Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.202 | 0.2001 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0038 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0261 | 0.0377 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0038 | 0.002 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0062 | 0.0411 | 0.0388 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0038 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0471 | 0.6289 | 0.628 |
Brugia malayi | TAR-binding protein | 0.0261 | 0.327 | 0.52 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.028 | 0.0445 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0096 | 0.0904 | 0.1437 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0161 | 0.0256 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0052 | 0.0278 | 0.0255 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0052 | 0.0278 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.028 | 0.0406 |
Onchocerca volvulus | 0.049 | 0.6558 | 1 | |
Echinococcus multilocularis | geminin | 0.0174 | 0.202 | 0.2001 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 0.0904 | 0.0882 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0025 | 0.0002 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0046 | 0.0186 | 0.0163 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0038 | 0.0337 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0062 | 0.0411 | 0.0388 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0161 | 0.0138 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0261 | 0.327 | 0.52 |
Onchocerca volvulus | 0.0096 | 0.0904 | 0.1345 | |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0127 | 0.1348 | 0.1328 |
Echinococcus granulosus | tumor protein p63 | 0.0707 | 0.9682 | 0.9682 |
Schistosoma mansoni | tar DNA-binding protein | 0.0261 | 0.327 | 0.3254 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0052 | 0.0278 | 0.0255 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0127 | 0.1348 | 0.1328 |
Schistosoma mansoni | tar DNA-binding protein | 0.0261 | 0.327 | 0.3254 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0729 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0041 | 0.0017 |
Brugia malayi | Pre-SET motif family protein | 0.0062 | 0.0411 | 0.0653 |
Trichomonas vaginalis | set domain proteins, putative | 0.049 | 0.6558 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0161 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0186 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0278 | 0.0403 |
Plasmodium vivax | SET domain protein, putative | 0.0062 | 0.0411 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0025 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0284 | 0.3602 | 0.3587 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0038 | 0.055 |
Schistosoma mansoni | thyroid hormone receptor | 0.0137 | 0.1495 | 0.1475 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0161 | 0.0138 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0052 | 0.0278 | 0.0442 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0062 | 0.0411 | 0.0388 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.028 | 0.0445 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0023 | 0.0037 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0062 | 0.0411 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0025 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0261 | 0.327 | 0.518 |
Schistosoma mansoni | tar DNA-binding protein | 0.0261 | 0.327 | 0.3254 |
Echinococcus multilocularis | tumor protein p63 | 0.0707 | 0.9682 | 0.9682 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0038 | 0.0015 |
Brugia malayi | Pre-SET motif family protein | 0.043 | 0.5704 | 0.9071 |
Loa Loa (eye worm) | RNA binding protein | 0.0261 | 0.327 | 0.518 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0161 | 0.0138 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0038 | 0.0015 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0038 | 0.002 |
Echinococcus multilocularis | tar DNA binding protein | 0.0261 | 0.327 | 0.3254 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0411 | 0.0615 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0046 | 0.0186 | 0.0163 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1011 | 0.1574 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0062 | 0.0411 | 0.0388 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0038 | 0.002 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.0261 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0046 | 0.0186 | 0.0163 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0186 | 0.0296 |
Echinococcus granulosus | tar DNA binding protein | 0.0261 | 0.327 | 0.3254 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0046 | 0.0186 | 0.0163 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0261 | 0.327 | 0.518 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0025 | 0.004 |
Schistosoma mansoni | tar DNA-binding protein | 0.0261 | 0.327 | 0.3254 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0051 | 0.0261 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0471 | 0.6289 | 0.628 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0052 | 0.0278 | 0.0255 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.202 | 0.2001 |
Onchocerca volvulus | 0.0046 | 0.0186 | 0.0246 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0025 | 0.0002 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.0261 | 0.5 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.0186 | 0.0163 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.2727 | 1 |
Brugia malayi | hypothetical protein | 0.0471 | 0.6289 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0051 | 0.0261 | 0.6123 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.1348 | 0.1328 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0185 | 0.2186 | 0.2168 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0051 | 0.0261 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0729 | 1 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.043 | 0.5704 | 0.9067 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0041 | 0.0065 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0038 | 0.0015 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0046 | 0.0186 | 0.0163 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0038 | 0.055 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0161 | 0.0138 |
Schistosoma mansoni | thyroid hormone receptor | 0.0137 | 0.1495 | 0.1475 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0046 | 0.0186 | 0.0257 |
Onchocerca volvulus | 0.0062 | 0.0411 | 0.059 | |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0025 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0041 | 0.0024 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0038 | 0.0061 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0046 | 0.0186 | 0.0246 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0261 | 0.0415 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0161 | 0.0138 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0062 | 0.0411 | 0.0388 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0038 | 0.0015 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0025 | 0.004 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.028 | 0.0406 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0051 | 0.0261 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0062 | 0.0411 | 0.0388 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0161 | 0.0138 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0038 | 0.055 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0051 | 0.0261 | 0.6123 |
Schistosoma mansoni | tar DNA-binding protein | 0.0261 | 0.327 | 0.3254 |
Loa Loa (eye worm) | MBCTL1 | 0.0052 | 0.0278 | 0.0403 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0052 | 0.0278 | 0.0255 |
Onchocerca volvulus | 0.0103 | 0.1011 | 0.1509 | |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0025 | 0.004 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0185 | 0.2186 | 0.2168 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0038 | 0.055 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0137 | 0.1495 | 0.1475 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0025 | 0.0002 |
Leishmania major | hypothetical protein, conserved | 0.0051 | 0.0261 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0096 | 0.0904 | 0.0882 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0025 | 0.004 |
Loa Loa (eye worm) | hypothetical protein | 0.0471 | 0.6289 | 1 |
Brugia malayi | RNA binding protein | 0.0261 | 0.327 | 0.52 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0161 | 0.0138 |
Echinococcus granulosus | geminin | 0.0174 | 0.202 | 0.2001 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0038 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0059 | 0.0378 | 0.0355 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0186 | 0.0296 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0062 | 0.0411 | 0.0388 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0038 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0103 | 0.1011 | 0.099 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.0186 | 0.0163 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.