Detailed information for compound 721131

Basic information

Technical information
  • TDR Targets ID: 721131
  • Name: 3-(5-ethylfuran-2-yl)-N-(5-ethyl-1,3,4-thiadi azol-2-yl)propanamide
  • MW: 279.358 | Formula: C13H17N3O2S
  • H donors: 1 H acceptors: 3 LogP: 2.53 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(o1)CCC(=O)Nc1nnc(s1)CC
  • InChi: 1S/C13H17N3O2S/c1-3-9-5-6-10(18-9)7-8-11(17)14-13-16-15-12(4-2)19-13/h5-6H,3-4,7-8H2,1-2H3,(H,14,16,17)
  • InChiKey: WQEXASNAPOZMNB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(5-ethyl-2-furyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)propanamide
  • 3-(5-ethyl-2-furyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)propionamide
  • ST063103
  • 3-(5-Ethyl-furan-2-yl)-N-(5-ethyl-[1,3,4]thiadiazol-2-yl)-propionamide
  • BAS 09687343
  • ZINC00537568
  • MLS000064880
  • SMR000077849

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax ataxin-2 like protein, putative 0.0107 0.0952 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0114 0.0004
Mycobacterium ulcerans beta-lactamase 0.0072 0.056 0.3427
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0114 0.0004
Loa Loa (eye worm) hypothetical protein 0.0072 0.056 0.0728
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0114 0.0148
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0138 1
Plasmodium vivax hypothetical protein, conserved 0.0072 0.056 0.5323
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0048 0.0279 0.0171
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0672 0.0568
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0072 0.056 0.0728
Mycobacterium tuberculosis Conserved protein 0.0072 0.056 0.1114
Toxoplasma gondii ABC1 family protein 0.0072 0.056 0.5323
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0114 0.0008
Mycobacterium tuberculosis Conserved protein 0.0072 0.056 0.1114
Brugia malayi Cytochrome P450 family protein 0.0025 0.0012 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0144 0.0077
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0138 0.0054
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0672 0.0873
Mycobacterium leprae conserved hypothetical protein 0.0072 0.056 1
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0547 0.0994
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0351 0.0441
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0114 0.0133
Leishmania major hypothetical protein, conserved 0.0072 0.056 0.0728
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0138 0.0164
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.056 0.1472
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0672 0.1063
Loa Loa (eye worm) RNA binding protein 0.0071 0.0547 0.0711
Leishmania major mitochondrial DNA polymerase beta 0.0316 0.3345 0.4349
Brugia malayi Cytochrome P450 family protein 0.0056 0.0372 0.0484
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.056 0.1114
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.011 0.0143
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0261 0.0153
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.056 0.0728
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.1177 0.1079
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.056 0.3427
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0261 0.0343
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1565 0.1472
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.056 0.0714
Schistosoma mansoni hypothetical protein 0.0082 0.0672 0.1277
Onchocerca volvulus 0.0072 0.056 0.1242
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.056 0.0728
Loa Loa (eye worm) hypothetical protein 0.0036 0.0144 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0144 0.0077
Leishmania major cytochrome p450-like protein 0.0025 0.0012 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.056 0.0714
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0672 0.0873
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0114 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0261 0.0343
Loa Loa (eye worm) hypothetical protein 0.0107 0.0952 0.1238
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0138 0.0029
Plasmodium falciparum ataxin-2 like protein, putative 0.0107 0.0952 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.011 0.0143
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2606 0.3389
Brugia malayi beta-lactamase family protein 0.0072 0.056 0.0728
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0138 0.018
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0143
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0672 0.1063
Brugia malayi TAR-binding protein 0.0071 0.0547 0.0711
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0239 0.0296
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0463 0.5027 1
Loa Loa (eye worm) beta-lactamase 0.0072 0.056 0.0728
Brugia malayi Pre-SET motif family protein 0.0251 0.2606 0.3389
Brugia malayi Pre-SET motif family protein 0.0036 0.0144 0.0187
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0114 0.0148
Echinococcus granulosus GPCR family 2 0.0082 0.0672 0.1063
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0114 0.0004
Mycobacterium ulcerans lipase LipD 0.0072 0.056 0.3427
Leishmania major C-8 sterol isomerase-like protein 0.0696 0.7691 1
Brugia malayi Cytochrome P450 family protein 0.0025 0.0012 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0261 0.0343
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.011 0.0143
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0012 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0261 0.0285
Loa Loa (eye worm) hypothetical protein 0.0082 0.0672 0.0873
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0547 0.0442
Echinococcus multilocularis neuropeptide receptor A26 0.0495 0.5398 0.5347
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0012 0.0016
Schistosoma mansoni hypothetical protein 0.0048 0.0279 0.0385
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0547 0.0711
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.011 0.0143
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0143
Echinococcus granulosus vesicular acetylcholine transporter 0.0418 0.451 0.8321
Onchocerca volvulus 0.0072 0.056 0.1242
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.011 0.0143
Mycobacterium tuberculosis Conserved protein 0.0072 0.056 0.1114
Mycobacterium ulcerans hypothetical protein 0.0166 0.1635 1
Brugia malayi beta-lactamase 0.0072 0.056 0.0728
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0261 0.0153
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0672 0.0873
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.056 0.1472
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0143
Loa Loa (eye worm) hypothetical protein 0.0072 0.056 0.0728
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0239 0.0296
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0138 0.018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.056 0.1024
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.3345 0.434
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.056 0.0456
Schistosoma mansoni lipoxygenase 0.0126 0.1177 0.2425
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.011 0.0143
Onchocerca volvulus 0.0286 0.3004 0.6659
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.1635 0.3252
Trypanosoma brucei PAB1-binding protein , putative 0.0107 0.0952 0.1224
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1442 0.1874
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0138 0.0164
Brugia malayi hypothetical protein 0.0069 0.052 0.0676
Mycobacterium leprae Probable lipase LipE 0.0072 0.056 1
Schistosoma mansoni hypothetical protein 0.0082 0.0672 0.1277
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0144 0.0064
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0114 0.0148
Loa Loa (eye worm) pigment dispersing factor receptor c 0.026 0.2703 0.3515
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.011 0.0143
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.011 0.0243
Brugia malayi nuclear hormone receptor 0.0033 0.011 0.0143
Loa Loa (eye worm) hypothetical protein 0.0696 0.7691 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0696 0.7691 1
Echinococcus multilocularis GPCR, family 2 0.0082 0.0672 0.0568
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.056 0.0852
Schistosoma mansoni alpha-glucosidase 0.0138 0.131 0.2727
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.056 0.0714
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.1177 0.2018
Brugia malayi ecdysteroid receptor 0.0033 0.011 0.0143
Onchocerca volvulus 0.0036 0.0144 0.0319
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.011 0.0143
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0418 0.451 0.5865
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0547 0.0711
Onchocerca volvulus 0.0033 0.011 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.011 0.0143
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3004 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.011 0.0243
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.056 0.1472
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0261 0.0339
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0144 0.0034
Schistosoma mansoni hypothetical protein 0.0082 0.0672 0.1277
Loa Loa (eye worm) hypothetical protein 0.026 0.2703 0.3515
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0372 0.0484
Loa Loa (eye worm) hypothetical protein 0.0356 0.38 0.494
Brugia malayi isocitrate dehydrogenase 0.0033 0.0114 0.0148
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.3345 0.434
Echinococcus multilocularis neuropeptide s receptor 0.0495 0.5398 0.5347
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0261 0.0339
Brugia malayi beta-lactamase family protein 0.0072 0.056 0.0728
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.056 0.1114
Schistosoma mansoni alpha-glucosidase 0.0138 0.131 0.2727
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.1442 0.1861
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0114 0.0133
Onchocerca volvulus 0.0093 0.0792 0.1756
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.1442 0.1861
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0048 0.0279 0.032
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0138 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0316 0.3345 0.434
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.1565 0.2752
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0072 0.056 0.0728
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0144 0.0355
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.011 0.0243
Schistosoma mansoni lipoxygenase 0.0088 0.0742 0.1436
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0547 0.0994
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0547 0.0994
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0114 0.0133
Leishmania major hypothetical protein, conserved 0.0107 0.0952 0.1238
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0239 0.0296
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0138 0.029
Trypanosoma cruzi PAB1-binding protein , putative 0.0107 0.0952 0.1224
Brugia malayi nuclear receptor NHR-88 0.0033 0.011 0.0143
Echinococcus granulosus tar DNA binding protein 0.0071 0.0547 0.0827
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.011 0.0143
Brugia malayi hypothetical protein 0.0107 0.0952 0.1238
Brugia malayi vesicular acetylcholine transporter unc-17 0.0418 0.451 0.5865
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.056 0.1024
Trypanosoma cruzi PAB1-binding protein , putative 0.0107 0.0952 0.1224
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.1565 0.2035
Echinococcus granulosus neuropeptide receptor A26 0.0495 0.5398 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0114 0.0227
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0143
Mycobacterium ulcerans hypothetical protein 0.0072 0.056 0.3427
Toxoplasma gondii LsmAD domain-containing protein 0.0107 0.0952 1
Echinococcus granulosus neuropeptide s receptor 0.0495 0.5398 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.011 0.0143
Plasmodium vivax SET domain protein, putative 0.0036 0.0144 0.0355
Loa Loa (eye worm) hypothetical protein 0.0072 0.056 0.0728
Brugia malayi latrophilin 2 splice variant baaae 0.0178 0.1763 0.2292
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0239 0.0296
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0129 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.011 0.0143
Schistosoma mansoni hypothetical protein 0.0082 0.0672 0.1277
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1565 0.1472
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.056 0.1114
Brugia malayi RNA binding protein 0.0071 0.0547 0.0711
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.011 0.0143
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.056 0.1472
Loa Loa (eye worm) hypothetical protein 0.0178 0.1763 0.2292
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0144 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0547 0.0994
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0143
Plasmodium falciparum ataxin-2 like protein, putative 0.0107 0.0952 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.011 0.0143
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.056 0.1114
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0696 0.7691 1
Brugia malayi steroid hormone receptor 0.0033 0.011 0.0143
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0138 0.018
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.056 0.1114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0144 0.0077
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.056 0.3427
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.011 0.0143
Brugia malayi Calcitonin receptor-like protein seb-1 0.026 0.2703 0.3515
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0696 0.7691 1
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0547 0.0711
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0418 0.451 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.1565 0.2035
Schistosoma mansoni vesicular acetylcholine transporter 0.0418 0.451 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.056 0.0728
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0144 0.0034
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.056 0.1114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.011 0.0143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.026 0.2703 0.3515
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0261 0.0285
Trypanosoma brucei glucosidase, putative 0.0036 0.0138 0.0164
Toxoplasma gondii hypothetical protein 0.0051 0.0314 0.2388
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.056 0.1472
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.056 0.1114
Onchocerca volvulus 0.0072 0.056 0.1242
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.011 0.0143
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0114 0.0004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0672 0.0568
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0114 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.011 0.0143
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0143
Schistosoma mansoni alpha glucosidase 0.0036 0.0138 0.0065
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.011 0.0143
Echinococcus multilocularis vesicular acetylcholine transporter 0.0418 0.451 0.445
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0547 0.0994
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.011 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.011 0.0143
Loa Loa (eye worm) hypothetical protein 0.0033 0.011 0.0143
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.011 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.011 0.0143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.011 0.0143
Trichomonas vaginalis esterase, putative 0.0072 0.056 0.1472
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0114 0.0004
Schistosoma mansoni hypothetical protein 0.0178 0.1763 0.3757

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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