Detailed information for compound 705766

Basic information

Technical information
  • TDR Targets ID: 705766
  • Name: 3-fluoro-N-[2-[2-(3-fluorophenyl)-[1,3]thiazo lo[2,3-e][1,2,4]triazol-6-yl]ethyl]-4-methoxy benzenesulfonamide
  • MW: 450.482 | Formula: C19H16F2N4O3S2
  • H donors: 1 H acceptors: 4 LogP: 3.64 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1F)S(=O)(=O)NCCc1csc2n1nc(n2)c1cccc(c1)F
  • InChi: 1S/C19H16F2N4O3S2/c1-28-17-6-5-15(10-16(17)21)30(26,27)22-8-7-14-11-29-19-23-18(24-25(14)19)12-3-2-4-13(20)9-12/h2-6,9-11,22H,7-8H2,1H3
  • InChiKey: WOGROGBVOQZIBR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-fluoro-N-[2-[2-(3-fluorophenyl)thiazolo[2,3-e][1,2,4]triazol-6-yl]ethyl]-4-methoxy-benzenesulfonamide
  • 3-fluoro-N-[2-[2-(3-fluorophenyl)-6-thiazolo[2,3-e][1,2,4]triazolyl]ethyl]-4-methoxybenzenesulfonamide
  • 3-fluoro-N-[2-[2-(3-fluorophenyl)-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-yl]ethyl]-4-methoxy-benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.0181 0.035
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0066 0.0578 0.1888
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0261 0.0852
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0181 0.0593
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0345 0.1129
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0345 0.0666
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0261 0.4631
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Loa Loa (eye worm) hypothetical protein 0.0038 0.0261 0.0852
Mycobacterium ulcerans glutaminase 0.0291 0.306 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0578 0.1888
Entamoeba histolytica protein kinase, putative 0.0066 0.0578 1
Schistosoma mansoni glucose transporter 0.0031 0.0181 0.0593
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0181 0.2661
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0587 0.1766
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0181 0.0415
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0345 0.1129
Trypanosoma cruzi sugar transporter, putative 0.0031 0.0181 0.2661
Onchocerca volvulus 0.0038 0.0261 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0076 0.0682 0.1032
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0195 0.2865
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0261 0.0205
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0578 0.0616
Giardia lamblia Hexose transporter 0.0031 0.0181 0.2462
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.0181 0.0593
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0065 0.0563 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0379 0.0324
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0379 0.0731
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Trypanosoma cruzi glucose transporter, putative 0.0031 0.0181 0.2661
Brugia malayi Cam kinase protein 1 0.0066 0.0578 0.1888
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.0181 0.2661
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0379 0.0404
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0066 0.0578 0.0875
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0261 0.0679
Schistosoma mansoni protein kinase 0.0066 0.0578 0.1888
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Plasmodium falciparum calcium-dependent protein kinase 4 0.0066 0.0578 0.0524
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0205 0.067
Loa Loa (eye worm) hypothetical protein 0.0038 0.0261 0.0852
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0099 0.0322
Loa Loa (eye worm) hypothetical protein 0.0038 0.0261 0.0852
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0379 0.6368
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0345 0.1129
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0578 0.0616
Brugia malayi hypothetical protein 0.0031 0.0181 0.0593
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0682 1
Loa Loa (eye worm) sugar transporter 0.0217 0.2238 0.7313
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0261 0.0679
Trypanosoma brucei glucose transporter, putative 0.0067 0.0587 0.8611
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0065 0.0563 0.1685
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Trypanosoma brucei glucose transporter, putative 0.0067 0.0587 0.8611
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.0181 0.0726
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0261 0.0679
Trypanosoma brucei glucose transporter, putative 0.0067 0.0587 0.8611
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Leishmania major cytochrome p450-like protein 0.0032 0.0195 0.2865
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.0181 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0181 0.0415
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.0181 0.0593
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0379 0.1239
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Onchocerca volvulus 0.0038 0.0261 1
Loa Loa (eye worm) sugar transporter 0.0031 0.0181 0.0593
Trypanosoma brucei glucose transporter, putative 0.0067 0.0587 0.8611
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Loa Loa (eye worm) hypothetical protein 0.0053 0.0428 0.14
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.0181 0.035
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0532 0.1027
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0181 0.0415
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Toxoplasma gondii sugar transporter ST3 0.0031 0.0181 0.0275
Plasmodium vivax hexose transporter 0.0217 0.2238 0.2193
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.0181 0.2661
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Brugia malayi major facilitator superfamily protein 0.0031 0.0181 0.0593
Giardia lamblia Prolyl-tRNA synthetase 0.0065 0.0563 1
Schistosoma mansoni hypothetical protein 0.0176 0.1791 0.5854
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0261 0.1042
Leishmania major hypothetical protein, conserved 0.0038 0.0261 0.3823
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0181 0.0415
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0065 0.0563 0.1839
Leishmania major glucose transporter/membrane transporter D2, putative 0.0067 0.0587 0.8611
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0261 0.3823
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0587 0.8611
Echinococcus granulosus solute carrier family 22 0.0031 0.0181 0.035
Brugia malayi Cytochrome P450 family protein 0.0032 0.0195 0.0638
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0057 0.011
Schistosoma mansoni glucose transport protein 0.0217 0.2238 0.7313
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0379 0.1239
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.0181 0.0726
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0261 0.1042
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Trypanosoma cruzi hexose transporter 0.0067 0.0587 0.8611
Brugia malayi Sugar transporter family protein 0.0217 0.2238 0.7313
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0066 0.0578 0.0524
Plasmodium falciparum calcium-dependent protein kinase 1 0.0066 0.0578 0.0524
Schistosoma mansoni ap endonuclease 0.0019 0.0057 0.0186
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0066 0.0578 0.1888
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0578 0.1115
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0066 0.0578 0.8473
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0563 0.1839
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0066 0.0578 0.0524
Plasmodium vivax calcium-dependent protein kinase, putative 0.0066 0.0578 0.0524
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0587 0.8611
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.2238 0.4317
Plasmodium vivax sugar transporter, putative 0.0031 0.0181 0.0125
Echinococcus multilocularis solute carrier family 22 0.0031 0.0181 0.0193
Mycobacterium ulcerans lipase LipD 0.0038 0.0261 0.0852
Schistosoma mansoni sugar transporter 0.0031 0.0181 0.0593
Echinococcus multilocularis neuropeptide receptor A26 0.0484 0.5183 0.5525
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0076 0.0682 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0066 0.0578 0.1888
Brugia malayi Sugar transporter family protein 0.0031 0.0181 0.0593
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.2238 0.2385
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0181 0.0415
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0217 0.2238 0.2385
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Toxoplasma gondii sugar transporter ST2 0.0031 0.0181 0.0275
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0299 0.1194
Plasmodium falciparum proline--tRNA ligase 0.0076 0.0682 0.0628
Loa Loa (eye worm) hypothetical protein 0.0065 0.0563 0.1839
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0578 0.0616
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0065 0.0563 0.06
Echinococcus granulosus solute carrier family 22 0.0031 0.0181 0.035
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0261 0.0679
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0057 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Brugia malayi glutaminase DH11.1 0.0291 0.306 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0379 0.1239
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0379 0.0574
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0261 0.0852
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0587 0.1766
Trypanosoma brucei glucose transporter, putative 0.0067 0.0587 0.8611
Schistosoma mansoni protein kinase 0.0066 0.0578 0.1888
Brugia malayi Sugar transporter family protein 0.0031 0.0181 0.0593
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0299 0.5305
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0587 0.8611
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0587 0.1766
Trichomonas vaginalis glutaminase, putative 0.0291 0.306 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0587 0.1766
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0345 0.0666
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0195 0.0638
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0313 0.0854
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0065 0.0563 0.1839
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0057 0.0834
Brugia malayi hypothetical protein 0.0031 0.0181 0.0593
Schistosoma mansoni hypothetical protein 0.0176 0.1791 0.5854
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0587 0.1766
Schistosoma mansoni sugar transporter 0.0031 0.0181 0.0593
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.2238 0.2385
Plasmodium falciparum mitogen-activated protein kinase 2 0.0351 0.3711 0.3675
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0181 0.0593
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0261 0.3823
Echinococcus granulosus General substrate transporter 0.0186 0.1901 0.3668
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0181 0.0593
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0261 0.1042
Brugia malayi beta-lactamase family protein 0.0038 0.0261 0.0852
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.014 0.0456
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0865 0.9381 1
Echinococcus granulosus neuropeptide receptor A26 0.0484 0.5183 1
Plasmodium vivax proline--tRNA ligase, putative 0.0076 0.0682 0.0628
Trypanosoma brucei glucose transporter, putative 0.0067 0.0587 0.8611
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0076 0.0682 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.0181 1
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0587 0.1766
Loa Loa (eye worm) glutaminase 2 0.0291 0.306 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0066 0.0578 0.0875
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.0181 0.0193
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Onchocerca volvulus 0.0038 0.0261 1
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0379 0.0324
Toxoplasma gondii facilitative glucose transporter GT1 0.0217 0.2238 0.3388
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0261 0.0503
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0261 0.1042
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0532 0.0567
Leishmania major glucose transporter, lmgt2 0.0067 0.0587 0.8611
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0066 0.0578 0.1115
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0563 0.1839
Echinococcus granulosus solute carrier family 22 0.0031 0.0181 0.035
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0379 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0261 0.0852
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0065 0.0563 0.1086
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0057 0.0834
Trypanosoma brucei glucose transporter 1E 0.0067 0.0587 0.8611
Brugia malayi beta-lactamase family protein 0.0038 0.0261 0.0852
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0345 0.0368
Brugia malayi beta-lactamase 0.0038 0.0261 0.0852
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0682 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0261 0.0852
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0587 0.8611
Schistosoma mansoni hypothetical protein 0.0217 0.2238 0.7313
Entamoeba histolytica hypothetical protein 0.0048 0.0379 0.6187
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0195 0.0638
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.2238 0.7262
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0578 0.1115
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0261 0.3823
Loa Loa (eye worm) beta-lactamase 0.0038 0.0261 0.0852
Loa Loa (eye worm) hypothetical protein 0.0038 0.0261 0.0852
Entamoeba histolytica protein kinase, putative 0.0066 0.0578 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.0181 0.0593
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0181 0.0415
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0261 0.0852
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0578 0.0616
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0578 0.1888
Leishmania major protein kinase, putative 0.0066 0.0578 0.8473
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0195 0.0638
Schistosoma mansoni protein kinase 0.0066 0.0578 0.1888
Echinococcus multilocularis solute carrier family 22 0.0031 0.0181 0.0193
Mycobacterium ulcerans beta-lactamase 0.0038 0.0261 0.0852
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Loa Loa (eye worm) glutaminase 0.0291 0.306 1
Toxoplasma gondii sugar transporter ST1 0.0031 0.0181 0.0275
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0578 0.1734
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.0181 0.0415
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0066 0.0578 0.0524
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0132
Trypanosoma brucei glucose transporter, putative 0.0067 0.0587 0.8611
Echinococcus multilocularis solute carrier family 22 0.0031 0.0181 0.0193
Trichomonas vaginalis esterase, putative 0.0038 0.0261 0.0679
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0587 0.8611
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0379 0.1239
Echinococcus multilocularis neuropeptide s receptor 0.0484 0.5183 0.5525
Brugia malayi hypothetical protein 0.0031 0.0181 0.0593
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0261 0.1042
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.0299 0.1194
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0261 0.1042
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0181 0.0593
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0195 0.0638
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0057 0.0834
Plasmodium falciparum calcium-dependent protein kinase 3 0.0066 0.0578 0.0524
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0379 0.556
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.0181 0.0193
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.0181 0.0593
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Brugia malayi Cytochrome P450 family protein 0.0033 0.0205 0.067
Brugia malayi major facilitator superfamily protein 0.0031 0.0181 0.0593
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0057 0.0186
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0351 0.3711 0.5619
Toxoplasma gondii ABC1 family protein 0.0038 0.0261 0.0395
Trypanosoma brucei glucose transporter 2A 0.0067 0.0587 0.8611
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.2238 0.2385
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.2238 0.4317
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0251 0.3676
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0195 0.2865
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0261 0.0852
Plasmodium vivax CDK-related protein kinase 6, putative 0.0921 1 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0181 0.0593
Schistosoma mansoni sugar transporter 0.0031 0.0181 0.0593
Schistosoma mansoni glutaminase 0.0291 0.306 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0066 0.0578 0.0524
Echinococcus granulosus solute carrier family 22 0.0031 0.0181 0.035
Schistosoma mansoni glucose transport protein 0.0217 0.2238 0.7313
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0195 0.2865
Loa Loa (eye worm) hypothetical protein 0.0038 0.0261 0.0852
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0261 0.0679
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.2238 0.4317
Trypanosoma brucei glucose transporter, putative 0.0067 0.0587 0.8611
Giardia lamblia Sugar-proton symporter 0.0031 0.0181 0.2462
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0379 0.1073
Echinococcus multilocularis General substrate transporter 0.0186 0.1901 0.2027
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0379 0.6735
Loa Loa (eye worm) hypothetical protein 0.0065 0.0563 0.1839
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0099 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Echinococcus multilocularis solute carrier family 22 0.0031 0.0181 0.0193
Leishmania major glucose transporter, lmgt3 0.0067 0.0587 0.8611
Schistosoma mansoni sugar transporter 0.0031 0.0181 0.0593
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.25 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0057 0.0061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0345 0.0368
Toxoplasma gondii exonuclease III APE 0.0019 0.0057 0.0086
Plasmodium falciparum protein kinase 7 0.0613 0.6605 0.6586
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0066 0.0578 0.0875
Echinococcus multilocularis geminin 0.0176 0.1791 0.1909
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0682 1
Brugia malayi Cytochrome P450 family protein 0.0032 0.0195 0.0638
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0379 0.556
Leishmania major hypothetical protein, conserved 0.0031 0.0181 0.2661
Leishmania major glucose transporter, lmgt1 0.0067 0.0587 0.8611
Mycobacterium ulcerans hypothetical protein 0.0038 0.0261 0.0852
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Loa Loa (eye worm) hypothetical protein 0.0038 0.0261 0.0852
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0587 0.1766
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0057 0.0186
Loa Loa (eye worm) hypothetical protein 0.0031 0.0181 0.0593
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0057 0.0227
Schistosoma mansoni ap endonuclease 0.0019 0.0057 0.0186
Toxoplasma gondii protein kinase, putative 0.0613 0.6605 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0057 0.0834
Plasmodium falciparum calcium-dependent protein kinase 2 0.0066 0.0578 0.0524
Echinococcus granulosus geminin 0.0176 0.1791 0.3456
Mycobacterium ulcerans sugar transporter 0.0031 0.0181 0.0593
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0379 0.1239
Mycobacterium leprae Probable lipase LipE 0.0038 0.0261 0.4631
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0345 0.1129
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.0181 0.0415
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0261 0.0278
Plasmodium falciparum hexose transporter 0.0217 0.2238 0.2193
Mycobacterium tuberculosis Conserved protein 0.0038 0.0261 0.1042
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0351 0.3711 0.3675
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Echinococcus granulosus neuropeptide s receptor 0.0484 0.5183 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.2238 0.4317
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0587 0.8611
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0578 0.1115
Mycobacterium tuberculosis Conserved protein 0.0038 0.0261 0.1042
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Loa Loa (eye worm) hypothetical protein 0.0048 0.0379 0.1239
Schistosoma mansoni glucose transport protein 0.0217 0.2238 0.7313
Mycobacterium tuberculosis Conserved protein 0.0038 0.0261 0.1042
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0181 0.0415
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.0181 0.0125
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0379 0.556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0345 0.1129
Trypanosoma brucei sugar transporter, putative 0.0031 0.0181 0.2661
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0065 0.0563 0.9715
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0261 0.1042

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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