Detailed information for compound 700324

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 456.533 | Formula: C23H25FN4O3S
  • H donors: 1 H acceptors: 4 LogP: 3.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1S(=O)(=O)Nc1ccc(cc1)c1ccc(nn1)N1CCC(CC1)C)F
  • InChi: 1S/C23H25FN4O3S/c1-16-11-13-28(14-12-16)23-10-8-20(25-26-23)17-3-6-19(7-4-17)27-32(29,30)22-15-18(24)5-9-21(22)31-2/h3-10,15-16,27H,11-14H2,1-2H3
  • InChiKey: MXTBETYAOSKUIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0066 0.006
Trypanosoma brucei C-8 sterol isomerase, putative 0.0357 0.5103 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0193 0.038
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0193 0.038
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.418 0.8177
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0193 0.0152
Schistosoma mansoni DNA polymerase eta 0.0033 0.0158 0.0154
Chlamydia trachomatis pyruvate kinase 0.0033 0.0151 1
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0215 0.2925 0.5731
Schistosoma mansoni lamin 0.0027 0.0056 0.0051
Plasmodium falciparum flap endonuclease 1 0.0026 0.0042 0.036
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0119 0.1462 0.2862
Schistosoma mansoni hypothetical protein 0.0058 0.0538 0.0534
Echinococcus multilocularis lamin 0.0027 0.0056 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0048 0.0094
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.0158 0.0154
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.418 0.8192
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1462 0.7174
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.1462 0.1458
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.2094 0.4104
Echinococcus multilocularis lamin dm0 0.0027 0.0056 0.0014
Leishmania major C-8 sterol isomerase-like protein 0.0357 0.5103 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0569 0.2789
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0569 0.0565
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1795 0.3515
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0042 0.0103
Echinococcus multilocularis pyruvate kinase 0.0026 0.0046 0.0004
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.4034 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.2094 0.2061
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0151 0.0297
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0151 0.0334
Echinococcus multilocularis chromobox protein 1 0.0069 0.0696 0.0657
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.0158 0.0154
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0002 0.5
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.4034 1
Entamoeba histolytica hypothetical protein 0.0023 0.0002 0.0004
Brugia malayi hypothetical protein 0.0058 0.0538 0.0981
Brugia malayi MH2 domain containing protein 0.0117 0.1441 0.2766
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0225 0.3076 0.3047
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.0158 0.0116
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0193 0.03
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0193 0.038
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0193 0.038
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0151 0.1025
Echinococcus multilocularis vesicular acetylcholine transporter 0.0215 0.2925 0.2895
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4034 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0556 0.1017
Schistosoma mansoni lamin 0.0027 0.0056 0.0051
Brugia malayi jmjC domain containing protein 0.0058 0.0533 0.0971
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0288 0.0487
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0538 0.0499
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0096 0.1109 0.2174
Echinococcus multilocularis mannose 6 phosphate isomerase 0.0096 0.1109 0.1072
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0237 0.0632
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0193 0.0152
Giardia lamblia Pyruvate kinase 0.0033 0.0151 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0257 0.0502
Trypanosoma brucei phosphomannose isomerase 0.0096 0.1109 0.2173
Echinococcus multilocularis microtubule associated protein 2 0.0679 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0207 0.0405
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0556 0.109
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0151 0.0334
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0329 0.0289
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0898 0.086
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0151 0.0217
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0151 0.0275
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0151 0.0217
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0288 0.0487
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0193 0.038
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0056 0.0109
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0151 0.0275
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0533 0.0494
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.0158 0.0309
Echinococcus multilocularis dna polymerase eta 0.0033 0.0158 0.0116
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0329 0.0568
Leishmania major DNA polymerase eta, putative 0.0033 0.0158 0.0305
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0193 0.03
Brugia malayi hypothetical protein 0.0058 0.0538 0.0981
Schistosoma mansoni lipoxygenase 0.012 0.1479 0.1475
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1462 0.7174
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0193 0.038
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0225 0.3076 0.3047
Onchocerca volvulus 0.0058 0.0538 0.1682
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0193 0.038
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0556 0.1289
Echinococcus granulosus lamin 0.0027 0.0056 0.0014
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.418 0.8177
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0533 0.0529
Loa Loa (eye worm) hypothetical protein 0.0183 0.2438 0.4777
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0898 0.086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0329 0.0325
Echinococcus multilocularis pyruvate kinase 0.0033 0.0151 0.011
Echinococcus multilocularis pyruvate kinase 0.0033 0.0151 0.011
Loa Loa (eye worm) mannose-6-phosphate isomerase 0.0096 0.1109 0.2174
Leishmania major pyruvate kinase 0.0033 0.0151 0.0293
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0151 0.0217
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0453 0.0889
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0556 0.109
Brugia malayi intermediate filament protein 0.0027 0.0056 0.0027
Brugia malayi jmjC domain containing protein 0.0058 0.0533 0.0971
Echinococcus multilocularis chromobox protein 1 0.0069 0.0696 0.0657
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0556 0.109
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0099 0.0194
Echinococcus granulosus dna polymerase kappa 0.0059 0.0556 0.0517
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0288 0.0564
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.0158 0.0116
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0556 0.109
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0329 0.0645
Schistosoma mansoni loxhd1 0.0058 0.0538 0.0534
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0696 0.1364
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0042 0.0082
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0556 0.109
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0207 0.0405
Schistosoma mansoni microtubule-associated protein tau 0.0679 1 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0898 0.0894
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.1795 0.3463
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0569 0.2789
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.0216
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4034 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0193 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0066 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0556 0.109
Plasmodium falciparum pyruvate kinase 0.0033 0.0151 0.1351
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1792 0.8798
Brugia malayi vesicular acetylcholine transporter unc-17 0.0215 0.2925 0.5696
Schistosoma mansoni intermediate filament proteins 0.0027 0.0056 0.0051
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0119 0.1462 0.7174
Trypanosoma brucei DNA polymerase IV, putative 0.0053 0.0457 0.0896
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0533 0.1045
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1441 0.2825
Toxoplasma gondii hypothetical protein 0.0048 0.0382 0.2602
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0151 0.1351
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0556 0.1017
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0569 0.2789
Schistosoma mansoni vesicular acetylcholine transporter 0.0215 0.2925 0.2922
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0533 0.0494
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0151 0.0297
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.0158 0.0391
Plasmodium falciparum LCCL domain-containing protein 0.0058 0.0538 0.4843
Echinococcus granulosus mannose 6 phosphate isomerase 0.0096 0.1109 0.1072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4034 1
Brugia malayi Heterochromatin protein 1 0.0069 0.0696 0.1293
Toxoplasma gondii phosphomannose isomerase type I protein 0.0096 0.1109 0.7586
Giardia lamblia DINP protein human, muc B family 0.004 0.0257 0.0538
Schistosoma mansoni alpha glucosidase 0.0036 0.0193 0.0189
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0569 0.1043
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0151 0.0217
Onchocerca volvulus 0.0058 0.0538 0.1682
Mycobacterium ulcerans mannose-6-phosphate isomerase ManA 0.0096 0.1109 0.5443
Onchocerca volvulus 0.003 0.011 0.0191
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0538 0.0499
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.418 0.8191
Echinococcus multilocularis RUN 0.0058 0.0538 0.0499
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0193 0.0479
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4034 1
Schistosoma mansoni alpha-glucosidase 0.0138 0.1754 0.1751
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0151 0.0296
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0569 0.053
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0042 0.036
Echinococcus granulosus intermediate filament protein 0.0027 0.0056 0.0014
Echinococcus granulosus Polycystic kidney disease protein 0.0058 0.0538 0.0499
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0056 0.0027
Trypanosoma cruzi phosphomannose isomerase, putative 0.0096 0.1109 0.2109
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0538 0.0499
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0257 0.1252
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0119 0.1462 0.1426
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0538 0.0499
Loa Loa (eye worm) hypothetical protein 0.0058 0.0538 0.1055
Brugia malayi polk-prov protein 0.0036 0.0207 0.0327
Echinococcus granulosus RUN 0.0058 0.0538 0.0499
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0556 0.1017
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0119 0.1462 0.1426
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0193 0.0479
Loa Loa (eye worm) hypothetical protein 0.0082 0.0898 0.176
Schistosoma mansoni rab6-interacting 0.0058 0.0538 0.0534
Mycobacterium ulcerans hypothetical protein 0.0156 0.2037 1
Leishmania major DNA polymerase kappa, putative 0.004 0.0257 0.0499
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0151 0.0297
Echinococcus granulosus lamin dm0 0.0027 0.0056 0.0014
Toxoplasma gondii aldehyde dehydrogenase 0.0119 0.1462 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.2094 0.4056
Schistosoma mansoni rab6-interacting 0.0058 0.0538 0.0534
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0329 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0237 0.0489
Echinococcus granulosus chromobox protein 1 0.0069 0.0696 0.0657
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0288 0.0487
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0042 0.0078
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0533 0.0494
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.4034 1
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0158 0.0229
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4034 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0329 0.0325
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0193 0.0379
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4034 1
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0533 0.0494
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0193 0.1312
Loa Loa (eye worm) hypothetical protein 0.0036 0.0207 0.0406
Trypanosoma brucei glucosidase, putative 0.0036 0.0193 0.0378
Trypanosoma cruzi phosphomannose isomerase, putative 0.0096 0.1109 0.2109
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0257 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0556 0.109
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.2094 0.2061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4034 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0569 0.1113
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0427 0.0762
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0193 0.0375
Brugia malayi follicle stimulating hormone receptor 0.0228 0.3125 0.6091
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0898 0.1692
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0193 0.038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0119 0.1462 0.7174
Brugia malayi chromobox protein homolog 3 0.0038 0.0237 0.0386
Leishmania major pyruvate kinase 0.0033 0.0151 0.0293
Mycobacterium tuberculosis Probable mannose-6-phosphate isomerase ManA (phosphomannose isomerase) (phosphomannoisomerase) (PMI) (phosphohexoisomerase) (pho 0.0052 0.0442 0.2162
Schistosoma mansoni lipoxygenase 0.0225 0.3076 0.3073
Loa Loa (eye worm) hypothetical protein 0.0357 0.5103 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0042 0.0273
Plasmodium vivax multidomain scavenger receptor, putative 0.0058 0.0538 0.4843
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.2094 0.2061
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0096 0.1109 0.2109
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0556 0.109
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0696 0.1639
Echinococcus granulosus vesicular acetylcholine transporter 0.0215 0.2925 0.2895
Echinococcus multilocularis Polycystic kidney disease protein 0.0058 0.0538 0.0499
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0151 0.0735
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1792 1
Trypanosoma brucei unspecified product 0.0053 0.0457 0.0896
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0056 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0556 0.109
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1441 0.2825
Schistosoma mansoni polycystin 1-related 0.0058 0.0538 0.0534
Schistosoma mansoni chromobox protein 0.0069 0.0696 0.0692
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0215 0.2925 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0158 0.0229
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0533 0.0529
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0556 0.2725
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.1795 0.3516
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0002 0.0003
Schistosoma mansoni chromobox protein 0.0069 0.0696 0.0692
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0569 0.053
Trichomonas vaginalis mannose-6-phosphate isomerase, putative 0.0096 0.1109 0.2674
Onchocerca volvulus 0.0093 0.1064 0.3516
Entamoeba histolytica mannose-6-phosphate isomerase, putative 0.0044 0.0319 0.079
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0556 0.109
Echinococcus granulosus dna polymerase eta 0.0033 0.0158 0.0116
Entamoeba histolytica phosphomannose isomerase, putative 0.0096 0.1109 0.275
Mycobacterium leprae probable mannose-6-phosphate isomerase ManA (PHOSPHOMANNOSE ISOMERASE) (PHOSPHOMANNOISOMERASE) (PMI) (PHOSPHOHEXOISOMERASE) (PHO 0.0052 0.0442 0.2457
Plasmodium falciparum mannose-6-phosphate isomerase, putative 0.0096 0.1109 1
Brugia malayi Doublecortin family protein 0.0058 0.0538 0.0981
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0237 0.0489
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0329 0.0325
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0556 0.109
Plasmodium vivax mannose-6-phosphate isomerase, putative 0.0096 0.1109 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4034 1
Loa Loa (eye worm) doublecortin family protein 0.0058 0.0538 0.1055
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0193 0.03
Schistosoma mansoni alpha-glucosidase 0.0138 0.1754 0.1751
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0696 0.1639
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0281 0.06
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0556 0.1289
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0099 0.0194
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0151 0.0835
Schistosoma mansoni aldehyde dehydrogenase 0.0119 0.1462 0.1458
Loa Loa (eye worm) hypothetical protein 0.0033 0.0158 0.0309
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0556 0.0517
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0151 0.0334
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0281 0.0787
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.0158 0.0308
Loa Loa (eye worm) hypothetical protein 0.0033 0.0151 0.0297
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0099 0.0194
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0357 0.5103 1
Schistosoma mansoni mannose-6-phosphate isomerase 0.0096 0.1109 0.1106
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1792 0.8798
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.0158 0.0229
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0329 0.0289
Loa Loa (eye worm) hypothetical protein 0.0038 0.0237 0.0464
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.4034 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.2037 1
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0556 0.2725
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.3125 0.6123
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0281 0.06
Echinococcus multilocularis musashi 0.0027 0.0056 0.0014
Leishmania major phosphomannose isomerase 0.0096 0.1109 0.2171
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.0109
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0042 0.0081
Schistosoma mansoni pyruvate kinase 0.0033 0.0151 0.0147
Echinococcus granulosus chromobox protein 1 0.0069 0.0696 0.0657
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0151 0.0735
Brugia malayi mannose-6-phosphate isomerase, class I family protein 0.0096 0.1109 0.2109
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0533 0.0529
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0329 0.0289
Echinococcus granulosus pyruvate kinase 0.0033 0.0151 0.011
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0357 0.5103 1
Echinococcus granulosus pyruvate kinase 0.0033 0.0151 0.011
Schistosoma mansoni pyruvate kinase 0.0033 0.0151 0.0147
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0151 0.0296
Loa Loa (eye worm) hypothetical protein 0.0058 0.0538 0.1055
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.0158 0.0766
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0556 0.1017
Onchocerca volvulus 0.0082 0.0898 0.2936

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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