Detailed information for compound 734821

Basic information

Technical information
  • TDR Targets ID: 734821
  • Name: 3-[(5-hydroxypyridine-3-carbonyl)amino]propan oic acid
  • MW: 210.187 | Formula: C9H10N2O4
  • H donors: 3 H acceptors: 5 LogP: -0.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCNC(=O)c1cncc(c1)O
  • InChi: 1S/C9H10N2O4/c12-7-3-6(4-10-5-7)9(15)11-2-1-8(13)14/h3-5,12H,1-2H2,(H,11,15)(H,13,14)
  • InChiKey: FHPYYJWFQPMLGL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[(5-hydroxy-3-pyridyl)-oxomethyl]amino]propanoic acid
  • 3-[(5-hydroxypyridine-3-carbonyl)amino]propionic acid
  • 3-[(5-hydroxypyridin-3-yl)carbonylamino]propanoic acid
  • 3-[(5-Hydroxy-pyridine-3-carbonyl)-amino]-propionic acid
  • BAS 01947694
  • ST5011416
  • CBKinase1_013350
  • CBKinase1_000950
  • Oprea1_870277
  • Oprea1_636079
  • 3-[(5-hydroxypyridin-1-ium-3-carbonyl)amino]propanoate
  • 3-[[(5-hydroxy-3-pyridin-1-iumyl)-oxomethyl]amino]propanoate
  • 3-[(5-hydroxypyridin-1-ium-3-carbonyl)amino]propionate
  • 3-[(5-hydroxypyridin-1-ium-3-yl)carbonylamino]propanoate
  • STOCK1N-02694

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0072 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1408 0.202
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.0343 0.0326
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0183 0.0778
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0057 0.0625 0.0554
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0084 0.0224
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0084 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0253 0.024
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1408 0.3625
Echinococcus multilocularis dna polymerase eta 0.0019 0.0084 0.0014
Loa Loa (eye worm) hypothetical protein 0.0112 0.1408 0.1605
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0018 0.0072 0.0024
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.1408 0.1343
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0183 0.0157
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0679 0.4516
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0137 0.0098
Onchocerca volvulus 0.0112 0.1408 0.202
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.1408 0.1343
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0625 0.0554
Echinococcus multilocularis solute carrier family 5 0.0037 0.0343 0.0326
Loa Loa (eye worm) hypothetical protein 0.0339 0.4619 0.5463
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.1408 0.1343
Plasmodium vivax hypothetical protein, conserved 0.0112 0.1408 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.1408 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0183 0.0782
Loa Loa (eye worm) hypothetical protein 0.0026 0.0183 0.0134
Onchocerca volvulus 0.0061 0.0679 0.0919
Brugia malayi G-protein alpha subunit 0.0018 0.0072 0.0024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0094 0.1146 0.1625
Onchocerca volvulus 0.0112 0.1408 0.202
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.0343 0.0326
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0094 0.1146 0.1625
Mycobacterium tuberculosis Conserved protein 0.0112 0.1408 0.1343
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0072 0.0024
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0277 0.3744 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.008 0.0005
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.008 0.0012
Leishmania major DNA polymerase kappa, putative 0.0019 0.0084 0.0012
Entamoeba histolytica CAAX amino terminal protease family 0.0057 0.0625 0.1505
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0094 0.1146 0.803
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0084 0.0224
Echinococcus granulosus histone acetyltransferase KAT2B 0.0311 0.4218 0.4982
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0084 0.0014
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.1408 0.1343
Toxoplasma gondii ABC1 family protein 0.0112 0.1408 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0183 0.0302
Schistosoma mansoni hypothetical protein 0.0508 0.7018 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0424 0.5831 0.6919
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0183 0.0778
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0253 0.0217
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.1408 0.1605
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0183 0.0109
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0183 0.1086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0424 0.5831 0.8291
Treponema pallidum hypothetical protein 0.0057 0.0625 1
Trypanosoma brucei unspecified product 0.0019 0.0084 0.0224
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0212 0.0566
Brugia malayi Sodium:solute symporter family protein 0.0037 0.0343 0.0349
Chlamydia trachomatis hypothetical protein 0.0057 0.0625 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1408 0.202
Toxoplasma gondii CAAX amino terminal protease family protein 0.0057 0.0625 0.4103
Plasmodium vivax importin-beta 2, putative 0.0028 0.0212 0.0998
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.008 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1408 0.3625
Echinococcus multilocularis snurportin 1 0.03 0.4069 0.4802
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0212 0.0566
Loa Loa (eye worm) beta-lactamase 0.0112 0.1408 0.1605
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0183 0.0282
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.032 0.4345 0.5135
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0253 0.0217
Giardia lamblia DINP protein human, muc B family 0.0019 0.0084 0.0012
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0094 0.1146 0.803
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.008 0.0212
Echinococcus granulosus snurportin 1 0.03 0.4069 0.4802
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0183 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0084 0.0224
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0679 0.073
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.1408 0.1605
Loa Loa (eye worm) hypothetical protein 0.0112 0.1408 0.1605
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.1408 0.1625
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0084 0.0014
Brugia malayi Muscleblind-like protein 0.0605 0.8395 1
Schistosoma mansoni ap endonuclease 0.0019 0.008 0.0011
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0057 0.0625 0.0554
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0084 0.0033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1408 0.1923
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0084 0.0224
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0277 0.3744 0.5287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0424 0.5831 0.8291
Mycobacterium tuberculosis Probable integral membrane protein 0.0057 0.0625 0.0554
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0183 0.049
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0277 0.3744 1
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0018 0.0072 0.0024
Brugia malayi beta-lactamase family protein 0.0112 0.1408 0.1625
Mycobacterium tuberculosis Conserved protein 0.0112 0.1408 0.1343
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0322 0.0361
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0277 0.3744 0.5287
Echinococcus granulosus dna polymerase kappa 0.0019 0.0084 0.0014
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.0343 0.0326
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0183 0.0283
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0424 0.5831 0.6919
Brugia malayi GH02984p 0.0339 0.4619 0.5474
Leishmania major DNA polymerase eta, putative 0.0019 0.0084 0.0012
Entamoeba histolytica hypothetical protein 0.0036 0.0322 0.0682
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0084 0.0224
Schistosoma mansoni inositol transporter 0.0037 0.0343 0.0391
Mycobacterium ulcerans hypothetical protein 0.0112 0.1408 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.1408 0.1343
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0084 0.0224
Schistosoma mansoni ap endonuclease 0.0019 0.008 0.0011
Schistosoma mansoni DNA polymerase eta 0.0019 0.0084 0.0017
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0084 0.0018
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0084 0.0038
Brugia malayi hypothetical protein 0.0026 0.0183 0.0157
Brugia malayi hypothetical protein 0.0018 0.0072 0.0024
Schistosoma mansoni hypothetical protein 0.0031 0.0253 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0679 0.0875
Plasmodium vivax SET domain protein, putative 0.0061 0.0679 0.4516
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0183 0.0778
Loa Loa (eye worm) hypothetical protein 0.0028 0.0212 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0084 0.0224
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.009 0.0105
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0084 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0084 0.0012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1201 0.1357
Schistosoma mansoni hypothetical protein 0.0508 0.7018 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.009 0.0015
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0018 0.0072 0.0024
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.008 0.5
Plasmodium falciparum protease, putative 0.0057 0.0625 0.5703
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0424 0.5831 0.6919
Entamoeba histolytica hypothetical protein 0.0036 0.0322 0.0682
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.008 0.0009
Echinococcus multilocularis muscleblind protein 1 0.0605 0.8395 1
Mycobacterium leprae conserved hypothetical protein 0.0112 0.1408 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0084 0.0224
Echinococcus granulosus geminin 0.0508 0.7018 0.8346
Loa Loa (eye worm) hypothetical protein 0.0605 0.8395 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0084 0.0017
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0183 0.0302
Brugia malayi acetyltransferase, GNAT family protein 0.032 0.4345 0.5146
Schistosoma mansoni inositol transporter 0.0037 0.0343 0.0391
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0277 0.3744 1
Loa Loa (eye worm) hypothetical protein 0.0605 0.8395 1
Echinococcus granulosus high affinity choline transporter 1 0.0339 0.4619 0.5463
Schistosoma mansoni hypothetical protein 0.03 0.4069 0.5754
Loa Loa (eye worm) hypothetical protein 0.0112 0.1408 0.1605
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.4069 0.4802
Echinococcus granulosus muscleblind protein 0.0605 0.8395 1
Echinococcus granulosus CAAX prenyl protease 2 0.0277 0.3744 0.4412
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0137 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0084 0.0224
Brugia malayi beta-lactamase family protein 0.0112 0.1408 0.1625
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0018 0.0072 0.0024
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.009 0.0075
Loa Loa (eye worm) hypothetical protein 0.0031 0.0253 0.0217
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0253 0.0217
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0183 0.0778
Echinococcus granulosus importin subunit beta 1 0.0028 0.0212 0.0168
Giardia lamblia Histone acetyltransferase GCN5 0.0086 0.1035 0.2608
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.009 0.0075
Trichomonas vaginalis set domain proteins, putative 0.0485 0.6684 1
Schistosoma mansoni hypothetical protein 0.0031 0.0253 0.026
Loa Loa (eye worm) hypothetical protein 0.0026 0.0183 0.0133
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0084 0.0224
Loa Loa (eye worm) hypothetical protein 0.0112 0.1408 0.1605
Entamoeba histolytica acetyltransferase, GNAT family 0.0086 0.1035 0.2623
Loa Loa (eye worm) acetyltransferase 0.032 0.4345 0.5135
Mycobacterium tuberculosis Conserved protein 0.0112 0.1408 0.1343
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.1408 0.1343
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0014
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0426 0.585 0.6943
Schistosoma mansoni high-affinity choline transporter 0.0339 0.4619 0.6546
Brugia malayi Pre-SET motif family protein 0.0426 0.585 0.695
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0647 0.0692
Echinococcus granulosus GPCR family 2 0.0031 0.0253 0.0217
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0018 0.0072 0.0024
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0212 0.0168
Entamoeba histolytica CAAX prenyl protease family 0.0277 0.3744 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0322 0.0301
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0084 0.0018
Brugia malayi RNA, U transporter 1 0.008 0.0947 0.1072
Loa Loa (eye worm) hypothetical protein 0.0061 0.0679 0.073
Plasmodium falciparum histone acetyltransferase GCN5 0.0086 0.1035 1
Giardia lamblia Hypothetical protein 0.0277 0.3744 1
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.0343 0.0326
Entamoeba histolytica hypothetical protein 0.0036 0.0322 0.0682
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.0021
Plasmodium falciparum importin beta, putative 0.0028 0.0212 0.1387
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0762 0.0851
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0084 0.0012
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.0343 0.0326
Plasmodium vivax protease, putative 0.0057 0.0625 0.4103
Onchocerca volvulus 0.0485 0.6684 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0084 0.001
Brugia malayi hypothetical protein 0.0036 0.0322 0.0324
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.1408 0.1343
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0212 0.0998
Toxoplasma gondii hypothetical protein 0.0057 0.0625 0.4103
Echinococcus granulosus solute carrier family 5 0.0037 0.0343 0.0326
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0183 0.0282
Leishmania major hypothetical protein, conserved 0.0026 0.0183 0.0283
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.1408 0.376
Mycobacterium ulcerans hypothetical protein 0.0026 0.0183 0.0778
Brugia malayi CAAX amino terminal protease family protein 0.0277 0.3744 0.4425
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0183 0.0778
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1201 0.1377
Echinococcus granulosus dna polymerase eta 0.0019 0.0084 0.0014
Loa Loa (eye worm) hypothetical protein 0.0098 0.1201 0.1357
Leishmania major importin beta-1 subunit, putative 0.0023 0.0137 0.0156
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.0343 0.0326
Loa Loa (eye worm) hypothetical protein 0.0067 0.0762 0.0829
Trypanosoma brucei CAAX amino terminal protease, putative 0.0277 0.3744 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0183 0.0133
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.032 0.4345 0.6153
Schistosoma mansoni hypothetical protein 0.0031 0.0253 0.026
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0018 0.0072 0.0024
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0094 0.1146 0.803
Mycobacterium ulcerans lipase LipD 0.0112 0.1408 1
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1408 0.202
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0084 0.0224
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0253 0.0217
Toxoplasma gondii hypothetical protein 0.0057 0.0625 0.4103
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0084 0.0224
Trichomonas vaginalis esterase, putative 0.0112 0.1408 0.202
Echinococcus granulosus histone acetyltransferase KAT2B 0.0094 0.1146 0.1291
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0183 0.0157
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.0343 0.1987
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.0021
Echinococcus multilocularis GPCR, family 2 0.0031 0.0253 0.0217
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0084 0.0014
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0277 0.3744 0.5553
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.008 0.0033
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.1408 0.1605
Onchocerca volvulus 0.0026 0.0183 0.0168
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0137 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0679 0.0875
Leishmania major hypothetical protein, conserved 0.0112 0.1408 0.3625
Schistosoma mansoni hypothetical protein 0.0067 0.0762 0.0994
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0679 0.0875
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0084 0.0017
Brugia malayi Pre-SET motif family protein 0.0061 0.0679 0.0752
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.0343 0.0326
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0084 0.001
Loa Loa (eye worm) hypothetical protein 0.0112 0.1408 0.1605
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1408 0.202
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0084 0.0012
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0137 0.0156
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0183 0.0778
Mycobacterium ulcerans integral membrane protein 0.0057 0.0625 0.4103
Onchocerca volvulus 0.0112 0.1408 0.202
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0183 0.1086
Mycobacterium ulcerans hypothetical protein 0.0057 0.0625 0.4103
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0679 0.073
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.0021
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0253 0.024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0343 0.0326
Schistosoma mansoni sodium/solute symporter 0.0037 0.0343 0.0391
Echinococcus multilocularis muscleblind protein 0.0605 0.8395 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0084 0.0224
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0424 0.5831 0.6926
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0183 0.0283
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0084 0.0224
Entamoeba histolytica hypothetical protein 0.0023 0.0137 0.0176
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0424 0.5831 0.6919
Loa Loa (eye worm) hypothetical protein 0.0277 0.3744 0.4412
Brugia malayi beta-lactamase 0.0112 0.1408 0.1625
Echinococcus multilocularis geminin 0.0508 0.7018 0.8346
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0084 0.0012
Entamoeba histolytica CAAX amino terminal protease family 0.0057 0.0625 0.1505
Loa Loa (eye worm) hypothetical protein 0.0026 0.0183 0.0133
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0424 0.5831 0.6919
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.008 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0424 0.5831 0.8291
Echinococcus multilocularis CAAX prenyl protease 2 0.0277 0.3744 0.4412
Mycobacterium ulcerans hypothetical protein 0.0057 0.0625 0.4103
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0183 0.0778
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0183 0.0282
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0253 0.0217
Brugia malayi Importin beta-1 subunit 0.0028 0.0212 0.0192
Echinococcus multilocularis high affinity choline transporter 1 0.0339 0.4619 0.5463
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0183 0.0302
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1408 0.1923
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0322 0.0301
Schistosoma mansoni hypothetical protein 0.0036 0.0322 0.0361
Loa Loa (eye worm) hypothetical protein 0.0112 0.1408 0.1605
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0084 0.0033
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0679 0.073
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0084 0.0012
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0183 0.0157
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0084 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.0021
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0084 0.0038
Entamoeba histolytica hypothetical protein 0.0036 0.0322 0.0682
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0183 0.0782
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0018 0.0072 0.0024
Onchocerca volvulus 0.0037 0.0343 0.0411
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0679 0.0875
Schistosoma mansoni hypothetical protein 0.0031 0.0253 0.026
Mycobacterium ulcerans beta-lactamase 0.0112 0.1408 1
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.1408 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.008 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1408 0.202
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1201 0.1377
Mycobacterium leprae Probable lipase LipE 0.0112 0.1408 1
Schistosoma mansoni importin beta-1 0.0028 0.0212 0.0202

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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