Detailed information for compound 699190

Basic information

Technical information
  • TDR Targets ID: 699190
  • Name: 7-[(2-fluorophenyl)methyl]-3-methyl-8-[4-[(2- methylphenyl)methyl]piperazin-1-yl]purine-2,6 -dione
  • MW: 462.519 | Formula: C25H27FN6O2
  • H donors: 1 H acceptors: 3 LogP: 3.21 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1CN1CCN(CC1)c1nc2c(n1Cc1ccccc1F)c(=O)[nH]c(=O)n2C
  • InChi: 1S/C25H27FN6O2/c1-17-7-3-4-8-18(17)15-30-11-13-31(14-12-30)24-27-22-21(23(33)28-25(34)29(22)2)32(24)16-19-9-5-6-10-20(19)26/h3-10H,11-16H2,1-2H3,(H,28,33,34)
  • InChiKey: JRYZJGSAYJJFAC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-[(2-fluorophenyl)methyl]-3-methyl-8-[4-[(2-methylphenyl)methyl]-1-piperazinyl]purine-2,6-dione
  • 7-(2-fluorobenzyl)-3-methyl-8-[4-(2-methylbenzyl)piperazin-1-yl]xanthine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0047 0.0202
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0373 0.0404
Schistosoma mansoni protein kinase 0.0032 0.0372 0.1118
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.2075 0.8861
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0471 0.1416
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0047 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0186 0.0558
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.047 0.6419
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.1834 0.5511
Leishmania major protein kinase, putative 0.0032 0.0372 0.5083
Echinococcus granulosus expressed conserved protein 0.0093 0.1673 0.1673
Brugia malayi isocitrate dehydrogenase 0.0016 0.0024 0.0037
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0471 0.0739
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0047 0.0078
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0023 0.0023
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.047 0.6419
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0047 0.0645
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.2251 0.3532
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.033 0.033
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0186 0.2536
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.1931 0.1931
Entamoeba histolytica protein kinase, putative 0.0032 0.0372 0.1155
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0047 0.0078
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0047 1
Onchocerca volvulus Alhambra homolog 0.003 0.0334 0.0525
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0023 0.0023
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0417 0.0654
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0047 0.2543
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0047 0.0047
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0358 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0047 0.0051
Schistosoma mansoni glucose transport protein 0.0105 0.1931 0.5804
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0645
Loa Loa (eye worm) hypothetical protein 0.003 0.0334 0.0525
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0047 0.0645
Loa Loa (eye worm) hypothetical protein 0.0032 0.0372 0.0584
Loa Loa (eye worm) hypothetical protein 0.0032 0.0358 0.0562
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0756 0.1186
Loa Loa (eye worm) hypothetical protein 0.0023 0.0186 0.0291
Leishmania major glucose transporter, lmgt1 0.0033 0.0381 0.5204
Trypanosoma brucei glucose transporter, putative 0.0033 0.0381 0.5204
Brugia malayi Sugar transporter family protein 0.0105 0.1931 0.303
Onchocerca volvulus Huntingtin homolog 0.0128 0.2417 0.3792
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1931 0.1931
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0373 0.0404
Schistosoma mansoni glucose transport protein 0.0105 0.1931 0.5804
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0024 0.0037
Schistosoma mansoni hypothetical protein 0.0041 0.056 0.1682
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0589 0.0589
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0381 0.5204
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0372 0.0372
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0732 0.1149
Schistosoma mansoni patched 1 0.0043 0.0593 0.1781
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0024 0.0024
Trypanosoma brucei glucose transporter, putative 0.0033 0.0381 0.5204
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0471 0.0471
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0023 0.0036
Trypanosoma brucei glucose transporter, putative 0.0033 0.0381 0.5204
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0023 0.0023
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0047 0.0645
Schistosoma mansoni hypothetical protein 0.003 0.0334 0.1005
Echinococcus multilocularis protein patched 0.0043 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0099 0.1801 0.2826
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0645
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0381 0.1973
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0024 0.0324
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0047 0.0047
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.1931 0.3201
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0372 0.0372
Echinococcus granulosus calcium dependent protein kinase 0.003 0.033 0.033
Schistosoma mansoni protein kinase 0.0032 0.0372 0.1118
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0593 0.0593
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0047 0.2543
Echinococcus granulosus GPCR family 2 0.0016 0.0023 0.0023
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0593 0.093
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0372 0.5083
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0358 0.1076
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0381 0.1973
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0186 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0381 0.1973
Loa Loa (eye worm) hypothetical protein 0.0032 0.0358 0.0562
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0186 0.0186
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0732 1
Schistosoma mansoni survival motor neuron protein 0.005 0.0753 0.2263
Schistosoma mansoni hypothetical protein 0.0171 0.3328 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0024 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0645
Brugia malayi jmjC domain containing protein 0.01 0.1814 0.2846
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.4925 0.4925
Loa Loa (eye worm) hypothetical protein 0.0043 0.0593 0.093
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0373 0.0404
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0047 0.0645
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.2251 0.3532
Trypanosoma brucei glucose transporter, putative 0.0033 0.0381 0.5204
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0047 0.0244
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0186 0.0558
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0047 0.0645
Toxoplasma gondii protein kinase, putative 0.0297 0.6033 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.017 0.3315 0.3595
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1801 0.1801
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0023 0.0023
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.2075 0.8861
Mycobacterium tuberculosis Probable reductase 0.0112 0.2075 0.8861
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0373 0.0617
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0645
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0024 0.0324
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0372 0.1118
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0373 0.0404
Loa Loa (eye worm) sugar transporter 0.0105 0.1931 0.303
Loa Loa (eye worm) hypothetical protein 0.0313 0.6374 1
Echinococcus multilocularis neuropeptide s receptor 0.0483 1 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1931 0.1931
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1931 0.1931
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1801 0.2826
Loa Loa (eye worm) hypothetical protein 0.0245 0.4925 0.7728
Echinococcus multilocularis General substrate transporter 0.009 0.1615 0.1615
Loa Loa (eye worm) hypothetical protein 0.0052 0.0797 0.125
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0024 0.0101
Brugia malayi PHD-finger family protein 0.003 0.0334 0.0525
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0381 0.1973
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0186 0.0201
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0186 0.2536
Leishmania major glucose transporter, lmgt3 0.0033 0.0381 0.5204
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.047 0.051
Echinococcus granulosus geminin 0.0171 0.3328 0.3328
Trypanosoma brucei glucose transporter, putative 0.0033 0.0381 0.5204
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1801 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0186 1
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0373 0.0617
Schistosoma mansoni hypothetical protein 0.0034 0.0417 0.1253
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.1814 0.1814
Loa Loa (eye worm) glutathione reductase 0.0049 0.0732 0.1149
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0047 0.0051
Trypanosoma cruzi hexose transporter 0.0033 0.0381 0.5204
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.017 0.3315 0.5495
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0024 0.0026
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.271 0.271
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0047 0.0051
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0023 0.0036
Echinococcus multilocularis GPCR, family 2 0.0016 0.0023 0.0023
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0471 0.1416
Plasmodium falciparum hexose transporter 0.0105 0.1931 0.2094
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0381 0.5204
Brugia malayi CHE-14 protein 0.0043 0.0593 0.093
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.047 0.6419
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0372 0.0372
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0047 0.0051
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0186 0.5182
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0372 0.0372
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.011 0.047
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0047 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1931 1
Brugia malayi hypothetical protein 0.0313 0.6374 1
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0593 0.0593
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0047 0.0645
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0593 0.0593
Brugia malayi glutathione reductase 0.0049 0.0732 0.1149
Leishmania major trypanothione reductase 0.0049 0.0732 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0732 0.0732
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0756 0.1186
Schistosoma mansoni hypothetical protein 0.0041 0.056 0.1682
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.2342 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.1814 0.1814
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0024 0.0324
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.2342 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0334 0.0554
Treponema pallidum NADH oxidase 0.0017 0.0047 0.5
Trypanosoma brucei glucose transporter 2A 0.0033 0.0381 0.5204
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0372 0.0584
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0186 0.2536
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.271 0.271
Echinococcus multilocularis expressed conserved protein 0.0093 0.1673 0.1673
Toxoplasma gondii thioredoxin reductase 0.0049 0.0732 0.1213
Plasmodium falciparum glutathione reductase 0.0049 0.0732 0.0794
Brugia malayi hypothetical protein 0.0128 0.2417 0.3792
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1931 0.1931
Schistosoma mansoni protein kinase 0.0032 0.0372 0.1118
Echinococcus multilocularis peregrin 0.003 0.0334 0.0334
Plasmodium falciparum phd finger protein, putative 0.003 0.0334 0.0363
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.2342 1
Echinococcus multilocularis neuropeptide receptor A26 0.0483 1 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0358 0.1068
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0024 0.0024
Brugia malayi hypothetical protein 0.0245 0.4925 0.7728
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0186 0.0201
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0186 1
Brugia malayi jmjC domain containing protein 0.0037 0.0471 0.0739
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0593 0.3068
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0047 0.0645
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0186 0.0961
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.011 0.047
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0047 0.1318
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0334 0.0334
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.4925 0.4925
Trypanosoma brucei glucose transporter, putative 0.0033 0.0381 0.5204
Onchocerca volvulus 0.0313 0.6374 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0232 0.0364
Leishmania major glucose transporter, lmgt2 0.0033 0.0381 0.5204
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0381 0.5204
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0024 0.0037
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0372 0.0372
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0186 0.0339
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0334 0.0334
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0186 0.0186
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0372 0.1927
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0024 0.0324
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0024 0.0324
Echinococcus multilocularis geminin 0.0171 0.3328 0.3328
Loa Loa (eye worm) hypothetical protein 0.005 0.0756 0.1186
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0732 0.3126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0645
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1931 0.1931
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0124 0.0641
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0358 0.1855
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0023 0.0036
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0756 0.1186
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0024 0.0024
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0024 0.0071
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0373 0.0404
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0589 0.0589
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0732 0.0732
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0732 0.0794
Brugia malayi Thioredoxin reductase 0.0049 0.0732 0.1149
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0334 0.0554
Loa Loa (eye worm) hypothetical protein 0.0128 0.2417 0.3792
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0381 0.5204
Plasmodium falciparum thioredoxin reductase 0.0017 0.0047 0.0051
Loa Loa (eye worm) hypothetical protein 0.0128 0.2417 0.3792
Giardia lamblia PHD finger protein 15 0.003 0.0334 0.9335
Plasmodium falciparum thioredoxin reductase 0.0049 0.0732 0.0794
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0358 0.1112
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0358 0.0358
Schistosoma mansoni hypothetical protein 0.005 0.0753 0.2263
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0373 0.0404
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0186 0.0308
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0047 0.0244
Trypanosoma brucei glucose transporter, putative 0.0033 0.0381 0.5204
Loa Loa (eye worm) hypothetical protein 0.0016 0.0023 0.0036
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0186 0.0291
Brugia malayi Cam kinase protein 1 0.0032 0.0372 0.0584
Schistosoma mansoni hypothetical protein 0.0041 0.056 0.1682
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1931 0.1931
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0373 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0381 0.5204
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0024 0.0024
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0358 0.0562
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.007
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0372 0.0372
Plasmodium vivax hexose transporter 0.0105 0.1931 0.2094
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1931 0.1931
Entamoeba histolytica protein kinase, putative 0.0032 0.0372 0.1155
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0372 0.0584
Brugia malayi Bromodomain containing protein 0.003 0.0334 0.0525
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.047 0.6419
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1801 0.1801
Schistosoma mansoni hypothetical protein 0.0041 0.056 0.1682
Echinococcus multilocularis protein dispatched 1 0.0049 0.0721 0.0721
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.007
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0381 0.5204
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.017 0.3315 0.3595
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0373 0.0404
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0024 0.0024
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0334 0.1005
Plasmodium falciparum proline--tRNA ligase 0.0037 0.047 0.051
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0381 0.5204
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0024 0.0039
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0471 0.0471
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0358 0.1076
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0024 0.0026
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0372 0.0584
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0381 0.1973
Onchocerca volvulus Huntingtin homolog 0.0128 0.2417 0.3792
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0358 0.0562
Plasmodium falciparum protein kinase 7 0.0297 0.6033 0.6542
Echinococcus granulosus General substrate transporter 0.009 0.1615 0.1615
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.007
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.2342 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0446 0.9222 1
Trypanosoma brucei trypanothione reductase 0.0049 0.0732 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0047 0.0074
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0373 0.0404
Echinococcus granulosus neuropeptide receptor A26 0.0483 1 1
Onchocerca volvulus 0.005 0.0753 0.1182
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.2075 0.8861
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0065 0.0888
Trypanosoma brucei glucose transporter, putative 0.0033 0.0381 0.5204
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0373 0.0617
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0372 0.0372
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0047 0.2543
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.1027 0.1611
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0024 0.0039
Plasmodium falciparum protein kinase 6 0.0446 0.9222 1
Echinococcus granulosus peregrin 0.003 0.0334 0.0334
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0753 0.1182
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.2075 0.8861
Schistosoma mansoni hypothetical protein 0.0105 0.1931 0.5804
Trypanosoma brucei glucose transporter 1E 0.0033 0.0381 0.5204
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0645
Schistosoma mansoni jumonji domain containing protein 0.0079 0.1376 0.4136
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0372 0.0372
Plasmodium falciparum glutathione reductase 0.0017 0.0047 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0645
Plasmodium vivax hypothetical protein, conserved 0.003 0.0334 0.0363
Loa Loa (eye worm) hypothetical protein 0.0052 0.0799 0.1254
Schistosoma mansoni hypothetical protein 0.0171 0.3328 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0381 0.1973
Schistosoma mansoni glucose transport protein 0.0105 0.1931 0.5804
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.2075 0.8861
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.007
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.2075 0.8804
Loa Loa (eye worm) hypothetical protein 0.0034 0.0417 0.0654
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.047 0.6419
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.047 0.0779
Plasmodium vivax glutathione reductase, putative 0.0049 0.0732 0.0794
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0047 0.0645
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0047 0.0142
Brugia malayi MH2 domain containing protein 0.012 0.2251 0.3532
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0334 0.0525
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0358 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0381 0.1973

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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