Detailed information for compound 699319

Basic information

Technical information
  • TDR Targets ID: 699319
  • Name: N-[2-(4-methoxyphenyl)sulfonyl-2-thiophen-2-y lethyl]-2-(4-methylphenoxy)acetamide
  • MW: 445.552 | Formula: C22H23NO5S2
  • H donors: 1 H acceptors: 3 LogP: 3.75 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)S(=O)(=O)C(c1cccs1)CNC(=O)COc1ccc(cc1)C
  • InChi: 1S/C22H23NO5S2/c1-16-5-7-18(8-6-16)28-15-22(24)23-14-21(20-4-3-13-29-20)30(25,26)19-11-9-17(27-2)10-12-19/h3-13,21H,14-15H2,1-2H3,(H,23,24)
  • InChiKey: SDQMMLCGHNBEFF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-methoxyphenyl)sulfonyl-2-(2-thienyl)ethyl]-2-(4-methylphenoxy)acetamide
  • N-[2-(4-methoxyphenyl)sulfonyl-2-thiophen-2-yl-ethyl]-2-(4-methylphenoxy)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0768 0.1188
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0728 0.1125
Schistosoma mansoni hypothetical protein 0.0039 0.0569 0.1682
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.2339 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.183 0.283
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0332
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0602 0.0602
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0728 0.0728
Brugia malayi Thioredoxin reductase 0.0046 0.0728 0.1125
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.2754 0.2754
Echinococcus granulosus expressed conserved protein 0.0089 0.17 0.17
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0728 0.3112
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0728 0.0777
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.2339 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.033 0.051
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0042 0.0582
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5319
Schistosoma mansoni protein kinase 0.0031 0.0378 0.1118
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0189 0.0201
Schistosoma mansoni patched 1 0.0041 0.0602 0.1781
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0478 0.6562
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0387 0.5319
Plasmodium falciparum thioredoxin reductase 0.0016 0.0042 0.0045
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0189 0.0189
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0163 0.3369 0.3595
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0042 0.0216
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0024 0.0037
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.2754 0.2754
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0332
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0024 0.0332
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0478 0.051
Loa Loa (eye worm) sugar transporter 0.0101 0.1963 0.3035
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0387 0.1973
Schistosoma mansoni glucose transport protein 0.0101 0.1963 0.5804
Brugia malayi hypothetical protein 0.03 0.6468 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0602 0.0931
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0042 0.2246
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0379 0.0617
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0112 0.0478
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0582
Loa Loa (eye worm) hypothetical protein 0.005 0.081 0.1252
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0024 0.0024
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0387 0.1973
Schistosoma mansoni hypothetical protein 0.0029 0.033 0.0975
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0189 0.0558
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0189 0.0189
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0379 0.0404
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0478 0.6562
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.181 0.181
Loa Loa (eye worm) hypothetical protein 0.0232 0.4925 0.7614
Echinococcus granulosus General substrate transporter 0.0087 0.1642 0.1642
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.183 0.183
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0728 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0582
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Echinococcus multilocularis geminin 0.0164 0.3382 0.3382
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0378 0.0378
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.181 0.181
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0189 0.0308
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0387 0.5319
Schistosoma mansoni hypothetical protein 0.0033 0.0424 0.1253
Leishmania major glucose transporter, lmgt1 0.0031 0.0387 0.5319
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0042 0.2246
Brugia malayi MH2 domain containing protein 0.0115 0.2288 0.3537
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0042 0.0069
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0189 0.0292
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0582
Loa Loa (eye worm) hypothetical protein 0.0095 0.183 0.283
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0602 0.0602
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.4925 0.4925
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0364 0.1855
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0364 0.0364
Schistosoma mansoni hypothetical protein 0.0101 0.1963 0.5804
Echinococcus granulosus neuropeptide receptor A26 0.0456 1 1
Onchocerca volvulus 0.03 0.6468 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.1963 0.1963
Schistosoma mansoni glucose transport protein 0.0101 0.1963 0.5804
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0042
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0163 0.3369 0.5495
Toxoplasma gondii protein kinase, putative 0.0285 0.6131 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.2072 0.8858
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0024 0.0036
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.183 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0042 0.0582
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.2072 0.8858
Schistosoma mansoni protein kinase 0.0031 0.0378 0.1118
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0024 0.0024
Echinococcus granulosus peregrin 0.0029 0.033 0.033
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0364 0.1068
Echinococcus multilocularis protein patched 0.0041 0.0602 0.0602
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0042 1
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.183 0.183
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0042 0.0045
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0387 0.1973
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0042 0.0181
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.1963 0.1963
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0387 0.5319
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5319
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0189 0.0201
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0768 0.1188
Echinococcus granulosus geminin 0.0164 0.3382 0.3382
Onchocerca volvulus 0.0047 0.0749 0.1158
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.007
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0024 0.0026
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0602 0.0602
Trypanosoma cruzi hexose transporter 0.0031 0.0387 0.5319
Loa Loa (eye worm) hypothetical protein 0.003 0.0364 0.0563
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0189 0.2592
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5319
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0379 0.0617
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0728 0.0728
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0602 0.0931
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0024 0.0103
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0378 0.0585
Echinococcus granulosus jumonji domain containing protein 0.004 0.0584 0.0584
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0024 0.0036
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0024 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0582
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.033 0.0538
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0602 0.3068
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0387 0.1973
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0466 0.0466
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0424 0.0655
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0582
Treponema pallidum NADH oxidase 0.0016 0.0042 0.5
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0378 0.5196
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0042 0.0045
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0042 0.2246
Brugia malayi Sugar transporter family protein 0.0101 0.1963 0.3035
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0189 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5319
Plasmodium falciparum hexose transporter 0.0101 0.1963 0.2094
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0042
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0042 0.0582
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.033 0.033
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.007
Schistosoma mansoni glucose transport protein 0.0101 0.1963 0.5804
Onchocerca volvulus Huntingtin homolog 0.0121 0.2413 0.3731
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.1963 1
Leishmania major protein kinase, putative 0.0031 0.0378 0.5196
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.1963 0.1963
Brugia malayi isocitrate dehydrogenase 0.0015 0.0024 0.0037
Schistosoma mansoni hypothetical protein 0.0039 0.0569 0.1682
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.033 0.0975
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0042 0.0582
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5319
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0379 0.0404
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0189 1
Echinococcus multilocularis protein dispatched 1 0.0047 0.0733 0.0733
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0378 0.1927
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Brugia malayi jmjC domain containing protein 0.0035 0.0466 0.0721
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1864 0.5511
Echinococcus multilocularis expressed conserved protein 0.0089 0.17 0.17
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0364 0.1133
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0582
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0364 1
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0387 0.5319
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.2072 0.8858
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0478 0.051
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0189 0.0961
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0042 0.0045
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0042 0.0045
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0335 0.0335
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.2288 0.3537
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0024 0.0037
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0478 0.6562
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0042 0.0216
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0478 0.6562
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0466 0.1379
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0466 0.0466
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.1963 0.1963
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.2072 0.8801
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0024 0.0024
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.2072 0.8858
Loa Loa (eye worm) hypothetical protein 0.0033 0.0424 0.0655
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0378 0.0585
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0335 0.0335
Trypanosoma brucei glucose transporter 2A 0.0031 0.0387 0.5319
Plasmodium vivax glutathione reductase, putative 0.0046 0.0728 0.0777
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0042 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0042 0.0582
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.2288 0.3537
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5319
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0042 0.0582
Schistosoma mansoni jumonji domain containing protein 0.0075 0.1372 0.4057
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0379 0.0404
Plasmodium vivax CDK-related protein kinase 6, putative 0.0429 0.9372 1
Brugia malayi Bromodomain containing protein 0.0029 0.033 0.051
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0749 0.1158
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.1963 0.3201
Mycobacterium tuberculosis Probable reductase 0.0106 0.2072 0.8858
Schistosoma mansoni hypothetical protein 0.0164 0.3382 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0582
Entamoeba histolytica protein kinase, putative 0.0031 0.0378 0.1155
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0042 0.0125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0582
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.033 0.0538
Loa Loa (eye worm) hypothetical protein 0.0049 0.0794 0.1228
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.2072 0.8858
Trypanosoma brucei glucose transporter 1E 0.0031 0.0387 0.5319
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0066 0.0907
Leishmania major glucose transporter, lmgt2 0.0031 0.0387 0.5319
Echinococcus multilocularis neuropeptide receptor A26 0.0456 1 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0749 0.2214
Echinococcus multilocularis GPCR, family 2 0.0015 0.0024 0.0024
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0042 0.1164
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0379 0.0404
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1022 0.1581
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0478 0.6562
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0387 0.1973
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0024 0.0039
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0364 0.1076
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0466 0.0721
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0387 0.5319
Plasmodium falciparum mitogen-activated protein kinase 2 0.0163 0.3369 0.3595
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0364 0.1076
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0024 0.0024
Onchocerca volvulus Alhambra homolog 0.0029 0.033 0.051
Echinococcus multilocularis General substrate transporter 0.0087 0.1642 0.1642
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.007
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.2339 1
Plasmodium falciparum protein kinase 6 0.0429 0.9372 1
Leishmania major trypanothione reductase 0.0046 0.0728 1
Plasmodium falciparum glutathione reductase 0.0016 0.0042 0.0045
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0379 0.0404
Loa Loa (eye worm) hypothetical protein 0.0015 0.0024 0.0036
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5319
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0387 0.1973
Loa Loa (eye worm) hypothetical protein 0.0121 0.2413 0.3731
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0387 0.5319
Plasmodium falciparum protein kinase 7 0.0285 0.6131 0.6542
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.1963 0.1963
Leishmania major glucose transporter, lmgt3 0.0031 0.0387 0.5319
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0378 0.1118
Schistosoma mansoni hypothetical protein 0.0015 0.0024 0.007
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0024 0.0039
Plasmodium vivax hexose transporter 0.0101 0.1963 0.2094
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0379 0.0404
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.1963 0.1963
Loa Loa (eye worm) hypothetical protein 0.0031 0.0378 0.0585
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0024 0.0024
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0189 0.0558
Loa Loa (eye worm) hypothetical protein 0.003 0.0364 0.0563
Schistosoma mansoni hypothetical protein 0.0039 0.0569 0.1682
Schistosoma mansoni hypothetical protein 0.0039 0.0569 0.1682
Trypanosoma brucei trypanothione reductase 0.0046 0.0728 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0024 0.0026
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0379 0.0404
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0364 0.0563
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.033 0.033
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0478 0.0779
Brugia malayi jmjC domain containing protein 0.0094 0.181 0.2799
Brugia malayi glutathione reductase 0.0046 0.0728 0.1125
Echinococcus multilocularis peregrin 0.0029 0.033 0.033
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0024 0.0071
Trypanosoma brucei glucose transporter, putative 0.0031 0.0387 0.5319
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0584 0.0584
Loa Loa (eye worm) glutathione reductase 0.0046 0.0728 0.1125
Toxoplasma gondii thioredoxin reductase 0.0046 0.0728 0.1187
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0582
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.033 0.051
Loa Loa (eye worm) hypothetical protein 0.0121 0.2413 0.3731
Plasmodium falciparum glutathione reductase 0.0046 0.0728 0.0777
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0379 0.0404
Schistosoma mansoni protein kinase 0.0031 0.0378 0.1118
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0387 0.5319
Schistosoma mansoni hypothetical protein 0.0047 0.0749 0.2214
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0042 0.0069
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0189 0.0345
Brugia malayi hypothetical protein 0.0121 0.2413 0.3731
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0378 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0387 0.1973
Entamoeba histolytica protein kinase, putative 0.0031 0.0378 0.1155
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0024 0.0332
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0023 0.0189 0.0292
Plasmodium falciparum phd finger protein, putative 0.0029 0.033 0.0352
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0025 0.0236 0.0364
Loa Loa (eye worm) hypothetical protein 0.03 0.6468 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0768 0.1188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0042 0.0582
Plasmodium falciparum thioredoxin reductase 0.0046 0.0728 0.0777
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0126 0.0641
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.1963 0.1963
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0379 0.0617
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0768 0.1188
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0024 0.0024
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0189 0.5182
Echinococcus granulosus GPCR family 2 0.0015 0.0024 0.0024
Brugia malayi Cam kinase protein 1 0.0031 0.0378 0.0585
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0024 0.0332
Schistosoma mansoni hypothetical protein 0.0164 0.3382 1
Giardia lamblia PHD finger protein 15 0.0029 0.033 0.9053
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.2339 1
Brugia malayi PHD-finger family protein 0.0029 0.033 0.051
Echinococcus multilocularis neuropeptide s receptor 0.0456 1 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0379 0.0404
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0024 0.0024
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0189 0.2592
Brugia malayi hypothetical protein 0.0232 0.4925 0.7614
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0189 0.2592
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.1963 0.1963
Onchocerca volvulus Huntingtin homolog 0.0121 0.2413 0.3731
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0364 0.0563
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0042 0.0582
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0189 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.033 0.0352
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0112 0.0478
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0042 0.0066
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.4925 0.4925
Brugia malayi CHE-14 protein 0.0041 0.0602 0.0931
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0466 0.1379

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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