1078	0.6263
Echinococcus multilocularis	cysteine protease	0.015	0.1717	0.1712
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0494	0.0488
Echinococcus granulosus	snurportin 1	0.0304	0.3891	0.3887
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0637	0.8577	0.8571
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.015	0.1717	0.1986
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.015	0.1717	0.1996
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0039	0.0159	0.0836
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.015	0.1717	1
Toxoplasma gondii	cathepsin CPL	0.015	0.1717	0.1996
Schistosoma mansoni	hypothetical protein	0.0034	0.0083	0.0077
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0074	0.0642	0.0636
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0105	0.1078	0.1072
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0074	0.0642	0.3715
Onchocerca volvulus	Cathepsin L homolog	0.015	0.1717	1
Brugia malayi	cathepsin L-like precursor	0.0119	0.1281	0.1275
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1078	0.624
Giardia lamblia	Cathepsin L precursor	0.0074	0.0642	0.073
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0007	0.0001
Entamoeba histolytica	cysteine protease, putative	0.0074	0.0642	0.3676
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0074	0.0642	0.0636
Schistosoma mansoni	hypothetical protein	0.0304	0.3891	0.3887
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1078	0.624
Giardia lamblia	Hypothetical protein	0.0074	0.0642	0.073
Schistosoma mansoni	ap endonuclease	0.0039	0.0159	0.0153
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0074	0.0642	0.0636
Schistosoma mansoni	cathepsin F (C01 family)	0.015	0.1717	0.1712
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0642	0.0642
Plasmodium falciparum	serine repeat antigen 3	0.0074	0.0642	0.3715
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0304	0.0298
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.015	0.1717	0.1986
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.0642	0.073
Brugia malayi	exodeoxyribonuclease III family protein	0.0039	0.0159	0.0153
Leishmania major	cathepsin L-like protease	0.015	0.1717	0.1851
Onchocerca volvulus		0.0074	0.0642	0.3711
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0642	0.073
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.0159	0.0166
Schistosoma mansoni	inositol transporter	0.0038	0.0143	0.0136
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0074	0.0642	0.0636
Onchocerca volvulus		0.015	0.1717	1
Brugia malayi	Cathepsin L-like precursor	0.015	0.1717	0.1712
Echinococcus multilocularis	lamin dm0	0.0029	0.0007	0.0001
Leishmania major	cathepsin L-like protease	0.015	0.1717	0.1851
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.015	0.1717	0.1986
Brugia malayi	Papain family cysteine protease containing protein	0.0074	0.0642	0.0636
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0074	0.0642	0.073
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Leishmania major	cathepsin L-like protease	0.015	0.1717	0.1851
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.015	0.1717	0.1717
Echinococcus granulosus	cathepsin L cysteine proteinase	0.015	0.1717	0.1712
Plasmodium vivax	serine-repeat antigen (SERA)	0.0074	0.0642	0.3715
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1078	0.624
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.015	0.1717	0.1996
Plasmodium vivax	unspecified product	0.0105	0.1078	0.6263
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0017	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1281	0.1281
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0105	0.1078	0.1072
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.113	0.6547
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0108	0.113	0.1311
Giardia lamblia	Cathepsin B precursor	0.0637	0.8577	1
Schistosoma mansoni	lamin	0.0029	0.0007	0.0001
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.015	0.1717	0.1996
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.0642	0.073
Entamoeba histolytica	hypothetical protein	0.0038	0.0137	0.0709
Plasmodium falciparum	serine repeat antigen 5	0.0074	0.0642	0.3715
Loa Loa (eye worm)	hypothetical protein	0.0346	0.4481	0.4481
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0317	0.0311
Trypanosoma cruzi	cysteine proteinase, putative	0.0105	0.1078	0.1041
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0642	0.0642
Entamoeba histolytica	cysteine proteinase 1, putative	0.0105	0.1078	0.624
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0017	0.5
Echinococcus granulosus	cathepsin L	0.0105	0.1078	0.1072
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.015	0.1717	0.1986
Echinococcus granulosus	cathepsin b	0.0738	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.015	0.1717	0.1683
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0074	0.0642	0.073
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0074	0.0642	0.0636
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0494	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0738	1	1
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0038	0.0143	0.0136
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0494	0.0488
Giardia lamblia	Cysteine protease	0.0074	0.0642	0.073
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0119	0.1281	0.1275
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0017	0.0012
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0074	0.0642	0.3715
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0083	0.0077
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.113	0.6547
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.1281	0.1477
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0108	0.113	1
Schistosoma mansoni	6-phosphofructokinase	0.0108	0.113	0.1124
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0038	0.0143	0.0136
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0074	0.0642	0.3715
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0642	0.0642
Echinococcus multilocularis	cysteine protease	0.015	0.1717	0.1712
Echinococcus multilocularis	6 phosphofructokinase	0.0108	0.113	0.1124
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0074	0.0642	0.073
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0074	0.0642	0.3715
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0119	0.1281	0.1245
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0038	0.0143	0.0136
Loa Loa (eye worm)	phosphofructokinase	0.0108	0.113	0.113
Toxoplasma gondii	cathepsin B	0.0637	0.8577	1
Giardia lamblia	Cysteine protease	0.0074	0.0642	0.073
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.015	0.1717	0.1717
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0074	0.0642	0.3715
Loa Loa (eye worm)	cysteine protease	0.015	0.1717	0.1717
Schistosoma mansoni	cathepsin B (C01 family)	0.0074	0.0642	0.0636
Echinococcus granulosus	intermediate filament protein	0.0029	0.0007	0.0001
Echinococcus multilocularis	cathepsin b	0.0738	1	1
Loa Loa (eye worm)	fibroinase	0.015	0.1717	0.1717
Brugia malayi	Papain family cysteine protease containing protein	0.0074	0.0642	0.0636
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0317	0.0311
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0074	0.0642	0.3715
Trypanosoma cruzi	cysteine peptidase, putative	0.015	0.1717	0.1683
Brugia malayi	Papain family cysteine protease containing protein	0.0105	0.1078	0.1072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.015	0.1717	0.1996
Leishmania major	cathepsin L-like protease	0.015	0.1717	0.1851
Echinococcus multilocularis	cathepsin L	0.0074	0.0642	0.0636
Entamoeba histolytica	cysteine protease, putative	0.015	0.1717	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0642	0.0642
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1078	0.624
Leishmania major	cysteine peptidase A (CPA)	0.015	0.1717	0.1851
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0637	0.8577	0.8576
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1078	0.624
Plasmodium vivax	serine-repeat antigen (SERA)	0.0074	0.0642	0.3715
Giardia lamblia	Cathepsin L precursor	0.0074	0.0642	0.073
Trypanosoma cruzi	cysteine peptidase, putative	0.015	0.1717	0.1683
Schistosoma mansoni	hypothetical protein	0.0367	0.4769	0.4766
Entamoeba histolytica	hypothetical protein	0.0038	0.0137	0.0709
Onchocerca volvulus		0.015	0.1717	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0074	0.0642	0.3715
Brugia malayi	Papain family cysteine protease containing protein	0.0105	0.1078	0.1072
Giardia lamblia	Cathepsin B precursor	0.0074	0.0642	0.073
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Giardia lamblia	Cathepsin L-like protease	0.0074	0.0642	0.073
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0074	0.0642	0.0642
Entamoeba histolytica	hypothetical protein	0.0074	0.0642	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1281	0.1281
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0074	0.0642	0.3715
Schistosoma mansoni	hypothetical protein	0.0038	0.0137	0.0131
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.015	0.1717	0.1996
Toxoplasma gondii	cathepsin CPC2	0.0074	0.0642	0.0741
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0074	0.0642	0.073
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.015	0.1717	0.1986
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0038	0.0143	0.0136
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0074	0.0642	0.3676
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.015	0.1717	0.1986
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0108	0.113	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0642	0.073
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0039	0.0159	0.1276
Plasmodium falciparum	serine repeat antigen 8	0.0074	0.0642	0.3715
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1078	0.624
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0007	0.0007
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0074	0.0642	0.073
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0074	0.0642	0.0642
Giardia lamblia	Cathepsin B precursor	0.0637	0.8577	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.015	0.1717	0.1986
Giardia lamblia	Cathepsin L precursor	0.0074	0.0642	0.073
Leishmania major	cathepsin L-like protease	0.015	0.1717	0.1851
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0083	0.0083
Entamoeba histolytica	cysteine proteinase, putative	0.015	0.1717	1
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0038	0.0143	0.0136
Entamoeba histolytica	cysteine proteinase, putative	0.0105	0.1078	0.624
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0017	0.0061
Echinococcus granulosus	high affinity choline transporter 1	0.0346	0.4481	0.4478
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.113	0.13
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0317	0.0317
Brugia malayi	RNA binding protein	0.0063	0.0494	0.0488
Echinococcus multilocularis	cathepsin L cysteine protease	0.015	0.1717	0.1712
Giardia lamblia	Cysteine protease	0.0074	0.0642	0.073
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Brugia malayi	cathepsin F-like cysteine proteinase	0.0074	0.0642	0.0636
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0074	0.0642	0.3715
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.015	0.1717	0.1986
Entamoeba histolytica	hypothetical protein	0.0038	0.0137	0.0709
Leishmania major	cathepsin L-like protease	0.015	0.1717	0.1851
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0738	1	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0039	0.0159	0.0153
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0074	0.0642	0.0636
Brugia malayi	TAR-binding protein	0.0063	0.0494	0.0488
Giardia lamblia	Cathepsin L precursor	0.0074	0.0642	0.073
Onchocerca volvulus		0.015	0.1717	1
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0642	0.073
Schistosoma mansoni	hypothetical protein	0.0367	0.4769	0.4766
Echinococcus granulosus	sodium:glucose cotransporter	0.0038	0.0143	0.0136
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.015	0.1717	0.1986
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0642	0.0642
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.113	0.6547
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.113	0.13
Entamoeba histolytica	cysteine proteinase, putative	0.0119	0.1281	0.7436
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.015	0.1717	0.1986
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0738	1	1
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1078	0.624
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0074	0.0642	0.073
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0041	0.0034
Leishmania major	cathepsin L-like protease	0.015	0.1717	0.1851
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0738	1	1
Onchocerca volvulus		0.0119	0.1281	0.745
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0074	0.0642	0.073
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0494	0.0488
Entamoeba histolytica	cysteine protease, putative	0.0074	0.0642	0.3676
Brugia malayi	phosphofructokinase	0.0108	0.113	0.1124
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0074	0.0642	0.3715
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0074	0.0642	0.073
Schistosoma mansoni	cathepsin F (C01 family)	0.015	0.1717	0.1712
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0317	0.0311
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1078	0.624
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0494	0.0488
Echinococcus granulosus	cathepsin L cysteine protease	0.0105	0.1078	0.1072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0074	0.0642	0.073
Entamoeba histolytica	hypothetical protein	0.0038	0.0137	0.0709
Giardia lamblia	Cathepsin B precursor	0.0074	0.0642	0.073
Entamoeba histolytica	cysteine protease, putative	0.0105	0.1078	0.624
Echinococcus granulosus	cathepsin b	0.0738	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 684264