Detailed information for compound 705140

Basic information

Technical information
  • TDR Targets ID: 705140
  • Name: N-[2-(4-chlorophenyl)sulfonyl-2-thiophen-2-yl ethyl]-4-fluorobenzenesulfonamide
  • MW: 459.962 | Formula: C18H15ClFNO4S3
  • H donors: 1 H acceptors: 4 LogP: 3.79 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)S(=O)(=O)NCC(S(=O)(=O)c1ccc(cc1)Cl)c1cccs1
  • InChi: 1S/C18H15ClFNO4S3/c19-13-3-7-15(8-4-13)27(22,23)18(17-2-1-11-26-17)12-21-28(24,25)16-9-5-14(20)6-10-16/h1-11,18,21H,12H2
  • InChiKey: CDXFDHMWUMMZDJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-chlorophenyl)sulfonyl-2-(2-thienyl)ethyl]-4-fluoro-benzenesulfonamide
  • N-[2-(4-chlorophenyl)sulfonyl-2-(2-thienyl)ethyl]-4-fluorobenzenesulfonamide
  • N-[2-(4-chlorophenyl)sulfonyl-2-thiophen-2-yl-ethyl]-4-fluoro-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) sugar transporter 0.0014 0.0042 0.0061
Trypanosoma cruzi serine sulfhydrylase 0.002 0.0184 0.0711
Onchocerca volvulus 0.0031 0.0439 0.1996
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.6437 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0064 0.0107
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0475 0.0631
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0439 0.0621
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.009 0.0161
Trypanosoma cruzi cystathionine beta-synthase 0.002 0.0184 0.0711
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0439 0.0777
Trypanosoma cruzi cystathionine beta-synthase 0.002 0.0184 0.0711
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0251 0.1049
Entamoeba histolytica hypothetical protein 0.0023 0.0242 0.0093
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0475 0.0847
Entamoeba histolytica protein kinase, putative 0.0033 0.0475 0.0466
Trypanosoma brucei glucose transporter, putative 0.0032 0.0452 0.2061
Brugia malayi jmjC domain containing protein 0.0015 0.0064 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0251 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0452 0.0641
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6437 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0251 0.0363
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0439 0.0621
Brugia malayi Cam kinase protein 1 0.0033 0.0475 0.0631
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0251 0.0707
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0251 0.0319
Echinococcus granulosus General substrate transporter 0.0088 0.1781 0.3403
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.1057 0.2603
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0439 0.0579
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1101 0.359
Echinococcus granulosus aldehyde reductase 0.0022 0.0226 0.0359
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.009 0.0161
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0098 0.2032 0.3048
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0439 0.0777
Schistosoma mansoni cysteine synthase 0.002 0.0184 0.0363
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Schistosoma mansoni cysteine synthase 0.002 0.0184 0.0363
Trypanosoma brucei glucose transporter, putative 0.0032 0.0452 0.2061
Plasmodium vivax glycogen synthase kinase 3, putative 0.0098 0.2032 0.1998
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3643 0.5517
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0428 0.0603
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0064 0.0042
Echinococcus multilocularis aldo keto reductase 0.0031 0.0439 0.0777
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0439 0.0621
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6437 1
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0112 0.0352
Loa Loa (eye worm) hypothetical protein 0.0031 0.0439 0.0636
Brugia malayi Muscleblind-like protein 0.0145 0.3144 0.4521
Giardia lamblia Aldose reductase 0.0031 0.0439 0.0621
Loa Loa (eye worm) hypothetical protein 0.0033 0.0487 0.0706
Plasmodium vivax CDK-related protein kinase 6, putative 0.0434 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Trichomonas vaginalis cysteine synthase, putative 0.002 0.0184 0.0221
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0999 0.1496
Schistosoma mansoni survival motor neuron protein 0.0047 0.0814 0.1978
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Loa Loa (eye worm) cbs-prov protein 0.002 0.0184 0.0266
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0242 0.0512
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.6437 1
Trypanosoma cruzi serine sulfhydrylase 0.002 0.0184 0.0711
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0439 0.0621
Schistosoma mansoni aldo-keto reductase 0.0031 0.0439 0.1018
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0064 0.0107
Giardia lamblia Aldose reductase 0.0031 0.0439 0.0621
Echinococcus granulosus hypothetical protein 0.0031 0.0439 0.0777
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0439 0.0621
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0251 0.0707
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0452 0.2061
Echinococcus multilocularis dual specificity 0.0055 0.0999 0.1872
Onchocerca volvulus 0.0031 0.0439 0.1996
Onchocerca volvulus 0.0023 0.0251 0.1049
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0548 0.0508
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0066 0.0046
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0162
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0064 0.0042
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.002 0.0184 0.0479
Trypanosoma cruzi cysteine synthase, putative 0.002 0.0184 0.0711
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0476 0.0664
Plasmodium vivax hexose transporter 0.0102 0.2121 0.2087
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0439 0.0777
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2121 0.3185
Trichomonas vaginalis cysteine synthase, putative 0.002 0.0184 0.0221
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0098 0.2032 0.2943
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0452 0.2061
Schistosoma mansoni protein kinase 0.0033 0.0475 0.111
Echinococcus granulosus aldo keto reductase 0.0031 0.0439 0.0777
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0452 0.0641
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0064 0.0042
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0064 0.0107
Onchocerca volvulus 0.0047 0.0814 0.3878
Echinococcus granulosus protein kinase shaggy 0.0098 0.2032 0.3894
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0064 0.0021
Loa Loa (eye worm) oxidoreductase 0.0031 0.0439 0.0636
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Trypanosoma cruzi hexose transporter 0.0032 0.0452 0.2061
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0476 0.0435
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0161 0.0401
Echinococcus granulosus aldo keto reductase 0.0031 0.0439 0.0777
Brugia malayi jmjC domain containing protein 0.0057 0.1057 0.148
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0999 0.1496
Echinococcus granulosus dual specificity 0.0055 0.0999 0.1872
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.1057 0.1987
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1101 0.2715
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0452 0.0641
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0428 0.039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.009 0.0161
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0439 0.0621
Schistosoma mansoni jumonji domain containing protein 0.0057 0.1057 0.2603
Leishmania major hypothetical protein, conserved 0.0015 0.0064 0.0107
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0066 0.0034
Loa Loa (eye worm) hypothetical protein 0.0145 0.3144 0.4555
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0092
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0548 0.2542
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0476 0.0435
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0452 0.0641
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0064 0.0092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1101 0.359
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0439 0.0621
Onchocerca volvulus 0.0031 0.0439 0.1996
Onchocerca volvulus 0.0031 0.0439 0.1996
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3643 0.3616
Schistosoma mansoni aldo-keto reductase 0.0031 0.0439 0.1018
Leishmania major cystathionine beta-synthase 0.002 0.0184 0.0711
Leishmania major glucose transporter, lmgt3 0.0032 0.0452 0.2061
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.1057 0.1532
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0251 0.0107
Loa Loa (eye worm) integrin beta-2 0.0303 0.6904 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0251 0.1049
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1101 0.2073
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0064 0.0042
Leishmania major protein kinase, putative 0.0033 0.0475 0.2177
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0439 0.0777
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0452 0.2061
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0064 0.0033
Echinococcus multilocularis GPCR, family 2 0.0015 0.0066 0.0046
Plasmodium falciparum hexose transporter 0.0102 0.2121 0.2087
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0098 0.2032 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0242 0.0512
Toxoplasma gondii pyridoxal-phosphate dependent superfamily protein 0.002 0.0184 0.0217
Loa Loa (eye worm) hypothetical protein 0.0033 0.0475 0.0688
Trypanosoma cruzi aldo-keto reductase 0.0031 0.0439 0.1996
Mycobacterium leprae Conserved hypothetical protein 0.0022 0.0226 0.023
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0251 0.0304
Echinococcus granulosus aldo keto reductase 0.0031 0.0439 0.0777
Trichomonas vaginalis cysteine synthase, putative 0.002 0.0184 0.0221
Loa Loa (eye worm) hypothetical protein 0.0031 0.0428 0.062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.009 0.0161
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0475 0.0688
Trypanosoma cruzi cystathionine beta-synthase, putative 0.002 0.0184 0.0711
Mycobacterium ulcerans cystathionine beta-synthase 0.002 0.0184 0.0479
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.5151 1
Trypanosoma cruzi cystathionine beta-synthase, putative 0.002 0.0184 0.0711
Onchocerca volvulus 0.0031 0.0439 0.1996
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0242 0.1004
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.0439 0.1346
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0851 0.1179
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0064 0.0042
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0112 0.007
Brugia malayi hypothetical protein 0.0046 0.0796 0.1099
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0475 0.0688
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0452 0.0641
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.6437 0.5
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0475 0.0847
Loa Loa (eye worm) hypothetical protein 0.0023 0.0242 0.0351
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0487 0.0649
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3643 0.3616
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0428 0.0988
Leishmania major glucose transporter, lmgt2 0.0032 0.0452 0.2061
Echinococcus granulosus muscleblind protein 0.0145 0.3144 0.6072
Giardia lamblia Kinase, CMGC GSK 0.0098 0.2032 0.3111
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0439 0.0777
Plasmodium falciparum protein kinase 7 0.0289 0.6568 0.6554
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.1057 0.1987
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0439 0.0777
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0548 0.2542
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2121 0.4068
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.2992 1
Brugia malayi intracellular kinase 0.0098 0.2032 0.2899
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0251 0.1049
Mycobacterium ulcerans cysteine synthase B 0.002 0.0184 0.0479
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0064 0.0042
Loa Loa (eye worm) hypothetical protein 0.0046 0.0796 0.1154
Loa Loa (eye worm) hypothetical protein 0.0048 0.0851 0.1233
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0439 0.0777
Echinococcus multilocularis muscleblind protein 1 0.0145 0.3144 0.6072
Trypanosoma cruzi aldo/keto reductase, putative 0.0031 0.0439 0.1996
Trypanosoma brucei cystathionine beta-synthase, putative 0.002 0.0184 0.0711
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.1057 0.1987
Brugia malayi cbs-prov protein 0.002 0.0184 0.0206
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0475 0.0847
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0439 0.0777
Trichomonas vaginalis cysteine synthase, putative 0.002 0.0184 0.0221
Entamoeba histolytica protein kinase, putative 0.0033 0.0475 0.0466
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0064 0.0042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1101 0.359
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2121 0.4068
Schistosoma mansoni glucose transport protein 0.0102 0.2121 0.5329
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0439 0.0621
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0251 0.0707
Toxoplasma gondii protein kinase, putative 0.0289 0.6568 1
Trichomonas vaginalis threonine synthase, putative 0.002 0.0184 0.0221
Plasmodium falciparum glycogen synthase kinase 3 0.0098 0.2032 0.1998
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0475 0.0677
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0548 0.2542
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0439 0.0621
Loa Loa (eye worm) hypothetical protein 0.0031 0.0428 0.062
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0042 0.0061
Echinococcus multilocularis General substrate transporter 0.0088 0.1781 0.3403
Trypanosoma brucei aldo-keto reductase, putative 0.0031 0.0439 0.1996
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0251 0.0319
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0428 0.0562
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0066 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0251 0.0707
Schistosoma mansoni hypothetical protein 0.0033 0.0487 0.1141
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0031 0.0439 0.0984
Trypanosoma cruzi serine sulfhydrylase 0.002 0.0184 0.0711
Loa Loa (eye worm) hypothetical protein 0.023 0.5151 0.7462
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0064 0.0055
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0439 0.0579
Echinococcus multilocularis aldo keto reductase 0.0031 0.0439 0.0777
Loa Loa (eye worm) hypothetical protein 0.0025 0.0292 0.0423
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0428 0.0755
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0476 0.0664
Entamoeba histolytica protein kinase domain containing protein 0.0098 0.2032 0.2955
Schistosoma mansoni hypothetical protein 0.0015 0.0066 0.006
Echinococcus multilocularis aldo keto reductase 0.0031 0.0439 0.0777
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0439 0.0621
Schistosoma mansoni glucose transport protein 0.0102 0.2121 0.5329
Echinococcus multilocularis aldo keto reductase 0.0031 0.0439 0.0777
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0439 0.0777
Brugia malayi Kelch motif family protein 0.0046 0.0796 0.1099
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0475 0.2177
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0439 0.0579
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0251 0.0707
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0476 0.0435
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0042 0.0061
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0476 0.0435
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0031 0.0439 0.1996
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0548 0.2542
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0475 0.0847
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1101 0.359
Loa Loa (eye worm) oxidoreductase 0.0031 0.0439 0.0636
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Mycobacterium ulcerans oxidoreductase 0.0031 0.0439 0.1346
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0452 0.2061
Schistosoma mansoni glucose transport protein 0.0102 0.2121 0.5329
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0999 0.2452
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0242 0.0306
Loa Loa (eye worm) sugar transporter 0.0102 0.2121 0.3072
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2121 0.4068
Trypanosoma cruzi serine sulfhydrylase 0.002 0.0184 0.0711
Schistosoma mansoni integrin beta subunit 0.0179 0.3943 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0439 0.0621
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0428 0.0943
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0162
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0092
Mycobacterium ulcerans hypothetical protein 0.0023 0.0251 0.0707
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0439 0.0777
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2121 0.4068
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0055 0.0999 0.4808
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0452 0.0641
Trypanosoma brucei glucose transporter 1E 0.0032 0.0452 0.2061
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0098 0.2032 0.51
Trypanosoma brucei protein kinase, putative 0.0098 0.2032 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0452 0.2061
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0055 0.0999 0.1394
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0439 0.0777
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0242 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0439 0.0777
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0814 0.1124
Leishmania major cysteine synthase 0.002 0.0184 0.0711
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0251 0.0304
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Schistosoma mansoni hypothetical protein 0.0047 0.0814 0.1978
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0428 0.0988
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.2992 1
Loa Loa (eye worm) oxidoreductase 0.0031 0.0439 0.0636
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0439 0.0777
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2121 0.4068
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0476 0.0435
Entamoeba histolytica aldose reductase, putative 0.0031 0.0439 0.0409
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0098 0.2032 0.3894
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0066 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0251 0.0304
Loa Loa (eye worm) hypothetical protein 0.0023 0.0251 0.0363
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0475 0.0847
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0999 0.1496
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0064 0.0042
Loa Loa (eye worm) hypothetical protein 0.0015 0.0066 0.0095
Toxoplasma gondii aldose reductase, putative 0.0031 0.0439 0.0608
Loa Loa (eye worm) oxidoreductase 0.0031 0.0439 0.0636
Trypanosoma brucei glucose transporter, putative 0.0032 0.0452 0.2061
Trichomonas vaginalis threonine synthase, putative 0.002 0.0184 0.0221
Trypanosoma brucei glucose transporter, putative 0.0032 0.0452 0.2061
Schistosoma mansoni hypothetical protein 0.0015 0.0066 0.006
Schistosoma mansoni hypothetical protein 0.0015 0.0066 0.006
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0476 0.0664
Schistosoma mansoni protein kinase 0.0033 0.0475 0.111
Loa Loa (eye worm) oxidoreductase 0.0031 0.0439 0.0636
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0452 0.2061
Echinococcus granulosus dual specificity 0.0055 0.0999 0.1872
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0397 0.0694
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0397 0.0694
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0112 0.007
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0439 0.0621
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0476 0.0435
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1101 0.5324
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1101 0.2073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6437 1
Plasmodium vivax JmjC domain containing protein 0.0015 0.0064 0.0021
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0476 0.0435
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0055 0.0999 0.1466
Entamoeba histolytica aldose reductase, putative 0.0031 0.0439 0.0409
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0999 0.1496
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0064 0.0033
Trichomonas vaginalis cysteine synthase, putative 0.002 0.0184 0.0221
Trypanosoma brucei glucose transporter 2A 0.0032 0.0452 0.2061
Brugia malayi jmjC domain containing protein 0.0057 0.1057 0.148
Brugia malayi jmjC domain containing protein 0.0015 0.0064 0.0031
Brugia malayi Pyridoxal-phosphate dependent enzyme family protein 0.002 0.0184 0.0206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0851 0.1179
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0548 0.0508
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0066 0.0034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0112 0.0237
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0242 0.0312
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0064 0.0055
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0439 0.0621
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0999 0.1496
Onchocerca volvulus 0.0031 0.0439 0.1996
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0548 0.2542
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0251 0.0707
Echinococcus granulosus phd:f box containing protein 0.0015 0.0064 0.0042
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0251 0.0107
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0064 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0251 0.0707
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0064 0.0055
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.2032 0.3111
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0098 0.2032 0.3894
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6437 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0475 0.0847
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0439 0.0621
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0439 0.0777
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0055 0.0999 0.4808
Entamoeba histolytica aldose reductase, putative 0.0031 0.0439 0.0409
Giardia lamblia Kinase, CMGC GSK 0.0098 0.2032 0.3111
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0475 0.111
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0031 0.0439 0.0621
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0066 0.0046
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0162
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0046 0.0796 0.1154
Trichomonas vaginalis aldo/keto reductase, putative 0.0031 0.0439 0.0621
Onchocerca volvulus 0.0098 0.2032 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0452 0.2061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6437 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0066 0.0046
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0475 0.0847
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0161 0.0401
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0439 0.0777
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0112 0.0237
Schistosoma mansoni protein kinase 0.0033 0.0475 0.111
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0098 0.2032 1
Trichomonas vaginalis cysteine synthase, putative 0.002 0.0184 0.0221
Giardia lamblia Kinase, CMGC DYRK 0.0055 0.0999 0.1496
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0064 0.0092
Mycobacterium ulcerans cysteine synthase a CysK1 0.002 0.0184 0.0479
Entamoeba histolytica protein kinase, putative 0.0098 0.2032 0.2955
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6437 1
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0999 0.1496
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0162
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0439 0.0621
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0548 0.0775
Mycobacterium tuberculosis Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A) 0.002 0.0184 0.0479
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.2992 1
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0428 0.0603
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0428 0.0562
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0251 0.0707
Leishmania major aldo-keto reductase-like protein 0.0031 0.0439 0.1996
Trypanosoma brucei glucose transporter, putative 0.0032 0.0452 0.2061
Schistosoma mansoni hypothetical protein 0.0015 0.0066 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2121 0.325
Entamoeba histolytica protein kinase domain containing protein 0.0098 0.2032 0.2955
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0242 0.0677
Brugia malayi hypothetical protein 0.023 0.5151 0.7446
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6437 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0242 0.0677
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Schistosoma mansoni pol-related 0.0031 0.0439 0.1018
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2121 0.4068
Trypanosoma brucei glucose transporter, putative 0.0032 0.0452 0.2061
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0242 0.0391
Leishmania major prostaglandin f synthase, putative 0.0031 0.0439 0.1996
Echinococcus multilocularis aldehyde reductase 0.0022 0.0226 0.0359
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6437 1
Brugia malayi Integrin beta pat-3 precursor 0.0303 0.6904 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2121 0.4068
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0042 0.5
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0098 0.2032 0.2943
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0064 0.0092
Brugia malayi Sugar transporter family protein 0.0102 0.2121 0.3029
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0242 0.1004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0042 0.0061
Trypanosoma brucei glucose transporter, putative 0.0032 0.0452 0.2061
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0242 0.0312
Trypanosoma brucei glucose transporter, putative 0.0032 0.0452 0.2061
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0999 0.1303
Echinococcus granulosus dual specificity 0.0055 0.0999 0.1872
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.1057 0.2603
Mycobacterium leprae PROBABLE CYSTEINE SYNTHASE A CYSK (O-ACETYLSERINE SULFHYDRYLASE A) (O-ACETYLSERINE (THIOL)-LYASE A) (CSASE A) 0.002 0.0184 0.0081
Brugia malayi jmjC domain containing protein 0.0015 0.0064 0.0031
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0242 0.0287
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0064 0.0042
Echinococcus multilocularis dual specificity 0.0055 0.0999 0.1872
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1101 0.1623
Entamoeba histolytica protein kinase, putative 0.0055 0.0999 0.1303
Echinococcus multilocularis protein kinase shaggy 0.0098 0.2032 0.3894
Loa Loa (eye worm) hypothetical protein 0.0145 0.3144 0.4555
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0476 0.0435
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0064 0.0055
Trypanosoma cruzi cystathionine beta-synthase 0.002 0.0184 0.0711
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0428 0.0755
Leishmania major glucose transporter, lmgt1 0.0032 0.0452 0.2061
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0439 0.0777
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0439 0.0777
Echinococcus multilocularis muscleblind protein 0.0145 0.3144 0.6072
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0242 0.1004
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1101 0.2715
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.002 0.0184 0.0081
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0092
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.1057 0.1987
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0242 0.0201
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0242 0.0291
Trichomonas vaginalis CMGC family protein kinase 0.0098 0.2032 0.3111
Echinococcus multilocularis integrin beta 2 0.0225 0.5037 0.9776
Mycobacterium tuberculosis Cysteine synthase B CysM (CSASE B) (O-phosphoserine sulfhydrylase B) (O-phosphoserine (thiol)-lyase B) 0.002 0.0184 0.0479
Loa Loa (eye worm) hypothetical protein 0.0017 0.0112 0.0162
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0251 0.0107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2121 0.4068
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0475 0.0847
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0055 0.0999 0.4808
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0251 0.0707
Echinococcus granulosus survival motor neuron protein 1 0.023 0.5151 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0242 0.0391
Trypanosoma brucei prostaglandin f synthase 0.0031 0.0439 0.1996
Echinococcus granulosus integrin beta 2 0.0225 0.5037 0.9776
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0439 0.0777
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0031 0.0439 0.0777
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0175 0.0208
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0452 0.0641
Toxoplasma gondii CBS family protein 0.002 0.0184 0.0217
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0242 0.0201
Echinococcus granulosus GPCR family 2 0.0015 0.0066 0.0046
Trichomonas vaginalis aldo-keto reductase, putative 0.0031 0.0439 0.0621
Echinococcus multilocularis dual specificity 0.0055 0.0999 0.1872
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0851 0.1233
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0031 0.0439 0.1996
Brugia malayi jmjC domain containing protein 0.0015 0.0064 0.0031
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0031 0.0439 0.0777
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0476 0.0435
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0031 0.0439 0.0579
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.6437 1
Schistosoma mansoni hypothetical protein 0.0102 0.2121 0.5329
Trypanosoma cruzi cysteine synthase, putative 0.002 0.0184 0.0711
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0055 0.0999 0.1447
Trypanosoma cruzi cystathionine beta-synthase, putative 0.002 0.0184 0.0711

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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