Detailed information for compound 737758

Basic information

Technical information
  • TDR Targets ID: 737758
  • Name: N-(2-methylsulfanylphenyl)-2-(methylsulfonyl- naphthalen-1-ylamino)acetamide
  • MW: 400.514 | Formula: C20H20N2O3S2
  • H donors: 1 H acceptors: 3 LogP: 3.73 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccccc1NC(=O)CN(S(=O)(=O)C)c1cccc2c1cccc2
  • InChi: 1S/C20H20N2O3S2/c1-26-19-13-6-5-11-17(19)21-20(23)14-22(27(2,24)25)18-12-7-9-15-8-3-4-10-16(15)18/h3-13H,14H2,1-2H3,(H,21,23)
  • InChiKey: VYZOCFZRCFIUOF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-methylsulfanylphenyl)-2-(methylsulfonyl-(1-naphthyl)amino)acetamide
  • 2-(methylsulfonyl-(1-naphthyl)amino)-N-[2-(methylthio)phenyl]acetamide
  • 2-(mesyl-(1-naphthyl)amino)-N-[2-(methylthio)phenyl]acetamide
  • N-(2-methylsulfanylphenyl)-2-(methylsulfonyl-naphthalen-1-yl-amino)ethanamide
  • ZINC01121784
  • CBKinase1_019613
  • CBKinase1_007213
  • T5296853

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Loa Loa (eye worm) hypothetical protein 0.0229 0.11 0.4928
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0061 0.0167 0.0198
Plasmodium falciparum calcium-dependent protein kinase 4 0.0132 0.0564 0.0404
Brugia malayi hypothetical protein 0.0061 0.0167 0.0721
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0061 0.0167 0.4131
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0027 0.0026
Echinococcus granulosus lysyl tRNA synthetase 0.0096 0.0364 0.0452
Brugia malayi Pre-SET motif family protein 0.0222 0.1063 0.476
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1092 1
Trichomonas vaginalis glucose transporter, putative 0.0134 0.0573 0.2481
Leishmania major lysyl-tRNA synthetase, putative 0.0096 0.0364 0.5266
Echinococcus multilocularis calcium dependent protein kinase 0.0124 0.0518 0.0634
Toxoplasma gondii sugar transporter ST1 0.0061 0.0167 0.0243
Schistosoma mansoni protein kinase 0.0132 0.0563 0.0691
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0167 0.0634
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0082 0.0284 0.2409
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0167 0.0634
Toxoplasma gondii facilitative glucose transporter GT1 0.0432 0.2226 0.3366
Plasmodium vivax proline--tRNA ligase, putative 0.0151 0.0668 0.0662
Leishmania major glucose transporter/membrane transporter D2, putative 0.0134 0.0573 0.8519
Plasmodium falciparum calcium-dependent protein kinase 5 0.0132 0.0564 0.0404
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0061 0.0167 0.4131
Echinococcus multilocularis microtubule associated protein 2 0.1487 0.807 1
Trypanosoma brucei glucose transporter, putative 0.0134 0.0573 0.8519
Brugia malayi Sugar transporter family protein 0.0061 0.0167 0.0721
Schistosoma mansoni lysyl-tRNA synthetase 0.0096 0.0364 0.0444
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Schistosoma mansoni protein kinase 0.0132 0.0563 0.0691
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Brugia malayi Sugar transporter family protein 0.0061 0.0167 0.0721
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0019 0.0024
Echinococcus granulosus microtubule associated protein 2 0.1487 0.807 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0132 0.0564 0.0845
Echinococcus granulosus solute carrier family 22 0.0061 0.0167 0.0206
Echinococcus multilocularis lysyl tRNA synthetase 0.0096 0.0364 0.0444
Trypanosoma cruzi glucose transporter, putative 0.0061 0.0167 0.2175
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0151 0.0668 0.1003
Schistosoma mansoni glucose transport protein 0.0432 0.2226 0.2752
Echinococcus multilocularis solute carrier family 22 0.0061 0.0167 0.0198
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Trypanosoma cruzi hexose transporter, putative 0.0073 0.0236 0.3257
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0019 0.0058
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0432 0.2226 0.2758
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Plasmodium falciparum protein kinase 7 0.1221 0.66 0.6542
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0027 0.0021
Trypanosoma brucei glucose transporter, putative 0.0134 0.0573 0.8519
Trichomonas vaginalis set domain proteins, putative 0.0253 0.1233 0.5485
Plasmodium falciparum calcium-dependent protein kinase 2 0.0132 0.0564 0.0404
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0027 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0096 0.0364 0.5266
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0432 0.2226 0.2758
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0094
Onchocerca volvulus 0.0061 0.0167 0.1305
Loa Loa (eye worm) hypothetical protein 0.0108 0.0429 0.1906
Entamoeba histolytica hypothetical protein 0.0096 0.0364 0.4237
Brugia malayi hypothetical protein 0.007 0.0218 0.0954
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0429 0.1906
Trypanosoma brucei glucose transporter, putative 0.0134 0.0573 0.8519
Schistosoma mansoni sugar transporter 0.0061 0.0167 0.0198
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Echinococcus multilocularis solute carrier family 22 0.0061 0.0167 0.0198
Onchocerca volvulus 0.0036 0.0027 0.0169
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0132 0.0563 0.2509
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.013 0.0549 0.2371
Schistosoma mansoni hypothetical protein 0.0034 0.0019 0.0016
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.013 0.0549 0.957
Trypanosoma cruzi hexose transporter, putative 0.0061 0.0167 0.2175
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Loa Loa (eye worm) hypothetical protein 0.0096 0.0364 0.1613
Leishmania major glucose transporter, lmgt2 0.0134 0.0573 0.8519
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Onchocerca volvulus 0.0036 0.0027 0.0169
Trypanosoma brucei glucose transporter 1E 0.0134 0.0573 0.8519
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0085 0.0299 0.1234
Onchocerca volvulus 0.0061 0.0167 0.1305
Leishmania major glucose transporter, lmgt3 0.0134 0.0573 0.8519
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0061 0.0167 0.1308
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0089 0.0371
Echinococcus granulosus General substrate transporter 0.0371 0.1889 0.2341
Chlamydia trachomatis lysine--tRNA ligase 0.0096 0.0364 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0132 0.0564 0.0558
Onchocerca volvulus 0.0061 0.0167 0.1305
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Toxoplasma gondii transporter, major facilitator family protein 0.0061 0.0167 0.0243
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Onchocerca volvulus 0.0061 0.0167 0.1305
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0432 0.2226 0.2752
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Leishmania major protein kinase, putative 0.0132 0.0563 0.8372
Trypanosoma cruzi sugar transporter, putative 0.0061 0.0167 0.2175
Loa Loa (eye worm) hypothetical protein 0.013 0.0549 0.2442
Loa Loa (eye worm) hypothetical protein 0.0132 0.0563 0.2509
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0132 0.0563 0.8372
Onchocerca volvulus 0.0061 0.0167 0.1305
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0094
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0563 0.0691
Onchocerca volvulus 0.0061 0.0167 0.1305
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0019 0.0058
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Loa Loa (eye worm) sugar transporter 0.0432 0.2226 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0019 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Onchocerca volvulus 0.0061 0.0167 0.1305
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0094
Plasmodium vivax calcium-dependent protein kinase, putative 0.0132 0.0564 0.0558
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0094
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0563 0.0691
Schistosoma mansoni glucose transporter 0.0061 0.0167 0.0198
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0132 0.0564 0.0558
Echinococcus granulosus solute carrier family 22 0.0061 0.0167 0.0206
Trypanosoma brucei THT1 - hexose transporter, putative 0.0134 0.0573 0.8519
Toxoplasma gondii protein kinase, putative 0.1221 0.66 1
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0167 0.0634
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0096 0.0364 1
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Onchocerca volvulus 0.0061 0.0167 0.1305
Schistosoma mansoni hypothetical protein 0.0034 0.0019 0.0016
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0218 0.027
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Echinococcus multilocularis solute carrier family 22 0.0061 0.0167 0.0198
Plasmodium falciparum calcium-dependent protein kinase 3 0.0132 0.0564 0.0404
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0096 0.0364 0.6469
Schistosoma mansoni glucose transport protein 0.0432 0.2226 0.2752
Echinococcus granulosus Sugar transporter ERD6 protein 0.0061 0.0167 0.0206
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Echinococcus granulosus solute carrier family 22 0.0061 0.0167 0.0206
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Echinococcus multilocularis solute carrier family 22 0.0061 0.0167 0.0198
Schistosoma mansoni hypothetical protein 0.0432 0.2226 0.2752
Trichomonas vaginalis glucose transporter, putative 0.0134 0.0573 0.2481
Schistosoma mansoni survival motor neuron protein 0.0047 0.0089 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Brugia malayi Sugar transporter family protein 0.0432 0.2226 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0061 0.0167 0.5
Brugia malayi major facilitator superfamily protein 0.0061 0.0167 0.0721
Echinococcus multilocularis General substrate transporter 0.0371 0.1889 0.2334
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0061 0.0167 0.1308
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Plasmodium vivax CDK-related protein kinase 6, putative 0.1835 1 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0096 0.0364 1
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Onchocerca volvulus 0.0047 0.0089 0.0671
Onchocerca volvulus 0.0061 0.0167 0.1305
Brugia malayi hypothetical protein 0.0229 0.11 0.4928
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0563 0.0691
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0132 0.0563 0.2509
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0019 0.0016
Trypanosoma brucei glucose transporter, putative 0.0134 0.0573 0.8519
Schistosoma mansoni glucose transport protein 0.0432 0.2226 0.2752
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0132 0.0564 0.0845
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0132 0.0563 0.0691
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0132 0.0563 0.0698
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0027 0.0094
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.013 0.0549 0.068
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.0563 0.0691
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0132 0.0564 0.0845
Trypanosoma cruzi hexose transporter, putative 0.0134 0.0573 0.8519
Onchocerca volvulus 0.0253 0.1233 1
Trichomonas vaginalis glucose transporter, putative 0.0061 0.0167 0.0634
Toxoplasma gondii sugar transporter ST3 0.0061 0.0167 0.0243
Trypanosoma brucei sugar transporter, putative 0.0061 0.0167 0.2175
Schistosoma mansoni sugar transporter 0.0061 0.0167 0.0198
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0698 0.3702 0.3698
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0151 0.0668 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132 0.0563 0.0698
Echinococcus multilocularis GPCR, family 2 0.0034 0.0019 0.0016
Leishmania major glucose transporter, lmgt1 0.0134 0.0573 0.8519
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0218 0.0263
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.013 0.0549 0.2442
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0019 0.0058
Plasmodium falciparum hexose transporter 0.0432 0.2226 0.2094
Brugia malayi beta-lactamase family protein 0.0036 0.0027 0.0094
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0053 0.0125 0.0533
Onchocerca volvulus 0.0036 0.0027 0.0169
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0432 0.2226 0.2752
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Toxoplasma gondii sugar transporter ST2 0.0061 0.0167 0.0243
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.013 0.0549 0.0672
Echinococcus granulosus calcium dependent protein kinase 0.0124 0.0518 0.0642
Giardia lamblia Lysyl-tRNA synthetase 0.0096 0.0364 0.5182
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.0573 0.2481
Onchocerca volvulus 0.0061 0.0167 0.1305
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0432 0.2226 0.2752
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0096 0.0364 0.1534
Brugia malayi hypothetical protein 0.0061 0.0167 0.0721
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0218 0.0263
Trypanosoma cruzi hexose transporter 0.0134 0.0573 0.8519
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132 0.0563 0.0698
Schistosoma mansoni hypothetical protein 0.0034 0.0019 0.0016
Trichomonas vaginalis sugar transporter, putative 0.0134 0.0573 0.2481
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.0573 0.2481
Plasmodium vivax hexose transporter 0.0432 0.2226 0.2221
Schistosoma mansoni hypothetical protein 0.007 0.0218 0.0263
Plasmodium vivax sugar transporter, putative 0.0061 0.0167 0.016
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.013 0.0549 1
Schistosoma mansoni protein kinase 0.0132 0.0563 0.0691
Treponema pallidum prolyl-tRNA synthetase 0.0046 0.0084 0.5
Onchocerca volvulus 0.0061 0.0167 0.1305
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.024 0.1051
Plasmodium falciparum proline--tRNA ligase 0.0151 0.0668 0.051
Loa Loa (eye worm) beta-lactamase 0.0036 0.0027 0.0094
Trypanosoma brucei glucose transporter, putative 0.0134 0.0573 0.8519
Plasmodium falciparum mitogen-activated protein kinase 2 0.0698 0.3702 0.3595
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0432 0.2226 0.2758
Brugia malayi beta-lactamase family protein 0.0036 0.0027 0.0094
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Echinococcus multilocularis synaptic vesicle 2 protein 0.0061 0.0167 0.0198
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.1063 0.476
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0698 0.3702 0.5604
Schistosoma mansoni microtubule-associated protein tau 0.1487 0.807 1
Trichomonas vaginalis sugar transporter, putative 0.0134 0.0573 0.2481
Trypanosoma brucei glucose transporter, putative 0.0134 0.0573 0.8519
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0151 0.0668 1
Onchocerca volvulus 0.0061 0.0167 0.1305
Onchocerca volvulus Putative transporter 0.0061 0.0167 0.1305
Trypanosoma cruzi hexose transporter, putative 0.0134 0.0573 0.8519
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0432 0.2226 0.2758
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.013 0.0549 0.0672
Echinococcus granulosus solute carrier family 22 0.0061 0.0167 0.0206
Brugia malayi lysyl-tRNA synthetase 0.0096 0.0364 0.1613
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.11 0.1356
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Schistosoma mansoni hypothetical protein 0.0034 0.0019 0.0016
Trichomonas vaginalis sugar transport protein, putative 0.0061 0.0167 0.0634
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Loa Loa (eye worm) sugar transporter 0.0061 0.0167 0.0721
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0082 0.0284 0.4923
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0082 0.0284 0.2409
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0061 0.0167 0.2175
Plasmodium falciparum calcium-dependent protein kinase 1 0.0132 0.0564 0.0404
Toxoplasma gondii ABC1 family protein 0.0036 0.0027 0.0031
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0027 0.0026
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Loa Loa (eye worm) major facilitator superfamily transporter 0.0061 0.0167 0.0721
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0432 0.2226 0.2752
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0132 0.0564 0.0558
Trichomonas vaginalis CAMK family protein kinase 0.0132 0.0563 0.2438
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0151 0.0668 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Schistosoma mansoni sugar transporter 0.0061 0.0167 0.0198
Trypanosoma cruzi hexose transporter, putative 0.0134 0.0573 0.8519
Echinococcus granulosus GPCR family 2 0.0034 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.0074 0.024 0.1051
Entamoeba histolytica protein kinase, putative 0.0132 0.0563 1
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0061 0.0167 0.0198
Leishmania major hypothetical protein, conserved 0.0061 0.0167 0.2175
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0429 0.1906
Toxoplasma gondii lysine-tRNA ligase 0.0096 0.0364 0.0543
Loa Loa (eye worm) hypothetical protein 0.0034 0.0019 0.0058
Brugia malayi Major Facilitator Superfamily protein 0.0061 0.0167 0.0721
Entamoeba histolytica protein kinase, putative 0.0132 0.0563 1
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0019 0.0016
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0096 0.0364 0.5266
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0094
Schistosoma mansoni lysyl-tRNA synthetase 0.0096 0.0364 0.0444
Loa Loa (eye worm) hypothetical protein 0.013 0.0549 0.2442
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0046 0.0084 0.1669
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0132 0.0563 0.2509
Brugia malayi Cam kinase protein 1 0.0132 0.0563 0.2509
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0721
Onchocerca volvulus 0.0061 0.0167 0.1305
Brugia malayi hypothetical protein 0.0061 0.0167 0.0721
Plasmodium falciparum lysine--tRNA ligase 0.0096 0.0364 0.0201
Schistosoma mansoni hypothetical protein 0.0074 0.024 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0167 0.0634
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0132 0.0563 0.0698
Mycobacterium ulcerans integral membrane transport protein 0.0061 0.0167 0.4131
Brugia malayi major facilitator superfamily protein 0.0061 0.0167 0.0721
Trypanosoma brucei THT1 - hexose transporter, putative 0.0134 0.0573 0.8519
Giardia lamblia Prolyl-tRNA synthetase 0.013 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0027 0.0094
Trypanosoma brucei glucose transporter, putative 0.0134 0.0573 0.8519
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0151 0.0668 1
Trichomonas vaginalis conserved hypothetical protein 0.0432 0.2226 1
Brugia malayi Major Facilitator Superfamily protein 0.0061 0.0167 0.0721
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0027 0.0094
Onchocerca volvulus 0.0061 0.0167 0.1305
Schistosoma mansoni hypothetical protein 0.0047 0.0089 0.0102
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Onchocerca volvulus 0.0061 0.0167 0.1305
Trypanosoma brucei glucose transporter, putative 0.0134 0.0573 0.8519
Trypanosoma brucei THT1 - hexose transporter, putative 0.0134 0.0573 0.8519
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0167 0.0634
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Brugia malayi Major Facilitator Superfamily protein 0.0061 0.0167 0.0721
Plasmodium vivax lysine--tRNA ligase, putative 0.0096 0.0364 0.0358
Trichomonas vaginalis myo-inositol transporter, putative 0.0061 0.0167 0.0634
Loa Loa (eye worm) major facilitator superfamily transporter 0.0061 0.0167 0.0721
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0027 0.0026
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0429 0.1906
Brugia malayi beta-lactamase 0.0036 0.0027 0.0094
Loa Loa (eye worm) hypothetical protein 0.0105 0.0414 0.1835
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Schistosoma mansoni sugar transporter 0.0061 0.0167 0.0198
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.11 0.1363
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Trichomonas vaginalis sugar transporter, putative 0.0061 0.0167 0.0634
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0007 0.0008
Echinococcus granulosus synaptic vesicle 2 protein 0.0061 0.0167 0.0206
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.013 0.0549 0.0672
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0151 0.0668 1
Onchocerca volvulus 0.0061 0.0167 0.1305
Mycobacterium ulcerans sugar transporter 0.0061 0.0167 0.4131
Trypanosoma brucei glucose transporter 2A 0.0134 0.0573 0.8519
Trichomonas vaginalis sugar transporter, putative 0.0134 0.0573 0.2481
Leishmania major myo-inositol/proton symporter (MIT) 0.0061 0.0167 0.2175
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.013 0.0549 0.2442

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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