Detailed information for compound 739524

Basic information

Technical information
  • TDR Targets ID: 739524
  • Name: N-(4-chlorophenyl)-2-[4-(furan-2-carbonyl)pip erazin-1-yl]acetamide
  • MW: 347.796 | Formula: C17H18ClN3O3
  • H donors: 1 H acceptors: 2 LogP: 2.12 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Cl)CN1CCN(CC1)C(=O)c1ccco1
  • InChi: 1S/C17H18ClN3O3/c18-13-3-5-14(6-4-13)19-16(22)12-20-7-9-21(10-8-20)17(23)15-2-1-11-24-15/h1-6,11H,7-10,12H2,(H,19,22)
  • InChiKey: ULMUDHWUBXYOEX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-chlorophenyl)-2-[4-(2-furyl-oxomethyl)-1-piperazinyl]acetamide
  • N-(4-chlorophenyl)-2-(4-furan-2-ylcarbonylpiperazin-1-yl)ethanamide
  • IVK/0023767

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0522 0.3077
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0522 0.3623
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.003 0.5
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0114 0.052
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0969 0.1549
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0114 0.0188
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2184 0.3611
Loa Loa (eye worm) hypothetical protein 0.0012 0.0067 0.0048
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0039 0.0092
Echinococcus granulosus solute carrier family 22 0.0014 0.0114 0.0188
Leishmania major protein kinase, putative 0.0031 0.0512 0.3006
Plasmodium vivax vivapain-2 0.0018 0.0212 0.0212
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0212 0.1707
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2184 0.3611
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0212 0.0288
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0039 0.0064
Onchocerca volvulus Putative transporter 0.0014 0.0114 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0039 0.0064
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0498 0.9709
Trypanosoma brucei glucose transporter, putative 0.0032 0.0522 0.3623
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0617 0.0617
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0969 0.1603
Brugia malayi Sugar transporter family protein 0.0102 0.2184 0.3611
Trypanosoma brucei glucose transporter 1E 0.0032 0.0522 0.3623
Trypanosoma cruzi hexose transporter 0.0032 0.0522 0.3623
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0522 0.239
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0212 0.0742
Echinococcus multilocularis survival motor neuron protein 1 0.0265 0.6048 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1441 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trypanosoma brucei glucose transporter, putative 0.0032 0.0522 0.3623
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0114 0.0188
Schistosoma mansoni coup transcription factor 0.0011 0.0039 0.0092
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0313 1
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0193 0.0319
Leishmania major cathepsin L-like protease 0.0018 0.0212 0.0742
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0231 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0039 0.0092
Brugia malayi Cathepsin L-like precursor 0.0018 0.0212 0.0351
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0522 0.239
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0498 0.1185
Brugia malayi major facilitator superfamily protein 0.0014 0.0114 0.0188
Loa Loa (eye worm) hypothetical protein 0.0025 0.0362 0.0538
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.1441 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0513 0.0513
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0114 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2184 1
Onchocerca volvulus 0.0014 0.0114 0.0737
Schistosoma mansoni hypothetical protein 0.0102 0.2184 0.52
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0212 0.0351
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0067 0.0161
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0467 0.0772
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.1054 0.1743
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0522 0.3623
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0039 0.0064
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0067 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0512 0.122
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0212 0.1707
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0969 0.1603
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0212 0.0971
Loa Loa (eye worm) sugar transporter 0.0102 0.2184 0.357
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0039 0.0064
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0512 0.3557
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0498 0.0823
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0212 0.0971
Plasmodium vivax vivapain-2 0.0018 0.0212 0.0212
Entamoeba histolytica protein kinase, putative 0.0031 0.0512 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0617 0.4285
Loa Loa (eye worm) hypothetical protein 0.0031 0.0498 0.0764
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0039 0.0064
Brugia malayi ecdysteroid receptor 0.0011 0.0039 0.0064
Echinococcus multilocularis solute carrier family 22 0.0014 0.0114 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0039 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0969 0.2308
Schistosoma mansoni hypothetical protein 0.0038 0.0679 0.1616
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0165 0.3668 0.5495
Plasmodium falciparum protein kinase 7 0.0288 0.6582 0.6582
Schistosoma mansoni hypothetical protein 0.0187 0.42 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1441 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0039 0.0092
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.1097 0.1814
Brugia malayi nuclear receptor NHR-88 0.0011 0.0039 0.0064
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0114 0.0114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1441 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0212 0.0971
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0114 0.0788
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0212 0.0971
Onchocerca volvulus 0.0014 0.0114 0.0737
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1441 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0969 0.1603
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2184 0.3611
Schistosoma mansoni hypothetical protein 0.0187 0.42 1
Onchocerca volvulus 0.0014 0.0114 0.0737
Leishmania major cathepsin L-like protease 0.007 0.1441 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0212 0.0212
Entamoeba histolytica cysteine protease, putative 0.0018 0.0212 0.4137
Echinococcus granulosus cathepsin l1 0.0018 0.0212 0.0351
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0114 0.052
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0512 0.0847
Echinococcus granulosus General substrate transporter 0.0088 0.1845 0.3051
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0114 0.052
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0212 0.0351
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Onchocerca volvulus 0.0014 0.0114 0.0737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Onchocerca volvulus 0.0018 0.0212 0.1707
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0039 0.0064
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0114 0.052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0969 0.1603
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0522 0.3623
Plasmodium falciparum mitogen-activated protein kinase 2 0.0165 0.3668 0.3668
Loa Loa (eye worm) hypothetical protein 0.0012 0.0067 0.0048
Toxoplasma gondii cathepsin CPL 0.0018 0.0212 0.0152
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0114 0.2954
Echinococcus granulosus cathepsin l1 0.0012 0.0067 0.0112
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0193 0.0319
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0313 0.0517
Leishmania major glucose transporter, lmgt3 0.0032 0.0522 0.3077
Schistosoma mansoni glucose transport protein 0.0102 0.2184 0.52
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0617 0.3796
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0039 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0039 0.0064
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0513 0.0617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0513 0.0617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Trypanosoma brucei glucose transporter, putative 0.0032 0.0522 0.3623
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0039 0.0064
Trypanosoma brucei glucose transporter, putative 0.0032 0.0522 0.3623
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0039 0.0064
Leishmania major cathepsin L-like protease 0.0018 0.0212 0.0742
Loa Loa (eye worm) hypothetical protein 0.0018 0.0193 0.0257
Onchocerca volvulus 0.0018 0.0212 0.1707
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Schistosoma mansoni hypothetical protein 0.0018 0.0193 0.046
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0313 0.0744
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1441 1
Schistosoma mansoni hypothetical protein 0.0018 0.0193 0.046
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0039 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0969 0.2308
Echinococcus multilocularis solute carrier family 22 0.0014 0.0114 0.0188
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0114 0.2954
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0498 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0212 0.0351
Trypanosoma brucei glucose transporter, putative 0.0032 0.0522 0.3623
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0498 0.0823
Onchocerca volvulus 0.0014 0.0114 0.0737
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0114 0.0788
Brugia malayi nuclear hormone receptor 0.0011 0.0039 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Schistosoma mansoni protein kinase 0.0031 0.0512 0.122
Loa Loa (eye worm) hypothetical protein 0.0031 0.0512 0.0788
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0039 0.0092
Onchocerca volvulus 0.0012 0.0067 0.0283
Brugia malayi hypothetical protein 0.0014 0.0114 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0039 0.0064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0522 0.239
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0039 0.0092
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0522 0.3623
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0246 0.1127
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0039 0.0064
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0039 0.0064
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0513 0.0617
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0513 0.0513
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0212 0.0351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1441 1
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0114 0.0788
Entamoeba histolytica protein kinase, putative 0.0031 0.0512 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.1097 0.1814
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1441 1
Echinococcus granulosus solute carrier family 22 0.0014 0.0114 0.0188
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2184 0.3611
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0313 0.0517
Onchocerca volvulus 0.0014 0.0114 0.0737
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0313 0.0744
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0193 0.0319
Loa Loa (eye worm) hypothetical protein 0.0031 0.0498 0.0764
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0512 0.0847
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0617 0.0779
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0212 0.0351
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0193 0.0257
Brugia malayi Cathepsin L-like precursor 0.0018 0.0212 0.0351
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.1296 0.8997
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0193 0.0319
Brugia malayi Cathepsin L-like precursor 0.0018 0.0212 0.0351
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0498 0.0823
Brugia malayi hypothetical protein 0.0014 0.0114 0.0188
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0313 0.2169
Onchocerca volvulus 0.0014 0.0114 0.0737
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0039 0.0064
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0114 0.0788
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0212 0.0971
Onchocerca volvulus 0.0014 0.0114 0.0737
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.1097 0.1762
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0313 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0039 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0193 0.0319
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0212 0.0971
Leishmania major cathepsin L-like protease 0.007 0.1441 1
Echinococcus granulosus GPCR family 2 0.0018 0.0193 0.0319
Schistosoma mansoni protein kinase 0.0031 0.0512 0.122
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0114 0.0188
Onchocerca volvulus 0.0014 0.0114 0.0737
Onchocerca volvulus 0.0014 0.0114 0.0737
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0114 0.027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0039 0.0064
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0513 0.0513
Schistosoma mansoni survival motor neuron protein 0.0054 0.1054 0.251
Onchocerca volvulus 0.0018 0.0212 0.1707
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0969 0.1603
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0513 0.0513
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0212 0.0505
Loa Loa (eye worm) sugar transporter 0.0014 0.0114 0.0125
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0039 0.0064
Brugia malayi Cathepsin L-like precursor 0.0012 0.0067 0.0112
Brugia malayi Sugar transporter family protein 0.0014 0.0114 0.0188
Schistosoma mansoni hypothetical protein 0.0018 0.0193 0.046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1441 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0512 0.0847
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0212 0.0351
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0212 0.1707
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0313 0.5182
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0212 0.0971
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0313 0.0517
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0039 0.0092
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0212 0.0351
Echinococcus multilocularis General substrate transporter 0.0088 0.1845 0.3051
Onchocerca volvulus 0.0014 0.0114 0.0737
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trypanosoma brucei glucose transporter, putative 0.0032 0.0522 0.3623
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0114 0.052
Brugia malayi major facilitator superfamily protein 0.0014 0.0114 0.0188
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0039 0.0064
Schistosoma mansoni protein kinase 0.0031 0.0512 0.122
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0512 0.0847
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0512 0.0847
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1441 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1441 1
Schistosoma mansoni hypothetical protein 0.0054 0.1054 0.251
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0512 0.0847
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0114 0.052
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Schistosoma mansoni glucose transport protein 0.0102 0.2184 0.52
Echinococcus multilocularis cysteine protease 0.0018 0.0212 0.0351
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0617 0.0617
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Trypanosoma brucei sugar transporter, putative 0.0014 0.0114 0.0788
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0039 0.0092
Loa Loa (eye worm) hypothetical protein 0.0038 0.0679 0.1065
Schistosoma mansoni sugar transporter 0.0014 0.0114 0.027
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0313 0.3046
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0512 0.0788
Schistosoma mansoni hypothetical protein 0.0018 0.0193 0.046
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.1441 1
Leishmania major glucose transporter, lmgt2 0.0032 0.0522 0.3077
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.1441 1
Loa Loa (eye worm) cysteine protease 0.0018 0.0212 0.0288
Echinococcus granulosus solute carrier family 22 0.0014 0.0114 0.0188
Echinococcus granulosus survival motor neuron protein 1 0.0265 0.6048 1
Schistosoma mansoni glucose transporter 0.0014 0.0114 0.027
Onchocerca volvulus 0.0014 0.0114 0.0737
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0617 0.3796
Schistosoma mansoni sugar transporter 0.0014 0.0114 0.027
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0313 0.1431
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0039 0.0092
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0212 0.0505
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0512 0.0847
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0212 0.4137
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0039 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0039 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.1441 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Toxoplasma gondii protein kinase, putative 0.0288 0.6582 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0522 0.239
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0114 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0212 0.0971
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0183 0.1271
Plasmodium falciparum hexose transporter 0.0102 0.2184 0.2184
Brugia malayi hypothetical protein 0.0265 0.6048 1
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0679 0.1122
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0522 0.3623
Echinococcus multilocularis geminin 0.0187 0.42 0.6944
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0212 0.0351
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0313 0.1499
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0513 0.0513
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0114 0.2954
Plasmodium vivax hexose transporter 0.0102 0.2184 0.2184
Echinococcus multilocularis solute carrier family 22 0.0014 0.0114 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0212 0.0971
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0498 0.2278
Loa Loa (eye worm) hypothetical protein 0.0012 0.0067 0.0048
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0039 0.0064
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0498 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0512 0.0788
Brugia malayi Sugar transporter family protein 0.0014 0.0114 0.0188
Schistosoma mansoni sugar transporter 0.0014 0.0114 0.027
Echinococcus multilocularis GPCR, family 2 0.0018 0.0193 0.0319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0067 0.0309
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0513 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0114 0.052
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0212 0.0971
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2184 0.3611
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0071 0.0055
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0522 0.3623
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0513 0.0513
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0039 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0512 0.2347
Brugia malayi steroid hormone receptor 0.0011 0.0039 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0969 0.2308
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0039 0.0064
Echinococcus multilocularis cysteine protease 0.0018 0.0212 0.0351
Onchocerca volvulus 0.0018 0.0212 0.1707
Loa Loa (eye worm) hypothetical protein 0.0023 0.0313 0.0456
Leishmania major cathepsin L-like protease 0.007 0.1441 1
Entamoeba histolytica hypothetical protein 0.0023 0.0313 0.6098
Onchocerca volvulus 0.0014 0.0114 0.0737
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.1441 1
Plasmodium vivax sugar transporter, putative 0.0014 0.0114 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0512 0.0847
Onchocerca volvulus 0.0054 0.1054 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0114 0.0125
Onchocerca volvulus 0.0018 0.0212 0.1707
Mycobacterium ulcerans sugar transporter 0.0014 0.0114 0.2954
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0512 0.0847
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0212 0.4137
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0193 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0067 0.1316
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0513 0.0513
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0039 0.0092
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0039 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0522 0.239
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0313 0.2169
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0039 0.0092
Onchocerca volvulus 0.0018 0.0212 0.1707
Onchocerca volvulus 0.0014 0.0114 0.0737
Brugia malayi Cathepsin L-like precursor 0.0018 0.0212 0.0351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2184 0.3201
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0114 0.0125
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trypanosoma brucei glucose transporter, putative 0.0032 0.0522 0.3623
Onchocerca volvulus 0.0018 0.0212 0.1707
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0039 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0039 0.0064
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0039 0.0092
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2184 0.3611
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0498 0.0823
Leishmania major glucose transporter, lmgt1 0.0032 0.0522 0.3077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0513 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0522 0.239
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0522 0.239
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0313 0.0313
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0114 0.0125
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0039 0.0064
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0313 0.0308
Onchocerca volvulus 0.0014 0.0114 0.0737
Echinococcus multilocularis solute carrier family 22 0.0014 0.0114 0.0188
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0617 0.4285
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trypanosoma brucei glucose transporter 2A 0.0032 0.0522 0.3623
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0617 0.4285
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.1084 0.7525
Brugia malayi cathepsin L-like precursor 0.0012 0.0067 0.0112
Leishmania major cathepsin L-like protease 0.0018 0.0212 0.0742
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0231 1
Brugia malayi hypothetical protein 0.0014 0.0114 0.0188
Schistosoma mansoni glucose transport protein 0.0102 0.2184 0.52
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0114 0.5
Leishmania major cathepsin L-like protease 0.0018 0.0212 0.0742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Brugia malayi Cathepsin L-like precursor 0.0012 0.0067 0.0112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0114 0.0188
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Onchocerca volvulus 0.0014 0.0114 0.0737
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0313 1
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0467 0.0772
Loa Loa (eye worm) fibroinase 0.0018 0.0212 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0039 0.0064
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0039 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Loa Loa (eye worm) hypothetical protein 0.0265 0.6048 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0212 0.0971
Brugia malayi Cam kinase protein 1 0.0031 0.0512 0.0847
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0039 0.0064
Schistosoma mansoni sugar transporter 0.0014 0.0114 0.027
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0114 0.052
Echinococcus granulosus geminin 0.0187 0.42 0.6944
Echinococcus granulosus solute carrier family 22 0.0014 0.0114 0.0188
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0212 0.1472
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0212 0.0212
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0039 0.0064
Leishmania major cathepsin L-like protease 0.0018 0.0212 0.0742
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0212 0.0288
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0212 0.0212
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0498 0.1185
Trypanosoma brucei glucose transporter, putative 0.0032 0.0522 0.3623
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0039 0.0064
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0114 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0039 0.0064
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0165 0.3668 0.3668
Brugia malayi Cathepsin L-like precursor 0.0018 0.0212 0.0351
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2184 0.3611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0067 0.0309
Loa Loa (eye worm) hypothetical protein 0.0018 0.0212 0.0288
Loa Loa (eye worm) ctsf protein 0.0018 0.0212 0.0288
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0313 0.0313
Plasmodium vivax CDK-related protein kinase 6, putative 0.0432 1 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0114 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0212 0.0971
Loa Loa (eye worm) hypothetical protein 0.0056 0.1097 0.1762
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2184 0.3611

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.