Detailed information for compound 705510

Basic information

Technical information
  • TDR Targets ID: 705510
  • Name: N-(4-ethylphenyl)-2-[1-[(2-methoxyphenyl)meth yl]imidazol-2-yl]sulfanylacetamide
  • MW: 381.491 | Formula: C21H23N3O2S
  • H donors: 1 H acceptors: 2 LogP: 4.12 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)NC(=O)CSc1nccn1Cc1ccccc1OC
  • InChi: 1S/C21H23N3O2S/c1-3-16-8-10-18(11-9-16)23-20(25)15-27-21-22-12-13-24(21)14-17-6-4-5-7-19(17)26-2/h4-13H,3,14-15H2,1-2H3,(H,23,25)
  • InChiKey: XMJCLEVQGUUKMZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-ethylphenyl)-2-[1-[(2-methoxyphenyl)methyl]imidazol-2-yl]sulfanyl-acetamide
  • N-(4-ethylphenyl)-2-[[1-[(2-methoxyphenyl)methyl]-2-imidazolyl]thio]acetamide
  • N-(4-ethylphenyl)-2-[[1-(2-methoxybenzyl)imidazol-2-yl]thio]acetamide
  • N-(4-ethylphenyl)-2-[1-[(2-methoxyphenyl)methyl]imidazol-2-yl]sulfanyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.003 0.0555 0.0555
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0459 0.0432
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0362 0.1108
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0435 0.0432
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0051 0.005
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0614 0.0614
Schistosoma mansoni hypothetical protein 0.0169 0.3582 0.3582
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0629 0.0603
Plasmodium vivax importin-beta 2, putative 0.0028 0.0523 0.052
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0629 0.0606
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0051 0.005
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0362 0.0335
Leishmania major protein kinase, putative 0.0033 0.0629 0.1994
Trypanosoma brucei sugar transporter, putative 0.0065 0.1331 0.4324
Trichomonas vaginalis sugar transporter, putative 0.0144 0.3041 0.3041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1202 0.1202
Brugia malayi Major Facilitator Superfamily protein 0.0065 0.1331 0.131
Leishmania major glucose transporter, lmgt2 0.0144 0.3041 1
Brugia malayi RNA, U transporter 1 0.008 0.1648 0.1628
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0065 0.1331 0.1331
Onchocerca volvulus 0.0065 0.1331 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0362 0.0338
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0614 0.0592
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Mycobacterium ulcerans sugar transporter 0.0065 0.1331 1
Schistosoma mansoni protein kinase 0.0033 0.0629 0.0629
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0759 0.5552
Leishmania major hypothetical protein, conserved 0.0065 0.1331 0.4324
Trypanosoma brucei glucose transporter, putative 0.0144 0.3041 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0435 0.6932
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Trichomonas vaginalis glucose transporter, putative 0.0144 0.3041 0.3041
Trypanosoma brucei glucose transporter 2A 0.0144 0.3041 1
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0044 0.0054
Echinococcus granulosus dnaJ subfamily B 0.0398 0.857 0.8567
Schistosoma mansoni importin beta-1 0.0028 0.0523 0.0523
Echinococcus granulosus importin 5 0.0005 0.0028 0.0004
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0759 1
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0435 0.135
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0459 0.0432
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0629 0.0606
Trichomonas vaginalis glucose transporter, putative 0.0144 0.3041 0.3041
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0065 0.1331 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0614 0.0592
Trypanosoma brucei glucose transporter, putative 0.0144 0.3041 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0614 0.0614
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0629 0.0603
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0521 0.0498
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0065 0.1331 1
Echinococcus multilocularis glycyl tRNA synthetase 0.0006 0.0044 0.002
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Echinococcus multilocularis importin 5 0.0005 0.0028 0.0004
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0044 0.0118
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0362 0.0338
Entamoeba histolytica protein kinase, putative 0.0033 0.0629 0.8223
Echinococcus granulosus solute carrier family 22 0.0065 0.1331 0.131
Schistosoma mansoni protein kinase 0.0033 0.0629 0.0629
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0435 0.0434
Loa Loa (eye worm) major facilitator superfamily transporter 0.0065 0.1331 0.131
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0435 0.0412
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0005 0.0029 0.0003
Schistosoma mansoni importin-beta 2 0.0005 0.0028 0.0028
Onchocerca volvulus 0.0065 0.1331 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Loa Loa (eye worm) hypothetical protein 0.0025 0.0459 0.0435
Echinococcus granulosus solute carrier family 22 0.0065 0.1331 0.131
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0051 0.005
Brugia malayi hypothetical protein 0.0065 0.1331 0.131
Onchocerca volvulus 0.0065 0.1331 1
Echinococcus granulosus translational activator gcn1 0.0005 0.0028 0.0004
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0065 0.1331 1
Leishmania major hypothetical protein, conserved 0.0005 0.0029 0.0003
Trichomonas vaginalis glucose transporter, putative 0.0065 0.1331 0.133
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0629 0.0627
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Brugia malayi Sugar transporter family protein 0.0065 0.1331 0.131
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0435 0.0412
Onchocerca volvulus 0.0065 0.1331 1
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0435 1
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0044 0.0044
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0629 0.0606
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0065 0.1331 0.131
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0463 1 1
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0614 0.0614
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Trypanosoma brucei THT1 - hexose transporter, putative 0.0144 0.3041 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0614 0.0592
Trypanosoma cruzi hexose transporter, putative 0.0144 0.3041 1
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0029 0.0028
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0362 0.0338
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0408 0.0407
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Schistosoma mansoni bromodomain containing protein 0.0005 0.0024 0.0024
Onchocerca volvulus 0.0065 0.1331 1
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0585 0.0562
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0731 0.0705
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0044 0.0051
Brugia malayi hypothetical protein 0.0065 0.1331 0.131
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.3051 0.3034
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0435 0.0408
Trypanosoma brucei THT1 - hexose transporter, putative 0.0144 0.3041 1
Echinococcus granulosus General substrate transporter 0.0398 0.8582 0.8578
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0463 1 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0435 0.0435
Schistosoma mansoni sugar transporter 0.0065 0.1331 0.1331
Echinococcus granulosus geminin 0.0169 0.3582 0.3566
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0614 0.8025
Loa Loa (eye worm) hypothetical protein 0.0032 0.0614 0.0592
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0356 0.2512
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0101 0.0077
Schistosoma mansoni glucose transport protein 0.0463 1 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0463 1 1
Trichomonas vaginalis sugar transporter, putative 0.0144 0.3041 0.3041
Trichomonas vaginalis hypothetical protein 0.0005 0.0028 0.0027
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.3051 0.3051
Trypanosoma cruzi hexose transporter 0.0144 0.3041 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0362 0.2468
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0836 0.0835
Leishmania major GTP-binding protein, putative 0.0021 0.0362 0.1108
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0836 0.0835
Trypanosoma brucei glucose transporter, putative 0.0144 0.3041 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0101 0.0077
Schistosoma mansoni hypothetical protein 0.0463 1 1
Onchocerca volvulus 0.0065 0.1331 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0051 0.005
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0629 0.0606
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0051 0.005
Schistosoma mansoni hypothetical protein 0.0169 0.3582 0.3582
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0629 0.0627
Echinococcus granulosus importin subunit beta 1 0.0028 0.0523 0.05
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0614 1
Trichomonas vaginalis ran, putative 0.0021 0.0362 0.0361
Toxoplasma gondii sugar transporter ST1 0.0065 0.1331 0.1307
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0044 0.0016
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Trypanosoma cruzi hexose transporter, putative 0.0144 0.3041 1
Brugia malayi major facilitator superfamily protein 0.0065 0.1331 0.131
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0629 0.0606
Plasmodium vivax hexose transporter 0.0463 1 1
Brugia malayi kap beta 3 protein 0.0005 0.0028 0.0004
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0051 0.005
Entamoeba histolytica protein kinase, putative 0.0033 0.0629 0.8223
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0044 0.0051
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0044 0.0054
Trypanosoma brucei THT1 - hexose transporter, putative 0.0144 0.3041 1
Onchocerca volvulus 0.0065 0.1331 1
Schistosoma mansoni ran 0.0021 0.0362 0.0362
Schistosoma mansoni bromodomain containing protein 0.0005 0.0024 0.0024
Trypanosoma cruzi hexose transporter, putative 0.0144 0.3041 1
Giardia lamblia Sugar-proton symporter 0.0065 0.1331 1
Loa Loa (eye worm) sugar transporter 0.0463 1 1
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0629 0.0606
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0629 0.0606
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Onchocerca volvulus 0.0065 0.1331 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0459 0.1426
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0731 0.233
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0029 0.0028
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0523 0.0496
Loa Loa (eye worm) kap beta 3 protein 0.0005 0.0028 0.0004
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0629 0.0627
Brugia malayi major facilitator superfamily protein 0.0065 0.1331 0.131
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0614 0.0592
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0463 1 1
Loa Loa (eye worm) acetyltransferase 0.0144 0.3051 0.3034
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0101 0.0077
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0064 0.004
Onchocerca volvulus 0.0065 0.1331 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0408 0.1259
Trichomonas vaginalis sugar transporter, putative 0.0144 0.3041 0.3041
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0362 0.1105
Plasmodium vivax CDK-related protein kinase 6, putative 0.0456 0.9839 0.9839
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0435 0.0435
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0435 0.0408
Loa Loa (eye worm) hypothetical protein 0.0026 0.0483 0.046
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.857 0.8567
Echinococcus granulosus cpg binding protein 0.003 0.0555 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0051 0.005
Echinococcus granulosus glycyl tRNA synthetase 0.0006 0.0044 0.002
Toxoplasma gondii sugar transporter ST3 0.0065 0.1331 0.1307
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0371 0.037
Schistosoma mansoni zinc finger protein 0.0005 0.0024 0.0024
Brugia malayi Cam kinase protein 1 0.0033 0.0629 0.0606
Onchocerca volvulus 0.0065 0.1331 1
Loa Loa (eye worm) sugar transporter 0.0065 0.1331 0.131
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0064 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0629 0.0603
Trypanosoma cruzi sugar transporter, putative 0.0065 0.1331 0.4323
Brugia malayi hypothetical protein 0.0025 0.0459 0.0435
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0174 0.3692 0.3674
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0731 0.2332
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0201 0.0177
Onchocerca volvulus 0.0065 0.1331 1
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0006 0.0044 0.002
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0005 0.0029 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Brugia malayi hypothetical protein 0.0016 0.0265 0.0241
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0362 0.1105
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.2963 0.2946
Brugia malayi glycyl-tRNA synthetase 0.0006 0.0044 0.002
Echinococcus multilocularis General substrate transporter 0.0398 0.8582 0.8578
Plasmodium vivax threonine--tRNA ligase, putative 0.0006 0.0044 0.0041
Onchocerca volvulus 0.0065 0.1331 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0065 0.1331 0.131
Echinococcus granulosus Threonyl tRNA synthetase C 0.0006 0.0044 0.002
Onchocerca volvulus Putative transporter 0.0065 0.1331 1
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0435 0.0412
Onchocerca volvulus 0.0065 0.1331 1
Onchocerca volvulus 0.0065 0.1331 1
Onchocerca volvulus 0.0065 0.1331 1
Trypanosoma brucei glucose transporter, putative 0.0144 0.3041 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0174 0.3692 0.3674
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Echinococcus granulosus synaptic vesicle 2 protein 0.0065 0.1331 0.131
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0161 0.2978
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0051 0.005
Plasmodium falciparum hexose transporter 0.0463 1 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0629 0.0606
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0073 0.0148
Loa Loa (eye worm) hypothetical protein 0.0032 0.0614 0.0592
Echinococcus multilocularis cpg binding protein 0.003 0.0555 0.0532
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0629 0.1994
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0759 0.0733
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0044 0.0262
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0836 0.081
Toxoplasma gondii protein kinase, putative 0.0304 0.6521 0.6511
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.3041 0.3041
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0459 0.0432
Plasmodium vivax transportin, putative 0.0005 0.0028 0.0025
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0629 0.0606
Schistosoma mansoni glucose transport protein 0.0463 1 1
Schistosoma mansoni protein kinase 0.0033 0.0629 0.0629
Echinococcus granulosus snurportin 1 0.0299 0.6428 0.6419
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0836 0.0813
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0006 0.0044 0.002
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0629 0.0603
Schistosoma mansoni sugar transporter 0.0065 0.1331 0.1331
Toxoplasma gondii facilitative glucose transporter GT1 0.0463 1 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0065 0.1331 0.4324
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0408 0.1257
Trichomonas vaginalis conserved hypothetical protein 0.0463 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0408 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0629 0.0629
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0435 0.1347
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0435 0.3035
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Echinococcus granulosus solute carrier family 22 0.0065 0.1331 0.131
Loa Loa (eye worm) hypothetical protein 0.0028 0.0523 0.05
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0158 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1331 0.133
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0629 0.0606
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0044 0.0118
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.3051 0.3034
Loa Loa (eye worm) hypothetical protein 0.0006 0.0044 0.002
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0006 0.0044 0.0221
Schistosoma mansoni glucose transport protein 0.0463 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0629 0.0628
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0629 0.0603
Plasmodium vivax glycine--tRNA ligase, putative 0.0006 0.0044 0.0041
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0731 0.233
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0064 0.004
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0006 0.0044 0.002
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0362 0.0335
Entamoeba histolytica hypothetical protein 0.0024 0.0435 0.5566
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1331 0.133
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1141 0.1116
Leishmania major hypothetical protein, conserved 0.0005 0.0029 0.0003
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.6428 0.6419
Loa Loa (eye worm) importin-beta domain-containing protein 0.0005 0.0028 0.0004
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Trichomonas vaginalis myo-inositol transporter, putative 0.0065 0.1331 0.133
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Trypanosoma cruzi hexose transporter, putative 0.0065 0.1331 0.4323
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0629 0.0603
Brugia malayi CXXC zinc finger family protein 0.0028 0.0521 0.0498
Echinococcus multilocularis snurportin 1 0.0299 0.6428 0.6419
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0731 0.0705
Schistosoma mansoni cpg binding protein 0.0028 0.0521 0.0521
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0006 0.0044 0.0221
Brugia malayi Sugar transporter family protein 0.0065 0.1331 0.131
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1331 0.133
Echinococcus multilocularis synaptic vesicle 2 protein 0.0065 0.1331 0.131
Mycobacterium ulcerans integral membrane transport protein 0.0065 0.1331 1
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Brugia malayi Major Facilitator Superfamily protein 0.0065 0.1331 0.131
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0459 0.0456
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0051 0.005
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0731 0.2332
Echinococcus multilocularis solute carrier family 22 0.0065 0.1331 0.131
Echinococcus multilocularis translational activator gcn1 0.0005 0.0028 0.0004
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Leishmania major glucose transporter, lmgt3 0.0144 0.3041 1
Echinococcus granulosus transportin 1 0.0005 0.0028 0.0004
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0629 0.0606
Brugia malayi hypothetical protein 0.0065 0.1331 0.131
Plasmodium vivax sugar transporter, putative 0.0065 0.1331 0.1329
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0051 0.005
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0435 0.135
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Echinococcus multilocularis solute carrier family 22 0.0065 0.1331 0.131
Schistosoma mansoni ran 0.0021 0.0362 0.0362
Echinococcus multilocularis solute carrier family 22 0.0065 0.1331 0.131
Schistosoma mansoni glucose transporter 0.0065 0.1331 0.1331
Loa Loa (eye worm) hypothetical protein 0.0033 0.0629 0.0606
Schistosoma mansoni hypothetical protein 0.0011 0.0158 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0098 0.0074
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0006 0.0044 0.002
Toxoplasma gondii transporter, major facilitator family protein 0.0065 0.1331 0.1307
Trypanosoma brucei glucose transporter, putative 0.0144 0.3041 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0459 0.1428
Trypanosoma brucei glucose transporter, putative 0.0144 0.3041 1
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0006 0.0044 0.002
Leishmania major glucose transporter, lmgt1 0.0144 0.3041 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0065 0.1331 0.1307
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Brugia malayi Major Facilitator Superfamily protein 0.0065 0.1331 0.131
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0459 0.1426
Toxoplasma gondii sugar transporter ST2 0.0065 0.1331 0.1307
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0463 1 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0065 0.1331 1
Entamoeba histolytica hypothetical protein 0.0023 0.0408 0.5194
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Plasmodium falciparum protein kinase 7 0.0304 0.6521 0.6511
Schistosoma mansoni cpg binding protein 0.003 0.0555 0.0555
Trypanosoma cruzi glucose transporter, putative 0.0065 0.1331 0.4323
Schistosoma mansoni hypothetical protein 0.0299 0.6428 0.6428
Trypanosoma cruzi hexose transporter, putative 0.0079 0.1623 0.5291
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0463 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0435 0.0412
Onchocerca volvulus 0.0065 0.1331 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0435 0.3116
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0051 0.005
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0629 0.0603
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0051 0.005
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Plasmodium falciparum threonine--tRNA ligase 0.0006 0.0044 0.0016
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0044 0.0054
Schistosoma mansoni hypothetical protein 0.0398 0.857 0.857
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0836 0.0833
Schistosoma mansoni glycyl-tRNA synthetase 0.0006 0.0044 0.0044
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0435 0.3116
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0836 0.081
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Echinococcus multilocularis transportin 1 0.0005 0.0028 0.0004
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0044 0.0118
Loa Loa (eye worm) major facilitator superfamily transporter 0.0065 0.1331 0.131
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0065 0.1331 1
Giardia lamblia Hexose transporter 0.0065 0.1331 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0356 0.2512
Trichomonas vaginalis helicase, putative 0.0006 0.0051 0.005
Schistosoma mansoni sugar transporter 0.0065 0.1331 0.1331
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0523 0.1643
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0161 0.1011
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0408 0.0407
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0158 0.0134
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0463 1 1
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0356 0.5587
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0629 0.0627
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Schistosoma mansoni sugar transporter 0.0065 0.1331 0.1331
Trypanosoma brucei glucose transporter 1E 0.0144 0.3041 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0629 0.0603
Echinococcus granulosus solute carrier family 22 0.0065 0.1331 0.131
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0523 0.1643
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0523 0.05
Entamoeba histolytica Ran family GTPase 0.0021 0.0362 0.4569
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0161 1
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0064 0.004
Plasmodium falciparum importin beta, putative 0.0028 0.0523 0.0496
Plasmodium falciparum protein kinase 6 0.0456 0.9839 0.9839
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.3041 0.3041
Trypanosoma brucei glucose transporter, putative 0.0144 0.3041 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1331 0.133
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0731 0.0728
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0362 0.0338
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0463 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0051 0.005
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0065 0.1331 0.4324
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0614 0.443
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0585 0.0562
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0174 0.3692 0.369
Brugia malayi Importin beta-1 subunit 0.0028 0.0523 0.05
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0064 0.004
Echinococcus multilocularis solute carrier family 22 0.0065 0.1331 0.131
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0044 0.0016
Trichomonas vaginalis sugar transport protein, putative 0.0065 0.1331 0.133
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0731 0.2332
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0051 0.005
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133
Leishmania major hypothetical protein, conserved 0.0025 0.0459 0.1428
Loa Loa (eye worm) hypothetical protein 0.0065 0.1331 0.131
Trypanosoma brucei glucose transporter, putative 0.0144 0.3041 1
Echinococcus multilocularis geminin 0.0169 0.3582 0.3566
Leishmania major glucose transporter/membrane transporter D2, putative 0.0144 0.3041 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0362 0.0359
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0051 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0029 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1331 0.133
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1331 0.133

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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