TDR Targets

Basic information

Technical information

TDR Targets ID: 705686
Name: 6-(4-ethylpiperazin-1-yl)-N-(3-fluorophenyl)- 1-phenylpyrazolo[4,5-e]pyrimidin-4-amine
MW: 417.482 | Formula: C23H24FN7
H donors: 1 H acceptors: 3 LogP: 4.45 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCN1CCN(CC1)c1nc(Nc2cccc(c2)F)c2c(n1)n(nc2)c1ccccc1
InChi: 1S/C23H24FN7/c1-2-29-11-13-30(14-12-29)23-27-21(26-18-8-6-7-17(24)15-18)20-16-25-31(22(20)28-23)19-9-4-3-5-10-19/h3-10,15-16H,2,11-14H2,1H3,(H,26,27,28)
InChiKey: HCILRMNVXPNYEG-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

6-(4-ethylpiperazin-1-yl)-N-(3-fluorophenyl)-1-phenyl-pyrazolo[4,5-e]pyrimidin-4-amine
6-(4-ethyl-1-piperazinyl)-N-(3-fluorophenyl)-1-phenyl-4-pyrazolo[4,5-e]pyrimidinamine
[6-(4-ethylpiperazin-1-yl)-1-phenyl-pyrazolo[4,5-e]pyrimidin-4-yl]-(3-fluorophenyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0037	0.0323	1
Brugia malayi	major facilitator superfamily protein	0.0029	0.0231	0.064
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0323	0.1183
Entamoeba histolytica	protein kinase, putative	0.0064	0.0625	1
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.003	0.0218
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2277	0.2349
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0063	0.061	0.1891
Brugia malayi	lysyl-tRNA synthetase	0.0047	0.0427	0.1268
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0012	0.003	0.0262
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0111	0.688
Leishmania major	glucose transporter, lmgt1	0.0065	0.0634	0.868
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0209	0.2277	0.2349
Echinococcus granulosus	General substrate transporter	0.018	0.1942	0.3574
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0427	0.1311
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.024	0.2624	1
Trypanosoma cruzi	sugar transporter, putative	0.0029	0.0231	0.303
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.003	0.0218
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0405	0.0701
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0042	0.0038
Trichomonas vaginalis	myo-inositol transporter, putative	0.0029	0.0231	0.0687
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0111	0.0308
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0634	0.868
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Mycobacterium ulcerans	integral membrane transport protein	0.0029	0.0231	0.0687
Plasmodium falciparum	lysine--tRNA ligase	0.0047	0.0427	0.0399
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0323	0.1183
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0065	0.0634	0.868
Toxoplasma gondii	protein kinase, putative	0.0591	0.6622	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0111	0.1358
Brugia malayi	major facilitator superfamily protein	0.0029	0.0231	0.064
Echinococcus multilocularis	geminin	0.0176	0.1895	0.195
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0729	1
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0064	0.0625	0.0597
Giardia lamblia	Sugar-proton symporter	0.0029	0.0231	0.346
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0042	0.0133
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0323	0.0979
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0111	0.4055
Trypanosoma cruzi	hexose transporter	0.0065	0.0634	0.868
Schistosoma mansoni	hypothetical protein	0.0176	0.1895	0.5949
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0323	0.1021
Toxoplasma gondii	sugar transporter ST1	0.0029	0.0231	0.0327
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0047	0.0427	0.5783
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0111	0.0352
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0064	0.0625	0.0597
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0111	0.0308
Plasmodium falciparum	protein kinase 7	0.0591	0.6622	0.6612
Schistosoma mansoni	protein kinase	0.0064	0.0625	0.1898
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0634	0.1967
Plasmodium falciparum	hexose transporter	0.0209	0.2277	0.2253
Echinococcus multilocularis	neuropeptide s receptor	0.0481	0.538	0.5594
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0323	0.1021
Schistosoma mansoni	hypothetical protein	0.0209	0.2277	0.7165
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0026	0.0189	0.0598
Leishmania major	hypothetical protein, conserved	0.0037	0.0323	0.4322
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0405	0.1195
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0338	0.3743	0.3724
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0323	0.1021
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0405	0.0392
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0427	0.1311
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0323	0.518
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0063	0.061	1
Echinococcus granulosus	solute carrier family 22	0.0029	0.0231	0.0375
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0012	0.003	0.0095
Toxoplasma gondii	ABC1 family protein	0.0037	0.0323	0.0467
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.2277	0.7179
Leishmania major	lysyl-tRNA synthetase, putative	0.0047	0.0427	0.5783
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0012	0.003	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.061	0.1851
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0625	0.0622
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0323	0.0935
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0323	0.0979
Echinococcus granulosus	solute carrier family 22	0.0029	0.0231	0.0375
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0634	0.1967
Echinococcus granulosus	calcium dependent protein kinase	0.006	0.058	0.1028
Echinococcus granulosus	solute carrier family 22	0.0029	0.0231	0.0375
Brugia malayi	beta-lactamase	0.0037	0.0323	0.0935
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0634	0.868
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0405	0.1195
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0323	0.1021
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0634	0.868
Trichomonas vaginalis	glucose transporter, putative	0.0029	0.0231	0.0687
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0323	0.0979
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0729	1
Leishmania major	cytochrome p450-like protein	0.0013	0.0042	0.0385
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0012	0.003	0.0049
Chlamydia trachomatis	lysine--tRNA ligase	0.0047	0.0427	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0029	0.0231	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0111	0.0372
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0323	0.4322
Loa Loa (eye worm)	hypothetical protein	0.0063	0.061	0.1928
Chlamydia trachomatis	proline--tRNA ligase	0.0022	0.0148	0.2978
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0323	0.1021
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0625	0.1938
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0012	0.003	0.0049
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Brugia malayi	Sugar transporter family protein	0.0029	0.0231	0.064
Toxoplasma gondii	facilitative glucose transporter GT1	0.0209	0.2277	0.3424
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0029	0.0231	0.0829
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0323	0.0979
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0323	0.1183
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0064	0.0625	0.1975
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0047	0.0427	0.1311
Schistosoma mansoni	glucose transport protein	0.0209	0.2277	0.7165
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Entamoeba histolytica	protein kinase, putative	0.0064	0.0625	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Onchocerca volvulus		0.0037	0.0323	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0625	0.0622
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0064	0.0625	0.0925
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0064	0.0625	0.0597
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0231	0.064
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0634	0.868
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0013	0.0042	0.0087
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0625	0.0622
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0625	0.1112
Trypanosoma cruzi	glucose transporter, putative	0.0029	0.0231	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0634	0.868
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0323	0.1183
Schistosoma mansoni	sugar transporter	0.0029	0.0231	0.064
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0231	0.0687
Trichomonas vaginalis	glutaminase, putative	0.0287	0.3166	1
Echinococcus granulosus	synaptic vesicle 2 protein	0.0029	0.0231	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0323	0.1021
Brugia malayi	beta-lactamase family protein	0.0037	0.0323	0.0935
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.004	0.0347	0.1276
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0323	0.0306
Trypanosoma cruzi	hexose transporter, putative	0.0029	0.0231	0.303
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0111	0.1358
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0012	0.003	0.0218
Loa Loa (eye worm)	sugar transporter	0.0029	0.0231	0.0729
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0012	0.003	0.006
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Toxoplasma gondii	lysine-tRNA ligase	0.0047	0.0427	0.0625
Echinococcus granulosus	neuropeptide s receptor	0.0481	0.538	1
Toxoplasma gondii	sugar transporter ST3	0.0029	0.0231	0.0327
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0012	0.003	0.0024
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0231	0.021
Trypanosoma brucei	sugar transporter, putative	0.0029	0.0231	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0029	0.0231	0.064
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0029	0.0231	0.0201
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0042	0.0133
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0338	0.3743	0.5643
Trypanosoma brucei	cytochrome P450, putative	0.0013	0.0042	0.0385
Echinococcus multilocularis	lysyl tRNA synthetase	0.0047	0.0427	0.0416
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0064	0.0625	0.1898
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0887	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0323	0.0979
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Brugia malayi	Sugar transporter family protein	0.0209	0.2277	0.7165
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.03	0.3994
Schistosoma mansoni	glutaminase	0.0287	0.3166	1
Plasmodium vivax	sugar transporter, putative	0.0029	0.0231	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0231	0.0687
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2277	0.4199
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0634	0.868
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0323	0.0548
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0012	0.003	0.0049
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2277	0.4199
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0111	0.0085
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0634	0.1967
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0111	0.0308
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0064	0.0625	0.0597
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0625	0.0622
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0111	0.1358
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2277	0.2349
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0231	0.0729
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0323	0.1021
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0231	0.021
Leishmania major	threonyl-tRNA synthetase, putative	0.0012	0.003	0.0218
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0047	0.0427	0.6932
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2277	0.2349
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.0634	0.1967
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0064	0.0625	0.1112
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0625	0.1975
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0063	0.061	0.1085
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0625	0.1112
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0064	0.0625	0.0597
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0625	0.1898
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0064	0.0625	0.1975
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0042	0.0038
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0042	0.0385
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0073	0.0729	1
Echinococcus granulosus	neuropeptide receptor A26	0.0481	0.538	1
Brugia malayi	Sugar transporter family protein	0.0029	0.0231	0.064
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0231	0.021
Onchocerca volvulus		0.0037	0.0323	1
Echinococcus granulosus	solute carrier family 22	0.0029	0.0231	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0063	0.061	0.1928
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0064	0.0625	0.0597
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0029	0.0231	0.0829
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0323	0.0979
Schistosoma mansoni	ap endonuclease	0.0019	0.0111	0.026
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2277	0.4199
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Loa Loa (eye worm)	sugar transporter	0.0209	0.2277	0.7192
Treponema pallidum	prolyl-tRNA synthetase	0.0022	0.0148	1
Giardia lamblia	Prolyl-tRNA synthetase	0.0063	0.061	1
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.004	0.0347	0.5587
Plasmodium vivax	proline--tRNA ligase, putative	0.0073	0.0729	0.0701
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Schistosoma mansoni	protein kinase	0.0064	0.0625	0.1898
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.0634	0.1967
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.004	0.0347	0.1276
Brugia malayi	hypothetical protein	0.0029	0.0231	0.064
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0047	0.0427	0.5783
Loa Loa (eye worm)	glutaminase 2	0.0287	0.3166	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0323	0.1183
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0634	0.868
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0427	0.135
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0405	0.1195
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Leishmania major	myo-inositol/proton symporter (MIT)	0.0029	0.0231	0.303
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0634	0.868
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0063	0.061	0.1851
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0231	0.021
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0231	0.0729
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0041	0.0362	0.1103
Mycobacterium ulcerans	glutaminase	0.0287	0.3166	1
Leishmania major	glucose transporter, lmgt3	0.0065	0.0634	0.868
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0634	0.868
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0111	0.1403
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0111	0.1358
Brugia malayi	beta-lactamase family protein	0.0037	0.0323	0.0935
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0323	0.518
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0111	0.026
Plasmodium falciparum	proline--tRNA ligase	0.0073	0.0729	0.0701
Trypanosoma brucei	glucose transporter 2A	0.0065	0.0634	0.868
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0729	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0481	0.538	0.5594
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0852	0.9595	1
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0042	0.0385
Mycobacterium ulcerans	sugar transporter	0.0029	0.0231	0.0687
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0111	0.0152
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0323	0.1183
Echinococcus multilocularis	General substrate transporter	0.018	0.1942	0.1999
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0029	0.0231	0.0687
Trichomonas vaginalis	sugar transport protein, putative	0.0029	0.0231	0.0687
Schistosoma mansoni	glucose transport protein	0.0209	0.2277	0.7165
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0338	0.3743	0.3724
Echinococcus granulosus	geminin	0.0176	0.1895	0.3487
Leishmania major	hypothetical protein, conserved	0.0029	0.0231	0.303
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0634	0.868
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0323	0.0979
Brugia malayi	hypothetical protein	0.0029	0.0231	0.064
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0022	0.0148	0.0425
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Toxoplasma gondii	glycyl-tRNA synthetase	0.0012	0.003	0.0024
Plasmodium vivax	hexose transporter	0.0209	0.2277	0.2253
Plasmodium vivax	lysine--tRNA ligase, putative	0.0047	0.0427	0.0399
Schistosoma mansoni	sugar transporter	0.0029	0.0231	0.064
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0064	0.0625	0.0597
Loa Loa (eye worm)	glutaminase	0.0287	0.3166	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0042	0.0133
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0634	0.1967
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0064	0.0625	0.0597
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0064	0.0625	0.0925
Brugia malayi	glutaminase DH11.1	0.0287	0.3166	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0323	0.0979
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0064	0.0625	0.855
Giardia lamblia	Hexose transporter	0.0029	0.0231	0.346
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0323	0.0935
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0405	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0405	0.1279
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0323	0.1021
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0323	0.4322
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Toxoplasma gondii	transporter, major facilitator family protein	0.0029	0.0231	0.0327
Schistosoma mansoni	protein kinase	0.0064	0.0625	0.1898
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0405	0.1195
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0029	0.0231	0.303
Toxoplasma gondii	exonuclease III APE	0.0019	0.0111	0.0147
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0634	0.1967
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0029	0.0231	0.0687
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0323	0.1183
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0073	0.0729	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0231	0.0687
Entamoeba histolytica	hypothetical protein	0.0047	0.0427	0.6679
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Brugia malayi	Cam kinase protein 1	0.0064	0.0625	0.1898
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0111	0.1368
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.061	0.1851
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0427	0.1268
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0012	0.003	0.0218
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0625	0.1112
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0323	0.0979
Leishmania major	protein kinase, putative	0.0064	0.0625	0.855
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Giardia lamblia	Lysyl-tRNA synthetase	0.0047	0.0427	0.6849
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0064	0.0625	0.0925
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2277	0.4199
Loa Loa (eye worm)	hypothetical protein	0.0012	0.003	0.0095
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0073	0.0729	0.1081
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0634	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0063	0.061	0.0607
Trypanosoma brucei	glucose transporter 1E	0.0065	0.0634	0.868
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0323	0.4322
Brugia malayi	hypothetical protein	0.0029	0.0231	0.064
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0064	0.0625	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0405	0.0392
Echinococcus granulosus	lysyl tRNA synthetase	0.0047	0.0427	0.0743
Schistosoma mansoni	glucose transporter	0.0029	0.0231	0.064
Schistosoma mansoni	ap endonuclease	0.0019	0.0111	0.026
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0323	0.1183
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0323	0.1183
Mycobacterium ulcerans	lipase LipD	0.0037	0.0323	0.0979
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0427	0.1268
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0029	0.0231	0.021
Schistosoma mansoni	sugar transporter	0.0029	0.0231	0.064
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0231	0.064
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0634	0.868
Trichomonas vaginalis	esterase, putative	0.0037	0.0323	0.0979
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0634	0.868
Schistosoma mansoni	sugar transporter	0.0029	0.0231	0.064
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Schistosoma mansoni	glucose transport protein	0.0209	0.2277	0.7165
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0231	0.0729
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0231	0.064
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0476	0.1505
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0231	0.0687
Echinococcus multilocularis	calcium dependent protein kinase	0.006	0.058	0.0575
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0029	0.0231	0.0375
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0111	0.0082
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0231	0.0687
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0063	0.061	0.1851
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0634	0.868
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0323	0.0935
Leishmania major	glucose transporter, lmgt2	0.0065	0.0634	0.868
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0323	0.0294
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0323	0.1183
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0063	0.061	0.9752
Schistosoma mansoni	hypothetical protein	0.0176	0.1895	0.5949
Toxoplasma gondii	sugar transporter ST2	0.0029	0.0231	0.0327
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0111	0.0082
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0029	0.0231	0.021
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0231	0.0687

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 705686