TDR Targets

Basic information

Technical information

TDR Targets ID: 705688
Name: N-(2,5-dimethoxyphenyl)-N',N'-dimethyl-1-phen ylpyrazolo[4,5-e]pyrimidine-4,6-diamine
MW: 390.438 | Formula: C21H22N6O2
H donors: 1 H acceptors: 3 LogP: 4.12 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1)Nc1nc(nc2c1cnn2c1ccccc1)N(C)C)OC
InChi: 1S/C21H22N6O2/c1-26(2)21-24-19(23-17-12-15(28-3)10-11-18(17)29-4)16-13-22-27(20(16)25-21)14-8-6-5-7-9-14/h5-13H,1-4H3,(H,23,24,25)
InChiKey: DNBPZYYXIAEXGF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,5-dimethoxyphenyl)-N',N'-dimethyl-1-phenyl-pyrazolo[4,5-e]pyrimidine-4,6-diamine
(2,5-dimethoxyphenyl)-(6-dimethylamino-1-phenyl-pyrazolo[4,5-e]pyrimidin-4-yl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0122	0.1673
Toxoplasma gondii	sugar transporter ST1	0.0029	0.0219	0.0327
Toxoplasma gondii	transporter, major facilitator family protein	0.0029	0.0219	0.0327
Trypanosoma brucei	sugar transporter, putative	0.0029	0.0219	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0623	0.2013
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0268	0.2946	1
Toxoplasma gondii	glycyl-tRNA synthetase	0.0012	0.0017	0.0024
Giardia lamblia	Hexose transporter	0.0029	0.0219	0.346
Toxoplasma gondii	lysine-tRNA ligase	0.0047	0.0415	0.0625
Loa Loa (eye worm)	CYP4Cod1	0.0014	0.0047	0.0153
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0122	0.1673
Plasmodium falciparum	protein kinase 7	0.059	0.6618	0.6612
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0219	0.0215
Echinococcus multilocularis	geminin	0.0197	0.2127	0.2252
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0986	0.3159
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0623	0.868
Entamoeba histolytica	hypothetical protein	0.0047	0.0415	0.6679
Brugia malayi	hypothetical protein	0.0029	0.0219	0.0655
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0623	0.2013
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0363	0.117
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0613	0.0636
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0012	0.0017	0.0057
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Trypanosoma cruzi	hexose transporter, putative	0.0029	0.0219	0.303
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2267	0.2402
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0363	0.117
Brugia malayi	hypothetical protein	0.0029	0.0219	0.0655
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0363	0.5046
Trypanosoma brucei	glucose transporter 2A	0.0065	0.0623	0.868
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2267	0.2402
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Schistosoma mansoni	hypothetical protein	0.0197	0.2127	0.6875
Giardia lamblia	Prolyl-tRNA synthetase	0.0063	0.0598	1
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0012	0.0017	0.0053
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0064	0.0614	0.0597
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0063	0.0598	0.1894
Schistosoma mansoni	ap endonuclease	0.0021	0.0122	0.0339
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0026	0.0177	0.0573
Onchocerca volvulus		0.0042	0.0363	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0415	0.1341
Schistosoma mansoni	hypothetical protein	0.0209	0.2267	0.7332
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0338	0.3735	0.3724
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0363	0.1176
Leishmania major	glucose transporter, lmgt2	0.0065	0.0623	0.868
Echinococcus multilocularis	neuropeptide s receptor	0.0539	0.604	0.6431
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Plasmodium falciparum	hexose transporter	0.0209	0.2267	0.2253
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0613	0.0636
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0363	0.1226
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0012	0.0017	0.0057
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0047	0.0415	0.1341
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.004	0.0335	0.1132
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0017	0.0057
Loa Loa (eye worm)	sugar transporter	0.0209	0.2267	0.7347
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.0598	0.1894
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0415	0.1297
Schistosoma mansoni	sugar transporter	0.0029	0.0219	0.0655
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.004	0.0335	0.1132
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0063	0.0598	0.062
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.0363	0.1226
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0029	0.0219	0.0334
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0122	0.0173
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0623	0.2013
Leishmania major	myo-inositol/proton symporter (MIT)	0.0029	0.0219	0.303
Leishmania major	cytochrome p450-like protein	0.0014	0.0047	0.0633
Toxoplasma gondii	protein kinase, putative	0.059	0.6618	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0122	0.0406
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0623	0.868
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0122	0.0339
Schistosoma mansoni	hypothetical protein	0.0197	0.2127	0.6875
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0047	0.0415	0.5783
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0363	0.117
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0209	0.2267	0.2402
Schistosoma mansoni	lysyl-tRNA synthetase	0.0047	0.0415	0.1297
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0029	0.0219	0.303
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2267	0.3735
Brugia malayi	beta-lactamase family protein	0.0042	0.0363	0.1125
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.0613	0.1983
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0012	0.0017	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0363	0.1176
Onchocerca volvulus		0.0042	0.0363	1
Trypanosoma cruzi	hexose transporter	0.0065	0.0623	0.868
Trypanosoma cruzi	glucose transporter, putative	0.0029	0.0219	0.303
Mycobacterium ulcerans	integral membrane transport protein	0.0029	0.0219	0.0703
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0363	0.1176
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0064	0.0614	0.0925
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0613	0.0636
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0613	0.0989
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0064	0.0614	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Trichomonas vaginalis	esterase, putative	0.0042	0.0363	0.117
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0363	0.0573
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0219	0.0708
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0063	0.0598	0.1894
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0623	0.868
Brugia malayi	Cam kinase protein 1	0.0064	0.0613	0.1942
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0064	0.0614	0.0597
Trichomonas vaginalis	sugar transport protein, putative	0.0029	0.0219	0.0703
Echinococcus granulosus	lysyl tRNA synthetase	0.0047	0.0415	0.0661
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0047	0.0097
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0012	0.0017	0.0218
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0022	0.0136	0.0435
Loa Loa (eye worm)	sugar transporter	0.0029	0.0219	0.0708
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0122	0.1673
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0064	0.0614	0.0597
Mycobacterium leprae	Probable lipase LipE	0.0042	0.0363	0.6048
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.0363	0.1226
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0073	0.0717	1
Chlamydia trachomatis	lysine--tRNA ligase	0.0047	0.0415	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0363	0.0346
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0097	0.0986	0.3197
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.0363	0.1226
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0986	0.3159
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0063	0.0598	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0613	0.0989
Toxoplasma gondii	sugar transporter ST3	0.0029	0.0219	0.0327
Trypanosoma brucei	cytochrome P450, putative	0.0014	0.0047	0.0633
Mycobacterium ulcerans	sugar transporter	0.0029	0.0219	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0047	0.0633
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0338	0.3735	0.3724
Schistosoma mansoni	glucose transport protein	0.0209	0.2267	0.7332
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0717	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0041	0.035	0.1128
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0029	0.0219	1
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0287	0.3994
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2267	0.3735
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0887	1	1
Onchocerca volvulus		0.0042	0.0363	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0029	0.0219	0.0703
Loa Loa (eye worm)	glutaminase	0.0281	0.3085	1
Schistosoma mansoni	glucose transporter	0.0029	0.0219	0.0655
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0029	0.0219	0.0201
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0363	0.1226
Trichomonas vaginalis	myo-inositol transporter, putative	0.0029	0.0219	0.0703
Trichomonas vaginalis	glutaminase, putative	0.0281	0.3085	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0623	0.868
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0014	0.0047	0.0147
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0064	0.0614	0.0597
Giardia lamblia	Sugar-proton symporter	0.0029	0.0219	0.346
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0717	1
Brugia malayi	Sugar transporter family protein	0.0029	0.0219	0.0655
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0363	0.117
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0623	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Leishmania major	lysyl-tRNA synthetase, putative	0.0047	0.0415	0.5783
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0017	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Echinococcus granulosus	neuropeptide receptor A26	0.0539	0.604	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0363	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0363	0.1176
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0219	0.0703
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.0363	0.6048
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0012	0.0017	0.0051
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0122	0.8782
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0012	0.0017	0.0051
Brugia malayi	major facilitator superfamily protein	0.0029	0.0219	0.0655
Mycobacterium ulcerans	lipase LipD	0.0042	0.0363	0.117
Trypanosoma cruzi	sugar transporter, putative	0.0029	0.0219	0.303
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0986	0.1609
Echinococcus multilocularis	neuropeptide receptor A26	0.0539	0.604	0.6431
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0047	0.0153
Schistosoma mansoni	protein kinase	0.0064	0.0613	0.1942
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0047	0.0153
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Trichomonas vaginalis	conserved hypothetical protein	0.0209	0.2267	0.7346
Chlamydia trachomatis	proline--tRNA ligase	0.0022	0.0136	0.2978
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Plasmodium vivax	hexose transporter	0.0209	0.2267	0.2253
Leishmania major	hypothetical protein, conserved	0.0029	0.0219	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Plasmodium vivax	sugar transporter, putative	0.0029	0.0219	0.0201
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0064	0.0614	0.0925
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0097	0.0986	0.3159
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0363	0.117
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.0613	0.1942
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0063	0.0598	0.0965
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.0363	0.1226
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0122	0.1791
Echinococcus granulosus	solute carrier family 22	0.0029	0.0219	0.0334
Schistosoma mansoni	sugar transporter	0.0029	0.0219	0.0655
Brugia malayi	major facilitator superfamily protein	0.0029	0.0219	0.0655
Schistosoma mansoni	ap endonuclease	0.0021	0.0122	0.0339
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2267	0.3735
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0219	0.0703
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0047	0.0415	0.1341
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0012	0.0017	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0363	0.1176
Schistosoma mansoni	sugar transporter	0.0029	0.0219	0.0655
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0012	0.0017	0.0262
Schistosoma mansoni	glucose transport protein	0.0209	0.2267	0.7332
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0122	0.1747
Leishmania major	glucose transporter, lmgt1	0.0065	0.0623	0.868
Trypanosoma cruzi	hexose transporter, putative	0.0065	0.0623	0.868
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0122	0.0388
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0064	0.0613	0.1988
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0613	0.1988
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0064	0.0613	0.1988
Schistosoma mansoni	protein kinase	0.0064	0.0613	0.1942
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0064	0.0613	0.0989
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0623	0.868
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0064	0.0614	0.0597
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0209	0.2267	0.3735
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0623	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0047	0.0097
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0122	0.0394
Brugia malayi	Sugar transporter family protein	0.0209	0.2267	0.7332
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0338	0.3735	0.5643
Echinococcus multilocularis	General substrate transporter	0.018	0.1932	0.2044
Trichomonas vaginalis	glucose transporter, putative	0.0029	0.0219	0.0703
Trypanosoma brucei	glucose transporter 1E	0.0065	0.0623	0.868
Echinococcus granulosus	geminin	0.0197	0.2127	0.3502
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0363	0.1125
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0363	0.1125
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0122	0.0388
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.004	0.0335	0.5587
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0986	0.3159
Echinococcus granulosus	neuropeptide s receptor	0.0539	0.604	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0832	0.9382	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0122	0.0111
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0986	0.1609
Plasmodium vivax	proline--tRNA ligase, putative	0.0073	0.0717	0.0701
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0029	0.0219	0.0215
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0623	0.868
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0047	0.0633
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0064	0.0613	0.0989
Mycobacterium ulcerans	glutaminase	0.0281	0.3085	1
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0363	0.5046
Treponema pallidum	prolyl-tRNA synthetase	0.0022	0.0136	1
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0219	0.0655
Leishmania major	threonyl-tRNA synthetase, putative	0.0012	0.0017	0.0218
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0209	0.2267	0.2402
Brugia malayi	lysyl-tRNA synthetase	0.0047	0.0415	0.1297
Toxoplasma gondii	sugar transporter ST2	0.0029	0.0219	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Schistosoma mansoni	glutaminase	0.0281	0.3085	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0047	0.0415	0.6849
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0363	0.1125
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.0623	0.2013
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0063	0.0598	0.1935
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0623	0.868
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0064	0.0614	0.0597
Brugia malayi	Sugar transporter family protein	0.0029	0.0219	0.0655
Leishmania major	hypothetical protein, conserved	0.0042	0.0363	0.5046
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0065	0.0623	0.868
Loa Loa (eye worm)	glutaminase 2	0.0281	0.3085	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0065	0.0623	0.868
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0122	0.5176
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0623	0.2013
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0415	0.1346
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0219	0.0708
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0029	0.0219	0.0703
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.0363	0.1226
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0064	0.0614	0.0597
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0122	0.0104
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0012	0.0017	0.0218
Echinococcus multilocularis	calcium dependent protein kinase	0.006	0.0568	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0598	0.194
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0464	0.1505
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0219	0.0215
Echinococcus granulosus	solute carrier family 22	0.0029	0.0219	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0029	0.0219	0.0736
Entamoeba histolytica	protein kinase, putative	0.0064	0.0613	1
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0047	0.0415	0.5783
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0064	0.0613	0.1942
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0363	0.117
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0064	0.0613	0.0636
Schistosoma mansoni	protein kinase	0.0064	0.0613	0.1942
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0219	0.0215
Entamoeba histolytica	protein kinase, putative	0.0064	0.0613	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.0363	0.1226
Brugia malayi	beta-lactamase family protein	0.0042	0.0363	0.1125
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0047	0.0415	0.6932
Plasmodium falciparum	lysine--tRNA ligase	0.0047	0.0415	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0363	0.1176
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Trichomonas vaginalis	sugar transporter, putative	0.0065	0.0623	0.2013
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0623	0.868
Brugia malayi	glutaminase DH11.1	0.0281	0.3085	1
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0623	0.868
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0219	0.0655
Plasmodium vivax	lysine--tRNA ligase, putative	0.0047	0.0415	0.0399
Toxoplasma gondii	exonuclease III APE	0.0021	0.0122	0.0181
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0029	0.0219	0.0655
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0363	0.117
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0986	0.1035
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Brugia malayi	beta-lactamase	0.0042	0.0363	0.1125
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0064	0.0614	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0598	0.194
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Echinococcus granulosus	synaptic vesicle 2 protein	0.0029	0.0219	0.0334
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0063	0.0598	0.1894
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0122	0.1673
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0219	0.0703
Toxoplasma gondii	facilitative glucose transporter GT1	0.0209	0.2267	0.3424
Echinococcus granulosus	solute carrier family 22	0.0029	0.0219	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0122	0.0388
Toxoplasma gondii	ABC1 family protein	0.0042	0.0363	0.0545
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0363	0.1176
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0064	0.0614	0.0925
Echinococcus granulosus	General substrate transporter	0.018	0.1932	0.3179
Schistosoma mansoni	sugar transporter	0.0029	0.0219	0.0655
Echinococcus granulosus	solute carrier family 22	0.0029	0.0219	0.0334
Leishmania major	protein kinase, putative	0.0064	0.0613	0.855
Trypanosoma brucei	glucose transporter, putative	0.0065	0.0623	0.868
Trichomonas vaginalis	glucose transporter, putative	0.0065	0.0623	0.2013
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0363	0.5046
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0219	0.0215
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0219	0.0703
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0363	0.1226
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0122	0.0104
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.0363	0.1226
Leishmania major	glucose transporter, lmgt3	0.0065	0.0623	0.868
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0029	0.0219	0.0215
Echinococcus multilocularis	lysyl tRNA synthetase	0.0047	0.0415	0.0425
Echinococcus granulosus	calcium dependent protein kinase	0.006	0.0568	0.0914
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0986	0.1035
Schistosoma mansoni	glucose transport protein	0.0209	0.2267	0.7332
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0012	0.0017	0.0024
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0073	0.0717	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0363	0.1176
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0073	0.0717	0.1081
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0029	0.0219	0.0736
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0064	0.0613	0.855
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0363	0.117
Plasmodium falciparum	proline--tRNA ligase	0.0073	0.0717	0.0701
Brugia malayi	hypothetical protein	0.0029	0.0219	0.0655
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0219	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0063	0.0598	0.9752
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0219	0.0655
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0363	0.117
Trichomonas vaginalis	sugar transporter, putative	0.0029	0.0219	0.0703
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0073	0.0717	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0219	0.0708

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 705688