Detailed information for compound 700050

Basic information

Technical information
  • TDR Targets ID: 700050
  • Name: methyl 2-amino-4-(4-chlorophenyl)-6-ethyl-7-m ethyl-5-oxo-4H-pyrano[5,6-c]pyridine-3-carbox ylate
  • MW: 374.818 | Formula: C19H19ClN2O4
  • H donors: 1 H acceptors: 2 LogP: 2.99 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1=C(N)Oc2c(C1c1ccc(cc1)Cl)c(=O)n(c(c2)C)CC
  • InChi: 1S/C19H19ClN2O4/c1-4-22-10(2)9-13-15(18(22)23)14(11-5-7-12(20)8-6-11)16(17(21)26-13)19(24)25-3/h5-9,14H,4,21H2,1-3H3
  • InChiKey: CDOLNCJFXUUVBX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-4-(4-chlorophenyl)-6-ethyl-7-methyl-5-oxo-4H-pyrano[5,6-c]pyridine-3-carboxylic acid methyl ester
  • 2-amino-4-(4-chlorophenyl)-6-ethyl-5-keto-7-methyl-4H-pyrano[5,6-c]pyridine-3-carboxylic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.245 0.2477
Echinococcus granulosus PHD finger protein rhinoceros 0.0025 0.0207 0.0324
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0253 0.0228
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0207 0.2815
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0038 0.0039
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0396 0.0661
Onchocerca volvulus 0.0028 0.0253 0.0175
Schistosoma mansoni biogenic amine receptor 0.0028 0.0253 0.0675
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0063 0.0769 0.1513
Echinococcus granulosus lamin dm0 0.0043 0.0473 0.0798
Brugia malayi GnHR receptor homolog 0.0028 0.0253 0.0508
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0046 0.0524 0.053
Mycobacterium tuberculosis Conserved protein 0.0038 0.0396 0.0718
Brugia malayi Pre-SET motif family protein 0.0349 0.4977 1
Plasmodium vivax ataxin-2 like protein, putative 0.0046 0.0524 0.8853
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0028 0.0253 0.046
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Echinococcus multilocularis chromobox protein 1 0.0052 0.0606 0.0582
Schistosoma mansoni neuropeptide receptor 0.0028 0.0253 0.0675
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0116 0.1547 0.2717
Schistosoma mansoni lamin 0.0043 0.0473 0.1326
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0051 0.0584 0.056
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0067 0.012
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.0524 0.6457
Loa Loa (eye worm) hypothetical protein 0.0015 0.0059 0.0067
Schistosoma mansoni opsin-like receptor 0.0028 0.0253 0.0675
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Brugia malayi hypothetical protein 0.0028 0.0253 0.0508
Loa Loa (eye worm) hypothetical protein 0.0038 0.0396 0.0748
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0396 0.1099
Onchocerca volvulus 0.0028 0.0253 0.0175
Brugia malayi AKH receptor 0.0028 0.0253 0.0508
Loa Loa (eye worm) hypothetical protein 0.0021 0.0143 0.0237
Trichomonas vaginalis inositol monophosphatase, putative 0.0063 0.0769 0.0777
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0253 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0253 0.0228
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Mycobacterium tuberculosis Conserved protein 0.0038 0.0396 0.0718
Schistosoma mansoni inositol monophosphatase 0.0063 0.0769 0.2206
Echinococcus granulosus somatostatin receptor 0.0028 0.0253 0.0407
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0046 0.0524 0.053
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0253 0.0228
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0334 0.4752 1
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2591 0.2619
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0461 0.0879
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0028 0.0253 0.0675
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.3818 0.3858
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0396 0.0718
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0032 0.0307 0.3318
Echinococcus multilocularis sex peptide receptor 0.0028 0.0253 0.0228
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0684 0.9894 1
Schistosoma mansoni hypothetical protein 0.0028 0.0253 0.0675
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0116 0.1547 0.4514
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.245 0.2477
Mycobacterium ulcerans hypothetical protein 0.0038 0.0396 0.0718
Echinococcus multilocularis neuropeptide FF receptor 2 0.0028 0.0253 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0253 0.0228
Schistosoma mansoni opsin-like receptor 0.0028 0.0253 0.0675
Schistosoma mansoni neuropeptide f receptor 76f 0.0028 0.0253 0.0675
Onchocerca volvulus 0.0043 0.0473 0.0571
Onchocerca volvulus 0.0028 0.0253 0.0175
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0396 0.1099
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.2591 0.2619
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Brugia malayi follicle stimulating hormone receptor 0.0217 0.3027 0.6081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0253 0.0675
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0253 0.0675
Onchocerca volvulus 0.0023 0.0178 0.0038
Schistosoma mansoni alpha-1 adrenergic receptor 0.0028 0.0253 0.0675
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0253 0.0407
Brugia malayi hypothetical protein 0.0028 0.0253 0.0508
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0524 0.053
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0084 0.0168
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Brugia malayi beta-lactamase family protein 0.0038 0.0396 0.0794
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0046 0.0524 0.053
Loa Loa (eye worm) hypothetical protein 0.0038 0.0396 0.0748
Schistosoma mansoni hypothetical protein 0.0144 0.1965 0.5754
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0021 0.0148 0.0218
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0253 0.0675
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0253 0.0407
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0253 0.0675
Onchocerca volvulus 0.0028 0.0253 0.0175
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0046 0.0524 0.6461
Loa Loa (eye worm) hypothetical protein 0.0021 0.0146 0.0243
Echinococcus multilocularis G-protein coupled receptor, putative 0.0028 0.0253 0.0228
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0063 0.0769 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0021 0.0143 0.0209
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0021 0.0146 0.0215
Echinococcus granulosus serotonin receptor 0.0028 0.0253 0.0407
Echinococcus multilocularis vesicular acetylcholine transporter 0.0242 0.3395 0.3378
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0116 0.1547 0.3107
Echinococcus granulosus sex peptide receptor 0.0028 0.0253 0.0407
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Onchocerca volvulus 0.0028 0.0253 0.0175
Echinococcus multilocularis allatostatin A receptor 0.0028 0.0253 0.0228
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0584 0.056
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0253 0.0675
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0063 0.0769 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0253 0.0407
Echinococcus granulosus g protein coupled receptor 0.0028 0.0253 0.0407
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0396 0.04
Loa Loa (eye worm) hypothetical protein 0.0038 0.0396 0.0748
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0028 0.0253 0.0407
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0253 0.0675
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0028 0.0253 0.046
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0253 0.0228
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0684 0.9894 1
Loa Loa (eye worm) heterochromatin protein 1 0.0052 0.0606 0.1172
Brugia malayi Melatonin receptor type 1A 0.0028 0.0253 0.0508
Onchocerca volvulus 0.0038 0.0396 0.0433
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.3818 0.3858
Loa Loa (eye worm) melatonin receptor type 1A 0.0028 0.0253 0.046
Onchocerca volvulus 0.0038 0.0396 0.0433
Echinococcus multilocularis serotonin receptor 0.0128 0.1722 0.17
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0028 0.0253 0.0228
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Leishmania major hypothetical protein, conserved 0.0038 0.0396 0.4607
Echinococcus granulosus neuropeptide s receptor 0.0393 0.5623 1
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0396 0.0718
Brugia malayi Calcitonin receptor-like protein seb-1 0.004 0.0424 0.085
Brugia malayi hypothetical protein 0.0028 0.0253 0.0508
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0028 0.0253 0.0508
Brugia malayi Intermediate filament tail domain containing protein 0.0043 0.0473 0.0948
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0584 0.1657
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0396 0.04
Echinococcus multilocularis PHD finger protein rhinoceros 0.0025 0.0207 0.0182
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0028 0.0253 0.0407
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0253 0.0228
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.0537 0.1517
Brugia malayi Tachykinin-like peptides receptor 99D 0.0028 0.0253 0.0508
Trichomonas vaginalis chromobox protein, putative 0.0031 0.0303 0.0306
Echinococcus granulosus alpha 1A adrenergic receptor 0.0028 0.0253 0.0407
Entamoeba histolytica hypothetical protein 0.0033 0.0325 0.0252
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0005 0.0005
Plasmodium falciparum phd finger protein, putative 0.0025 0.0207 0.3179
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0046 0.0524 0.053
Schistosoma mansoni amine GPCR 0.0028 0.0253 0.0675
Brugia malayi G-protein coupled receptor 0.0028 0.0253 0.0508
Schistosoma mansoni amine GPCR 0.0028 0.0253 0.0675
Echinococcus granulosus peregrin 0.0025 0.0207 0.0324
Onchocerca volvulus 0.0028 0.0253 0.0175
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0048 0.055 0.0937
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0077 0.0346
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0253 0.0675
Brugia malayi hypothetical protein 0.0028 0.0253 0.0508
Schistosoma mansoni myosin xvIII 0.0028 0.0253 0.0675
Schistosoma mansoni amine GPCR 0.0028 0.0253 0.0675
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0046 0.0524 0.053
Brugia malayi hypothetical protein 0.0028 0.0253 0.0508
Giardia lamblia PHD finger protein 15 0.0025 0.0207 0.0132
Onchocerca volvulus 0.0028 0.0253 0.0175
Schistosoma mansoni intermediate filament proteins 0.0043 0.0473 0.1326
Schistosoma mansoni hypothetical protein 0.0028 0.0253 0.0675
Schistosoma mansoni hypothetical protein 0.0033 0.0325 0.0888
Brugia malayi sulfakinin receptor protein 0.0028 0.0253 0.0508
Schistosoma mansoni jumonji domain containing protein 0.0065 0.0792 0.2274
Entamoeba histolytica hypothetical protein 0.0033 0.0325 0.0252
Trichomonas vaginalis chromobox protein, putative 0.0031 0.0303 0.0306
Loa Loa (eye worm) hypothetical protein 0.0046 0.0524 0.1006
Schistosoma mansoni hypothetical protein 0.0144 0.1965 0.5754
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0038 0.0039
Onchocerca volvulus 0.0038 0.0396 0.0433
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0253 0.0228
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Echinococcus multilocularis neuropeptide receptor 0.0028 0.0253 0.0228
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0016 0.0077 0.0039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0253 0.0407
Loa Loa (eye worm) pigment dispersing factor receptor c 0.004 0.0424 0.0803
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0116 0.1547 0.1525
Echinococcus multilocularis chromobox protein 1 0.0052 0.0606 0.0582
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0046 0.0524 0.053
Schistosoma mansoni hypothetical protein 0.0021 0.0148 0.0362
Brugia malayi hypothetical protein 0.0046 0.0524 0.1051
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0396 0.0718
Onchocerca volvulus 0.0398 0.5685 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Trypanosoma brucei PAB1-binding protein , putative 0.0046 0.0524 0.6457
Plasmodium vivax SET domain protein, putative 0.0051 0.0584 1
Echinococcus granulosus dro:myosuppressin receptor 0.0028 0.0253 0.0407
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0021 0.0143 0.0286
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0028 0.0253 0.0228
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0028 0.0253 0.0228
Echinococcus granulosus hypothetical protein 0.0028 0.0253 0.0407
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0077 0.0078
Brugia malayi putative neuropeptide receptor 0.0028 0.0253 0.0508
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.0524 0.6457
Schistosoma mansoni inositol monophosphatase 0.0063 0.0769 0.2206
Schistosoma mansoni hypothetical protein 0.0025 0.0207 0.0538
Schistosoma mansoni chromobox protein 0.0052 0.0606 0.1722
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0349 0.4977 1
Schistosoma mansoni hypothetical protein 0.0028 0.0253 0.0675
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0396 0.04
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.245 0.2477
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0028 0.0253 0.0228
Brugia malayi Serotonin receptor 0.0028 0.0253 0.0508
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0396 0.0748
Schistosoma mansoni biogenic amine receptor 0.0028 0.0253 0.0675
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0684 0.9894 1
Onchocerca volvulus 0.0028 0.0253 0.0175
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0063 0.0769 0.0777
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.0431
Onchocerca volvulus Glucosylceramidase homolog 0.0178 0.245 0.4148
Brugia malayi chromobox protein homolog 3 0.0029 0.027 0.0541
Brugia malayi G protein-coupled receptor F59B2.13 0.0028 0.0253 0.0508
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0077 0.0391
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0021 0.0146 0.0121
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0207 0.2082
Mycobacterium ulcerans lipase LipD 0.0038 0.0396 0.0718
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0253 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0145 0.0147
Onchocerca volvulus 0.0028 0.0253 0.0175
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0334 0.4752 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0116 0.1547 0.4514
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.3818 0.3858
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0684 0.9894 1
Brugia malayi RE15519p 0.0028 0.0253 0.0508
Brugia malayi Heterochromatin protein 1 0.0052 0.0606 0.1216
Onchocerca volvulus 0.0028 0.0253 0.0175
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.245 0.2477
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0077 0.0104
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0253 0.0407
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0028 0.0253 0.0675
Onchocerca volvulus 0.0028 0.0253 0.0175
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0021 0.0148 0.0122
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.3383 0.7082
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0493
Echinococcus granulosus chromobox protein 1 0.0052 0.0606 0.1037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Brugia malayi hypothetical protein 0.0028 0.0253 0.0508
Echinococcus multilocularis neuropeptides capa receptor 0.0028 0.0253 0.0228
Loa Loa (eye worm) hypothetical protein 0.0128 0.1722 0.3425
Echinococcus multilocularis orexin receptor type 2 0.0028 0.0253 0.0228
Onchocerca volvulus 0.0028 0.0253 0.0175
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0396 0.0718
Loa Loa (eye worm) hypothetical protein 0.0128 0.1722 0.3425
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0253 0.0228
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0077 0.0078
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0157 0.0264
Brugia malayi beta-lactamase family protein 0.0038 0.0396 0.0794
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0021 0.0143 0.0145
Onchocerca volvulus Neuropeptide F receptor homolog 0.0028 0.0253 0.0175
Brugia malayi jmjC domain containing protein 0.0031 0.0302 0.0605
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0038 0.0039
Echinococcus granulosus g-protein coupled receptor 0.0028 0.0253 0.0407
Brugia malayi intermediate filament protein 0.0043 0.0473 0.0948
Brugia malayi Serotonin receptor 0.0028 0.0253 0.0508
Echinococcus granulosus G protein coupled receptor 139 0.0028 0.0253 0.0407
Echinococcus granulosus neuropeptide FF receptor 2 0.0028 0.0253 0.0407
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0032 0.0307 0.031
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0038 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0253 0.0675
Toxoplasma gondii PHD-finger domain-containing protein 0.0025 0.0207 0.2082
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0396 0.4607
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0021 0.0143 0.0145
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0046 0.0524 0.6461
Brugia malayi Inositol-1 0.0063 0.0769 0.1544
Schistosoma mansoni jumonji/arid domain-containing protein 0.0031 0.0302 0.0819
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0043 0.0473 0.0902
Echinococcus granulosus lysine specific demethylase 5A 0.0031 0.0302 0.0493
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0038 0.0039
Echinococcus multilocularis neuropeptide s receptor 0.0393 0.5623 0.5611
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0028 0.0253 0.0675
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0046 0.0524 0.6461
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0253 0.0228
Loa Loa (eye worm) hypothetical protein 0.0025 0.0207 0.0366
Echinococcus multilocularis cpg binding protein 0.0023 0.0175 0.0149
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0063 0.0769 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Schistosoma mansoni ap endonuclease 0.0016 0.0077 0.0153
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0396 0.04
Schistosoma mansoni hypothetical protein 0.0027 0.024 0.0634
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0005 0.0005
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0028 0.0253 0.0407
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0396 0.0371
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0396 0.0718
Brugia malayi cytoplasmic intermediate filament protein 0.0023 0.018 0.036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Schistosoma mansoni vesicular acetylcholine transporter 0.0242 0.3395 1
Echinococcus multilocularis inositol monophosphatase 1 0.0063 0.0769 0.0745
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.044 0.0445
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0038 0.0039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Echinococcus multilocularis jumonji domain containing protein 0.0035 0.035 0.0325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0116 0.1547 0.4514
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0038 0.0039
Schistosoma mansoni jumonji/arid domain-containing protein 0.0031 0.0302 0.0819
Schistosoma mansoni neuropeptide receptor 0.0028 0.0253 0.0675
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0584 0.0998
Schistosoma mansoni opsin-like receptor 0.0028 0.0253 0.0675
Brugia malayi PHD-finger family protein 0.0025 0.0207 0.0414
Brugia malayi Bromodomain containing protein 0.0025 0.0207 0.0414
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0081 0.1038 0.1808
Brugia malayi CXXC zinc finger family protein 0.0021 0.0157 0.0314
Onchocerca volvulus 0.0028 0.0253 0.0175
Schistosoma mansoni ap endonuclease 0.0016 0.0077 0.0153
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0051 0.0584 0.7396
Loa Loa (eye worm) hypothetical protein 0.0043 0.0473 0.0902
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0116 0.1547 0.2717
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0253 0.046
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0046 0.0524 0.6461
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0253 0.0228
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0396 0.0718
Echinococcus granulosus fmrfamide receptor 0.0028 0.0253 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0059 0.006
Brugia malayi hypothetical protein 0.0033 0.0325 0.0652
Loa Loa (eye worm) jmjC domain-containing protein 0.0051 0.0596 0.1151
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.245 0.2477
Onchocerca volvulus 0.0028 0.0253 0.0175
Trichomonas vaginalis chromobox protein, putative 0.0052 0.0606 0.0613
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0063 0.0769 0.0777
Echinococcus multilocularis dro:myosuppressin receptor 0.0028 0.0253 0.0228
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0253 0.0228
Loa Loa (eye worm) hypothetical protein 0.0051 0.0584 0.1128
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0028 0.0253 0.0675
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0116 0.1547 0.3072
Toxoplasma gondii LsmAD domain-containing protein 0.0046 0.0524 0.6547
Schistosoma mansoni biogenic amine (5HT) receptor 0.0028 0.0253 0.0675
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0056 0.0672 0.1306
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0271 0.3818 0.767
Schistosoma mansoni lamin 0.0043 0.0473 0.1326
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0253 0.0407
Brugia malayi hypothetical protein 0.0028 0.0253 0.0508
Brugia malayi hypothetical protein 0.0028 0.0253 0.0508
Treponema pallidum fructose-bisphosphate aldolase 0.0684 0.9894 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0325 0.03
Echinococcus granulosus jumonji domain containing protein 0.0035 0.035 0.0579
Echinococcus multilocularis somatostatin receptor 0.0028 0.0253 0.0228
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0028 0.0253 0.0228
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0021 0.0143 0.0286
Echinococcus multilocularis fmrfamide receptor 0.0028 0.0253 0.0228
Mycobacterium leprae Probable lipase LipE 0.0038 0.0396 0.0718
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.0524 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Brugia malayi hypothetical protein 0.0028 0.0253 0.0508
Brugia malayi neuropeptide F receptor 0.0028 0.0253 0.0508
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0028 0.0253 0.0407
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0081 0.1038 0.1015
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0016 0.0077 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0253 0.0228
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0056 0.0672 0.1306
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0325 0.0535
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0028 0.0253 0.0675
Echinococcus granulosus tachykinin peptides receptor 99D 0.0028 0.0253 0.0407
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0584 0.1657
Schistosoma mansoni neuropeptide receptor 0.0028 0.0253 0.0675
Schistosoma mansoni histamine h1 receptor 0.0028 0.0253 0.0675
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0253 0.0675
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0145 0.0147
Mycobacterium ulcerans beta-lactamase 0.0038 0.0396 0.0718
Toxoplasma gondii histone lysine methyltransferase SET1 0.0042 0.0466 0.5726
Brugia malayi neuropeptide F receptor 0.0028 0.0253 0.0508
Schistosoma mansoni hypothetical protein 0.0028 0.0253 0.0675
Echinococcus granulosus intermediate filament protein 0.0043 0.0473 0.0798
Onchocerca volvulus 0.0028 0.0253 0.0175
Loa Loa (eye worm) hypothetical protein 0.004 0.0424 0.0803
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Echinococcus multilocularis neuropeptide Y receptor 0.0028 0.0253 0.0228
Brugia malayi beta-lactamase 0.0038 0.0396 0.0794
Onchocerca volvulus 0.0059 0.0709 0.0999
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0046 0.0524 0.05
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0028 0.0253 0.0508
Echinococcus granulosus neuropeptide receptor A26 0.0393 0.5623 1
Echinococcus multilocularis neuropeptide receptor A26 0.0393 0.5623 0.5611
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0028 0.0253 0.0228
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0046 0.0524 0.053
Brugia malayi ORL1-like opioid receptor 0.0028 0.0253 0.0508
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.044 0.0445
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0032 0.0307 0.031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0253 0.0228
Echinococcus multilocularis serotonin receptor 0.0128 0.1722 0.17
Echinococcus granulosus lamin 0.0043 0.0473 0.0798
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0253 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.044 0.0445
Schistosoma mansoni biogenic amine (5HT) receptor 0.0128 0.1722 0.5032
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0028 0.0253 0.0675
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0063 0.0769 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.027 0.0273
Schistosoma mansoni chromobox protein 0.0052 0.0606 0.1722
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.245 0.2477
Loa Loa (eye worm) TYRA-2 protein 0.0028 0.0253 0.046
Echinococcus multilocularis g-protein coupled receptor 0.0028 0.0253 0.0228
Schistosoma mansoni adenoreceptor 0.0028 0.0253 0.0675
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0253 0.046
Echinococcus multilocularis G protein coupled receptor 139 0.0028 0.0253 0.0228
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0023 0.018 0.0311
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0028 0.0253 0.0228
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Echinococcus granulosus g protein coupled receptor 0.0028 0.0253 0.0407
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0253 0.0675
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.3818 0.3858
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.245 0.2477
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.022
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0253 0.0407
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0325 0.0888
Onchocerca volvulus Alhambra homolog 0.0025 0.0207 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.3818 0.3858
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0046 0.0524 0.053
Trichomonas vaginalis set domain proteins, putative 0.0398 0.5685 0.5746
Schistosoma mansoni neuropeptide receptor 0.0028 0.0253 0.0675
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0077 0.0154
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0217 0.3027 0.6061
Loa Loa (eye worm) hypothetical protein 0.0043 0.0468 0.0893
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0253 0.0407
Loa Loa (eye worm) inositol-1 0.0063 0.0769 0.1501
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0028 0.0253 0.046
Echinococcus granulosus peptide allatostatin:somatostatin 0.0028 0.0253 0.0407
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0028 0.0253 0.0675
Echinococcus granulosus cpg binding protein 0.0023 0.0175 0.0266
Echinococcus multilocularis musashi 0.0043 0.0473 0.0448
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0396 0.0718
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Brugia malayi hypothetical protein 0.0028 0.0253 0.0508
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0396 0.0718
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0063 0.0769 1
Brugia malayi G-protein coupled receptor 0.0028 0.0253 0.0508
Onchocerca volvulus 0.0043 0.0473 0.0571
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0046 0.0524 0.6461
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0253 0.0228
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0028 0.0253 0.0508
Trichomonas vaginalis chromobox protein, putative 0.0052 0.0606 0.0613
Brugia malayi G protein-coupled receptor 0.0028 0.0253 0.0508
Onchocerca volvulus 0.0028 0.0253 0.0175
Schistosoma mansoni cpg binding protein 0.0023 0.0175 0.0442
Brugia malayi Pre-SET motif family protein 0.0051 0.0584 0.1172
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0253 0.0228
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0028 0.0253 0.0508
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0709 0.2028
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0046 0.0524 0.0891
Schistosoma mansoni neuropeptide F-like receptor 0.0028 0.0253 0.0675
Onchocerca volvulus 0.0028 0.0253 0.0175
Echinococcus multilocularis rhodopsin orphan GPCR 0.0028 0.0253 0.0228
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0028 0.0253 0.0675
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0242 0.3395 0.5858
Brugia malayi Dopamine receptor 0.0028 0.0253 0.0508
Schistosoma mansoni amine GPCR 0.0028 0.0253 0.0675
Echinococcus granulosus inositol monophosphatase 1 0.0063 0.0769 0.1328
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.022
Brugia malayi putative neuropeptide receptor NPR1 0.0028 0.0253 0.0508
Mycobacterium tuberculosis Conserved protein 0.0038 0.0396 0.0718
Schistosoma mansoni growth hormone secretagogue receptor 0.0028 0.0253 0.0675
Echinococcus granulosus allatostatin A receptor 0.0028 0.0253 0.0407
Brugia malayi Dopamine receptor protein 2 0.0028 0.0253 0.0508
Echinococcus granulosus geminin 0.0144 0.1965 0.3464
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.3818 0.3858
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0077 0.0092
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Echinococcus granulosus biogenic amine 5HT receptor 0.0028 0.0253 0.0407
Loa Loa (eye worm) hypothetical protein 0.0038 0.0396 0.0748
Echinococcus granulosus neuropeptide receptor 0.0028 0.0253 0.0407
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0046 0.0524 0.053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0684 0.9894 1
Schistosoma mansoni cpg binding protein 0.0021 0.0157 0.0389
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0028 0.0253 0.046
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0396 0.4607
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0396 0.6416
Brugia malayi jmjC domain containing protein 0.0081 0.1038 0.2084
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.027 0.0273
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0684 0.9894 1
Leishmania major hypothetical protein, conserved 0.0046 0.0524 0.6457
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0396 0.04
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0242 0.3395 0.6805
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0046 0.0524 0.053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0253 0.0675
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0302 0.0557
Entamoeba histolytica hypothetical protein 0.0033 0.0325 0.0252
Echinococcus granulosus tm gpcr rhodopsin 0.0028 0.0253 0.0407
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0028 0.0253 0.0675
Brugia malayi vesicular acetylcholine transporter unc-17 0.0242 0.3395 0.6821
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Echinococcus granulosus biogenic amine 5HT receptor 0.0128 0.1722 0.303
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0046 0.0524 0.053
Echinococcus granulosus neuropeptides capa receptor 0.0028 0.0253 0.0407
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0116 0.1547 0.1525
Loa Loa (eye worm) intermediate filament protein 0.0043 0.0473 0.0902
Toxoplasma gondii exonuclease III APE 0.0016 0.0077 0.0256
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0253 0.0407
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0207 0.0366
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0253 0.0675
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0253 0.0407
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0584 0.1657
Giardia lamblia Fructose-bisphosphate aldolase 0.0684 0.9894 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0396 0.0748
Schistosoma mansoni amine GPCR 0.0028 0.0253 0.0675
Echinococcus granulosus chromobox protein 1 0.0052 0.0606 0.1037
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0026 0.005
Schistosoma mansoni biogenic amine receptor 0.0028 0.0253 0.0675
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Echinococcus granulosus orexin receptor type 2 0.0028 0.0253 0.0407
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0334 0.4752 1
Loa Loa (eye worm) beta-lactamase 0.0038 0.0396 0.0748
Echinococcus granulosus neuropeptide receptor 0.0028 0.0253 0.0407
Echinococcus granulosus 7TM GPCR rhodopsin 0.0028 0.0253 0.0407
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Echinococcus granulosus rhodopsin orphan GPCR 0.0028 0.0253 0.0407
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0046 0.0524 0.1479
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0684 0.9894 1
Echinococcus granulosus neuropeptide Y receptor 0.0028 0.0253 0.0407
Echinococcus multilocularis geminin 0.0144 0.1965 0.1944
Echinococcus granulosus vesicular acetylcholine transporter 0.0242 0.3395 0.602
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0021 0.0143 0.0348
Brugia malayi Dopamine receptor protein 1 0.0028 0.0253 0.0508
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0028 0.0253 0.0228
Schistosoma mansoni cpg binding protein 0.0023 0.0175 0.0442
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0684 0.9894 1
Brugia malayi latrophilin 2 splice variant baaae 0.0027 0.024 0.048
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0396 0.0718
Brugia malayi larval opioid receptor 0.0028 0.0253 0.0508
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0396 0.4607
Echinococcus granulosus g protein coupled receptor 0.0028 0.0253 0.0407
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0684 0.9894 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0028 0.0253 0.0228
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0031 0.0303 0.0264
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0271 0.3818 0.7658
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0396 0.0794
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0028 0.0253 0.0228
Loa Loa (eye worm) hypothetical protein 0.0023 0.0178 0.0307
Loa Loa (eye worm) neuropeptide F receptor 0.0028 0.0253 0.046
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0029 0.027 0.0205
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.0524 1
Toxoplasma gondii ABC1 family protein 0.0038 0.0396 0.4745
Echinococcus multilocularis lamin 0.0043 0.0473 0.0448
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0028 0.0253 0.0508
Echinococcus multilocularis peregrin 0.0025 0.0207 0.0182
Echinococcus granulosus 7tm_1 domain containing protein 0.0028 0.0253 0.0407
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0028 0.0253 0.0175
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0025 0.0207 0.0538
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0063 0.0769 0.0705
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0684 0.9894 1
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0396 0.0718
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0028 0.0253 0.0675
Echinococcus multilocularis lysine specific demethylase 5A 0.003 0.0284 0.0259
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0028 0.0253 0.0228
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0046 0.0524 0.053
Echinococcus multilocularis lamin dm0 0.0043 0.0473 0.0448
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0021 0.0143 0.0145
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0063 0.0769 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.004 0.0424 0.085
Brugia malayi hypothetical protein 0.003 0.0282 0.0565
Toxoplasma gondii hypothetical protein 0.0041 0.044 0.537
Trichomonas vaginalis esterase, putative 0.0038 0.0396 0.04
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0021 0.0143 0.0118
Echinococcus multilocularis g protein coupled receptor 0.0028 0.0253 0.0228
Loa Loa (eye worm) hypothetical protein 0.0028 0.0253 0.046
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0077 0.0052
Loa Loa (eye worm) G-protein coupled receptor 0.0028 0.0253 0.046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0028 0.0253 0.0675
Loa Loa (eye worm) hypothetical protein 0.0038 0.0396 0.0748
Entamoeba histolytica hypothetical protein 0.0033 0.0325 0.0252
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0026 0.005

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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