Detailed information for compound 699255

Basic information

Technical information
  • TDR Targets ID: 699255
  • Name: 3,4-dimethyl-N-[3-(2-methyl-4-oxoquinazolin-3 -yl)phenyl]benzenesulfonamide
  • MW: 419.496 | Formula: C23H21N3O3S
  • H donors: 1 H acceptors: 3 LogP: 3.69 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1C)S(=O)(=O)Nc1cccc(c1)n1c(C)nc2c(c1=O)cccc2
  • InChi: 1S/C23H21N3O3S/c1-15-11-12-20(13-16(15)2)30(28,29)25-18-7-6-8-19(14-18)26-17(3)24-22-10-5-4-9-21(22)23(26)27/h4-14,25H,1-3H3
  • InChiKey: SQXSILJBQIQXJX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4-dimethyl-N-[3-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]benzenesulfonamide
  • 3,4-dimethyl-N-[3-(2-methyl-4-oxo-3-quinazolinyl)phenyl]benzenesulfonamide
  • N-[3-(4-keto-2-methyl-quinazolin-3-yl)phenyl]-3,4-dimethyl-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.3369 0.3595
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0024 0.0037
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0042 0.0216
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.2753 0.2753
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0332
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0024 0.0332
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0477 0.051
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Loa Loa (eye worm) sugar transporter 0.0102 0.1962 0.3034
Echinococcus multilocularis protein patched 0.0041 0.0602 0.0602
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0477 0.656
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0387 0.5318
Plasmodium falciparum thioredoxin reductase 0.0016 0.0042 0.0045
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0189 0.0189
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0379 0.0617
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0112 0.0478
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0583
Schistosoma mansoni glucose transport protein 0.0102 0.1962 0.5804
Brugia malayi hypothetical protein 0.0302 0.6467 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0602 0.0931
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0042 0.225
Loa Loa (eye worm) hypothetical protein 0.0041 0.0602 0.0931
Brugia malayi Thioredoxin reductase 0.0047 0.0728 0.1125
Loa Loa (eye worm) glutathione reductase 0.0047 0.0728 0.1125
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0768 0.1188
Brugia malayi glutathione reductase 0.0047 0.0728 0.1125
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0584 0.0584
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.2339 1
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.183 0.183
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0332
Loa Loa (eye worm) hypothetical protein 0.0029 0.033 0.051
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.2339 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0042 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0387 0.1973
Schistosoma mansoni protein kinase 0.0031 0.0378 0.1118
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0189 0.0201
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.2753 0.2753
Echinococcus granulosus expressed conserved protein 0.009 0.1699 0.1699
Echinococcus multilocularis protein dispatched 1 0.0047 0.0732 0.0732
Plasmodium vivax glutathione reductase, putative 0.0047 0.0728 0.0777
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0583
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.183 0.2829
Schistosoma mansoni patched 1 0.0041 0.0602 0.1781
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.4925 0.4925
Leishmania major glucose transporter, lmgt1 0.0031 0.0387 0.5318
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0042 0.225
Brugia malayi MH2 domain containing protein 0.0116 0.2287 0.3537
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0042 0.0069
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0189 0.0292
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0042
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.3369 0.5495
Toxoplasma gondii protein kinase, putative 0.0287 0.613 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0024 0.0036
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.2072 0.8858
Loa Loa (eye worm) hypothetical protein 0.0096 0.183 0.2829
Schistosoma mansoni protein kinase 0.0031 0.0378 0.1118
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.2072 0.8858
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0042 0.0583
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0024 0.0024
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0364 0.1855
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0364 0.0364
Schistosoma mansoni hypothetical protein 0.0102 0.1962 0.5804
Echinococcus granulosus neuropeptide receptor A26 0.0459 1 1
Onchocerca volvulus 0.0302 0.6467 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1962 0.1962
Schistosoma mansoni glucose transport protein 0.0102 0.1962 0.5804
Brugia malayi jmjC domain containing protein 0.0095 0.181 0.2799
Loa Loa (eye worm) hypothetical protein 0.0233 0.4925 0.7614
Echinococcus granulosus General substrate transporter 0.0087 0.1641 0.1641
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.005 0.0795 0.1228
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0387 0.1973
Schistosoma mansoni hypothetical protein 0.0029 0.033 0.0975
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0189 0.0189
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0189 0.0558
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0387 0.1973
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0477 0.656
Echinococcus multilocularis geminin 0.0165 0.3381 0.3381
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0378 0.0585
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0189 0.0308
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0387 0.5318
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.181 0.181
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0423 0.0655
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.183 0.183
Plasmodium falciparum thioredoxin reductase 0.0047 0.0728 0.0777
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0583
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0387 0.1973
Loa Loa (eye worm) hypothetical protein 0.0031 0.0378 0.0585
Schistosoma mansoni hypothetical protein 0.004 0.0569 0.1682
Leishmania major trypanothione reductase 0.0047 0.0728 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0379 0.0617
Brugia malayi CHE-14 protein 0.0041 0.0602 0.0931
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0024 0.0103
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0477 0.656
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0024 0.0036
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0378 0.0378
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0024 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0583
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.033 0.0538
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0602 0.0602
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.183 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0042 0.0045
Entamoeba histolytica protein kinase, putative 0.0031 0.0378 0.1155
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0042 0.0181
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0387 0.5318
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1962 0.1962
Echinococcus granulosus peregrin 0.0029 0.033 0.033
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0364 0.1068
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0602 0.0602
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0042 1
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0602 0.0602
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0024 0.0026
Trypanosoma cruzi hexose transporter 0.0031 0.0387 0.5318
Loa Loa (eye worm) hypothetical protein 0.003 0.0364 0.0563
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0378 0.1927
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0387 0.1973
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0189 0.2591
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5318
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0189 0.0201
Echinococcus granulosus geminin 0.0165 0.3381 0.3381
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0728 0.0777
Onchocerca volvulus 0.0048 0.0749 0.1158
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0583
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0387 0.5318
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0364 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0477 0.0779
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.2072 0.8858
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0189 0.0961
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0042 0.0045
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0477 0.656
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1863 0.5511
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0364 0.1132
Echinococcus multilocularis expressed conserved protein 0.009 0.1699 0.1699
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0024 0.0037
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0467 0.138
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0042 0.0216
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0467 0.0721
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0042 0.0045
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2287 0.3537
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0335 0.0335
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5318
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0189 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1962 0.1962
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0042
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0042 0.0583
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.007
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.033 0.033
Schistosoma mansoni hypothetical protein 0.0033 0.0423 0.1253
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0583
Treponema pallidum NADH oxidase 0.0016 0.0042 0.5
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0378 0.5195
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0042 0.0045
Brugia malayi Sugar transporter family protein 0.0102 0.1962 0.3034
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0042 0.225
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.033 0.0975
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0042 0.0583
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0379 0.0404
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5318
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0189 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0749 0.2215
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Schistosoma mansoni glucose transport protein 0.0102 0.1962 0.5804
Onchocerca volvulus Huntingtin homolog 0.0122 0.2413 0.3731
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.1962 1
Leishmania major protein kinase, putative 0.0031 0.0378 0.5195
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1962 0.1962
Brugia malayi isocitrate dehydrogenase 0.0015 0.0024 0.0037
Echinococcus granulosus jumonji domain containing protein 0.004 0.0584 0.0584
Plasmodium vivax CDK-related protein kinase 6, putative 0.0431 0.937 1
Brugia malayi Bromodomain containing protein 0.0029 0.033 0.051
Loa Loa (eye worm) hypothetical protein 0.0048 0.0768 0.1188
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.1962 0.3201
Mycobacterium tuberculosis Probable reductase 0.0106 0.2072 0.8858
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5318
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0042 0.0583
Schistosoma mansoni jumonji domain containing protein 0.0075 0.1372 0.4058
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0379 0.0404
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0583
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.033 0.0538
Loa Loa (eye worm) hypothetical protein 0.005 0.081 0.1252
Schistosoma mansoni hypothetical protein 0.0165 0.3381 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0583
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5318
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1962 0.1962
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.2072 0.8801
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0024 0.0024
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.2072 0.8858
Loa Loa (eye worm) hypothetical protein 0.0033 0.0423 0.0655
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0477 0.656
Brugia malayi jmjC domain containing protein 0.0035 0.0467 0.0721
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0728 0.0728
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0042 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0042 0.0583
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2287 0.3537
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0378 0.0585
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0335 0.0335
Trypanosoma brucei glucose transporter 2A 0.0031 0.0387 0.5318
Trypanosoma brucei glucose transporter 1E 0.0031 0.0387 0.5318
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.3369 0.3595
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0364 0.1076
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0024 0.0024
Onchocerca volvulus Alhambra homolog 0.0029 0.033 0.051
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0467 0.0467
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0387 0.1973
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0024 0.0039
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0364 0.1076
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0477 0.051
Entamoeba histolytica protein kinase, putative 0.0031 0.0378 0.1155
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5318
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0036
Loa Loa (eye worm) hypothetical protein 0.0122 0.2413 0.3731
Plasmodium falciparum protein kinase 7 0.0287 0.613 0.6542
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0387 0.5318
Echinococcus multilocularis General substrate transporter 0.0087 0.1641 0.1641
Plasmodium falciparum protein kinase 6 0.0431 0.937 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.2339 1
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.007
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0728 0.1125
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0379 0.0404
Plasmodium falciparum glutathione reductase 0.0016 0.0042 0.0045
Echinococcus multilocularis neuropeptide receptor A26 0.0459 1 1
Schistosoma mansoni hypothetical protein 0.0048 0.0749 0.2215
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.2072 0.8858
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0066 0.0907
Leishmania major glucose transporter, lmgt2 0.0031 0.0387 0.5318
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0379 0.0404
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0042 0.1166
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1023 0.1581
Echinococcus multilocularis GPCR, family 2 0.0015 0.0024 0.0024
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0024 0.0071
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5318
Schistosoma mansoni hypothetical protein 0.004 0.0569 0.1682
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0728 1
Toxoplasma gondii thioredoxin reductase 0.0047 0.0728 0.1187
Echinococcus multilocularis peregrin 0.0029 0.033 0.033
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0728 0.0728
Brugia malayi hypothetical protein 0.0122 0.2413 0.3731
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0378 0.0585
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0583
Loa Loa (eye worm) hypothetical protein 0.0122 0.2413 0.3731
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.033 0.051
Trypanosoma brucei trypanothione reductase 0.0047 0.0728 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0379 0.0404
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0749 0.1158
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0387 0.5318
Schistosoma mansoni protein kinase 0.0031 0.0378 0.1118
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0189 0.0345
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0042 0.0069
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0379 0.0404
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0024 0.0024
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0189 0.0558
Schistosoma mansoni hypothetical protein 0.004 0.0569 0.1682
Loa Loa (eye worm) hypothetical protein 0.003 0.0364 0.0563
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.1962 0.1962
Leishmania major glucose transporter, lmgt3 0.0031 0.0387 0.5318
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0387 0.5318
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0378 0.1118
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0024 0.0039
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0379 0.0404
Plasmodium vivax hexose transporter 0.0102 0.1962 0.2094
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.1962 0.1962
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0379 0.0404
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0364 0.0563
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.033 0.033
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0467 0.138
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.181 0.181
Schistosoma mansoni hypothetical protein 0.004 0.0569 0.1682
Plasmodium falciparum glutathione reductase 0.0047 0.0728 0.0777
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0024 0.0026
Plasmodium falciparum hexose transporter 0.0102 0.1962 0.2094
Onchocerca volvulus Huntingtin homolog 0.0122 0.2413 0.3731
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0364 0.0563
Giardia lamblia PHD finger protein 15 0.0029 0.033 0.9057
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.2339 1
Brugia malayi PHD-finger family protein 0.0029 0.033 0.051
Echinococcus multilocularis neuropeptide s receptor 0.0459 1 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0379 0.0404
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0189 0.2591
Brugia malayi hypothetical protein 0.0233 0.4925 0.7614
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0189 0.2591
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0602 0.3068
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0467 0.0467
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0042 0.0583
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0189 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.033 0.0352
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0042 0.0066
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0112 0.0478
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.4925 0.4925
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5318
Loa Loa (eye worm) hypothetical protein 0.0025 0.0236 0.0364
Loa Loa (eye worm) hypothetical protein 0.0302 0.6467 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0387 0.1973
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0024 0.0332
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0023 0.0189 0.0292
Plasmodium falciparum phd finger protein, putative 0.0029 0.033 0.0352
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0189 0.5182
Echinococcus granulosus GPCR family 2 0.0015 0.0024 0.0024
Brugia malayi Cam kinase protein 1 0.0031 0.0378 0.0585
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0332
Schistosoma mansoni hypothetical protein 0.0165 0.3381 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0768 0.1188
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0728 0.3112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0583
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0126 0.0641
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.1962 0.1962
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0379 0.0617
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0768 0.1188
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0024 0.0024

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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