Detailed information for compound 687489

Basic information

Technical information
  • TDR Targets ID: 687489
  • Name: 2-[(4-amino-5-furan-2-yl-1,2,4-triazol-3-yl)s ulfanyl]-N-(2,4-dimethylphenyl)acetamide
  • MW: 343.403 | Formula: C16H17N5O2S
  • H donors: 2 H acceptors: 3 LogP: 2.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1C)C)CSc1nnc(n1N)c1ccco1
  • InChi: 1S/C16H17N5O2S/c1-10-5-6-12(11(2)8-10)18-14(22)9-24-16-20-19-15(21(16)17)13-4-3-7-23-13/h3-8H,9,17H2,1-2H3,(H,18,22)
  • InChiKey: ZOLVEXLNMAOUBN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-amino-5-(2-furyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2,4-dimethylphenyl)acetamide
  • 2-[[4-amino-5-(2-furyl)-1,2,4-triazol-3-yl]thio]-N-(2,4-dimethylphenyl)acetamide
  • 2-[(4-amino-5-furan-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2,4-dimethylphenyl)ethanamide
  • ZINC04585973

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Echinococcus granulosus solute carrier family 22 0.003 0.0201 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0201 0.0894
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0606 0.269
Onchocerca volvulus 0.003 0.0201 0.5778
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0348 0.4964
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0043 0.0347 0.5822
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0399 0.1155
Onchocerca volvulus 0.003 0.0201 0.5778
Schistosoma mansoni tyrosine kinase 0.0174 0.1792 0.5193
Trypanosoma cruzi sugar transporter, putative 0.003 0.0201 0.2874
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Plasmodium falciparum protein kinase 7 0.0608 0.6612 0.6612
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Onchocerca volvulus 0.003 0.0201 0.5778
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0348 0.4964
Loa Loa (eye worm) hypothetical protein 0.0066 0.0597 0.173
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Echinococcus granulosus neuropeptide receptor A26 0.0452 0.4882 1
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0201 0.0584
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0215 0.2253 0.4616
Loa Loa (eye worm) hypothetical protein 0.0043 0.0348 0.1008
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0348 0.3724 0.3724
Schistosoma mansoni glucose transport protein 0.0215 0.2253 0.6531
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0399 0.0817
Mycobacterium tuberculosis Conserved protein 0.0043 0.0348 0.1181
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0348 0.1181
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1222
Plasmodium vivax sugar transporter, putative 0.003 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0048 0.0399 0.1155
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0065 0.0582 0.1687
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0001 0.0002
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0318 0.5469
Brugia malayi steroid hormone receptor 0.0012 0.0001 0.0003
Brugia malayi major facilitator superfamily protein 0.003 0.0201 0.0584
Brugia malayi nuclear receptor NHR-88 0.0012 0.0001 0.0003
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.2253 0.4616
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0348 0.1181
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0001 0.0003
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0399 0.5689
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0399 0.1155
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0348 0.1008
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0348 0.0712
Echinococcus granulosus solute carrier family 22 0.003 0.0201 0.0413
Schistosoma mansoni glucose transport protein 0.0215 0.2253 0.6531
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0001 0.0003
Trypanosoma cruzi hexose transporter 0.0067 0.0606 0.8651
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0001 0.0002
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0066 0.0597 0.8517
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0065 0.0582 0.2583
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0001 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0001 0.0003
Echinococcus granulosus epidermal growth factor receptor 0.0174 0.1792 0.367
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0065 0.0582 0.1192
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0201 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0701 1
Echinococcus multilocularis General substrate transporter 0.0185 0.1918 0.3928
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0399 0.0399
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Schistosoma mansoni glucose transport protein 0.0215 0.2253 0.6531
Toxoplasma gondii sugar transporter ST3 0.003 0.0201 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0606 0.269
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.0318 0.108
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Brugia malayi Sugar transporter family protein 0.003 0.0201 0.0584
Loa Loa (eye worm) hypothetical protein 0.0043 0.0348 0.1008
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0606 0.269
Brugia malayi ecdysteroid receptor 0.0012 0.0001 0.0003
Echinococcus multilocularis solute carrier family 22 0.003 0.0201 0.0413
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0065 0.0582 0.1687
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0348 0.1544
Echinococcus granulosus insulin receptor 0.0103 0.1011 0.2071
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Schistosoma mansoni tyrosine kinase 0.0174 0.1792 0.5193
Echinococcus multilocularis neuropeptide receptor A26 0.0452 0.4882 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0606 0.269
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0201 0.0201
Schistosoma mansoni sugar transporter 0.003 0.0201 0.0584
Entamoeba histolytica hypothetical protein 0.0043 0.0347 0.5822
Plasmodium vivax proline--tRNA ligase, putative 0.0075 0.0701 0.0701
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0001 0.0003
Onchocerca volvulus 0.003 0.0201 0.5778
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0001 0.0002
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0201 0.2874
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0606 0.8651
Echinococcus granulosus solute carrier family 22 0.003 0.0201 0.0413
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0066 0.0597 0.1222
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2946 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Loa Loa (eye worm) beta-lactamase 0.0043 0.0348 0.1008
Trypanosoma brucei sugar transporter, putative 0.003 0.0201 0.2874
Trypanosoma cruzi glucose transporter, putative 0.003 0.0201 0.2874
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0001 0.0003
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0333 0.1477
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0348 0.1008
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0399 0.6849
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0399 0.0399
Brugia malayi Sugar transporter family protein 0.003 0.0201 0.0584
Echinococcus granulosus neuropeptide s receptor 0.0452 0.4882 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0001 0.0003
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0399 0.1769
Loa Loa (eye worm) TK/EGFR protein kinase 0.0323 0.345 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0001 0.0003
Trypanosoma cruzi hexose transporter, putative 0.003 0.0201 0.2874
Onchocerca volvulus 0.003 0.0201 0.5778
Mycobacterium tuberculosis Conserved protein 0.0043 0.0348 0.1181
Onchocerca volvulus 0.003 0.0201 0.5778
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0119 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0201 0.5052
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0001 0.0002
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0065 0.0582 0.1192
Entamoeba histolytica protein kinase, putative 0.0066 0.0597 1
Onchocerca volvulus 0.003 0.0201 0.5778
Echinococcus granulosus epidermal growth factor receptor 0.0323 0.345 0.7067
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0001 0.0002
Brugia malayi hypothetical protein 0.003 0.0201 0.0584
Plasmodium vivax CDK-related protein kinase 6, putative 0.0914 1 1
Onchocerca volvulus 0.0043 0.0348 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0318 0.108
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0348 0.1008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0215 0.2253 1
Echinococcus multilocularis 0.01 0.0975 0.1997
Brugia malayi Sugar transporter family protein 0.0215 0.2253 0.6531
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0348 0.8725
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0001 0.0002
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0001 0.0003
Plasmodium vivax calcium-dependent protein kinase, putative 0.0066 0.0597 0.0597
Trypanosoma brucei glucose transporter 2A 0.0067 0.0606 0.8651
Leishmania major glucose transporter, lmgt2 0.0067 0.0606 0.8651
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1222
Brugia malayi hypothetical protein 0.0043 0.0347 0.1007
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0348 0.4964
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0001 0.0003
Schistosoma mansoni tyrosine kinase 0.0103 0.1011 0.2931
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0348 0.1008
Echinococcus granulosus geminin 0.0167 0.1717 0.3516
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0347 0.0712
Giardia lamblia Hexose transporter 0.003 0.0201 0.346
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0399 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0075 0.0701 0.106
Onchocerca volvulus 0.0043 0.0348 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0001 0.0003
Onchocerca volvulus 0.003 0.0201 0.5778
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0201 0.0894
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0347 0.1007
Plasmodium falciparum calcium-dependent protein kinase 3 0.0066 0.0597 0.0597
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0001 0.0003
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0552 0.113
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0001 0.0003
Onchocerca volvulus 0.003 0.0201 0.5778
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0348 0.1544
Trypanosoma brucei glucose transporter 1E 0.0067 0.0606 0.8651
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0348 0.1181
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0347 0.0712
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0606 0.8651
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0001 0.0003
Echinococcus granulosus solute carrier family 22 0.003 0.0201 0.0413
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0348 0.8725
Toxoplasma gondii facilitative glucose transporter GT1 0.0215 0.2253 0.3408
Schistosoma mansoni coup transcription factor 0.0012 0.0001 0.0003
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0065 0.0582 0.9752
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0001 0.0002
Plasmodium falciparum hexose transporter 0.0215 0.2253 0.2253
Schistosoma mansoni hypothetical protein 0.0043 0.0347 0.1007
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0066 0.0597 0.173
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Entamoeba histolytica protein kinase, putative 0.0066 0.0597 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0001 0.0003
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0201 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0348 0.1008
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0399 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0001 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0001 0.0003
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0201 0.0413
Plasmodium falciparum calcium-dependent protein kinase 4 0.0066 0.0597 0.0597
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0001 0.0003
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0701 1
Leishmania major glucose transporter, lmgt3 0.0067 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0348 0.5976
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0582 0.1687
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0052 0.0448 0.1298
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0001 0.0003
Brugia malayi Furin-like cysteine rich region family protein 0.0323 0.345 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0066 0.0597 0.173
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0399 0.5689
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0001 0.0002
Onchocerca volvulus 0.0043 0.0348 1
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0399 0.5689
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0606 0.269
Giardia lamblia Sugar-proton symporter 0.003 0.0201 0.346
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0001 0.0003
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Schistosoma mansoni tyrosine kinase 0.0323 0.345 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0606 0.8651
Leishmania major glucose transporter/membrane transporter D2, putative 0.0067 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Schistosoma mansoni hypothetical protein 0.0167 0.1717 0.4975
Schistosoma mansoni tyrosine kinase 0.0103 0.1011 0.2931
Echinococcus multilocularis geminin 0.0167 0.1717 0.3516
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0348 0.3724 0.5632
Toxoplasma gondii protein kinase, putative 0.0608 0.6612 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.0348 0.8725
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0348 0.1544
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0174 0.1792 0.367
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0201 0.5052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0348 0.1008
Schistosoma mansoni sugar transporter 0.003 0.0201 0.0584
Plasmodium falciparum mitogen-activated protein kinase 2 0.0348 0.3724 0.3724
Schistosoma mansoni hypothetical protein 0.0215 0.2253 0.6531
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0201 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0606 0.269
Echinococcus multilocularis epidermal growth factor receptor 0.0174 0.1792 0.367
Leishmania major hypothetical protein, conserved 0.003 0.0201 0.2874
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0201 0.0584
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0201 0.0413
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0001 0.0002
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0215 0.2253 0.4616
Loa Loa (eye worm) hypothetical protein 0.0065 0.0582 0.1687
Loa Loa (eye worm) hypothetical protein 0.0043 0.0348 0.1008
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0201 0.0684
Plasmodium falciparum calcium-dependent protein kinase 2 0.0066 0.0597 0.0597
Echinococcus multilocularis epidermal growth factor receptor 0.0323 0.345 0.7067
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0075 0.0701 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0201 0.5052
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0606 0.8651
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0001 0.0003
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.2253 0.4616
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0001 0.0003
Trichomonas vaginalis glucose transporter, putative 0.003 0.0201 0.0894
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Toxoplasma gondii ABC1 family protein 0.0043 0.0348 0.0526
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0201 0.0894
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0119 0.2978
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0399 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0348 0.8725
Plasmodium vivax hexose transporter 0.0215 0.2253 0.2253
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Brugia malayi major facilitator superfamily protein 0.003 0.0201 0.0584
Schistosoma mansoni glucose transporter 0.003 0.0201 0.0584
Loa Loa (eye worm) sugar transporter 0.0215 0.2253 0.6531
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0701 1
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0606 0.269
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0066 0.0597 0.0597
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1222
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1222
Schistosoma mansoni protein kinase 0.0066 0.0597 0.173
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0001 0.0002
Schistosoma mansoni protein kinase 0.0066 0.0597 0.173
Onchocerca volvulus 0.003 0.0201 0.5778
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0066 0.0597 0.0597
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0119 0.2978
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.016 0.0463
Schistosoma mansoni hypothetical protein 0.0167 0.1717 0.4975
Echinococcus multilocularis neuropeptide s receptor 0.0452 0.4882 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0201 0.0413
Onchocerca volvulus Putative transporter 0.003 0.0201 0.5778
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0348 0.1544
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0001 0.0002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0348 0.1181
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0001 0.0003
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Onchocerca volvulus 0.003 0.0201 0.5778
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0066 0.0597 0.0903
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0066 0.0597 0.0597
Plasmodium falciparum calcium-dependent protein kinase 5 0.0066 0.0597 0.0597
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0103 0.1011 0.2071
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0399 0.0817
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0215 0.2253 0.4616
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0201 0.0894
Brugia malayi hypothetical protein 0.003 0.0201 0.0584
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0201 0.0584
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.2253 0.4616
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0201 0.2874
Echinococcus multilocularis insulin receptor 0.0103 0.1011 0.2071
Schistosoma mansoni sugar transporter 0.003 0.0201 0.0584
Plasmodium falciparum calcium-dependent protein kinase 1 0.0066 0.0597 0.0597
Brugia malayi Protein kinase domain containing protein 0.0103 0.1011 0.2931
Mycobacterium tuberculosis Conserved protein 0.0043 0.0348 0.1181
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0215 0.2253 0.4616
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0001 0.0002
Schistosoma mansoni tyrosine kinase 0.0172 0.1771 0.5134
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Loa Loa (eye worm) hypothetical protein 0.0065 0.0582 0.1687
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0399 0.0603
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0201 0.0894
Entamoeba histolytica hypothetical protein 0.0043 0.0347 0.5822
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0348 0.1181
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0348 0.1181
Echinococcus multilocularis solute carrier family 22 0.003 0.0201 0.0413
Echinococcus multilocularis solute carrier family 22 0.003 0.0201 0.0413
Loa Loa (eye worm) TK/INSR protein kinase 0.0103 0.1011 0.2931
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0348 0.1544
Loa Loa (eye worm) sugar transporter 0.003 0.0201 0.0584
Giardia lamblia Prolyl-tRNA synthetase 0.0065 0.0582 1
Onchocerca volvulus 0.003 0.0201 0.5778
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0201 0.0413
Toxoplasma gondii sugar transporter ST1 0.003 0.0201 0.0305
Mycobacterium ulcerans hypothetical protein 0.0043 0.0348 0.8725
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Onchocerca volvulus 0.003 0.0201 0.5778
Entamoeba histolytica hypothetical protein 0.0043 0.0347 0.5822
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0103 0.1011 0.2071
Echinococcus granulosus General substrate transporter 0.0185 0.1918 0.3928
Trypanosoma cruzi hexose transporter, putative 0.0037 0.027 0.386
Onchocerca volvulus 0.003 0.0201 0.5778
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0066 0.0597 0.0903
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0066 0.0597 0.0903
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0001 0.0003
Brugia malayi hypothetical protein 0.003 0.0201 0.0584
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0606 0.8651
Brugia malayi beta-lactamase 0.0043 0.0348 0.1008
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0075 0.0701 1
Brugia malayi Cam kinase protein 1 0.0066 0.0597 0.173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0001 0.0003
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Mycobacterium leprae Probable lipase LipE 0.0043 0.0348 0.5976
Trichomonas vaginalis esterase, putative 0.0043 0.0348 0.1544
Schistosoma mansoni tyrosine kinase 0.0172 0.1771 0.5134
Leishmania major protein kinase, putative 0.0066 0.0597 0.8517
Onchocerca volvulus 0.003 0.0201 0.5778
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0201 0.0684
Toxoplasma gondii sugar transporter ST2 0.003 0.0201 0.0305
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0215 0.2253 0.4616
Leishmania major glucose transporter, lmgt1 0.0067 0.0606 0.8651
Brugia malayi beta-lactamase family protein 0.0043 0.0348 0.1008
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Brugia malayi beta-lactamase family protein 0.0043 0.0348 0.1008
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0399 0.6849
Entamoeba histolytica hypothetical protein 0.0048 0.0399 0.6679
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0348 0.0348
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0001 0.0002
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0201 0.0305
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0597 0.173
Onchocerca volvulus 0.003 0.0201 0.5778
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1222
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0001 0.0002
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0001 0.0002
Leishmania major hypothetical protein, conserved 0.0043 0.0348 0.4964
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0348 0.0712
Schistosoma mansoni tyrosine kinase 0.0172 0.1771 0.5134
Loa Loa (eye worm) hypothetical protein 0.0043 0.0348 0.1008
Echinococcus multilocularis solute carrier family 22 0.003 0.0201 0.0413
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0399 0.1155
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Plasmodium falciparum proline--tRNA ligase 0.0075 0.0701 0.0701
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.0584
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0201 0.0584
Schistosoma mansoni protein kinase 0.0066 0.0597 0.173
Mycobacterium ulcerans sugar transporter 0.003 0.0201 0.5052
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0201 0.0584
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0065 0.0582 1
Schistosoma mansoni sugar transporter 0.003 0.0201 0.0584
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0582 0.1687
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1222
Brugia malayi nuclear hormone receptor 0.0012 0.0001 0.0003
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0201 0.0894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0003
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0066 0.0597 0.173
Trichomonas vaginalis sugar transporter, putative 0.003 0.0201 0.0894
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0001 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0597 0.2648
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0348 0.1181
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0001 0.0003
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0552 0.113
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1222

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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