TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 356.419 | Formula: C19H24N4O3
H donors: 1 H acceptors: 3 LogP: 1.58 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1ccc(cc1)CN1CCC(CC1)n1nccc1NC(=O)C
InChi: 1S/C19H24N4O3/c1-14(24)21-18-7-10-20-23(18)17-8-11-22(12-9-17)13-15-3-5-16(6-4-15)19(25)26-2/h3-7,10,17H,8-9,11-13H2,1-2H3,(H,21,24)
InChiKey: MGQLKGLXYDKGQA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0212	0.0491
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0366	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0212	0.0619
Trypanosoma cruzi	hexose transporter, putative	0.0063	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0212	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0212	0.2535
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0212	0.0491
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0212	0.2535
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0062	0.0484	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0212	0.0483
Entamoeba histolytica	protein kinase, putative	0.0062	0.0484	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0061	0.0469	0.0467
Trichomonas vaginalis	CAMK family protein kinase	0.0062	0.0484	0.1535
Brugia malayi	Pre-SET motif family protein	0.0217	0.2333	0.83
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0062	0.0484	0.1607
Plasmodium vivax	proline--tRNA ligase, putative	0.0071	0.0589	0.051
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0061	0.0469	0.9457
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0212	0.0619
Trichomonas vaginalis	esterase, putative	0.0039	0.0212	0.0491
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0029	0.0084	0.2954
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0045	0.0283	0.395
Leishmania major	glucose transporter, lmgt2	0.0063	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0212	0.0619
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0493	0.1571
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0212	0.0367
Schistosoma mansoni	protein kinase	0.0062	0.0484	0.0485
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0493	0.1571
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0493	0.8107
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0212	0.0483
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.004	0.0217	0.0511
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0029	0.0084	0.5
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0212	0.0483
Leishmania major	hypothetical protein, conserved	0.0039	0.0212	0.2535
Onchocerca volvulus		0.0052	0.0366	0.1083
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0045	0.0283	0.0766
Toxoplasma gondii	facilitative glucose transporter GT1	0.0203	0.216	0.3201
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0045	0.0283	0.3046
Toxoplasma gondii	ABC1 family protein	0.0039	0.0212	0.0197
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0212	0.7476
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0062	0.0484	0.1607
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0062	0.0484	0.0485
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0084	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0203	0.216	0.2518
Chlamydia trachomatis	lysine--tRNA ligase	0.0045	0.0283	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0062	0.0484	0.0485
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0212	0.0483
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0061	0.0469	0.1421
Entamoeba histolytica	protein kinase, putative	0.0062	0.0484	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0062	0.0484	0.0404
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0061	0.0469	0.0467
Brugia malayi	beta-lactamase family protein	0.0039	0.0212	0.0473
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0045	0.0283	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0062	0.0484	0.0617
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0062	0.0484	0.0404
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0102	0.0022
Schistosoma mansoni	hypothetical protein	0.0039	0.0208	0.0151
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0062	0.0484	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0212	0.0619
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0208	0.0151
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0212	0.7476
Onchocerca volvulus		0.0248	0.2691	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0212	0.0619
Plasmodium falciparum	lysine--tRNA ligase	0.0045	0.0283	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0062	0.0484	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0115	0.0038
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0212	0.0367
Onchocerca volvulus		0.0039	0.0212	0.0491
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0493	0.8107
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0061	0.0469	0.1477
Trypanosoma brucei	glucose transporter 1E	0.0063	0.0493	0.8107
Schistosoma mansoni	protein kinase	0.0062	0.0484	0.0485
Plasmodium falciparum	proline--tRNA ligase	0.0071	0.0589	0.051
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0484	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0484	0.1607
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0493	0.8107
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0203	0.216	0.2518
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0115	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Toxoplasma gondii	protein kinase, putative	0.0573	0.6571	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0208	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0063	0.0493	0.8107
Leishmania major	lysyl-tRNA synthetase, putative	0.0045	0.0283	0.395
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Trichomonas vaginalis	glucose transporter, putative	0.0063	0.0493	0.1571
Mycobacterium ulcerans	sugar transporter	0.0029	0.0084	0.2954
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0208	0.0151
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0212	0.0483
Echinococcus multilocularis	lysyl tRNA synthetase	0.0045	0.0283	0.0242
Brugia malayi	beta-lactamase	0.0039	0.0212	0.0473
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0038	0.0202	0.0447
Schistosoma mansoni	hypothetical protein	0.0052	0.0366	0.0342
Brugia malayi	Cam kinase protein 1	0.0062	0.0484	0.1476
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0045	0.0283	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0333	0.1059
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0203	0.216	0.2518
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0256	0.2794	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0115	0.0038
Treponema pallidum	prolyl-tRNA synthetase	0.0022	0	0.5
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0061	0.0469	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0115	0.0038
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0071	0.0589	1
Plasmodium vivax	hexose transporter	0.0203	0.216	0.2094
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0038	0.0202	0.0447
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0493	0.8107
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0212	0.0155
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0493	0.8107
Mycobacterium ulcerans	integral membrane transport protein	0.0029	0.0084	0.2954
Trypanosoma cruzi	hexose transporter, putative	0.0063	0.0493	0.8107
Echinococcus multilocularis	survival motor neuron protein 1	0.0256	0.2794	0.3287
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0212	0.0491
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0203	0.216	0.2518
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0115	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0212	0.0155
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0061	0.0469	0.0467
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0861	1	1
Echinococcus granulosus	lysyl tRNA synthetase	0.0045	0.0283	0.0242
Loa Loa (eye worm)	sugar transporter	0.0029	0.0084	0.0153
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0203	0.216	0.2518
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0212	0.0155
Schistosoma mansoni	protein kinase	0.0062	0.0484	0.0485
Plasmodium falciparum	hexose transporter	0.0203	0.216	0.2094
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0115	0.0038
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0062	0.0484	0.7919
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0062	0.0484	0.0485
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0212	0.0483
Brugia malayi	Pre-SET motif family protein	0.0031	0.0115	0.0117
Onchocerca volvulus		0.0039	0.0212	0.0491
Leishmania major	glucose transporter, lmgt3	0.0063	0.0493	0.8107
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0203	0.216	0.2518
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0062	0.0484	0.0404
Toxoplasma gondii	lysine-tRNA ligase	0.0045	0.0283	0.0308
Echinococcus granulosus	General substrate transporter	0.0174	0.1821	0.2106
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0203	0.216	0.2518
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0062	0.0484	0.0617
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0493	0.8107
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0062	0.0484	0.1476
Giardia lamblia	Prolyl-tRNA synthetase	0.0061	0.0469	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0062	0.0484	0.0485
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0062	0.0484	0.0617
Trypanosoma brucei	glucose transporter 2A	0.0063	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0283	0.0878
Echinococcus granulosus	calcium dependent protein kinase	0.0058	0.0438	0.043
Loa Loa (eye worm)	sugar transporter	0.0203	0.216	0.7697
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0084	0.0153
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0062	0.0484	0.0404
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0212	0.0483
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0212	0.7476
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0328	0.3649	0.3595
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0071	0.0589	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0217	0.2333	0.8326
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0062	0.0484	0.0404
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0493	0.1571
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0062	0.0484	0.0404
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0071	0.0589	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0115	0.0038
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0212	0.0483
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0493	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0469	0.1553
Schistosoma mansoni	glucose transport protein	0.0203	0.216	0.2518
Schistosoma mansoni	hypothetical protein	0.0203	0.216	0.2518
Echinococcus granulosus	microtubule associated protein 2	0.0721	0.833	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0063	0.0493	0.8107
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0212	0.0473
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0212	0.2535
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0469	0.1553
Schistosoma mansoni	lysyl-tRNA synthetase	0.0045	0.0283	0.0242
Echinococcus multilocularis	calcium dependent protein kinase	0.0058	0.0438	0.043
Leishmania major	protein kinase, putative	0.0062	0.0484	0.7919
Schistosoma mansoni	lysyl-tRNA synthetase	0.0045	0.0283	0.0242
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0029	0.0084	0.2954
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0212	0.0483
Trypanosoma cruzi	hexose transporter, putative	0.0063	0.0493	0.8107
Trichomonas vaginalis	set domain proteins, putative	0.0248	0.2691	1
Brugia malayi	hypothetical protein	0.0039	0.0208	0.0459
Brugia malayi	lysyl-tRNA synthetase	0.0045	0.0283	0.0736
Mycobacterium ulcerans	lipase LipD	0.0039	0.0212	0.7476
Trichomonas vaginalis	sugar transporter, putative	0.0063	0.0493	0.1571
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0062	0.0484	0.0485
Leishmania major	glucose transporter, lmgt1	0.0063	0.0493	0.8107
Schistosoma mansoni	microtubule-associated protein tau	0.0721	0.833	1
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0493	0.8107
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0062	0.0484	0.0404
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0251	0.2733	1
Onchocerca volvulus		0.0039	0.0212	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Plasmodium vivax	lysine--tRNA ligase, putative	0.0045	0.0283	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0212	0.0491
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0061	0.0469	0.0467
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0062	0.0484	0.0485
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0115	0.0038
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0212	0.7476
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0071	0.0589	0.0779
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0063	0.0493	0.8107
Echinococcus granulosus	survival motor neuron protein 1	0.0256	0.2794	0.3287
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0071	0.0589	1
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0212	0.0129
Schistosoma mansoni	glucose transport protein	0.0203	0.216	0.2518
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0328	0.3649	0.3595
Echinococcus multilocularis	General substrate transporter	0.0174	0.1821	0.2106
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0212	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0212	0.0619
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0212	0.0619
Brugia malayi	Sugar transporter family protein	0.0203	0.216	0.7662
Echinococcus multilocularis	microtubule associated protein 2	0.0721	0.833	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0328	0.3649	0.5495
Trichomonas vaginalis	glucose transporter, putative	0.0063	0.0493	0.1571
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0212	0.0491
Trypanosoma brucei	glucose transporter, putative	0.0063	0.0493	0.8107
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0071	0.0589	1
Trichomonas vaginalis	conserved hypothetical protein	0.0203	0.216	0.7965
Plasmodium falciparum	protein kinase 7	0.0573	0.6571	0.6542
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0154	0.1383
Trypanosoma cruzi	hexose transporter	0.0063	0.0493	0.8107
Plasmodium vivax	SET domain protein, putative	0.0031	0.0115	0.0032
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0062	0.0484	0.0404
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0063	0.0493	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0061	0.0469	0.1421
Brugia malayi	hypothetical protein	0.0256	0.2794	1
Entamoeba histolytica	hypothetical protein	0.0045	0.0283	0.2729
Onchocerca volvulus		0.0031	0.0115	0.0121
Schistosoma mansoni	glucose transport protein	0.0203	0.216	0.2518
Giardia lamblia	Lysyl-tRNA synthetase	0.0045	0.0283	0.5182
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0203	0.216	0.2518
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0084	0.0153
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0115	0.0049
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0366	0.1042
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0045	0.0283	0.395
Brugia malayi	beta-lactamase family protein	0.0039	0.0212	0.0473
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0212	0.0155

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 732121