Detailed information for compound 685038

Basic information

Technical information
  • TDR Targets ID: 685038
  • Name: 3-methylsulfonyl-N-(4-phenyl-1,3-thiazol-2-yl )benzamide
  • MW: 358.435 | Formula: C17H14N2O3S2
  • H donors: 1 H acceptors: 4 LogP: 3.02 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)S(=O)(=O)C)Nc1scc(n1)c1ccccc1
  • InChi: 1S/C17H14N2O3S2/c1-24(21,22)14-9-5-8-13(10-14)16(20)19-17-18-15(11-23-17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19,20)
  • InChiKey: IPVXTCPIIZSMAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-methylsulfonyl-N-(4-phenylthiazol-2-yl)benzamide
  • 3-methylsulfonyl-N-(4-phenyl-2-thiazolyl)benzamide
  • 3-mesyl-N-(4-phenylthiazol-2-yl)benzamide
  • ZINC04517839

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0044 0.0301 0.0218
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.1501 0.5761
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0006 0.0011
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0559 0.1457
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0218 0.0969
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0918 0.1565
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0007 0.0019
Mycobacterium tuberculosis Probable hydrolase 0.0184 0.1501 0.1428
Echinococcus multilocularis pyruvate kinase 0.0018 0.0075 0.0195
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.0778 0.2028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0687 0.1791
Onchocerca volvulus 0.0184 0.1501 0.7805
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0309 0.2578 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0085 0.0193
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0404 0.1456
Brugia malayi Pre-SET motif family protein 0.003 0.0179 0.0305
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0298 0.2483 0.7415
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0687 0.1172
Schistosoma mansoni ap endonuclease 0.0019 0.0085 0.0254
Echinococcus granulosus importin subunit beta 1 0.0029 0.0175 0.0455
Loa Loa (eye worm) hypothetical protein 0.0063 0.046 0.0785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0687 0.2052
Echinococcus multilocularis pyruvate kinase 0.0027 0.0156 0.0407
Trichomonas vaginalis set domain proteins, putative 0.0232 0.1913 0.7381
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0559 0.2056
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0036 0.0062
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0036 0.0095
Echinococcus multilocularis ornithine aminotransferase 0.0044 0.0301 0.0785
Mycobacterium tuberculosis Probable lipase LipD 0.0184 0.1501 0.1428
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0218 0.072
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0218 0.0538
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0404 0.1279
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0236 0.1954 0.5092
Echinococcus granulosus cpg binding protein 0.003 0.0178 0.0463
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0443 0.1323
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0559 0.1457
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0614 0.2868
Leishmania major importin beta-1 subunit, putative 0.0024 0.0127 0.036
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0676 0.3202
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0179 0.0466
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0218 0.1113
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0432 0.035
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0155 0.1254 0.4791
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0044 0.0301 0.1156
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0432 0.129
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0623 0.2918
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0676 0.1763
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0184 0.1501 0.1428
Brugia malayi CXXC zinc finger family protein 0.0028 0.0164 0.028
Schistosoma mansoni pyruvate kinase 0.0034 0.0218 0.0651
Schistosoma mansoni pyruvate kinase 0.0034 0.0218 0.0651
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0179 0.0534
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0175 0.0362
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0218 0.072
Echinococcus granulosus transient receptor potential ion channel A 0.0096 0.075 0.1954
Mycobacterium tuberculosis Probable lipase LipE 0.0184 0.1501 0.1428
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0357 0.1067
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.1313 0.1238
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0404 0.1279
Brugia malayi RNA, U transporter 1 0.0083 0.0638 0.1087
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0175 0.0455
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0245 0.0417
Loa Loa (eye worm) hypothetical protein 0.0184 0.1501 0.2559
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0108 0.0185
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0559 0.1457
Mycobacterium ulcerans hypothetical protein 0.0184 0.1501 0.5678
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0236 0.1954 1
Mycobacterium tuberculosis Conserved protein 0.0184 0.1501 0.1428
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0164 0.0428
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.1501 0.5761
Entamoeba histolytica hypothetical protein 0.0024 0.0127 0.0797
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0085 0.0145
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0218 0.0372
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0687 0.1791
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0179 0.0466
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0108 0.0094
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0129 0.022
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0309 0.2578 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0218 0.0372
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0218 0.0969
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0236 0.1954 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0236 0.1954 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0184 0.1501 0.3912
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0044 0.0301 0.0866
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0241 0.0629
Toxoplasma gondii hypothetical protein 0.005 0.0349 0.1459
Schistosoma mansoni transient receptor potential channel 0.0066 0.0489 0.146
Schistosoma mansoni cpg binding protein 0.0028 0.0164 0.049
Mycobacterium ulcerans beta-lactamase 0.0184 0.1501 0.5678
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0184 0.1501 0.2559
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0108 0.0282
Brugia malayi beta-lactamase 0.0184 0.1501 0.2559
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0687 0.2052
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0081 0.0623 0.2308
Brugia malayi hypothetical protein 0.0169 0.1379 0.2352
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0432 0.129
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0676 0.2518
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0236 0.1954 0.7495
Schistosoma mansoni peptidase Clp (S14 family) 0.0236 0.1954 0.5834
Mycobacterium tuberculosis Probable esterase LipL 0.0184 0.1501 0.1428
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0044 0.0301 0.1204
Loa Loa (eye worm) hypoxia-induced factor 1 0.0156 0.1266 0.216
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0013 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0432 0.1392
Echinococcus multilocularis pyruvate kinase 0.0018 0.0075 0.0195
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0404 0.1053
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0489 0.1274
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0155 0.0792
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0559 0.1457
Echinococcus granulosus Aminotransferase class III 0.0044 0.0301 0.0785
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0614 1
Onchocerca volvulus 0.0184 0.1501 0.7805
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0294 0.1022
Loa Loa (eye worm) hypothetical protein 0.0184 0.1501 0.2559
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0155 0.1254 0.1179
Echinococcus multilocularis neuropeptide s receptor 0.0456 0.3837 1
Echinococcus granulosus ubiquitin specific protease 41 0.0074 0.0559 0.1457
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0028 0.0072
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0075 0.0379
Echinococcus granulosus neuropeptide receptor A26 0.0456 0.3837 1
Schistosoma mansoni ap endonuclease 0.0019 0.0085 0.0254
Chlamydia trachomatis pyruvate kinase 0.0034 0.0218 0.0948
Schistosoma mansoni hypothetical protein 0.0012 0.0028 0.0082
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0085 0.019
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0074 0.0559 0.1669
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0236 0.1954 1
Leishmania major pyruvate kinase 0.0034 0.0218 0.072
Echinococcus multilocularis pyruvate kinase 0.0034 0.0218 0.0569
Brugia malayi hypoxia-induced factor 1 0.0156 0.1266 0.216
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0218 0.0134
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0236 0.1954 0.5092
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0623 0.3186
Schistosoma mansoni transient receptor potential channel 0.0066 0.0489 0.146
Loa Loa (eye worm) hypothetical protein 0.0027 0.0155 0.0265
Plasmodium vivax importin-beta 2, putative 0.0029 0.0175 0.089
Brugia malayi PAS domain containing protein 0.0051 0.0357 0.061
Schistosoma mansoni pyruvate kinase 0.0018 0.0075 0.0223
Mycobacterium ulcerans acetylornithine aminotransferase 0.0044 0.0301 0.0866
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0451 0.2003
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1172 0.4389
Echinococcus multilocularis snurportin 1 0.0312 0.2604 0.6787
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0179 0.0534
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0179 0.0534
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0404 0.0689
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0687 0.1172
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0687 0.2052
Echinococcus multilocularis ubiquitin specific protease 41 0.0074 0.0559 0.1457
Loa Loa (eye worm) hypothetical protein 0.0074 0.0559 0.0953
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0085 0.0193
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.0778 0.2028
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0155 0.0471
Loa Loa (eye worm) hypothetical protein 0.0029 0.0175 0.0298
Loa Loa (eye worm) hypothetical protein 0.0034 0.0218 0.0372
Plasmodium vivax ornithine aminotransferase, putative 0.0044 0.0301 0.1537
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0074 0.0559 0.8984
Echinococcus granulosus pyruvate kinase 0.0034 0.0218 0.0569
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0155 0.0284
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0432 0.1902
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0175 0.0532
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0218 0.0372
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0236 0.1954 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0155 0.0471
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0692 0.5864 1
Trichomonas vaginalis D-aminoacylase, putative 0.0184 0.1501 0.5761
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0218 0.0372
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.1501 0.58
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0559 0.2056
Mycobacterium ulcerans hypothetical protein 0.0162 0.1313 0.4925
Trichomonas vaginalis ran, putative 0.0022 0.0108 0.0283
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0218 0.0538
Brugia malayi Pre-SET motif family protein 0.0204 0.1672 0.2851
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0044 0.0301 0.0218
Schistosoma mansoni cpg binding protein 0.003 0.0178 0.0531
Leishmania major hypothetical protein, conserved 0.0184 0.1501 0.58
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0155 0.0429
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0218 0.0715
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0559 0.1914
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0294 0.0846
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0432 0.1126
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0085 0.0145
Echinococcus granulosus pyruvate kinase 0.0018 0.0075 0.0195
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.1501 0.4481
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0294 0.1022
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0127 0.0357
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0108 0.0285
Echinococcus granulosus single minded 2 0.0037 0.0245 0.0638
Brugia malayi Probable ClpP-like protease 0.0236 0.1954 0.3332
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0432 0.1392
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0404 0.0322
Loa Loa (eye worm) beta-lactamase 0.0184 0.1501 0.2559
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0074 0.0559 0.8964
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0245 0.0638
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0127 0.036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0085 0.0193
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0245 0.064
Echinococcus granulosus ornithine aminotransferase 0.0044 0.0301 0.0785
Plasmodium vivax SET domain protein, putative 0.003 0.0179 0.0912
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0298 0.2483 0.6473
Toxoplasma gondii ABC1 family protein 0.0184 0.1501 0.7589
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0044 0.0301 0.1041
Echinococcus granulosus pyruvate kinase 0.0018 0.0075 0.0195
Trichomonas vaginalis esterase, putative 0.0184 0.1501 0.5761
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0236 0.1954 1
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.2561 1
Onchocerca volvulus 0.003 0.0179 0.0759
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0687 0.1791
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0432 0.1392
Entamoeba histolytica Ran family GTPase 0.0022 0.0108 0.0442
Schistosoma mansoni transient receptor potential channel 4 0.01 0.0778 0.2324
Echinococcus multilocularis transient receptor potential ion channel A 0.0096 0.075 0.1954
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0309 0.2578 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0184 0.1501 0.4481
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0007 0.0019
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0179 0.0466
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0044 0.0301 0.0513
Echinococcus granulosus neuropeptide s receptor 0.0456 0.3837 1
Onchocerca volvulus 0.0037 0.0245 0.1111
Mycobacterium ulcerans esterase/lipase LipP 0.0184 0.1501 0.5678
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0676 0.3459
Schistosoma mansoni cpg binding protein 0.003 0.0178 0.0531
Loa Loa (eye worm) hypothetical protein 0.0184 0.1501 0.2559
Echinococcus granulosus snurportin 1 0.0312 0.2604 0.6787
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0489 0.1274
Echinococcus multilocularis pyruvate kinase 0.0018 0.0075 0.0195
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0044 0.0301 0.0866
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0404 0.1053
Brugia malayi MH2 domain containing protein 0.0116 0.0918 0.1565
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.2604 0.444
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0044 0.0301 0.0218
Schistosoma mansoni transient receptor potential channel 0.01 0.0778 0.2324
Onchocerca volvulus 0.0184 0.1501 0.7805
Plasmodium falciparum importin beta, putative 0.0029 0.0175 0.0532
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0155 0.1254 0.1179
Loa Loa (eye worm) hypothetical protein 0.0151 0.1217 0.2076
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0614 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1172 0.4497
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0044 0.0301 0.1041
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0184 0.1501 0.1428
Brugia malayi hypothetical protein 0.0027 0.0155 0.0265
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0044 0.0301 0.0866
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0432 0.1567
Schistosoma mansoni importin beta-1 0.0029 0.0175 0.0522
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0108 0.0185
Echinococcus granulosus pyruvate kinase 0.0018 0.0075 0.0195
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0676 0.3202
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0127 0.0357
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0309 0.2578 0.2515
Echinococcus granulosus pyruvate kinase 0.0034 0.0218 0.0569
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0108 0.0551
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0044 0.0301 0.0866
Toxoplasma gondii hypothetical protein 0.0081 0.0623 0.2918
Plasmodium falciparum pyruvate kinase 0.0034 0.0218 0.0763
Mycobacterium leprae conserved hypothetical protein 0.0184 0.1501 0.5761
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0036 0.0095
Mycobacterium ulcerans L-lysine aminotransferase 0.0044 0.0301 0.0866
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0108 0.0179
Mycobacterium tuberculosis Probable aminotransferase 0.0309 0.2578 0.2515
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0044 0.0301 0.0899
Plasmodium falciparum ornithine aminotransferase 0.0044 0.0301 0.1204
Onchocerca volvulus 0.0028 0.0164 0.0681
Brugia malayi hypothetical protein 0.0151 0.1217 0.2076
Mycobacterium tuberculosis Conserved protein 0.0184 0.1501 0.1428
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0184 0.1501 0.1428
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.2561 1
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0218 0.0763
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0108 0.0179
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0236 0.1954 0.7495
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0164 0.028
Trypanosoma cruzi hypothetical protein, conserved 0.0184 0.1501 0.58
Mycobacterium tuberculosis Conserved protein 0.0184 0.1501 0.1428
Plasmodium vivax hypothetical protein, conserved 0.0184 0.1501 0.768
Echinococcus granulosus beta LACTamase domain containing family member 0.0184 0.1501 0.3912
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0085 0.0192
Brugia malayi follicle stimulating hormone receptor 0.0692 0.5864 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0085 0.0432
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0179 0.0554
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0559 0.2056
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0489 0.1274
Onchocerca volvulus 0.0151 0.1217 0.6294
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0218 0.0372
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0155 0.0429
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0028 0.0072
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0218 0.0534
Echinococcus granulosus peptidase Clp S14 family 0.0155 0.1254 0.3269
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0074 0.0559 0.1669
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1172 0.4497
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0404 0.1206
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0127 0.0357
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0687 0.1791
Mycobacterium ulcerans hypothetical protein 0.0309 0.2578 1
Loa Loa (eye worm) hypothetical protein 0.0184 0.1501 0.2559
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0623 0.2879
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.022
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0036 0.0095
Brugia malayi beta-lactamase family protein 0.0184 0.1501 0.2559
Loa Loa (eye worm) hypothetical protein 0.0034 0.0213 0.0363
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.3349 0.8729
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0108 0.0285
Leishmania major pyruvate kinase 0.0034 0.0218 0.072
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0085 0.0222
Toxoplasma gondii exonuclease III APE 0.0019 0.0085 0.0055
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0155 0.0429
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0175 0.0362
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0236 0.1954 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0108 0.0623
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0108 0.0282
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0236 0.1954 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0085 0.0192
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0044 0.0301 0.1041
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0559 0.207
Echinococcus multilocularis neuropeptide receptor A26 0.0456 0.3837 1
Giardia lamblia Pyruvate kinase 0.0034 0.0218 0.2661
Echinococcus multilocularis Aminotransferase class III 0.0044 0.0301 0.0785
Loa Loa (eye worm) hypothetical protein 0.0013 0.0036 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0179 0.0534
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.1501 0.5761
Loa Loa (eye worm) hypothetical protein 0.0236 0.1954 0.3332
Schistosoma mansoni hypothetical protein 0.0312 0.2604 0.7775
Mycobacterium ulcerans lipase LipD 0.0184 0.1501 0.5678
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0129 0.0832
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0241 0.0629
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.2561 1
Trypanosoma brucei hypothetical protein, conserved 0.0184 0.1501 0.5717
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0074 0.0559 0.207
Brugia malayi hypothetical protein 0.0017 0.0073 0.0125
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0085 0.0222
Brugia malayi beta-lactamase family protein 0.0184 0.1501 0.2559
Trichomonas vaginalis penicillin-binding protein, putative 0.0184 0.1501 0.5761
Schistosoma mansoni ran 0.0022 0.0108 0.0324
Echinococcus multilocularis cpg binding protein 0.003 0.0178 0.0463
Loa Loa (eye worm) hypothetical protein 0.0169 0.1379 0.2352
Loa Loa (eye worm) acetyltransferase 0.0298 0.2483 0.4235
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0294 0.1022
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0184 0.1501 0.5678
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0432 0.1126
Loa Loa (eye worm) hypothetical protein 0.003 0.0179 0.0305
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0074 0.0559 0.0953
Schistosoma mansoni hypothetical protein 0.0399 0.3349 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.029 0.2412 0.6286
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0241 0.0412
Leishmania major hypothetical protein, conserved 0.0027 0.0155 0.0471
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0489 0.1274
Echinococcus multilocularis ornithine aminotransferase 0.0044 0.0301 0.0785
Echinococcus multilocularis peptidase Clp (S14 family) 0.0155 0.1254 0.3269
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.2561 1
Mycobacterium leprae Probable lipase LipE 0.0184 0.1501 0.5761
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0044 0.0301 0.0218
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0559 0.207
Leishmania major GTP-binding protein, putative 0.0022 0.0108 0.0285
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1672 0.2851
Loa Loa (eye worm) hypothetical protein 0.0184 0.1501 0.2559
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0036 0.0095
Loa Loa (eye worm) hypothetical protein 0.01 0.0778 0.1327
Loa Loa (eye worm) hypothetical protein 0.0184 0.1501 0.2559
Schistosoma mansoni single-minded 0.0051 0.0357 0.1067
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0676 0.2518
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0372 0.0634
Loa Loa (eye worm) hypothetical protein 0.0037 0.0241 0.0412
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0218 0.0715
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0044 0.0301 0.138
Echinococcus granulosus dnaJ subfamily B 0.0399 0.3349 0.8729
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0218 0.0969
Loa Loa (eye worm) histone methyltransferase 0.001 0.0007 0.0012
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0184 0.1501 0.2559
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0376 0.1344
Brugia malayi Importin beta-1 subunit 0.0029 0.0175 0.0298
Onchocerca volvulus 0.0232 0.1913 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0236 0.1954 0.7543
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0085 0.0055
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0918 0.1565
Brugia malayi acetyltransferase, GNAT family protein 0.0298 0.2483 0.4235
Schistosoma mansoni ran 0.0022 0.0108 0.0324
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0218 0.0715
Echinococcus multilocularis pyruvate kinase 0.0034 0.0218 0.0569

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.