Detailed information for compound 699091

Basic information

Technical information
  • TDR Targets ID: 699091
  • Name: 2-ethoxy-N-[4-(2-methyl-4-oxoquinazolin-3-yl) phenyl]benzamide
  • MW: 399.442 | Formula: C24H21N3O3
  • H donors: 1 H acceptors: 2 LogP: 3.61 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1C(=O)Nc1ccc(cc1)n1c(C)nc2c(c1=O)cccc2
  • InChi: 1S/C24H21N3O3/c1-3-30-22-11-7-5-9-20(22)23(28)26-17-12-14-18(15-13-17)27-16(2)25-21-10-6-4-8-19(21)24(27)29/h4-15H,3H2,1-2H3,(H,26,28)
  • InChiKey: BCKSAVDHDYHWAH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-ethoxy-N-[4-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]benzamide
  • 2-ethoxy-N-[4-(2-methyl-4-oxo-3-quinazolinyl)phenyl]benzamide
  • 2-ethoxy-N-[4-(4-keto-2-methyl-quinazolin-3-yl)phenyl]benzamide
  • ZINC04585496

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0137 0.2739 0.4108
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0028
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0019 0.003
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0099 0.188 0.8103
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Loa Loa (eye worm) hypothetical protein 0.0041 0.058 0.0898
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0038 0.0513 0.0747
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0019 0.0079
Brugia malayi Cam kinase protein 1 0.0031 0.0355 0.055
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0165 0.0269
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.2053 0.8846
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.1943 0.3174
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0038 0.0513 0.0747
Toxoplasma gondii hypothetical protein 0.0099 0.188 0.3071
Leishmania major glucose transporter, lmgt2 0.0031 0.0364 0.0548
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.0513 0.0772
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0364 0.0548
Plasmodium falciparum phd finger protein, putative 0.0029 0.0307 0.0327
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0355 0.0508
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0001
Schistosoma mansoni jumonji domain containing protein 0.0075 0.1352 0.2035
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0272 0.5782 0.8703
Trichomonas vaginalis conserved hypothetical protein 0.0272 0.5782 0.8703
Schistosoma mansoni patched 1 0.0041 0.058 0.0873
Trypanosoma brucei glucose transporter, putative 0.0031 0.0364 0.0548
Brugia malayi jmjC domain containing protein 0.0035 0.0444 0.0687
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.0513 0.0747
Giardia lamblia PHD finger protein 15 0.0029 0.0307 0.5822
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0727 0.1126
Echinococcus multilocularis geminin 0.0165 0.3365 0.3365
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0038 0.0513 0.0773
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0019 0.0028
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0028
Echinococcus multilocularis expressed conserved protein 0.009 0.168 0.168
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0028
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0038 0.0513 0.0547
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0001
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.2321 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0038 0.0513 0.0513
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.058 0.058
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0341 0.6517
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.2053 0.8801
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0038 0.0513 0.0747
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0038 0.0513 0.0795
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0444 0.0444
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.2053 0.8846
Brugia malayi MH2 domain containing protein 0.0116 0.2269 0.3513
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1943 0.1943
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0088 0.0379
Schistosoma mansoni hypothetical protein 0.004 0.0546 0.0823
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0364 0.0522
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0038 0.0513 0.0747
Mycobacterium tuberculosis Probable reductase 0.0106 0.2053 0.8846
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Leishmania major protein kinase, putative 0.0031 0.0355 0.0534
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0364 0.0522
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0562 0.0562
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0513 0.0772
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0356 0.0379
Onchocerca volvulus Huntingtin homolog 0.0122 0.2395 0.3395
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0364 0.0522
Trypanosoma brucei trypanothione reductase 0.0047 0.0706 0.1062
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0102 0.0126
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0038 0.0513 0.0795
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0211 0.4415 0.6639
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0307 0.0307
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0455 0.0684
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.2053 0.8846
Brugia malayi hypothetical protein 0.0122 0.2395 0.3709
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0355 0.0355
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.031 0.6641 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0341 0.0514
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0048 0.0727 0.1095
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0341 0.1132
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.0513 0.0747
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0356 0.0379
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0341 0.0341
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0165 0.0787
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0038 0.0513 0.0513
Plasmodium falciparum glutathione reductase 0.0016 0.0019 0.002
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0364 0.0548
Plasmodium vivax glutathione reductase, putative 0.0047 0.0706 0.0753
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0706 0.1093
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0165 0.0345
Schistosoma mansoni glucose transport protein 0.0102 0.1943 0.2926
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1811 0.2803
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0355 0.0535
Echinococcus multilocularis peregrin 0.0029 0.0307 0.0307
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0513 0.0772
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0038 0.0513 0.0513
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0038 0.0513 0.0773
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0038 0.0513 0.0772
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0341 0.0341
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0038 0.0513 0.0772
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0165 0.0787
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.0513 0.0547
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0211 0.4415 0.6648
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.031 0.6641 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0019 0.0028
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0038 0.0513 0.0772
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.031 0.6641 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Loa Loa (eye worm) hypothetical protein 0.0033 0.0401 0.0621
Brugia malayi CHE-14 protein 0.0041 0.058 0.0898
Echinococcus granulosus neuropeptide receptor A26 0.0459 1 1
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0165 0.2963
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0038 0.0513 0.0513
Giardia lamblia hypothetical protein 0.0038 0.0513 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0444 0.0669
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0038 0.0513 0.0773
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0165 0.0248
Loa Loa (eye worm) hypothetical protein 0.003 0.0341 0.0528
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.2053 0.8846
Toxoplasma gondii thioredoxin reductase 0.0047 0.0706 0.1153
Echinococcus multilocularis protein dispatched 1 0.0047 0.0711 0.0711
Loa Loa (eye worm) hypothetical protein 0.0038 0.0513 0.0795
Schistosoma mansoni hypothetical protein 0.0029 0.0307 0.0462
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0028
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.1791 0.1791
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Leishmania major glucose transporter, lmgt3 0.0031 0.0364 0.0548
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.031 0.6641 1
Schistosoma mansoni hypothetical protein 0.0165 0.3365 0.5068
Entamoeba histolytica protein kinase, putative 0.0031 0.0355 0.1155
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1811 0.1811
Mycobacterium ulcerans putative regulatory protein 0.0099 0.188 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0341 0.0514
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0122 0.2395 0.3709
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0455 0.0684
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0455 0.0684
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0356 0.0379
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0019 0.003
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0364 0.0522
Onchocerca volvulus 0.0048 0.0727 0.0683
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0341 0.0528
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0455 0.0742
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.031 0.6641 1
Toxoplasma gondii hypothetical protein 0.0272 0.5782 0.9447
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.2321 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Loa Loa (eye worm) PDE1B protein 0.0038 0.0513 0.0795
Plasmodium falciparum protein kinase 6 0.0431 0.9368 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0355 0.0355
Echinococcus granulosus Protein patched homolog 1 0.0041 0.058 0.058
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0137 0.2739 0.4241
Loa Loa (eye worm) hypothetical protein 0.0029 0.0307 0.0475
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Echinococcus granulosus General substrate transporter 0.0087 0.1621 0.1621
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0137 0.2739 0.4108
Trypanosoma brucei glucose transporter 2A 0.0031 0.0364 0.0548
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.058 0.058
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0038 0.0513 0.0773
Loa Loa (eye worm) hypothetical protein 0.0025 0.0212 0.0329
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0356 0.0379
Trypanosoma brucei glucose transporter, putative 0.0031 0.0364 0.0548
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0355 0.0355
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.2321 1
Echinococcus multilocularis neuropeptide receptor A26 0.0459 1 1
Schistosoma mansoni protein kinase 0.0031 0.0355 0.0535
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0513 0.0747
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0038 0.0513 0.0772
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0746 0.1155
Plasmodium falciparum thioredoxin reductase 0.0016 0.0019 0.002
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0001 0.0001
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0001
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.031 0.6641 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0038 0.0513 0.0747
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.031 0.6641 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0706 0.0706
Loa Loa (eye worm) glutathione reductase 0.0047 0.0706 0.1093
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0356 0.0379
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0038 0.0513 0.0513
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0038 0.0513 0.0773
Schistosoma mansoni glucose transport protein 0.0102 0.1943 0.2926
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0355 0.055
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0431 0.9368 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.2739 0.4241
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.0513 0.0547
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0088 0.0379
Trypanosoma brucei glucose transporter, putative 0.0031 0.0364 0.0548
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0307 0.0475
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0307 0.0327
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0038 0.0513 0.0547
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.031 0.6641 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0746 0.1155
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0307 0.05
Brugia malayi PHD-finger family protein 0.0029 0.0307 0.0475
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0038 0.0513 1
Mycobacterium ulcerans putative regulatory protein 0.0099 0.188 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0028
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0165 0.0248
Schistosoma mansoni protein kinase 0.0031 0.0355 0.0535
Brugia malayi Thioredoxin reductase 0.0047 0.0706 0.1093
Loa Loa (eye worm) hypothetical protein 0.0096 0.1811 0.2803
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0746 0.1155
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0746 0.1155
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0038 0.0513 0.0513
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0001 0.0001
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0038 0.0513 0.0747
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0019 0.0028
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1943 0.1943
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0364 0.0548
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0355 0.055
Loa Loa (eye worm) hypothetical protein 0.0023 0.0165 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.031 0.6641 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2269 0.3513
Loa Loa (eye worm) hypothetical protein 0.0122 0.2395 0.3709
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.0513 0.0772
Plasmodium falciparum thioredoxin reductase 0.0047 0.0706 0.0753
Loa Loa (eye worm) hypothetical protein 0.0302 0.6459 1
Echinococcus multilocularis protein patched 0.0041 0.058 0.058
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0038 0.0513 0.0795
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0364 0.0548
Trypanosoma brucei glucose transporter, putative 0.0031 0.0364 0.0548
Brugia malayi glutathione reductase 0.0047 0.0706 0.1093
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0019 0.002
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.3353 0.3579
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0028
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0038 0.0513 0.0773
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0019 0.002
Plasmodium falciparum hexose transporter 0.0102 0.1943 0.2074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0513 0.0795
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0165 0.0248
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0038 0.0513 0.0513
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0099 0.188 0.8103
Brugia malayi jmjC domain containing protein 0.0095 0.1791 0.2772
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0019 0.0028
Brugia malayi Bromodomain containing protein 0.0029 0.0307 0.0475
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0019 0.0028
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0356 0.0379
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0165 0.0176
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1943 0.1943
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0038 0.0513 0.0772
Trypanosoma cruzi hexose transporter 0.0031 0.0364 0.0548
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0028
Trypanosoma brucei glucose transporter, putative 0.0031 0.0364 0.0548
Echinococcus granulosus expressed conserved protein 0.009 0.168 0.168
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0019 0.0028
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.1943 0.1943
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1001 0.155
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0165 0.0176
Schistosoma mansoni hypothetical protein 0.0033 0.0401 0.0604
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0001 0.0001
Loa Loa (eye worm) sugar transporter 0.0102 0.1943 0.3009
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0043 0.0063
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1943 0.1943
Schistosoma mansoni hypothetical protein 0.004 0.0546 0.0823
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.1791 0.1791
Schistosoma mansoni survival motor neuron protein 0.0048 0.0727 0.1095
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0038 0.0513 0.0795
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.2321 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0706 0.3041
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0355 0.0355
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0706 0.1062
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0038 0.0513 0.0772
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0038 0.0513 0.0513
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0356 0.0379
Toxoplasma gondii GAF domain-containing protein 0.0099 0.188 0.3071
Brugia malayi hypothetical protein 0.0233 0.4913 0.7606
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.0513 0.0747
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.4913 0.4913
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0341 0.0487
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.031 0.6641 1
Brugia malayi hypothetical protein 0.0302 0.6459 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0038 0.0513 0.0513
Leishmania major glucose transporter, lmgt1 0.0031 0.0364 0.0548
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0444 0.0444
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0019 0.0019
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0455 0.0684
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0211 0.4415 0.6639
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0001 0.0001
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0038 0.0513 0.0772
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.058 0.0898
Loa Loa (eye worm) hypothetical protein 0.0233 0.4913 0.7606
Leishmania major hypothetical protein, conserved 0.0038 0.0513 0.0772
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Plasmodium vivax phosphodiesterase gamma, putative 0.0038 0.0513 0.0547
Schistosoma mansoni hypothetical protein 0.004 0.0546 0.0823
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0513 0.0772
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1811 0.1811
Trypanosoma brucei glucose transporter, putative 0.0031 0.0364 0.0548
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0355 0.0355
Plasmodium falciparum GAF domain-related protein, putative 0.0099 0.188 0.2007
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0038 0.0513 0.0547
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1844 0.2777
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0364 0.0548
Echinococcus granulosus peregrin 0.0029 0.0307 0.0307
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0038 0.0513 0.0773
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0165 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0019 0.0028
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0455 0.0684
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Loa Loa (eye worm) hypothetical protein 0.0099 0.188 0.2911
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.031 0.6641 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0038 0.0513 0.0773
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0038 0.0513 0.0513
Trypanosoma brucei glucose transporter, putative 0.0031 0.0364 0.0548
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0513 0.0772
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0038 0.0513 0.0747
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0137 0.2739 0.4125
Schistosoma mansoni hypothetical protein 0.0165 0.3365 0.5068
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.188 0.2811
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Schistosoma mansoni hypothetical protein 0.004 0.0546 0.0823
Loa Loa (eye worm) hypothetical protein 0.005 0.0773 0.1196
Loa Loa (eye worm) hypothetical protein 0.003 0.0341 0.0528
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0019 0.0019
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0444 0.0687
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0513 0.0747
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0364 0.0522
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0019 0.002
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.2053 0.8846
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0356 0.058
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0312 0.0312
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2269 0.3513
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0165 0.0221
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0137 0.2739 0.4241
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0356 0.058
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0341 0.0528
Brugia malayi Sugar transporter family protein 0.0102 0.1943 0.3009
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0307 0.0462
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1943 0.1943
Schistosoma mansoni glucose transport protein 0.0102 0.1943 0.2926
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0001 0.0001
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0364 0.0548
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.3353 0.3579
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.031 0.6641 0.6641
Toxoplasma gondii hypothetical protein 0.0099 0.188 0.3071
Onchocerca volvulus Huntingtin homolog 0.0122 0.2395 0.3395
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.1943 0.2906
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0455 0.0485
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0513 0.0772
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.058 0.0847
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0019 0.0028
Plasmodium falciparum phosphodiesterase gamma, putative 0.0038 0.0513 0.0547
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0356 0.058
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1943 0.1943
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0355 0.0534
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.031 0.6641 1
Onchocerca volvulus 0.0302 0.6459 1
Plasmodium falciparum glutathione reductase 0.0047 0.0706 0.0753
Trichomonas vaginalis conserved hypothetical protein 0.0272 0.5782 0.8703
Mycobacterium leprae conserved hypothetical protein 0.0099 0.188 0.8028
Loa Loa (eye worm) hypothetical protein 0.0031 0.0355 0.055
Schistosoma mansoni protein kinase 0.0031 0.0355 0.0535
Trypanosoma brucei cAMP-specific phosphodiesterase 0.031 0.6641 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0364 0.0522
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0444 0.0669
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0355 0.0355
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.031 0.6641 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0019 0.5
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0038 0.0513 0.0547
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0307 0.0307
Echinococcus granulosus jumonji domain containing protein 0.004 0.0562 0.0562
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0356 0.0379
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0307 0.05
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0099 0.188 1
Schistosoma mansoni hypothetical protein 0.0102 0.1943 0.2926
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1811 1
Leishmania major hypothetical protein, conserved 0.0038 0.0513 0.0772
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0137 0.2739 0.4108
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0038 0.0513 0.0795
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0165 0.0249
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0019 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.0788 0.122
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0165 0.0256
Leishmania major trypanothione reductase 0.0047 0.0706 0.1062
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.0513 0.0547
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0165 0.0165
Plasmodium vivax hexose transporter 0.0102 0.1943 0.2074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0019 0.0028
Echinococcus granulosus geminin 0.0165 0.3365 0.3365
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0312 0.0312
Entamoeba histolytica protein kinase, putative 0.0031 0.0355 0.1155
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0019 0.002
Brugia malayi isocitrate dehydrogenase 0.0015 0.0001 0.0001
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.2736 0.2736
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0137 0.2739 0.2739
Plasmodium vivax hypothetical protein, conserved 0.0099 0.188 0.2007
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0706 0.0706
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0706 0.0753
Giardia lamblia Hypothetical protein 0.0038 0.0513 1
Treponema pallidum NADH oxidase 0.0016 0.0019 0.5
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0137 0.2739 0.2739
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0401 0.0621
Trypanosoma brucei glucose transporter 1E 0.0031 0.0364 0.0548
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.031 0.6641 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0038 0.0513 0.0773
Leishmania major cAMP-specific phosphodiesterase, putative 0.0038 0.0513 0.0772
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.2736 0.2736
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0355 0.055
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.031 0.6641 0.6641
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.031 0.6641 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0356 0.0379
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0513 0.0772
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0364 0.0548
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.4913 0.4913
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0019 0.0028
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0355 0.0355
Toxoplasma gondii protein kinase, putative 0.0287 0.6121 1
Echinococcus multilocularis neuropeptide s receptor 0.0459 1 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.031 0.6641 1
Plasmodium falciparum protein kinase 7 0.0287 0.6121 0.6533
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0355 0.0355
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0038 0.0513 0.0513
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0038 0.0513 0.0513
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.031 0.6641 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1943 0.1943
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.3353 0.5477
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0364 0.0522
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0513 0.0772
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0165 0.0249
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0038 0.0513 0.0838
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0455 0.0485
Echinococcus multilocularis General substrate transporter 0.0087 0.1621 0.1621
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0341 0.1068
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.031 0.6641 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0038 0.0513 0.0547
Trypanosoma brucei glucose transporter, putative 0.0031 0.0364 0.0548
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0019 0.0028
Loa Loa (eye worm) hypothetical protein 0.0038 0.0513 0.0795

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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