TDR Targets

Basic information

Technical information

TDR Targets ID: 737848
Name: 1-[1-(1-ethyl-3-methylpyrazol-4-yl)ethyl]-3-( 3-nitrophenyl)thiourea
MW: 333.409 | Formula: C15H19N5O2S
H donors: 2 H acceptors: 3 LogP: 2.26 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCn1nc(c(c1)C(NC(=S)Nc1cccc(c1)[N+](=O)[O-])C)C
InChi: 1S/C15H19N5O2S/c1-4-19-9-14(11(3)18-19)10(2)16-15(23)17-12-6-5-7-13(8-12)20(21)22/h5-10H,4H2,1-3H3,(H2,16,17,23)
InChiKey: XZDUKSHHCKAMIC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[1-(1-ethyl-3-methyl-pyrazol-4-yl)ethyl]-3-(3-nitrophenyl)thiourea
1-[1-(1-ethyl-3-methyl-4-pyrazolyl)ethyl]-3-(3-nitrophenyl)thiourea
CBKinase1_006711
CBKinase1_019111
IVK/1636731

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.0236	0.0297
Brugia malayi	hypothetical protein	0.0062	0.0181	0.0786
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0134	0.0578	0.0746
Trypanosoma cruzi	hexose transporter	0.0136	0.0587	0.8508
Giardia lamblia	Lysyl-tRNA synthetase	0.0098	0.0379	0.5182
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Trichomonas vaginalis	conserved hypothetical protein	0.0136	0.0587	0.2465
Onchocerca volvulus		0.0062	0.0181	0.1573
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0098	0.0379	0.1516
Loa Loa (eye worm)	sugar transporter	0.0438	0.2238	1
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0131	0.0563	1
Schistosoma mansoni	hypothetical protein	0.0072	0.0236	0.0297
Plasmodium vivax	sugar transporter, putative	0.0062	0.0181	0.0176
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Onchocerca volvulus		0.0062	0.0181	0.1573
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.0257	0.1126
Treponema pallidum	prolyl-tRNA synthetase	0.0046	0.0099	0.5
Schistosoma mansoni	protein kinase	0.0134	0.0578	0.0739
Schistosoma mansoni	hypothetical protein	0.0035	0.0036	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.0136	0.0587	0.2465
Schistosoma mansoni	glucose transport protein	0.0438	0.2238	0.2886
Trichomonas vaginalis	sugar transporter, putative	0.0136	0.0587	0.2465
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0587	0.8508
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0153	0.0682	1
Echinococcus multilocularis	microtubule associated protein 2	0.1445	0.7739	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0708	0.3711	0.5615
Trichomonas vaginalis	sugar transporter, putative	0.0136	0.0587	0.2465
Onchocerca volvulus	Putative transporter	0.0062	0.0181	0.1573
Onchocerca volvulus		0.0062	0.0181	0.1573
Brugia malayi	beta-lactamase family protein	0.0037	0.0047	0.0184
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.0967	0.4306
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0062	0.0181	0.0227
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0587	0.8508
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0047	0.0184
Plasmodium falciparum	proline--tRNA ligase	0.0153	0.0682	0.051
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0708	0.3711	0.3595
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0438	0.2238	0.2886
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Brugia malayi	lysyl-tRNA synthetase	0.0098	0.0379	0.1672
Brugia malayi	hypothetical protein	0.0231	0.1106	0.4928
Schistosoma mansoni	hypothetical protein	0.0035	0.0036	0.0039
Trichomonas vaginalis	sugar transport protein, putative	0.0062	0.0181	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0438	0.2238	0.2891
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0131	0.0563	0.072
Trypanosoma cruzi	hexose transporter, putative	0.0136	0.0587	0.8508
Echinococcus granulosus	solute carrier family 22	0.0062	0.0181	0.0234
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0134	0.0578	0.2562
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0134	0.0578	0.0739
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0036	0.0039
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0587	0.8508
Schistosoma mansoni	hypothetical protein	0.0438	0.2238	0.2886
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0098	0.0379	1
Onchocerca volvulus		0.0047	0.0102	0.0862
Onchocerca volvulus		0.0234	0.1122	1
Onchocerca volvulus		0.0062	0.0181	0.1573
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0047	0.0184
Trypanosoma cruzi	hexose transporter, putative	0.0136	0.0587	0.8508
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.1122	0.4907
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0131	0.0563	0.0727
Schistosoma mansoni	serine/threonine protein kinase	0.0134	0.0578	0.0739
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0134	0.0578	0.0867
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0134	0.0578	0.0867
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0134	0.0578	0.0746
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0134	0.0578	0.0739
Schistosoma mansoni	sugar transporter	0.0062	0.0181	0.0227
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0134	0.0578	0.0746
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0708	0.3711	0.3708
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0153	0.0682	1
Trichomonas vaginalis	glucose transporter, putative	0.0062	0.0181	0.0614
Trypanosoma brucei	sugar transporter, putative	0.0062	0.0181	0.2118
Toxoplasma gondii	sugar transporter ST3	0.0062	0.0181	0.0266
Toxoplasma gondii	sugar transporter ST2	0.0062	0.0181	0.0266
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Echinococcus granulosus	calcium dependent protein kinase	0.0126	0.0532	0.0688
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0131	0.0563	0.072
Leishmania major	glucose transporter, lmgt1	0.0136	0.0587	0.8508
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.0236	0.0297
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0131	0.0563	0.2495
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0036	0.0039
Brugia malayi	beta-lactamase family protein	0.0037	0.0047	0.0184
Trichomonas vaginalis	conserved hypothetical protein	0.0438	0.2238	1
Onchocerca volvulus		0.0037	0.0047	0.0368
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0054	0.014	0.0599
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0036	0.0134
Plasmodium falciparum	hexose transporter	0.0438	0.2238	0.2094
Giardia lamblia	Prolyl-tRNA synthetase	0.0131	0.0563	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0047	0.0184
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0587	0.8508
Brugia malayi	major facilitator superfamily protein	0.0062	0.0181	0.0786
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0136	0.0587	0.8508
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0438	0.2238	0.2891
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0153	0.0682	1
Schistosoma mansoni	hypothetical protein	0.0075	0.0257	0.0325
Plasmodium falciparum	lysine--tRNA ligase	0.0098	0.0379	0.0201
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0134	0.0578	0.0746
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0181	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Onchocerca volvulus		0.0062	0.0181	0.1573
Brugia malayi	hypothetical protein	0.0062	0.0181	0.0786
Mycobacterium ulcerans	integral membrane transport protein	0.0062	0.0181	0.4048
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0136	0.0587	0.8508
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0181	0.0614
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Trichomonas vaginalis	myo-inositol transporter, putative	0.0062	0.0181	0.0614
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0062	0.0181	0.0786
Brugia malayi	Major Facilitator Superfamily protein	0.0062	0.0181	0.0786
Plasmodium vivax	lysine--tRNA ligase, putative	0.0098	0.0379	0.0373
Onchocerca volvulus		0.0062	0.0181	0.1573
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0047	0.0184
Schistosoma mansoni	hypothetical protein	0.0047	0.0102	0.0124
Brugia malayi	Major Facilitator Superfamily protein	0.0062	0.0181	0.0786
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Onchocerca volvulus		0.0062	0.0181	0.1573
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0587	0.8508
Schistosoma mansoni	sugar transporter	0.0062	0.0181	0.0227
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.1106	0.1422
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.011	0.0448	0.1981
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0047	0.0053
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0428	0.1892
Brugia malayi	beta-lactamase	0.0037	0.0047	0.0184
Trichomonas vaginalis	sugar transporter, putative	0.0136	0.0587	0.2465
Leishmania major	myo-inositol/proton symporter (MIT)	0.0062	0.0181	0.2118
Trypanosoma brucei	glucose transporter 2A	0.0136	0.0587	0.8508
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0131	0.0563	0.2495
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0131	0.0563	0.072
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0153	0.0682	1
Onchocerca volvulus		0.0062	0.0181	0.1573
Mycobacterium ulcerans	sugar transporter	0.0062	0.0181	0.4048
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0006	0.0008
Echinococcus granulosus	synaptic vesicle 2 protein	0.0062	0.0181	0.0234
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0047	0.0053
Trichomonas vaginalis	CAMK family protein kinase	0.0134	0.0578	0.2422
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0438	0.2238	0.2886
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0134	0.0578	0.0572
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0062	0.0181	0.0786
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0083	0.0299	0.4877
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0083	0.0299	0.2311
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0062	0.0181	0.2118
Loa Loa (eye worm)	sugar transporter	0.0062	0.0181	0.0786
Toxoplasma gondii	ABC1 family protein	0.0037	0.0047	0.0062
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0134	0.0578	0.0404
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Entamoeba histolytica	protein kinase, putative	0.0134	0.0578	1
Leishmania major	hypothetical protein, conserved	0.0062	0.0181	0.2118
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0062	0.0181	0.0227
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0153	0.0682	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Echinococcus granulosus	GPCR family 2	0.0035	0.0036	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0257	0.1126
Schistosoma mansoni	sugar transporter	0.0062	0.0181	0.0227
Trypanosoma cruzi	hexose transporter, putative	0.0136	0.0587	0.8508
Entamoeba histolytica	protein kinase, putative	0.0134	0.0578	1
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Brugia malayi	Major Facilitator Superfamily protein	0.0062	0.0181	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0047	0.0184
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0036	0.0039
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0098	0.0379	0.5231
Toxoplasma gondii	lysine-tRNA ligase	0.0098	0.0379	0.0565
Brugia malayi	Calcitonin receptor-like protein seb-1	0.011	0.0448	0.1981
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0036	0.0134
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0046	0.0099	0.1552
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0134	0.0578	0.2562
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Brugia malayi	Cam kinase protein 1	0.0134	0.0578	0.2562
Schistosoma mansoni	lysyl-tRNA synthetase	0.0098	0.0379	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0563	0.2495
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0036	0.0046
Schistosoma mansoni	protein kinase	0.0134	0.0578	0.0739
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Brugia malayi	Sugar transporter family protein	0.0062	0.0181	0.0786
Trypanosoma cruzi	glucose transporter, putative	0.0062	0.0181	0.2118
Echinococcus granulosus	solute carrier family 22	0.0062	0.0181	0.0234
Echinococcus multilocularis	lysyl tRNA synthetase	0.0098	0.0379	0.0483
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0153	0.0682	0.1024
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0134	0.0578	0.0867
Schistosoma mansoni	microtubule-associated protein tau	0.1445	0.7739	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0134	0.0578	0.0404
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0047	0.0041
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0236	0.1136	1
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0587	0.8508
Plasmodium falciparum	protein kinase 7	0.1237	0.6605	0.6542
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0181	0.0227
Plasmodium vivax	hexose transporter	0.0438	0.2238	0.2233
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0438	0.2238	0.2891
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0036	0.0134
Trypanosoma cruzi	hexose transporter, putative	0.0074	0.0251	0.3208
Loa Loa (eye worm)	hypothetical protein	0.011	0.0448	0.1981
Onchocerca volvulus		0.0062	0.0181	0.1573
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0047	0.0184
Brugia malayi	hypothetical protein	0.0072	0.0236	0.103
Entamoeba histolytica	hypothetical protein	0.0098	0.0379	0.419
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0047	0.0061
Schistosoma mansoni	glucose transport protein	0.0438	0.2238	0.2886
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0098	0.0379	0.5231
Brugia malayi	hypothetical protein	0.0062	0.0181	0.0786
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0062	0.0181	0.4048
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0231	0.1106	0.4928
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0062	0.0181	0.0227
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0134	0.0578	0.0404
Leishmania major	lysyl-tRNA synthetase, putative	0.0098	0.0379	0.5231
Echinococcus multilocularis	calcium dependent protein kinase	0.0126	0.0532	0.0681
Echinococcus granulosus	lysyl tRNA synthetase	0.0098	0.0379	0.049
Brugia malayi	Pre-SET motif family protein	0.0205	0.0967	0.4306
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0047	0.0053
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.1106	0.1429
Trichomonas vaginalis	glucose transporter, putative	0.0136	0.0587	0.2465
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0083	0.0299	0.2311
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0181	0.0614
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0438	0.2238	0.2886
Schistosoma mansoni	protein kinase	0.0134	0.0578	0.0739
Toxoplasma gondii	sugar transporter ST1	0.0062	0.0181	0.0266
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0181	0.0614
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Brugia malayi	Sugar transporter family protein	0.0062	0.0181	0.0786
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0587	0.8508
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Schistosoma mansoni	lysyl-tRNA synthetase	0.0098	0.0379	0.0483
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0134	0.0578	0.0404
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0136	0.0587	0.8508
Plasmodium vivax	proline--tRNA ligase, putative	0.0153	0.0682	0.0676
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0062	0.0181	0.4048
Echinococcus granulosus	microtubule associated protein 2	0.1445	0.7739	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0047	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0047	0.0184
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0134	0.0578	0.0572
Onchocerca volvulus		0.0062	0.0181	0.1573
Echinococcus granulosus	solute carrier family 22	0.0062	0.0181	0.0234
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0136	0.0587	0.8508
Schistosoma mansoni	glucose transporter	0.0062	0.0181	0.0227
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0134	0.0578	0.0739
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0134	0.0578	0.0572
Schistosoma mansoni	glucose transport protein	0.0438	0.2238	0.2886
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0036	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0036	0.0134
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Onchocerca volvulus		0.0062	0.0181	0.1573
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0181	0.0227
Schistosoma mansoni	hypothetical protein	0.0035	0.0036	0.0039
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.0236	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Toxoplasma gondii	protein kinase, putative	0.1237	0.6605	1
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0181	0.0614
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0098	0.0379	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0438	0.2238	0.2891
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Echinococcus granulosus	solute carrier family 22	0.0062	0.0181	0.0234
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0062	0.0181	0.0234
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0134	0.0578	0.0404
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0098	0.0379	0.6437
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0062	0.0181	0.5
Brugia malayi	Sugar transporter family protein	0.0438	0.2238	1
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0102	0.0124
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1859	1	1
Echinococcus granulosus	General substrate transporter	0.0376	0.1901	0.2457
Brugia malayi	major facilitator superfamily protein	0.0062	0.0181	0.0786
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0062	0.0181	0.1235
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0181	0.0227
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0438	0.2238	0.2886
Trichomonas vaginalis	glucose transporter, putative	0.0136	0.0587	0.2465
Onchocerca volvulus		0.0037	0.0047	0.0368
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0134	0.0578	0.2562
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0131	0.0563	0.2355
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0587	0.8508
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.011	0.0448	0.1981
Schistosoma mansoni	sugar transporter	0.0062	0.0181	0.0227
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0181	0.0227
Trypanosoma brucei	glucose transporter 1E	0.0136	0.0587	0.8508
Leishmania major	glucose transporter, lmgt2	0.0136	0.0587	0.8508
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Onchocerca volvulus		0.0037	0.0047	0.0368
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0102	0.0431
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0062	0.0181	0.1235
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0086	0.0313	0.1215
Leishmania major	glucose transporter, lmgt3	0.0136	0.0587	0.8508
Onchocerca volvulus		0.0062	0.0181	0.1573
Trypanosoma cruzi	hexose transporter, putative	0.0062	0.0181	0.2118
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0131	0.0563	0.9566
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Schistosoma mansoni	hypothetical protein	0.0035	0.0036	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0379	0.1672
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Toxoplasma gondii	transporter, major facilitator family protein	0.0062	0.0181	0.0266
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0134	0.0578	0.0572
Onchocerca volvulus		0.0062	0.0181	0.1573
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0181	0.0786
Trypanosoma cruzi	sugar transporter, putative	0.0062	0.0181	0.2118
Leishmania major	protein kinase, putative	0.0134	0.0578	0.836
Toxoplasma gondii	facilitative glucose transporter GT1	0.0438	0.2238	0.3382
Onchocerca volvulus		0.0062	0.0181	0.1573
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0181	0.0614
Chlamydia trachomatis	lysine--tRNA ligase	0.0098	0.0379	1
Echinococcus multilocularis	General substrate transporter	0.0376	0.1901	0.2451
Onchocerca volvulus		0.0062	0.0181	0.1573
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0134	0.0578	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0578	0.2562
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0134	0.0578	0.836
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0563	0.2495
Onchocerca volvulus		0.0062	0.0181	0.1573
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0047	0.0184

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 737848